Nobuki Nakanishi

Summary

Affiliation: The Burnham Institute
Country: USA

Publications

  1. pmc Neuroprotection by the NR3A subunit of the NMDA receptor
    Nobuki Nakanishi
    Center for Neuroscience, Aging, and Stem Cell Research, Burnham Institute for Medical Research, La Jolla, California 92037, USA
    J Neurosci 29:5260-5. 2009
  2. ncbi request reprint Modulation of NMDA receptor properties and synaptic transmission by the NR3A subunit in mouse hippocampal and cerebrocortical neurons
    Gary Tong
    Center for Neuroscience, Aging, and Stem Cell Research, Burnham Institute for Medical Research, La Jolla, California 92037, USA
    J Neurophysiol 99:122-32. 2008
  3. pmc Excitatory glycine responses of CNS myelin mediated by NR1/NR3 "NMDA" receptor subunits
    Juan C Piña-Crespo
    Molecular Neurobiology Laboratory, Salk Institute, and Center for Neuroscience, Aging, and Stem Cell Research, Sanford Burnham Medical Research Institute, La Jolla, California 92037, USA
    J Neurosci 30:11501-5. 2010
  4. pmc MEF2C enhances dopaminergic neuron differentiation of human embryonic stem cells in a parkinsonian rat model
    Eun Gyung Cho
    Del E Webb Center for Neuroscience, Aging, and Stem Cell Research, Sanford Burnham Medical Research Institute, La Jolla, California, United States of America
    PLoS ONE 6:e24027. 2011
  5. ncbi request reprint Characterization and comparison of the NR3A subunit of the NMDA receptor in recombinant systems and primary cortical neurons
    Yasnory F Sasaki
    Center for Neuroscience and Aging, The Burnham Institute, La Jolla, California 92037, USA
    J Neurophysiol 87:2052-63. 2002
  6. pmc Synaptic protein α1-takusan mitigates amyloid-β-induced synaptic loss via interaction with tau and postsynaptic density-95 at postsynaptic sites
    Nobuki Nakanishi
    Del E Web Center for Neuroscience, Aging, and Stem Cell Research, and Bioinformatics Shared Resource, Sanford Burnham Medical Research Institute, La Jolla, California 92037, USA
    J Neurosci 33:14170-83. 2013
  7. pmc Takusan: a large gene family that regulates synaptic activity
    Shichun Tu
    Center for Neuroscience and Aging, Burnham Institute for Medical Research, La Jolla, CA 92037, USA
    Neuron 55:69-85. 2007
  8. ncbi request reprint Excitatory glycine receptors containing the NR3 family of NMDA receptor subunits
    Jon E Chatterton
    Center for Neuroscience and Aging, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA
    Nature 415:793-8. 2002
  9. doi request reprint Isogenic Human iPSC Parkinson's Model Shows Nitrosative Stress-Induced Dysfunction in MEF2-PGC1α Transcription
    Scott D Ryan
    Del E Web Center for Neuroscience, Aging, and Stem Cell Research, Sanford Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Cell 155:1351-64. 2013
  10. pmc Aβ induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss
    Maria Talantova
    Del E Webb Center for Neuroscience, Aging, and Stem Cell Research, Sanford Burnham Medical Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 110:E2518-27. 2013

