Affiliation: The Ohio State University
- Siomycin A targets brain tumor stem cells partially through a MELK-mediated pathwayIchiro Nakano
Department of Neurological Surgery, James Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA
Neuro Oncol 13:622-34. 2011..Together, this study may be the first model to partially target stemlike GBM cells through a MELK-mediated pathway with siomycin A to pave the way for effective treatment of GBM...
- Telomestatin impairs glioma stem cell survival and growth through the disruption of telomeric G-quadruplex and inhibition of the proto-oncogene, c-MybTakeshi Miyazaki
Department of Neurological Surgery, Dardinger, Center for Neuro Oncology, James Cancer Hospital and The Ohio State University, Columbus, Ohio 43210, USA
Clin Cancer Res 18:1268-80. 2012..Glioma stem cells (GSC) are a critical therapeutic target of glioblastoma multiforme (GBM)...
- Tumor-specific activation of the C-JUN/MELK pathway regulates glioma stem cell growth in a p53-dependent mannerChunyu Gu
Department of Neurological Surgery, The Ohio State University, Columbus, Ohio, USA
Stem Cells 31:870-81. 2013..Together, our data indicate that GSCs, but not normal cells, depend on JNK-driven MELK/c-JUN signaling to regulate their survival, maintain GSCs in an immature state, and facilitate tumor radioresistance in a p53-dependent manner...
- Impairment of glioma stem cell survival and growth by a novel inhibitor for Survivin-Ran protein complexHacer Güvenç
Department of Neurological Surgery, The Ohio State University, Columbus, OH 43210, USA
Clin Cancer Res 19:631-42. 2013..Glioblastoma multiforme (GBM) is a devastating disease. Recent studies suggest that the stem cell properties of GBM contribute to the development of therapy resistance...
- Mesenchymal glioma stem cells are maintained by activated glycolytic metabolism involving aldehyde dehydrogenase 1A3Ping Mao
Department of Neurological Surgery and James Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210
Proc Natl Acad Sci U S A 110:8644-9. 2013..Inhibition of ALDH1A3-mediated pathways therefore might provide a promising therapeutic approach for a subset of HGGs with the Mes signature...
- MELK-dependent FOXM1 phosphorylation is essential for proliferation of glioma stem cellsKaushal Joshi
Department of Neurological Surgery, The James Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA
Stem Cells 31:1051-63. 2013..Collectively, our data indicate that FOXM1 signaling through its direct interaction with MELK regulates key mitotic genes in GSCs in a PLK1-dependent manner and thus, this protein complex is a potential therapeutic target for GBM...
- Suppression of peroxiredoxin 4 in glioblastoma cells increases apoptosis and reduces tumor growthTae Hyong Kim
Dardinger Center for Neuro oncology and Neurosciences, Department of Neurological Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA
PLoS ONE 7:e42818. 2012..In a syngenic orthotopic transplantation model, Prdx4 knockdown limited GBM infiltration and significantly prolonged mouse survival. These data suggest that PRDX4 can be a novel target for GBM therapies in the future...
- CD44v6 regulates growth of brain tumor stem cells partially through the AKT-mediated pathwayMayumi Jijiwa
Department of Neurological Surgery, The Ohio State University, Columbus, Ohio, United States of America
PLoS ONE 6:e24217. 2011..Collectively, these data indicate that a subset of GBM expresses high CD44 in BTSC, and its growth may depend on CD44v6/AKT pathway...
- BMPing off glioma stem cellsIchiro Nakano
Department of Neurological Surgery, University of California, Los Angeles, School of Medicine, Los Angeles, CA 90095, USA
Cancer Cell 13:3-4. 2008..These findings document the importance of the BMP signaling system in BTSC as well as that of taking heterogeneity into account when studying BTSC as potential targets for therapy...
- [Cancer stem cells in malignant glioma-the mechanism of cancer initiation and the therapeutic development]Ichiro Nakano
Department of Neurological Surgery, The Ohio State University, Ohio, USA Ichiro Nakano osumc edu
No Shinkei Geka 38:879-89. 2010..In this study, we summarize the recent findings and approaches in the cancer stem cell field, mainly focusing on malignant glioma stem cells, and also describe potential future directions in this area...