Vinay M Nadkarni

Summary

Affiliation: The Children's Hospital of Philadelphia
Country: USA

Publications

  1. ncbi request reprint First documented rhythm and clinical outcome from in-hospital cardiac arrest among children and adults
    Vinay M Nadkarni
    Departments of Anesthesia, Critical Care, and Pediatrics, University of Pennsylvania School of Medicine, Philadelphia 19104 4399, USA
    JAMA 295:50-7. 2006
  2. ncbi request reprint Effect of one-rescuer compression/ventilation ratios on cardiopulmonary resuscitation in infant, pediatric, and adult manikins
    Shoba Krishnan Srikantan
    Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Pediatr Crit Care Med 6:293-7. 2005
  3. doi request reprint Survival from in-hospital cardiac arrest during nights and weekends
    Mary Ann Peberdy
    Virginia Commonwealth University, Richmond, VA 23298 0204, USA
    JAMA 299:785-92. 2008
  4. doi request reprint Effect of defibrillation energy dose during in-hospital pediatric cardiac arrest
    Peter A Meaney
    Department of Anesthesiology, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Pediatrics 127:e16-23. 2011
  5. doi request reprint Women of child-bearing age have better inhospital cardiac arrest survival outcomes than do equal-aged men
    Alexis A Topjian
    Department of Anesthesia and Critical Care Medicine, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Crit Care Med 38:1254-60. 2010
  6. doi request reprint Airway management in pediatric patients at referring hospitals compared to a receiving tertiary pediatric ICU
    Akira Nishisaki
    Department of Anesthesiology and Critical Care Medicine, The Children s Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, PA, United States
    Resuscitation 82:386-90. 2011
  7. doi request reprint Calcium use during in-hospital pediatric cardiopulmonary resuscitation: a report from the National Registry of Cardiopulmonary Resuscitation
    Vijay Srinivasan
    Department of Anesthesia and Critical Care Medicine, Children s Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA
    Pediatrics 121:e1144-51. 2008
  8. pmc Pediatric cardiopulmonary resuscitation: advances in science, techniques, and outcomes
    Alexis A Topjian
    Department of Anesthesia and Critical Care Medicine, University of Pennsylvania, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Pediatrics 122:1086-98. 2008
  9. doi request reprint Effect of high-fidelity simulation on Pediatric Advanced Life Support training in pediatric house staff: a randomized trial
    Aaron J Donoghue
    Division of Emergency Medicine, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Pediatr Emerg Care 25:139-44. 2009
  10. doi request reprint National survey of pediatric critical care medicine fellowship clinical and research time allocation
    Wynne E Morrison
    Division of Critical Care, Department of Anesthesia and Critical Care, The Children s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA, USA
    Pediatr Crit Care Med 10:397-9. 2009

