Research Topics
| Vinay M NadkarniSummaryAffiliation: The Children's Hospital of Philadelphia Country: USA Publications
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Detail Information
Publications
First documented rhythm and clinical outcome from in-hospital cardiac arrest among children and adultsVinay M Nadkarni
Departments of Anesthesia, Critical Care, and Pediatrics, University of Pennsylvania School of Medicine, Philadelphia 19104 4399, USA
JAMA 295:50-7. 2006..Cardiac arrests in children are typically asystole or PEA...- Effect of one-rescuer compression/ventilation ratios on cardiopulmonary resuscitation in infant, pediatric, and adult manikinsShoba Krishnan Srikantan
Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Pediatr Crit Care Med 6:293-7. 2005..We speculate that a universal 10:2 C:V ratio for one-rescuer layperson CPR is physiologically reasonable but warrants further study with particular attention to educational value and technique retention... 
Survival from in-hospital cardiac arrest during nights and weekendsMary Ann Peberdy
Virginia Commonwealth University, Richmond, VA 23298 0204, USA
JAMA 299:785-92. 2008..Patient physiology and process of care for in-hospital cardiac arrest may be different at night and on weekends because of hospital factors unrelated to patient, event, or location variables...- Effect of defibrillation energy dose during in-hospital pediatric cardiac arrestPeter A Meaney
Department of Anesthesiology, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
Pediatrics 127:e16-23. 2011..We hypothesized that (1) an initial shock dose of 2 ± 10 J/kg would be less effective for terminating fibrillation than suggested in published historical data and (2) a 4 J/kg shock dose would be more effective... - Women of child-bearing age have better inhospital cardiac arrest survival outcomes than do equal-aged menAlexis A Topjian
Department of Anesthesia and Critical Care Medicine, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Crit Care Med 38:1254-60. 2010..Our objective was to determine whether women of child-bearing age are more likely than men to survive to hospital discharge after in-hospital cardiac arrest... - Airway management in pediatric patients at referring hospitals compared to a receiving tertiary pediatric ICUAkira Nishisaki
Department of Anesthesiology and Critical Care Medicine, The Children s Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, PA, United States
Resuscitation 82:386-90. 2011..To describe the current practice of pediatric airway management at referring hospitals and the associated adverse events compared to a receiving tertiary pediatric ICU... - Calcium use during in-hospital pediatric cardiopulmonary resuscitation: a report from the National Registry of Cardiopulmonary ResuscitationVijay Srinivasan
Department of Anesthesia and Critical Care Medicine, Children s Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA
Pediatrics 121:e1144-51. 2008..We hypothesized that calcium is used frequently during in-hospital pediatric cardiopulmonary resuscitation and that its use is associated with worse survival to hospital discharge... 
Pediatric cardiopulmonary resuscitation: advances in science, techniques, and outcomesAlexis A Topjian
Department of Anesthesia and Critical Care Medicine, University of Pennsylvania, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
Pediatrics 122:1086-98. 2008..Outcomes from pediatric cardiac arrests are improving. Advances in resuscitation science and state-of-the-art implementation techniques provide the opportunity for further improvement in outcomes among children after cardiac arrest...- Effect of high-fidelity simulation on Pediatric Advanced Life Support training in pediatric house staff: a randomized trialAaron J Donoghue
Division of Emergency Medicine, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
Pediatr Emerg Care 25:139-44. 2009..To assess the effect of high-fidelity simulation (SIM) on cognitive performance after a training session involving several mock resuscitations designed to teach and reinforce Pediatric Advanced Life Support (PALS) algorithms... - National survey of pediatric critical care medicine fellowship clinical and research time allocationWynne E Morrison
Division of Critical Care, Department of Anesthesia and Critical Care, The Children s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA, USA
Pediatr Crit Care Med 10:397-9. 2009..Pediatric critical care medicine (PCCM) fellowship programs vary in the number of fellows per program and experiences offered. We evaluated whether program size and rotation distribution affect clinical and research time allocation... - Effect of preextracorporeal membrane oxygenation ventilation days and age on extracorporeal membrane oxygenation survival in critically ill childrenMichael L Nance
Department of Surgery, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
