Jorge M Naciff

Summary

Affiliation: The Procter and Gamble Company
Country: USA

Publications

  1. ncbi request reprint Gene expression profile induced by 17alpha-ethynyl estradiol, bisphenol A, and genistein in the developing female reproductive system of the rat
    Jorge M Naciff
    The Procter and Gamble Company, Miami Valley Laboratories, P O Box 538707, No 805, Cincinnati, OH 45253 8707, USA
    Toxicol Sci 68:184-99. 2002
  2. doi request reprint The genomic response of Ishikawa cells to bisphenol A exposure is dose- and time-dependent
    Jorge M Naciff
    Miami Valley Innovation Center, The Procter and Gamble Company, PO Box 538707 805, Cincinnati, OH 45253 8707, United States
    Toxicology 270:137-49. 2010
  3. ncbi request reprint Uterine temporal response to acute exposure to 17alpha-ethinyl estradiol in the immature rat
    Jorge M Naciff
    The Procter and Gamble Company, Miami Valley Innovation Center, Cincinnati, OH 45253, USA
    Toxicol Sci 97:467-90. 2007
  4. pmc Design of a microsphere-based high-throughput gene expression assay to determine estrogenic potential
    Jorge M Naciff
    Miami Valley Innovation Center, Procter and Gamble Company, Cincinnati, OH 45253, USA
    Environ Health Perspect 113:1164-71. 2005
  5. ncbi request reprint Gene expression changes induced in the testis by transplacental exposure to high and low doses of 17{alpha}-ethynyl estradiol, genistein, or bisphenol A
    Jorge M Naciff
    Miami Valley Innovation Center, The Procter and Gamble Company, Cincinnati, Ohio 45253, USA
    Toxicol Sci 86:396-416. 2005
  6. ncbi request reprint Evaluation of the gene expression changes induced by 17-alpha-ethynyl estradiol in the immature uterus/ovaries of the rat using high density oligonucleotide arrays
    Jorge M Naciff
    Miami Valley Innovation Center, The Procter and Gamble Company, Cincinnati, Ohio 45253 8707, USA
    Birth Defects Res B Dev Reprod Toxicol 74:164-84. 2005
  7. pmc Impact of the phytoestrogen content of laboratory animal feed on the gene expression profile of the reproductive system in the immature female rat
    Jorge M Naciff
    Miami Valley Laboratories, The Procter and Gamble Company, Cincinnati, Ohio 45253 8707, USA
    Environ Health Perspect 112:1519-26. 2004
  8. ncbi request reprint Toxicogenomic approach to endocrine disrupters: identification of a transcript profile characteristic of chemicals with estrogenic activity
    Jorge M Naciff
    Miami Valley Laboratories, The Procter and Gamble Company, Cincinnati, Ohio 45253, USA
    Toxicol Pathol 32:59-70. 2004
  9. ncbi request reprint Gene expression profile induced by 17 alpha-ethynyl estradiol in the prepubertal female reproductive system of the rat
    Jorge M Naciff
    Miami Valley Laboratories, The Procter and Gamble Company, Cincinnati, Ohio 45253, USA
    Toxicol Sci 72:314-30. 2003
  10. doi request reprint The genomic response of a human uterine endometrial adenocarcinoma cell line to 17alpha-ethynyl estradiol
    Jorge M Naciff
    Miami Valley Innovation Center, The Procter and Gamble Company, Cincinnati, Ohio 45253, USA
    Toxicol Sci 107:40-55. 2009