Research Grants

Detail Information

Publications49

  1. ncbi request reprint First documented rhythm and clinical outcome from in-hospital cardiac arrest among children and adults
    Vinay M Nadkarni
    Departments of Anesthesia, Critical Care, and Pediatrics, University of Pennsylvania School of Medicine, Philadelphia 19104 4399, USA
    JAMA 295:50-7. 2006
    ..Cardiac arrests in children are typically asystole or PEA...
  2. ncbi request reprint Effect of one-rescuer compression/ventilation ratios on cardiopulmonary resuscitation in infant, pediatric, and adult manikins
    Shoba Krishnan Srikantan
    Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Pediatr Crit Care Med 6:293-7. 2005
    ..C:V ratios influence effectiveness of CPR, but memorizing different ratios is educationally cumbersome. We hypothesized that a 10:2 ratio might provide adequate universal application for all age arrest victims...
  3. doi request reprint Survival from in-hospital cardiac arrest during nights and weekends
    Mary Ann Peberdy
    Virginia Commonwealth University, Richmond, VA 23298 0204, USA
    JAMA 299:785-92. 2008
    ..Patient physiology and process of care for in-hospital cardiac arrest may be different at night and on weekends because of hospital factors unrelated to patient, event, or location variables...
  4. doi request reprint Effect of defibrillation energy dose during in-hospital pediatric cardiac arrest
    Peter A Meaney
    Department of Anesthesiology, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Pediatrics 127:e16-23. 2011
    ..We hypothesized that (1) an initial shock dose of 2 ± 10 J/kg would be less effective for terminating fibrillation than suggested in published historical data and (2) a 4 J/kg shock dose would be more effective...
  5. doi request reprint Women of child-bearing age have better inhospital cardiac arrest survival outcomes than do equal-aged men
    Alexis A Topjian
    Department of Anesthesia and Critical Care Medicine, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Crit Care Med 38:1254-60. 2010
    ..Our objective was to determine whether women of child-bearing age are more likely than men to survive to hospital discharge after in-hospital cardiac arrest...
  6. doi request reprint Airway management in pediatric patients at referring hospitals compared to a receiving tertiary pediatric ICU
    Akira Nishisaki
    Department of Anesthesiology and Critical Care Medicine, The Children s Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, PA, United States
    Resuscitation 82:386-90. 2011
    ..To describe the current practice of pediatric airway management at referring hospitals and the associated adverse events compared to a receiving tertiary pediatric ICU...
  7. doi request reprint Calcium use during in-hospital pediatric cardiopulmonary resuscitation: a report from the National Registry of Cardiopulmonary Resuscitation
    Vijay Srinivasan
    Department of Anesthesia and Critical Care Medicine, Children s Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA
    Pediatrics 121:e1144-51. 2008
    ..We hypothesized that calcium is used frequently during in-hospital pediatric cardiopulmonary resuscitation and that its use is associated with worse survival to hospital discharge...
  8. pmc Pediatric cardiopulmonary resuscitation: advances in science, techniques, and outcomes
    Alexis A Topjian
    Department of Anesthesia and Critical Care Medicine, University of Pennsylvania, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Pediatrics 122:1086-98. 2008
    ..Outcomes from pediatric cardiac arrests are improving. Advances in resuscitation science and state-of-the-art implementation techniques provide the opportunity for further improvement in outcomes among children after cardiac arrest...
  9. doi request reprint Effect of high-fidelity simulation on Pediatric Advanced Life Support training in pediatric house staff: a randomized trial
    Aaron J Donoghue
    Division of Emergency Medicine, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Pediatr Emerg Care 25:139-44. 2009
    ..To assess the effect of high-fidelity simulation (SIM) on cognitive performance after a training session involving several mock resuscitations designed to teach and reinforce Pediatric Advanced Life Support (PALS) algorithms...
  10. doi request reprint National survey of pediatric critical care medicine fellowship clinical and research time allocation
    Wynne E Morrison
    Division of Critical Care, Department of Anesthesia and Critical Care, The Children s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA, USA
    Pediatr Crit Care Med 10:397-9. 2009
    ..Pediatric critical care medicine (PCCM) fellowship programs vary in the number of fellows per program and experiences offered. We evaluated whether program size and rotation distribution affect clinical and research time allocation...
  11. doi request reprint Effect of preextracorporeal membrane oxygenation ventilation days and age on extracorporeal membrane oxygenation survival in critically ill children
    Michael L Nance
    Department of Surgery, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    J Pediatr Surg 44:1606-10. 2009
    ..The aim of the study is to test the effect of age and preextracorporeal membrane oxygenation (pre-ECMO) days of ventilation on ECMO survival in the pediatric population...