J Pediatr Surg 44:1606-10. 2009..The aim of the study is to test the effect of age and preextracorporeal membrane oxygenation (pre-ECMO) days of ventilation on ECMO survival in the pediatric population... - Expert clinical assessment of thorax stiffness of infants and children during chest compressionsKristy B Arbogast
Center for Injury Research and Prevention, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
Resuscitation 80:1187-91. 2009..Similarity of manikin chest compression characteristics to real children is desirable. Little data exists on thorax stiffness in infants and children to guide manikin construction... - Rhythms and outcomes of adult in-hospital cardiac arrestPeter A Meaney
American Heart Association National Registry for Cardiopulmonary Resuscitation Investigators
Crit Care Med 38:101-8. 2010..To determine the relationship of electrocardiographic rhythm during cardiac arrest with survival outcomes... - Cardiopulmonary resuscitation for bradycardia with poor perfusion versus pulseless cardiac arrestAaron Donoghue
Department of Pediatrics, Division of Emergency Medicine, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
Pediatrics 124:1541-8. 2009.... - Childhood obesity and survival after in-hospital pediatric cardiopulmonary resuscitationVijay Srinivasan
Department of Anesthesiology and Critical Care Medicine, Children s Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA
Pediatrics 125:e481-8. 2010..We hypothesized that childhood obesity would be associated with decreased likelihood of survival to hospital discharge after in-hospital, pediatric cardiopulmonary resuscitation (CPR)... - Perception of realism during mock resuscitations by pediatric housestaff: the impact of simulated physical featuresAaron J Donoghue
Division of Emergency Medicine, Children s Hospital of Philadelphia, Pennsylvania 19104, USA
Simul Healthc 5:16-20. 2010..We surveyed pediatric housestaff as to the realism of scenarios with and without simulated physical signs... - Effect of just-in-time simulation training on tracheal intubation procedure safety in the pediatric intensive care unitAkira Nishisaki
Department of Anesthesiology and Critical Care Medicine, Center for Simulation, Advanced Education and Innovation, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
Anesthesiology 113:214-23. 2010..The authors hypothesized that "just-in-time" simulation-based intubation refresher training would improve resident participation, success, and decrease TIAEs... - Analysis of transthoracic impedance during real cardiac arrest defibrillation attempts in older children and adolescents: are stacked-shocks appropriate?Dana E Niles
Center for Simulation, Advanced Education and Innovation, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
Resuscitation 81:1540-3. 2010..The objective of this study was to characterize TTI following biphasic defibrillation attempts in children ≥ 8 yrs during cardiac arrest to assess whether a stacked-shock approach may be appropriate to improve defibrillation success... - Resuscitation training in developing countries: a systematic reviewPeter A Meaney
Department of Anesthesia and Critical Care, Children s Hospital of Philadelphia, Philadelphia, PA, USA
Resuscitation 81:1462-72. 2010..To evaluate whether the inclusion of any specific resuscitation training educational strategy in developing countries improves outcomes... - Anterior-posterior thoracic force-deflection characteristics measured during cardiopulmonary resuscitation: comparison to post-mortem human subject dataKristy B Arbogast
Center for Injury Research and Prevention, The Children s Hospital of Philadelphia, 34th and Civic Center Blvd, Suite 1024, Philadelphia, PA 19104, USA
Stapp Car Crash J 50:131-45. 2006..We contend that the thoracic compliance measured during CPR may continue to offer important force-deflection estimates in the future... - Higher survival rates among younger patients after pediatric intensive care unit cardiac arrestsPeter A Meaney
Department of Critical Care Medicine, 7th Floor, Room 7c03, Children s Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA
Pediatrics 118:2424-33. 2006..We, therefore, hypothesized that survival from cardiac arrest would be better among infants than older children... - Effect of hospital characteristics on outcomes from pediatric cardiopulmonary resuscitation: a report from the national registry of cardiopulmonary resuscitationAaron J Donoghue
Division of Emergency Medicine, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
Pediatrics 118:995-1001. 2006.... - An evaluation of a noninvasive cardiac output measurement using partial carbon dioxide rebreathing in childrenRichard J Levy
Department of Anesthesiology and Critical Care Medicine, The Children s Hospital of Philadelphia, 34th St and Civic Center Blvd, Philadelphia, PA 19104, USA
