Affiliation: The Ohio State University
Do P, Beckwith K, Cheney C, Tran M, Beaver L, Griffin B, et al
. Leukemic B Cell CTLA-4 Suppresses Costimulation of T Cells. J Immunol. 2019;202:2806-2816 pubmed publisher
..These data implicate tumor CTLA-4 in cancer cell-mediated immunosuppression in vitro and as having a functional role in tumor cells in vivo. ..
Mao Y, Wang J, Zhao Y, Wu Y, Kwak K, Chen C, et al
. A novel liposomal formulation of FTY720 (fingolimod) for promising enhanced targeted delivery. Nanomedicine. 2014;10:393-400 pubmed publisher
..The method expected to overcome the limited application of free FTY720 to B malignancy treatment. ..
Mani R, Goswami S, Gopalakrishnan B, Ramaswamy R, Wasmuth R, Tran M, et al
. The interleukin-3 receptor CD123 targeted SL-401 mediates potent cytotoxic activity against CD34+CD123+ cells from acute myeloid leukemia/myelodysplastic syndrome patients and healthy donors. Haematologica. 2018;103:1288-1297 pubmed publisher
..These findings indicate potential use of SL-401 as a "bridge-to-transplant" before allogeneic hematopoietic cell transplantation in acute myeloid leukemia / myelodysplastic syndrome patients. ..
Muthusamy N, Breidenbach H, Andritsos L, Flynn J, Jones J, Ramanunni A, et al
. Enhanced detection of chromosomal abnormalities in chronic lymphocytic leukemia by conventional cytogenetics using CpG oligonucleotide in combination with pokeweed mitogen and phorbol myristate acetate. Cancer Genet. 2011;204:77-83 pubmed publisher
..These studies provide evidence for potential use of GNKG168 in combination with PWM and PMA in karyotypic analysis of CLL patient samples to better identify chromosomal abnormalities for risk stratification. ..
Muthusamy N, Chen H, Rajgolikar G, Butz K, Frissora F, Gronostajski R. Recombination activation gene-2-deficient blastocyst complementation analysis reveals an essential role for nuclear factor I-A transcription factor in T-cell activation. Int Immunol. 2011;23:385-90 pubmed publisher
..These studies demonstrate for the first time a requirement for the NFI-A transcription factor in antigen receptor-induced T-cell activation events. ..
Mani R, Chiang C, Frissora F, Yan R, Mo X, Baskar S, et al
. ROR1-targeted delivery of OSU-2S, a nonimmunosuppressive FTY720 derivative, exerts potent cytotoxicity in mantle-cell lymphoma in vitro and in vivo. Exp Hematol. 2015;43:770-4.e2 pubmed publisher
..The newly developed OSU-2S delivery using ROR1-directed immunonanoparticles provide selective targeting of OSU-2S to MCL and other ROR1(+) malignancies, sparing normal B cells. ..