  12. doi request reprint Expert clinical assessment of thorax stiffness of infants and children during chest compressions
    Kristy B Arbogast
    Center for Injury Research and Prevention, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Resuscitation 80:1187-91. 2009
    ..Similarity of manikin chest compression characteristics to real children is desirable. Little data exists on thorax stiffness in infants and children to guide manikin construction...
  13. doi request reprint Rhythms and outcomes of adult in-hospital cardiac arrest
    Peter A Meaney
    American Heart Association National Registry for Cardiopulmonary Resuscitation Investigators
    Crit Care Med 38:101-8. 2010
    ..To determine the relationship of electrocardiographic rhythm during cardiac arrest with survival outcomes...
  14. doi request reprint Cardiopulmonary resuscitation for bradycardia with poor perfusion versus pulseless cardiac arrest
    Aaron Donoghue
    Department of Pediatrics, Division of Emergency Medicine, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Pediatrics 124:1541-8. 2009
    ....
  15. doi request reprint Childhood obesity and survival after in-hospital pediatric cardiopulmonary resuscitation
    Vijay Srinivasan
    Department of Anesthesiology and Critical Care Medicine, Children s Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA
    Pediatrics 125:e481-8. 2010
    ..We hypothesized that childhood obesity would be associated with decreased likelihood of survival to hospital discharge after in-hospital, pediatric cardiopulmonary resuscitation (CPR)...
  16. doi request reprint Perception of realism during mock resuscitations by pediatric housestaff: the impact of simulated physical features
    Aaron J Donoghue
    Division of Emergency Medicine, Children s Hospital of Philadelphia, Pennsylvania 19104, USA
    Simul Healthc 5:16-20. 2010
    ..We surveyed pediatric housestaff as to the realism of scenarios with and without simulated physical signs...
  17. doi request reprint Effect of just-in-time simulation training on tracheal intubation procedure safety in the pediatric intensive care unit
    Akira Nishisaki
    Department of Anesthesiology and Critical Care Medicine, Center for Simulation, Advanced Education and Innovation, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Anesthesiology 113:214-23. 2010
    ..The authors hypothesized that "just-in-time" simulation-based intubation refresher training would improve resident participation, success, and decrease TIAEs...
  18. pmc Analysis of transthoracic impedance during real cardiac arrest defibrillation attempts in older children and adolescents: are stacked-shocks appropriate?
    Dana E Niles
    Center for Simulation, Advanced Education and Innovation, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Resuscitation 81:1540-3. 2010
    ..The objective of this study was to characterize TTI following biphasic defibrillation attempts in children ≥ 8 yrs during cardiac arrest to assess whether a stacked-shock approach may be appropriate to improve defibrillation success...
  19. doi request reprint Resuscitation training in developing countries: a systematic review
    Peter A Meaney
    Department of Anesthesia and Critical Care, Children s Hospital of Philadelphia, Philadelphia, PA, USA
    Resuscitation 81:1462-72. 2010
    ..To evaluate whether the inclusion of any specific resuscitation training educational strategy in developing countries improves outcomes...
  20. ncbi request reprint Anterior-posterior thoracic force-deflection characteristics measured during cardiopulmonary resuscitation: comparison to post-mortem human subject data
    Kristy B Arbogast
    Center for Injury Research and Prevention, The Children s Hospital of Philadelphia, 34th and Civic Center Blvd, Suite 1024, Philadelphia, PA 19104, USA
    Stapp Car Crash J 50:131-45. 2006
    ..We contend that the thoracic compliance measured during CPR may continue to offer important force-deflection estimates in the future...
  21. ncbi request reprint Higher survival rates among younger patients after pediatric intensive care unit cardiac arrests
    Peter A Meaney
    Department of Critical Care Medicine, 7th Floor, Room 7c03, Children s Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA
    Pediatrics 118:2424-33. 2006
    ..We, therefore, hypothesized that survival from cardiac arrest would be better among infants than older children...
  22. ncbi request reprint Effect of hospital characteristics on outcomes from pediatric cardiopulmonary resuscitation: a report from the national registry of cardiopulmonary resuscitation
    Aaron J Donoghue
    Division of Emergency Medicine, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Pediatrics 118:995-1001. 2006
    ....
  23. ncbi request reprint An evaluation of a noninvasive cardiac output measurement using partial carbon dioxide rebreathing in children
    Richard J Levy
    Department of Anesthesiology and Critical Care Medicine, The Children s Hospital of Philadelphia, 34th St and Civic Center Blvd, Philadelphia, PA 19104, USA
    Anesth Analg 99:1642-7, table of contents. 2004
    ..6 m(2) ventilated with tidal volumes <300 mL. Based on these findings, noninvasive CO measurement using partial rebreathing may be clinically acceptable in children with >0.6 m(2) body surface area and >300 mL tidal volume...
