Ichiro Nakano

Summary

Affiliation: The Ohio State University
Country: USA

Publications

  1. pmc Siomycin A targets brain tumor stem cells partially through a MELK-mediated pathway
    Ichiro Nakano
    Department of Neurological Surgery, James Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA
    Neuro Oncol 13:622-34. 2011
  2. doi request reprint Telomestatin impairs glioma stem cell survival and growth through the disruption of telomeric G-quadruplex and inhibition of the proto-oncogene, c-Myb
    Takeshi Miyazaki
    Department of Neurological Surgery, Dardinger, Center for Neuro Oncology, James Cancer Hospital and The Ohio State University, Columbus, Ohio 43210, USA
    Clin Cancer Res 18:1268-80. 2012
  3. doi request reprint Tumor-specific activation of the C-JUN/MELK pathway regulates glioma stem cell growth in a p53-dependent manner
    Chunyu Gu
    Department of Neurological Surgery, The Ohio State University, Columbus, Ohio, USA
    Stem Cells 31:870-81. 2013
  4. doi request reprint Impairment of glioma stem cell survival and growth by a novel inhibitor for Survivin-Ran protein complex
    Hacer Güvenç
    Department of Neurological Surgery, The Ohio State University, Columbus, OH 43210, USA
    Clin Cancer Res 19:631-42. 2013
  5. pmc Mesenchymal glioma stem cells are maintained by activated glycolytic metabolism involving aldehyde dehydrogenase 1A3
    Ping Mao
    Department of Neurological Surgery and James Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210
    Proc Natl Acad Sci U S A 110:8644-9. 2013
  6. pmc MELK-dependent FOXM1 phosphorylation is essential for proliferation of glioma stem cells
    Kaushal Joshi
    Department of Neurological Surgery, The James Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA
    Stem Cells 31:1051-63. 2013
  7. pmc Suppression of peroxiredoxin 4 in glioblastoma cells increases apoptosis and reduces tumor growth
    Tae Hyong Kim
    Dardinger Center for Neuro oncology and Neurosciences, Department of Neurological Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA
    PLoS ONE 7:e42818. 2012
  8. pmc CD44v6 regulates growth of brain tumor stem cells partially through the AKT-mediated pathway
    Mayumi Jijiwa
    Department of Neurological Surgery, The Ohio State University, Columbus, Ohio, United States of America
    PLoS ONE 6:e24217. 2011
  9. doi request reprint BMPing off glioma stem cells
    Ichiro Nakano
    Department of Neurological Surgery, University of California, Los Angeles, School of Medicine, Los Angeles, CA 90095, USA
    Cancer Cell 13:3-4. 2008
  10. ncbi request reprint [Cancer stem cells in malignant glioma-the mechanism of cancer initiation and the therapeutic development]
    Ichiro Nakano
    Department of Neurological Surgery, The Ohio State University, Ohio, USA Ichiro Nakano osumc edu
    No Shinkei Geka 38:879-89. 2010

Collaborators

  • Harley I Kornblum
  • Ping Mao
  • Robert W Sobol
  • Bo Hu
  • Maode Wang
  • Monique Beullens
  • Hiroyuki Seimiya
  • Kazuo Shin-ya
  • Takeshi Miyazaki
  • Kaushal Joshi
  • Habibe Kurt
  • Chunyu Gu
  • Yeshavanth K Banasavadi-Siddegowda
  • Hacer Güvenç
  • Chang Hyuk Kwon
  • Snehalata Gupta
  • Tae Hyong Kim
  • Mayumi Jijiwa
  • Yuko Nakamura
  • Lionel M L Chow
  • Deepak Bhasin
  • Diana Nardini
  • Jann N Sarkaria
  • Christopher Hong
  • Ryosuke Yamada
  • Sung Hak Kim
  • Yeshavanth Banasavadi-Siddegowda
  • Ronald Waclaw
  • Somsundaram Chettiar
  • Marat S Pavlyukov
  • In Hee Park
  • Xiaokui Mo
  • Chenglong Li
  • Cenk Kig
  • Mihail I Shakhparonov
  • Gaspar Kitange
  • Ji Yeun Yi
  • Hong Wu
  • Kamalakannan Palanichamy
  • Sheila R Alcantara Llaguno
  • Jieun Song
  • Luis F Parada
  • Sung Ok Yoon
  • Eric Murnan
  • Sandya Liyanarachchi
  • Mariano Sebastian Viapiano
  • Crystal Leung
  • Ichiyo Shibahara
  • Jason A de Jesus
  • Habibe Demir
  • Paul S Mischel
  • Tiffany Huang
  • Soledad Fernandez
  • William H Yong
  • Nicholas Orozco
  • Vedat O Yildiz

