Affiliation: The University of Texas
Lee W, Ko S, Mohamed M, Kenny H, Lengyel E, Naora H. Neutrophils facilitate ovarian cancer premetastatic niche formation in the omentum. J Exp Med. 2018;: pubmed publisher
..Our findings implicate NET formation in rendering the premetastatic omental niche conducive for implantation of ovarian cancer cells and raise the possibility that blockade of NET formation prevents omental metastasis. ..
Usui A, Ko S, Barengo N, Naora H. P-cadherin promotes ovarian cancer dissemination through tumor cell aggregation and tumor-peritoneum interactions. Mol Cancer Res. 2014;12:504-13 pubmed publisher
..Inhibiting P-cadherin blocks multiple key steps of EOC progression and has therapeutic potential. ..
Naora H. Developmental patterning in the wrong context: the paradox of epithelial ovarian cancers. Cell Cycle. 2005;4:1033-5 pubmed
..This article discusses recent studies that implicate aberrant activation of embryonic pathways in ovarian cancer histogenesis, and highlights the intimate relationship between developmental plasticity and neoplasia. ..
Trinh B, Barengo N, Kim S, Lee J, Zweidler McKay P, Naora H. The homeobox gene DLX4 regulates erythro-megakaryocytic differentiation by stimulating IL-1Î² and NF-ÎºB signaling. J Cell Sci. 2015;128:3055-67 pubmed publisher
..Collectively, our findings indicate that DLX4 exerts opposing effects on the megakaryocytic and erythroid lineages in part by inducing IL-1Î² and NF-ÎºB signaling. ..
Trinh B, Ko S, Haria D, Barengo N, Naora H. The homeoprotein DLX4 controls inducible nitric oxide synthase-mediated angiogenesis in ovarian cancer. Mol Cancer. 2015;14:97 pubmed publisher
..These findings indicate that DLX4 promotes ovarian tumor angiogenesis in part by stimulating iNOS expression. ..
Ko S, Ladanyi A, Lengyel E, Naora H. Expression of the homeobox gene HOXA9 in ovarian cancer induces peritoneal macrophages to acquire an M2 tumor-promoting phenotype. Am J Pathol. 2014;184:271-81 pubmed publisher
..HOXA9 may, therefore, stimulate ovarian cancer progression by promoting an immunosuppressive microenvironment via paracrine effects on peritoneal macrophages. ..
Ko S, Naora H. HOXA9 promotes homotypic and heterotypic cell interactions that facilitate ovarian cancer dissemination via its induction of P-cadherin. Mol Cancer. 2014;13:170 pubmed publisher
..These findings indicate that HOXA9 contributes to poor outcomes in EOC in part by promoting intraperitoneal dissemination via its induction of P-cadherin. ..
Haria D, Trinh B, Ko S, Barengo N, Liu J, Naora H. The homeoprotein DLX4 stimulates NF-?B activation and CD44-mediated tumor-mesothelial cell interactions in ovarian cancer. Am J Pathol. 2015;185:2298-308 pubmed publisher
..Collectively, these findings indicate that DLX4 induces CD44 by stimulating IL-1?-mediated NF-?B activity, thereby promoting peritoneal metastasis of ovarian cancer. ..