  24. ncbi request reprint Spontaneous gasping decreases intracranial pressure and improves cerebral perfusion in a pig model of ventricular fibrillation
    Vijay Srinivasan
    Department of Anesthesia and Critical Care Medicine, Children s Hospital of Philadelphia, 34th Street and Civic Center Boulevard, PA 19104, USA
    Resuscitation 69:329-34. 2006
    ..The potential beneficial effect of gasping on cerebral perfusion may underlie the observed survival benefit, but mechanisms remain unknown...
  25. ncbi request reprint Cardiopulmonary resuscitation in children
    Alexis A Topjian
    University of Pennsylvania School of Medicine, Department of Anesthesia and Critical Care Medicine, The Children s Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA
    Curr Opin Crit Care 15:203-8. 2009
    ..To summarize recent advances in pediatric cardiopulmonary arrest prevention, resuscitation and postresuscitation management...
  26. ncbi request reprint Outcomes of in-hospital ventricular fibrillation in children
    Ricardo A Samson
    Steele Children s Research Center, University of Arizona, Tucson 85724 5073, USA
    N Engl J Med 354:2328-39. 2006
    ..These tachyarrhythmias can also begin during cardiopulmonary resuscitation (CPR), presumably as reperfusion arrhythmias. We determined whether the outcome is better for initial than for subsequent ventricular fibrillation or tachycardia...
  27. ncbi request reprint A model of determining a fair market value for teaching residents: who profits?
    Edward J Cullen
    Department of Anesthesiology and Critical Care Medicine, Nemours Children s Clinic, Alfred I duPont Hospital for Children, Wilmington, Delaware, USA
    Pediatrics 112:40-8. 2003
    ..Centers for Medicare & Medicaid Services (CMS) Health Resources and Services Administration Children's Hospitals Graduate Medical Education (GME) Payment Program now supports freestanding children's teaching hospitals...
  28. ncbi request reprint Pediatric cardiopulmonary-cerebral resuscitation: an overview and future directions
    Marilyn C Morris
    Department of Anesthesia and Critical Care Medicine, The Children s Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA
    Crit Care Clin 19:337-64. 2003
    ....
  29. ncbi request reprint A comparison of high-dose and standard-dose epinephrine in children with cardiac arrest
    Maria Beatriz M Perondi
    Department of Pediatrics, Children s Institute, Sao Paulo, Brazil
    N Engl J Med 350:1722-30. 2004
    ..e., the rescue dose) should be the same (standard) dose or a higher dose...
  30. ncbi request reprint Survival outcomes after extracorporeal cardiopulmonary resuscitation instituted during active chest compressions following refractory in-hospital pediatric cardiac arrest
    Marilyn C Morris
    Clinical Pediatrics, The Children s Hospital of New York, New York, NY, USA
    Pediatr Crit Care Med 5:440-6. 2004
    ..To report survival outcomes and to identify factors associated with survival following extracorporeal cardiopulmonary resuscitation for in-hospital pediatric cardiac arrest...
  31. ncbi request reprint Intrathoracic pressure regulator during continuous-chest-compression advanced cardiac resuscitation improves vital organ perfusion pressures in a porcine model of cardiac arrest
    Demetris Yannopoulos
    Department of Cardiology, Cardiac Arrhythmia Center, University of Minnesota, Minneapolis, MN, USA
    Circulation 112:803-11. 2005
    ..Compared with standard (STD) CPR, ITPR-CPR will enhance venous return, systemic arterial pressure, and vital organ perfusion in both porcine models of ventricular fibrillation and hypovolemic cardiac arrest...
  32. ncbi request reprint Rapid induction of cerebral hypothermia is enhanced with active compression-decompression plus inspiratory impedance threshold device cardiopulmonary resusitation in a porcine model of cardiac arrest
    Vijay Srinivasan
    Department of Anesthesia and Critical Care Medicine, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    J Am Coll Cardiol 47:835-41. 2006
    ....
  33. ncbi request reprint Comparison of a 10-breaths-per-minute versus a 2-breaths-per-minute strategy during cardiopulmonary resuscitation in a porcine model of cardiac arrest
    Keith G Lurie
    Department of Emergency Medicine, University of Minnesota, Minneapolis, Minnesota, USA
    Respir Care 53:862-70. 2008
    ..Hyperventilation during cardiopulmonary resuscitation (CPR) is harmful...
  34. doi request reprint Left ventricular systolic function and outcome after in-hospital cardiac arrest
    Maria M Gonzalez
    Heart Institute InCor, University of Sao Paulo Medical School, Sao Paulo, Brazil
    Circulation 117:1864-72. 2008
    ..The effect of prearrest left ventricular ejection fraction (LVEF) on outcome after cardiac arrest is unknown...
  35. doi request reprint Cardiopulmonary resuscitation in children
    Marc D Berg
    Division of Pediatric Critical Care Medicine, Department of Pediatrics, Member Steele Memorial Research Center, The University of Arizona College of Medicine, Tucson, Arizona 85724, USA
    Curr Opin Crit Care 14:254-60. 2008
    ..To summarize current opinion and advances in pediatric cardiopulmonary resuscitation, including etiology, pathophysiology, rationale for interventions, and postresuscitation management...