Anesth Analg 99:1642-7, table of contents. 2004..6 m(2) ventilated with tidal volumes <300 mL. Based on these findings, noninvasive CO measurement using partial rebreathing may be clinically acceptable in children with >0.6 m(2) body surface area and >300 mL tidal volume... - Spontaneous gasping decreases intracranial pressure and improves cerebral perfusion in a pig model of ventricular fibrillationVijay Srinivasan
Department of Anesthesia and Critical Care Medicine, Children s Hospital of Philadelphia, 34th Street and Civic Center Boulevard, PA 19104, USA
Resuscitation 69:329-34. 2006..The potential beneficial effect of gasping on cerebral perfusion may underlie the observed survival benefit, but mechanisms remain unknown... - Cardiopulmonary resuscitation in childrenAlexis A Topjian
University of Pennsylvania School of Medicine, Department of Anesthesia and Critical Care Medicine, The Children s Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA
Curr Opin Crit Care 15:203-8. 2009..To summarize recent advances in pediatric cardiopulmonary arrest prevention, resuscitation and postresuscitation management... - Outcomes of in-hospital ventricular fibrillation in childrenRicardo A Samson
Steele Children's Research Center, University of Arizona, Tucson 85724-5073, USA
N Engl J Med 354:2328-39. 2006..The outcomes for patients with subsequent ventricular fibrillation or tachycardia were substantially worse than those for patients with asystole or pulseless electrical activity... - A model of determining a fair market value for teaching residents: who profits?Edward J Cullen
Department of Anesthesiology and Critical Care Medicine, Nemours Children s Clinic, Alfred I duPont Hospital for Children, Wilmington, Delaware, USA
Pediatrics 112:40-8. 2003..Centers for Medicare & Medicaid Services (CMS) Health Resources and Services Administration Children's Hospitals Graduate Medical Education (GME) Payment Program now supports freestanding children's teaching hospitals... - Pediatric cardiopulmonary-cerebral resuscitation: an overview and future directionsMarilyn C Morris
Department of Anesthesia and Critical Care Medicine, The Children's Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA
Crit Care Clin 19:337-64. 2003.... - A comparison of high-dose and standard-dose epinephrine in children with cardiac arrestMaria Beatriz M Perondi
Department of Pediatrics, Children's Institute, , Brazil
N Engl J Med 350:1722-30. 2004..The data suggest that high-dose therapy may be worse than standard-dose therapy... - Survival outcomes after extracorporeal cardiopulmonary resuscitation instituted during active chest compressions following refractory in-hospital pediatric cardiac arrestMarilyn C Morris
Clinical Pediatrics, The Children's Hospital of New York, New York, NY, USA
Pediatr Crit Care Med 5:440-6. 2004..In this series, children with isolated heart disease were more likely to survive following extracorporeal cardiopulmonary resuscitation than were children with other medical conditions... - Intrathoracic pressure regulator during continuous-chest-compression advanced cardiac resuscitation improves vital organ perfusion pressures in a porcine model of cardiac arrestDemetris Yannopoulos
Department of Cardiology, Cardiac Arrhythmia Center, University of Minnesota, Minneapolis, MN, USA
Circulation 112:803-11. 2005..CONCLUSIONS: Compared with STD-CPR, use of ITPR-CPR improved hemodynamics and short-term survival rates after cardiac arrest... - Rapid induction of cerebral hypothermia is enhanced with active compression-decompression plus inspiratory impedance threshold device cardiopulmonary resusitation in a porcine model of cardiac arrestVijay Srinivasan
Department of Anesthesia and Critical Care Medicine, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
J Am Coll Cardiol 47:835-41. 2006..3 +/- 2) than S-CPR pigs (17.4 +/- 3, p < 0.01). CONCLUSIONS: A rapid ice-cold saline infusion combined with ACD + ITD CPR during cardiac arrest induces cerebral hypothermia more rapidly immediately after ROSC than with S-CPR... - Comparison of a 10-breaths-per-minute versus a 2-breaths-per-minute strategy during cardiopulmonary resuscitation in a porcine model of cardiac arrestKeith G Lurie
Department of Emergency Medicine, University of Minnesota, Minneapolis, Minnesota, USA
Respir Care 53:862-70. 2008..Hyperventilation during cardiopulmonary resuscitation (CPR) is harmful... - Left ventricular systolic function and outcome after in-hospital cardiac arrestMaria M Gonzalez
Heart Institute InCor, University of Sao Paulo Medical School, Sao Paulo, Brazil
Circulation 117:1864-72. 2008..The effect of prearrest left ventricular ejection fraction (LVEF) on outcome after cardiac arrest is unknown... - Cardiopulmonary resuscitation in childrenMarc D Berg
Division of Pediatric Critical Care Medicine, Department of Pediatrics, Member Steele Memorial Research Center, The University of Arizona College of Medicine, Tucson, Arizona 85724, USA
Curr Opin Crit Care 14:254-60. 2008..To summarize current opinion and advances in pediatric cardiopulmonary resuscitation, including etiology, pathophysiology, rationale for interventions, and postresuscitation management... - CPR-why the new emphasis?Marc D Berg
