Ichiro Nakano

Summary

Affiliation: The Ohio State University
Country: USA

Publications

  1. pmc CD44v6 regulates growth of brain tumor stem cells partially through the AKT-mediated pathway
    Mayumi Jijiwa
    Department of Neurological Surgery, The Ohio State University, Columbus, Ohio, United States of America
    PLoS ONE 6:e24217. 2011
  2. pmc Siomycin A targets brain tumor stem cells partially through a MELK-mediated pathway
    Ichiro Nakano
    Department of Neurological Surgery, James Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA
    Neuro Oncol 13:622-34. 2011
  3. ncbi Tumor-specific activation of the C-JUN/MELK pathway regulates glioma stem cell growth in a p53-dependent manner
    Chunyu Gu
    Department of Neurological Surgery, The Ohio State University, Columbus, Ohio, USA
    Stem Cells 31:870-81. 2013
  4. pmc MELK-dependent FOXM1 phosphorylation is essential for proliferation of glioma stem cells
    Kaushal Joshi
    Department of Neurological Surgery, The James Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA
    Stem Cells 31:1051-63. 2013
  5. pmc Telomestatin impairs glioma stem cell survival and growth through the disruption of telomeric G-quadruplex and inhibition of the proto-oncogene, c-Myb
    Takeshi Miyazaki
    Department of Neurological Surgery, Dardinger, Center for Neuro Oncology, James Cancer Hospital and The Ohio State University, Columbus, Ohio 43210, USA
    Clin Cancer Res 18:1268-80. 2012
  6. pmc Extracellular vesicles modulate the glioblastoma microenvironment via a tumor suppression signaling network directed by miR-1
    Agnieszka Bronisz
    Authors Affiliations Harvey Cushing Neuro oncology Laboratories, Department of Neurosurgery, Brigham and Women s Hospital, Harvard Medical School, Boston Neuroscience Center at Massachusetts General Hospital, Charlestown, Massachusetts Departments of Neurological Surgery and Molecular and Cellular Biochemistry, The Ohio State University Medical Center, Columbus, Ohio
    Cancer Res 74:738-50. 2014
  7. doi Impairment of glioma stem cell survival and growth by a novel inhibitor for Survivin-Ran protein complex
    Hacer Güvenç
    Department of Neurological Surgery, The Ohio State University, Columbus, OH 43210, USA
    Clin Cancer Res 19:631-42. 2013
  8. pmc Brain tumor initiating cells adapt to restricted nutrition through preferential glucose uptake
    William A Flavahan
    1 Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine at Case Western Reserve University, Cleveland, Ohio, USA 2 Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA
    Nat Neurosci 16:1373-82. 2013
  9. pmc Multi-kinase inhibitor C1 triggers mitotic catastrophe of glioma stem cells mainly through MELK kinase inhibition
    Mutsuko Minata
    Department of Neurological Surgery, The Ohio State University Medical Center, Columbus, Ohio, United States of America
    PLoS ONE 9:e92546. 2014
  10. pmc Mesenchymal glioma stem cells are maintained by activated glycolytic metabolism involving aldehyde dehydrogenase 1A3
    Ping Mao
    Department of Neurological Surgery, The Ohio State University, Columbus, OH 43210, USA
    Proc Natl Acad Sci U S A 110:8644-9. 2013