Research Grants

  1. GENETIC APPROACH TO EXCITATORY TRANSMISSION
    Nobuki Nakanishi; Fiscal Year: 2007

Collaborators

Detail Information

Publications15

  1. pmc Neuroprotection by the NR3A subunit of the NMDA receptor
    Nobuki Nakanishi
    Center for Neuroscience, Aging, and Stem Cell Research, Burnham Institute for Medical Research, La Jolla, California 92037, USA
    J Neurosci 29:5260-5. 2009
    ..These data suggest that endogenous NR3A protects neurons, and exogenously added NR3A increases neuroprotection and could be potentially exploited as a therapeutic...
  2. ncbi request reprint Modulation of NMDA receptor properties and synaptic transmission by the NR3A subunit in mouse hippocampal and cerebrocortical neurons
    Gary Tong
    Center for Neuroscience, Aging, and Stem Cell Research, Burnham Institute for Medical Research, La Jolla, California 92037, USA
    J Neurophysiol 99:122-32. 2008
    ..Taken together, these results show that NR3A subunits contribute to NMDAR responses from both synaptic and extrasynaptic receptors, likely composed of NR1, NR2, and NR3 subunits...
  3. pmc Excitatory glycine responses of CNS myelin mediated by NR1/NR3 "NMDA" receptor subunits
    Juan C Piña-Crespo
    Molecular Neurobiology Laboratory, Salk Institute, and Center for Neuroscience, Aging, and Stem Cell Research, Sanford Burnham Medical Research Institute, La Jolla, California 92037, USA
    J Neurosci 30:11501-5. 2010
    ..d-Serine responses were abrogated in NR3A-deficient mice. Our results suggest the presence of functional NR1/NR3 receptors in CNS myelin...
  4. pmc MEF2C enhances dopaminergic neuron differentiation of human embryonic stem cells in a parkinsonian rat model
    Eun Gyung Cho
    Del E Webb Center for Neuroscience, Aging, and Stem Cell Research, Sanford Burnham Medical Research Institute, La Jolla, California, United States of America
    PLoS ONE 6:e24027. 2011
    ..The enriched generation of dopaminergic neuronal lineages from hESCs by forced expression of MEF2CA in the proper context may prove valuable in cell-based therapy for CNS disorders such as PD...
  5. ncbi request reprint Characterization and comparison of the NR3A subunit of the NMDA receptor in recombinant systems and primary cortical neurons
    Yasnory F Sasaki
    Center for Neuroscience and Aging, The Burnham Institute, La Jolla, California 92037, USA
    J Neurophysiol 87:2052-63. 2002
    ..Finally, a new longer splice variant of NR3A has been cloned and found to be expressed in rodent cortical neurons by single-cell RT-PCR and in situ hybridization...
  6. pmc Synaptic protein α1-takusan mitigates amyloid-β-induced synaptic loss via interaction with tau and postsynaptic density-95 at postsynaptic sites
    Nobuki Nakanishi
    Del E Web Center for Neuroscience, Aging, and Stem Cell Research, and Bioinformatics Shared Resource, Sanford Burnham Medical Research Institute, La Jolla, California 92037, USA
    J Neurosci 33:14170-83. 2013
    ..In summary, α1-takusan protects synapses from Aβ-induced insult via interaction with PSD-95 and tau. Thus, takusan-based protein sequences from either mouse or human may be of potential therapeutic benefit in AD. ..
  7. pmc Takusan: a large gene family that regulates synaptic activity
    Shichun Tu
    Center for Neuroscience and Aging, Burnham Institute for Medical Research, La Jolla, CA 92037, USA
    Neuron 55:69-85. 2007
    ..Conversely, treating cultured neurons with RNAi targeting alpha-takusan variants resulted in the opposite phenotype. Hence, alpha-takusan represents a large gene family that regulates synaptic activity...
  8. ncbi request reprint Excitatory glycine receptors containing the NR3 family of NMDA receptor subunits
    Jon E Chatterton
    Center for Neuroscience and Aging, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA
    Nature 415:793-8. 2002
    ..By itself, glycine is normally thought of as an inhibitory neurotransmitter. In contrast, these NR1/NR3A or -3B 'NMDARs' constitute a type of excitatory glycine receptor...
  9. doi request reprint Isogenic Human iPSC Parkinson's Model Shows Nitrosative Stress-Induced Dysfunction in MEF2-PGC1α Transcription
    Scott D Ryan
    Del E Web Center for Neuroscience, Aging, and Stem Cell Research, Sanford Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Cell 155:1351-64. 2013
    ..Furthermore, using small-molecule high-throughput screening, we identify the MEF2C-PGC1α pathway as a therapeutic target to combat PD. ..
  10. pmc Aβ induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss
    Maria Talantova
    Del E Webb Center for Neuroscience, Aging, and Stem Cell Research, Sanford Burnham Medical Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 110:E2518-27. 2013
    ..Importantly, the improved NMDAR antagonist NitroMemantine, which selectively inhibits extrasynaptic over physiological synaptic NMDAR activity, protects synapses from Aβ-induced damage both in vitro and in vivo. ..
  11. pmc S-Nitrosylation of parkin as a novel regulator of p53-mediated neuronal cell death in sporadic Parkinson's disease
    Carmen R Sunico
    Sanford Burnham Medical Research Institute, Del E, Webb Center for Neuroscience, Aging, and Stem Cell Research, 10901, North Torrey Pines Road, La Jolla, CA 92037, USA
    Mol Neurodegener 8:29. 2013
    ..We hypothesized that oxidative posttranslational modification of parkin by environmental toxins may contribute to sporadic PD...
  12. pmc Transcription factor MEF2C influences neural stem/progenitor cell differentiation and maturation in vivo
    Hao Li
    Center for Neuroscience, Aging, and Stem Cell Research, Burnham Institute for Medical Research, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 105:9397-402. 2008
    ..Our data support a crucial role for MEF2C in programming early neuronal differentiation and proper distribution within the layers of the neocortex...
  13. ncbi request reprint A developmental influence of the N-methyl-D-aspartate receptor NR3A subunit on prepulse inhibition of startle
    Suzanne A Brody
    Department of Neuroscience, University of California, San Diego, La Jolla 92093 0804, USA
    Biol Psychiatry 57:1147-52. 2005
    ..NR3A reduces NMDA current in native neurons expressing NR1 and NR2 subunits and forms glycine receptors when expressed with NR1 in the absence of NR2 in both oocyte and mammalian expression systems...
  14. ncbi request reprint N-methyl-D-aspartate receptor subunit NR3A in the retina: developmental expression, cellular localization, and functional aspects
    Nikolaus J Sucher
    Department of Biology and Biotechnology Research Institute, Hong Kong University of Science and Technology, Hong Kong, China
    Invest Ophthalmol Vis Sci 44:4451-6. 2003
    ..The present study is the first to investigate the expression and cellular localization of NR3A on the protein level in the retina and to elucidate its putative functional roles within the retinal circuitry...
  15. ncbi request reprint Temporal and regional expression of NMDA receptor subunit NR3A in the mammalian brain
    Hon Kit Wong
    Department of Biology and Biotechnology Research Institute, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong SAR, China
    J Comp Neurol 450:303-17. 2002
    ..This information will facilitate future research on NMDARs by providing clues to possible inclusion of the NR3A subunit in NMDARs in many brain regions...

Research Grants2

  1. GENETIC APPROACH TO EXCITATORY TRANSMISSION
    Nobuki Nakanishi; Fiscal Year: 2007
    ..To examine neuronal damage in vivo following hypoxia/ischemia in NR3A KO and NR3A/3B Tg mice. 3. To examine molecular, functional, and structural properties of p16, the product of a novel gene family that is upregulated in NR3A KO mice...