  36. doi request reprint CPR-why the new emphasis?
    Marc D Berg
    Department of Pediatrics, Steele Research Center and Sarver Heart Center, The University of Arizona College of Medicine, Tucson, AZ 85724, USA
    Pediatr Clin North Am 55:861-72, ix. 2008
    ..In this article, the authors examine the differences in pediatric anatomy and the mechanisms of blood flow during CPR. Additionally, new evidence on the frequent poor performance of CPR and mechanisms to improve it are presented...
  37. ncbi request reprint Increasing amiodarone use in cardiopulmonary resuscitation: an analysis of the National Registry of Cardiopulmonary Resuscitation
    Tessie W October
    College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Crit Care Med 36:126-30. 2008
    ..Furthermore, this study examines the impact of hospital and patient specific factors on the use of amiodarone...
  38. ncbi request reprint Clinical and hemodynamic comparison of 15:2 and 30:2 compression-to-ventilation ratios for cardiopulmonary resuscitation
    Demetris Yannopoulos
    University of Minnesota, Minneapolis, MN, USA
    Crit Care Med 34:1444-9. 2006
    ..To compare cardiopulmonary resuscitation (CPR) with a compression to ventilation (C:V) ratio of 15:2 vs. 30:2, with and without use of an impedance threshold device (ITD)...
  39. ncbi request reprint Exception from informed consent for pediatric resuscitation research: community consultation for a trial of brain cooling after in-hospital cardiac arrest
    Marilyn C Morris
    Department of Anesthesia and Critical Care Medicine, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Pediatrics 114:776-81. 2004
    ....
  40. ncbi request reprint Recommended guidelines for monitoring, reporting, and conducting research on medical emergency team, outreach, and rapid response systems: an Utstein-style scientific statement: a scientific statement from the International Liaison Committee on Resuscitat
    Mary Ann Peberdy
    Virginia Commonwealth University, USA
    Circulation 116:2481-500. 2007
  41. ncbi request reprint Impact of the privacy rule on the study of out-of-hospital pediatric cardiac arrest
    Marilyn C Morris
    Department of Pediatrics, Division of Pediatric Critical Care, The Children s Hospital of New York Presbyterian, Columbia University, New York, New York 10032, USA
    Prehosp Emerg Care 11:272-7. 2007
    ..Compliance with the Privacy Rule is particularly challenging for prehospital research, because investigators often seek data from multiple emergency medical services (EMS) and receiving hospitals...
  42. ncbi request reprint Discovering the full spectrum of cardiovascular disease: Minority Health Summit 2003: report of the Outcomes Writing Group
    Emelia J Benjamin
    Circulation 111:e124-33. 2005
  43. ncbi request reprint Scientific knowledge gaps and clinical research priorities for cardiopulmonary resuscitation and emergency cardiovascular care identified during the 2005 International Consensus Conference on ECC and CPR Science with Treatment Recommendations. A consensus
    Raúl J Gazmuri
    Rosalind Franklin University of Medicine and Science, North Chicago Medical Center, Chicago, USA
    Resuscitation 75:400-11. 2007
  44. ncbi request reprint Major changes in the 2005 AHA Guidelines for CPR and ECC: reaching the tipping point for change
    Mary Fran Hazinski
    Circulation 112:IV206-11. 2005
  45. doi request reprint In-hospital pediatric cardiac arrest
    Marc D Berg
    Division of Pediatric Critical Care Medicine, Department of Pediatrics, Steele Memorial Research Center and Sarver Heart Center, The University of Arizona College of Medicine, Tucson, AZ 85724, USA
    Pediatr Clin North Am 55:589-604, x. 2008
    ..Performance of, and technologic advances in, the treatment of cardiac arrest make this an exciting time in the field...
  46. ncbi request reprint Temperature regulation after cardiac arrest... Timing is everything!
    Marilyn C Morris
    Crit Care Med 31:654-5. 2003
  47. ncbi request reprint Recommended guidelines for monitoring, reporting, and conducting research on medical emergency team, outreach, and rapid response systems: an Utstein-style scientific statement. A Scientific Statement from the International Liaison Committee on Resuscitat
    Mary Ann Peberdy
    Resuscitation 75:412-33. 2007
  48. ncbi request reprint Scientific knowledge gaps and clinical research priorities for cardiopulmonary resuscitation and emergency cardiovascular care identified during the 2005 International Consensus Conference on ECC [corrected] and CPR science with treatment recommendations:
    Raúl J Gazmuri
    North Chicago VA and Rosalind Franklin University of Medicine and Science, USA
    Circulation 116:2501-12. 2007
  49. ncbi request reprint Conflict of interest management before, during, and after the 2005 International Consensus Conference on cardiopulmonary resuscitation and emergency cardiovascular care science with treatment recommendations
    John E Billi
    Resuscitation 67:171-3. 2005

Research Grants1

  1. Improving patient safety with just-in-time pediatric simulation training
    Vinay Nadkarni; Fiscal Year: 2007
    ..If this study demonstrates that simulation overtraining improves safety, these techniques will be adopted and implemented in diverse high-risk settings to improve the care of critically ill children. ..