Detail Information

Publications10

  1. pmc Siomycin A targets brain tumor stem cells partially through a MELK-mediated pathway
    Ichiro Nakano
    Department of Neurological Surgery, James Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA
    Neuro Oncol 13:622-34. 2011
    ..Together, this study may be the first model to partially target stemlike GBM cells through a MELK-mediated pathway with siomycin A to pave the way for effective treatment of GBM...
  2. doi request reprint Telomestatin impairs glioma stem cell survival and growth through the disruption of telomeric G-quadruplex and inhibition of the proto-oncogene, c-Myb
    Takeshi Miyazaki
    Department of Neurological Surgery, Dardinger, Center for Neuro Oncology, James Cancer Hospital and The Ohio State University, Columbus, Ohio 43210, USA
    Clin Cancer Res 18:1268-80. 2012
    ..Glioma stem cells (GSC) are a critical therapeutic target of glioblastoma multiforme (GBM)...
  3. doi request reprint Tumor-specific activation of the C-JUN/MELK pathway regulates glioma stem cell growth in a p53-dependent manner
    Chunyu Gu
    Department of Neurological Surgery, The Ohio State University, Columbus, Ohio, USA
    Stem Cells 31:870-81. 2013
    ..Together, our data indicate that GSCs, but not normal cells, depend on JNK-driven MELK/c-JUN signaling to regulate their survival, maintain GSCs in an immature state, and facilitate tumor radioresistance in a p53-dependent manner...
  4. doi request reprint Impairment of glioma stem cell survival and growth by a novel inhibitor for Survivin-Ran protein complex
    Hacer Güvenç
    Department of Neurological Surgery, The Ohio State University, Columbus, OH 43210, USA
    Clin Cancer Res 19:631-42. 2013
    ..Glioblastoma multiforme (GBM) is a devastating disease. Recent studies suggest that the stem cell properties of GBM contribute to the development of therapy resistance...
  5. pmc Mesenchymal glioma stem cells are maintained by activated glycolytic metabolism involving aldehyde dehydrogenase 1A3
    Ping Mao
    Department of Neurological Surgery and James Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210
    Proc Natl Acad Sci U S A 110:8644-9. 2013
    ..Inhibition of ALDH1A3-mediated pathways therefore might provide a promising therapeutic approach for a subset of HGGs with the Mes signature...
  6. pmc MELK-dependent FOXM1 phosphorylation is essential for proliferation of glioma stem cells
    Kaushal Joshi
    Department of Neurological Surgery, The James Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA
    Stem Cells 31:1051-63. 2013
    ..Collectively, our data indicate that FOXM1 signaling through its direct interaction with MELK regulates key mitotic genes in GSCs in a PLK1-dependent manner and thus, this protein complex is a potential therapeutic target for GBM...
  7. pmc Suppression of peroxiredoxin 4 in glioblastoma cells increases apoptosis and reduces tumor growth
    Tae Hyong Kim
    Dardinger Center for Neuro oncology and Neurosciences, Department of Neurological Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA
    PLoS ONE 7:e42818. 2012
    ..In a syngenic orthotopic transplantation model, Prdx4 knockdown limited GBM infiltration and significantly prolonged mouse survival. These data suggest that PRDX4 can be a novel target for GBM therapies in the future...
  8. pmc CD44v6 regulates growth of brain tumor stem cells partially through the AKT-mediated pathway
    Mayumi Jijiwa
    Department of Neurological Surgery, The Ohio State University, Columbus, Ohio, United States of America
    PLoS ONE 6:e24217. 2011
    ..Collectively, these data indicate that a subset of GBM expresses high CD44 in BTSC, and its growth may depend on CD44v6/AKT pathway...
  9. doi request reprint BMPing off glioma stem cells
    Ichiro Nakano
    Department of Neurological Surgery, University of California, Los Angeles, School of Medicine, Los Angeles, CA 90095, USA
    Cancer Cell 13:3-4. 2008
    ..These findings document the importance of the BMP signaling system in BTSC as well as that of taking heterogeneity into account when studying BTSC as potential targets for therapy...
  10. ncbi request reprint [Cancer stem cells in malignant glioma-the mechanism of cancer initiation and the therapeutic development]
    Ichiro Nakano
    Department of Neurological Surgery, The Ohio State University, Ohio, USA Ichiro Nakano osumc edu
    No Shinkei Geka 38:879-89. 2010
    ..In this study, we summarize the recent findings and approaches in the cancer stem cell field, mainly focusing on malignant glioma stem cells, and also describe potential future directions in this area...