Collaborators

Detail Information

Publications14

  1. pmc CD44v6 regulates growth of brain tumor stem cells partially through the AKT-mediated pathway
    Mayumi Jijiwa
    Department of Neurological Surgery, The Ohio State University, Columbus, Ohio, United States of America
    PLoS ONE 6:e24217. 2011
    ..Collectively, these data indicate that a subset of GBM expresses high CD44 in BTSC, and its growth may depend on CD44v6/AKT pathway...
  2. pmc Siomycin A targets brain tumor stem cells partially through a MELK-mediated pathway
    Ichiro Nakano
    Department of Neurological Surgery, James Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA
    Neuro Oncol 13:622-34. 2011
    ..Together, this study may be the first model to partially target stemlike GBM cells through a MELK-mediated pathway with siomycin A to pave the way for effective treatment of GBM...
  3. ncbi Tumor-specific activation of the C-JUN/MELK pathway regulates glioma stem cell growth in a p53-dependent manner
    Chunyu Gu
    Department of Neurological Surgery, The Ohio State University, Columbus, Ohio, USA
    Stem Cells 31:870-81. 2013
    ..Together, our data indicate that GSCs, but not normal cells, depend on JNK-driven MELK/c-JUN signaling to regulate their survival, maintain GSCs in an immature state, and facilitate tumor radioresistance in a p53-dependent manner...
  4. pmc MELK-dependent FOXM1 phosphorylation is essential for proliferation of glioma stem cells
    Kaushal Joshi
    Department of Neurological Surgery, The James Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA
    Stem Cells 31:1051-63. 2013
    ..Collectively, our data indicate that FOXM1 signaling through its direct interaction with MELK regulates key mitotic genes in GSCs in a PLK1-dependent manner and thus, this protein complex is a potential therapeutic target for GBM...
  5. pmc Telomestatin impairs glioma stem cell survival and growth through the disruption of telomeric G-quadruplex and inhibition of the proto-oncogene, c-Myb
    Takeshi Miyazaki
    Department of Neurological Surgery, Dardinger, Center for Neuro Oncology, James Cancer Hospital and The Ohio State University, Columbus, Ohio 43210, USA
    Clin Cancer Res 18:1268-80. 2012
    ..Glioma stem cells (GSC) are a critical therapeutic target of glioblastoma multiforme (GBM)...
  6. pmc Extracellular vesicles modulate the glioblastoma microenvironment via a tumor suppression signaling network directed by miR-1
    Agnieszka Bronisz
    Authors Affiliations Harvey Cushing Neuro oncology Laboratories, Department of Neurosurgery, Brigham and Women s Hospital, Harvard Medical School, Boston Neuroscience Center at Massachusetts General Hospital, Charlestown, Massachusetts Departments of Neurological Surgery and Molecular and Cellular Biochemistry, The Ohio State University Medical Center, Columbus, Ohio
    Cancer Res 74:738-50. 2014
    ....
  7. doi Impairment of glioma stem cell survival and growth by a novel inhibitor for Survivin-Ran protein complex
    Hacer Güvenç
    Department of Neurological Surgery, The Ohio State University, Columbus, OH 43210, USA
    Clin Cancer Res 19:631-42. 2013
    ..Glioblastoma multiforme (GBM) is a devastating disease. Recent studies suggest that the stem cell properties of GBM contribute to the development of therapy resistance...
  8. pmc Brain tumor initiating cells adapt to restricted nutrition through preferential glucose uptake
    William A Flavahan
    1 Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine at Case Western Reserve University, Cleveland, Ohio, USA 2 Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA
    Nat Neurosci 16:1373-82. 2013
    ..As altered metabolism represents a cancer hallmark, metabolic reprogramming may maintain the tumor hierarchy and portend poor prognosis. ..
  9. pmc Multi-kinase inhibitor C1 triggers mitotic catastrophe of glioma stem cells mainly through MELK kinase inhibition
    Mutsuko Minata
    Department of Neurological Surgery, The Ohio State University Medical Center, Columbus, Ohio, United States of America
    PLoS ONE 9:e92546. 2014
    ..Lastly, C1 treatment sensitizes GSCs to radiation treatment. Collectively, these data indicate that targeting MELK kinase activity is a promising approach to attenuate GBM growth by eliminating GSCs in tumors. ..
  10. pmc Mesenchymal glioma stem cells are maintained by activated glycolytic metabolism involving aldehyde dehydrogenase 1A3
    Ping Mao
    Department of Neurological Surgery, The Ohio State University, Columbus, OH 43210, USA
    Proc Natl Acad Sci U S A 110:8644-9. 2013
    ..Inhibition of ALDH1A3-mediated pathways therefore might provide a promising therapeutic approach for a subset of HGGs with the Mes signature...
  11. pmc Suppression of peroxiredoxin 4 in glioblastoma cells increases apoptosis and reduces tumor growth
    Tae Hyong Kim
    Dardinger Center for Neuro oncology and Neurosciences, Department of Neurological Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA
    PLoS ONE 7:e42818. 2012
    ..In a syngenic orthotopic transplantation model, Prdx4 knockdown limited GBM infiltration and significantly prolonged mouse survival. These data suggest that PRDX4 can be a novel target for GBM therapies in the future...
  12. doi BMPing off glioma stem cells
    Ichiro Nakano
    Department of Neurological Surgery, University of California, Los Angeles, School of Medicine, Los Angeles, CA 90095, USA
    Cancer Cell 13:3-4. 2008
    ..These findings document the importance of the BMP signaling system in BTSC as well as that of taking heterogeneity into account when studying BTSC as potential targets for therapy...
  13. ncbi [Cancer stem cells in malignant glioma-the mechanism of cancer initiation and the therapeutic development]
    Ichiro Nakano
    Department of Neurological Surgery, The Ohio State University, Ohio, USA Ichiro Nakano osumc edu
    No Shinkei Geka 38:879-89. 2010
    ..In this study, we summarize the recent findings and approaches in the cancer stem cell field, mainly focusing on malignant glioma stem cells, and also describe potential future directions in this area...