Collaborators

Detail Information

Publications16

  1. ncbi request reprint Gene expression profile induced by 17alpha-ethynyl estradiol, bisphenol A, and genistein in the developing female reproductive system of the rat
    Jorge M Naciff
    The Procter and Gamble Company, Miami Valley Laboratories, P O Box 538707, No 805, Cincinnati, OH 45253 8707, USA
    Toxicol Sci 68:184-99. 2002
    ....
  2. doi request reprint The genomic response of Ishikawa cells to bisphenol A exposure is dose- and time-dependent
    Jorge M Naciff
    Miami Valley Innovation Center, The Procter and Gamble Company, PO Box 538707 805, Cincinnati, OH 45253 8707, United States
    Toxicology 270:137-49. 2010
    ..These results indicate that Ishikawa cells are capable of generating a biologically relevant estrogenic response after exposure to chemicals with varied estrogenic activity, and offer an in vitro model to assess this mode of action...
  3. ncbi request reprint Uterine temporal response to acute exposure to 17alpha-ethinyl estradiol in the immature rat
    Jorge M Naciff
    The Procter and Gamble Company, Miami Valley Innovation Center, Cincinnati, OH 45253, USA
    Toxicol Sci 97:467-90. 2007
    ..The compendium of genes here presented represents a comprehensive compilation of estrogen-responsive genes involved in the uterotrophic response...
  4. pmc Design of a microsphere-based high-throughput gene expression assay to determine estrogenic potential
    Jorge M Naciff
    Miami Valley Innovation Center, Procter and Gamble Company, Cincinnati, OH 45253, USA
    Environ Health Perspect 113:1164-71. 2005
    ..5 microg starting cRNA. This assay offers increased throughput with decreased costs compared with existing microarray technologies, with the trade-off being in the total number of transcripts that can be analyzed...
  5. ncbi request reprint Gene expression changes induced in the testis by transplacental exposure to high and low doses of 17{alpha}-ethynyl estradiol, genistein, or bisphenol A
    Jorge M Naciff
    Miami Valley Innovation Center, The Procter and Gamble Company, Cincinnati, Ohio 45253, USA
    Toxicol Sci 86:396-416. 2005
    ..These results indicate that gene expression data are diagnostic of mode of action and, if they are evaluated in the context of traditional toxicological end-points, can be used to elucidate dose-response characteristics...
  6. ncbi request reprint Evaluation of the gene expression changes induced by 17-alpha-ethynyl estradiol in the immature uterus/ovaries of the rat using high density oligonucleotide arrays
    Jorge M Naciff
    Miami Valley Innovation Center, The Procter and Gamble Company, Cincinnati, Ohio 45253 8707, USA
    Birth Defects Res B Dev Reprod Toxicol 74:164-84. 2005
    ..In order to better determine whether common sets of gene expression changes can be predictive of estrogenic activity, we have replicated the previous experiment using the more comprehensive microarray...
  7. pmc Impact of the phytoestrogen content of laboratory animal feed on the gene expression profile of the reproductive system in the immature female rat
    Jorge M Naciff
    Miami Valley Laboratories, The Procter and Gamble Company, Cincinnati, Ohio 45253 8707, USA
    Environ Health Perspect 112:1519-26. 2004
    ..Our results indicate that although diet composition has an impact on gene expression in uterus and ovaries, it does not contribute to the effects of an ER agonist...
  8. ncbi request reprint Toxicogenomic approach to endocrine disrupters: identification of a transcript profile characteristic of chemicals with estrogenic activity
    Jorge M Naciff
    Miami Valley Laboratories, The Procter and Gamble Company, Cincinnati, Ohio 45253, USA
    Toxicol Pathol 32:59-70. 2004
    ....
  9. ncbi request reprint Gene expression profile induced by 17 alpha-ethynyl estradiol in the prepubertal female reproductive system of the rat
    Jorge M Naciff
    Miami Valley Laboratories, The Procter and Gamble Company, Cincinnati, Ohio 45253, USA
    Toxicol Sci 72:314-30. 2003
    ..Moreover, those genes could be used as biomarkers to identify chemicals with estrogenic activity...
  10. doi request reprint The genomic response of a human uterine endometrial adenocarcinoma cell line to 17alpha-ethynyl estradiol
    Jorge M Naciff
    Miami Valley Innovation Center, The Procter and Gamble Company, Cincinnati, Ohio 45253, USA
    Toxicol Sci 107:40-55. 2009
    ....
  11. doi request reprint Effects of transplacental 17-α-ethynyl estradiol or bisphenol A on the developmental profile of steroidogenic acute regulatory protein in the rat testis
    Karla A Horstman
    Mason Business Center, The Procter and Gamble Company, Mason, OH, USA
    Birth Defects Res B Dev Reprod Toxicol 95:318-25. 2012
    ..High levels of estrogens decrease StAR expression in the fetal rat testis during late gestation...
  12. ncbi request reprint Gene expression changes related to growth and differentiation in the fetal and juvenile reproductive system of the female rat: evaluation of microarray results
    George P Daston
    Miami Valley Laboratories, The Procter and Gamble Company, P O Box 538707, Cincinnati, OH 45253, USA
    Reprod Toxicol 19:381-94. 2005
    ....
  13. doi request reprint Predicting developmental toxicity through toxicogenomics
    George P Daston
    Miami Valley Innovation Center, The Procter and Gamble Company, Cincinnati, Ohio 45253, USA
    Birth Defects Res C Embryo Today 90:110-7. 2010
    ..Although gene expression in response to estrogens is tissue, life stage, and sex specific, it is feasible to identify transcript profiles that are diagnostic of this mode of action...
  14. pmc Identification of putative gene based markers of renal toxicity
    Rupesh P Amin
    National Institute of Environmental Health Sciences, National Institutes of Health DHHS, Research Triangle Park, North Carolina, USA
    Environ Health Perspect 112:465-79. 2004
    ..We conclude that renal gene expression profiling coupled with analysis of classical end points affords promising opportunities to reveal potential new mechanistic markers of renal toxicity...
  15. pmc Identification of platform-independent gene expression markers of cisplatin nephrotoxicity
    Karol L Thompson
    Center for Drug Evaluation and Research, Division of Applied Pharmacology Research, U S Food and Drug Administration, 10903 New Hampshire Avenue, Life Sciences Building 64, Silver Spring, MD 20993, USA
    Environ Health Perspect 112:488-94. 2004
    ....
  16. pmc Overview on the application of transcription profiling using selected nephrotoxicants for toxicology assessment
    Jeffrey A Kramer
    Pfizer Inc, St Louis, Missouri, USA
    Environ Health Perspect 112:460-4. 2004
    ..The potential future extension of these applications for risk assessment is also discussed...