Department of Pediatrics, Steele Research Center and Sarver Heart Center, The University of Arizona College of Medicine, Tucson, AZ 85724, USA
Pediatr Clin North Am 55:861-72, ix. 2008..In this article, the authors examine the differences in pediatric anatomy and the mechanisms of blood flow during CPR. Additionally, new evidence on the frequent poor performance of CPR and mechanisms to improve it are presented... - Increasing amiodarone use in cardiopulmonary resuscitation: an analysis of the National Registry of Cardiopulmonary ResuscitationTessie W October
College of Physicians and Surgeons, Columbia University, New York, NY, USA
Crit Care Med 36:126-30. 2008..Furthermore, this study examines the impact of hospital and patient specific factors on the use of amiodarone... - Clinical and hemodynamic comparison of 15:2 and 30:2 compression-to-ventilation ratios for cardiopulmonary resuscitationDemetris Yannopoulos
University of Minnesota, Minneapolis, MN, USA
Crit Care Med 34:1444-9. 2006..CONCLUSIONS: These data strongly support the contention that a ratio of 30:2 is superior to 15:2 during manual CPR and that the ITD further enhances circulation with both C:V ratios... - Exception from informed consent for pediatric resuscitation research: community consultation for a trial of brain cooling after in-hospital cardiac arrestMarilyn C Morris
Department of Anesthesia and Critical Care Medicine, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
Pediatrics 114:776-81. 2004.... - Recommended guidelines for monitoring, reporting, and conducting research on medical emergency team, outreach, and rapid response systems: an Utstein-style scientific statement: a scientific statement from the International Liaison Committee on ResuscitatMary Ann Peberdy
Virginia Commonwealth University, USA
Circulation 116:2481-500. 2007 - Impact of the privacy rule on the study of out-of-hospital pediatric cardiac arrestMarilyn C Morris
Department of Pediatrics, Division of Pediatric Critical Care, The Children s Hospital of New York Presbyterian, Columbia University, New York, New York 10032, USA
Prehosp Emerg Care 11:272-7. 2007..Compliance with the Privacy Rule is particularly challenging for prehospital research, because investigators often seek data from multiple emergency medical services (EMS) and receiving hospitals... - Discovering the full spectrum of cardiovascular disease: Minority Health Summit 2003: report of the Outcomes Writing GroupEmelia J Benjamin
Circulation 111:e124-33. 2005 - Scientific knowledge gaps and clinical research priorities for cardiopulmonary resuscitation and emergency cardiovascular care identified during the 2005 International Consensus Conference on ECC and CPR Science with Treatment Recommendations. A consensusRaúl J Gazmuri
Rosalind Franklin University of Medicine and Science, North Chicago Medical Center, Chicago, USA
Resuscitation 75:400-11. 2007 - Major changes in the 2005 AHA Guidelines for CPR and ECC: reaching the tipping point for changeMary Fran Hazinski
Circulation 112:IV206-11. 2005 - In-hospital pediatric cardiac arrestMarc D Berg
Division of Pediatric Critical Care Medicine, Department of Pediatrics, Steele Memorial Research Center and Sarver Heart Center, The University of Arizona College of Medicine, Tucson, AZ 85724, USA
Pediatr Clin North Am 55:589-604, x. 2008..Performance of, and technologic advances in, the treatment of cardiac arrest make this an exciting time in the field... - Temperature regulation after cardiac arrest...Timing is everything!Marilyn C Morris
Crit Care Med 31:654-5. 2003 - Recommended guidelines for monitoring, reporting, and conducting research on medical emergency team, outreach, and rapid response systems: an Utstein-style scientific statement. A Scientific Statement from the International Liaison Committee on ResuscitatMary Ann Peberdy
Resuscitation 75:412-33. 2007 - Scientific knowledge gaps and clinical research priorities for cardiopulmonary resuscitation and emergency cardiovascular care identified during the 2005 International Consensus Conference on ECC [corrected] and CPR science with treatment recommendations:Raúl J Gazmuri
North Chicago VA and Rosalind Franklin University of Medicine and Science, USA
Circulation 116:2501-12. 2007 - Conflict of interest management before, during, and after the 2005 International Consensus Conference on cardiopulmonary resuscitation and emergency cardiovascular care science with treatment recommendationsJohn E Billi
Resuscitation 67:171-3. 2005
Research Grants
- Improving patient safety with just-in-time pediatric simulation trainingVinay Nadkarni; Fiscal Year: 2007..If this study demonstrates that simulation overtraining improves safety, these techniques will be adopted and implemented in diverse high-risk settings to improve the care of critically ill children. ..