Maureen E Murphy

Summary

Affiliation: The Wistar Institute
Country: USA

Publications

  1. pmc The HSP70 family and cancer
    Maureen E Murphy
    Program in Molecular and Cellular Oncogenesis, The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA
    Carcinogenesis 34:1181-8. 2013
  2. pmc Acetylation of the DNA binding domain regulates transcription-independent apoptosis by p53
    Stephen M Sykes
    Biomedical Graduate Studies, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 284:20197-205. 2009
  3. pmc Interaction of the ARF tumor suppressor with cytosolic HSP70 contributes to its autophagy function
    Julia Pimkina
    Program in Developmental Therapeutics, Philadelphia, PA, USA
    Cancer Biol Ther 12:503-9. 2011
  4. pmc ARF induces autophagy by virtue of interaction with Bcl-xl
    Julia Pimkina
    Division of Medical Sciences, the Smolensk State Medical Academy Graduate Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    J Biol Chem 284:2803-10. 2009
  5. pmc Wild-type and mutant p53 proteins interact with mitochondrial caspase-3
    Amanda K Frank
    Program in Developmental Therapeutics, Fox Chase Cancer Center, Philadelphia, PA, USA
    Cancer Biol Ther 11:740-5. 2011
  6. pmc Oligomerization of BAK by p53 utilizes conserved residues of the p53 DNA binding domain
    E Christine Pietsch
    Division of Medical Sciences and Program in Biomolecular Structure and Function, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    J Biol Chem 283:21294-304. 2008
  7. pmc HSP70 inhibition by the small-molecule 2-phenylethynesulfonamide impairs protein clearance pathways in tumor cells
    J I Ju Leu
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Mol Cancer Res 9:936-47. 2011
  8. pmc A small molecule inhibitor of inducible heat shock protein 70
    J I Ju Leu
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6145, USA
    Mol Cell 36:15-27. 2009
  9. pmc A modified HSP70 inhibitor shows broad activity as an anticancer agent
    Gregor M Balaburski
    Program in Molecular and Cellular Oncogenesis, The Wistar Institute, Philadelphia, PA 19104, USA
    Mol Cancer Res 11:219-29. 2013
  10. ncbi request reprint The tetramerization domain of p53 is required for efficient BAK oligomerization
    E Christine Pietsch
    Program in Cell and Developmental Biology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Cancer Biol Ther 6:1576-83. 2007

Collaborators

  • Jack T Zilfou
  • Neil Beeharry
  • Yan Zhou
  • Monica Hollstein
  • Julia Pimkina
  • J I Ju Leu
  • E Christine Pietsch
  • Amanda K Frank
  • Donna L George
  • Amanda Frank
  • Stephen M Sykes
  • Olivier Humbey
  • Gregor M Balaburski
  • Julia I Ju Leu
  • Roland L Dunbrack
  • Patrick Dumont
  • Michal Jarnik
  • Steven B McMahon
  • Hestia Mellert
  • Mark D Andrake
  • Jessie Villanueva
  • Meenhard Herlyn
  • Gao Zhang
  • Tim Yen
  • Seth Hayik
  • Andres Klein-Szanto
  • Karthik Devarajan
  • Pooja Pandey
  • Tatiana Nedelko
  • Joy Tao
  • Timothy J Stanek
  • Darren J Burgess
  • Adrian A Canutescu
  • Erin Perchiniak
  • Christine M Eischen
  • Guoli Wang
  • Carmen Dominguez-Brauer

Detail Information

Publications17

  1. pmc The HSP70 family and cancer
    Maureen E Murphy
    Program in Molecular and Cellular Oncogenesis, The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA
    Carcinogenesis 34:1181-8. 2013
    ..In this review, the history, regulation, mechanism of action and role in cancer of the HSP70 family are reviewed. Additionally, the promise of pharmacologically targeting this protein for cancer therapy is addressed...
  2. pmc Acetylation of the DNA binding domain regulates transcription-independent apoptosis by p53
    Stephen M Sykes
    Biomedical Graduate Studies, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 284:20197-205. 2009
    ..These data support a model whereby Lys-120 acetylation contributes to both the transcription-dependent and -independent apoptotic pathways induced by p53...
  3. pmc Interaction of the ARF tumor suppressor with cytosolic HSP70 contributes to its autophagy function
    Julia Pimkina
    Program in Developmental Therapeutics, Philadelphia, PA, USA
    Cancer Biol Ther 12:503-9. 2011
    ..High levels of ARF are characteristic of tumor cells with enhanced MAPK signaling and advanced stage; therefore, these data support the premise that PES may show preferential cytotoxicity to advanced stage cancers...
  4. pmc ARF induces autophagy by virtue of interaction with Bcl-xl
    Julia Pimkina
    Division of Medical Sciences, the Smolensk State Medical Academy Graduate Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    J Biol Chem 284:2803-10. 2009
    ..The combined data support the premise that ARF induces autophagy in a p53-independent manner in part by virtue of its interaction with Bcl-xl...
  5. pmc Wild-type and mutant p53 proteins interact with mitochondrial caspase-3
    Amanda K Frank
    Program in Developmental Therapeutics, Fox Chase Cancer Center, Philadelphia, PA, USA
    Cancer Biol Ther 11:740-5. 2011
    ..The combined data suggest that tumor-derived mutants of p53 may be selected for in tumor cells due to their ability to bind and inhibit the activation of caspase-3...
  6. pmc Oligomerization of BAK by p53 utilizes conserved residues of the p53 DNA binding domain
    E Christine Pietsch
    Division of Medical Sciences and Program in Biomolecular Structure and Function, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    J Biol Chem 283:21294-304. 2008
    ..The combined data point to the H2 helix and L1 and L3 loops of p53 as novel functional domains contributing to transcription-independent apoptosis by this tumor suppressor protein...
  7. pmc HSP70 inhibition by the small-molecule 2-phenylethynesulfonamide impairs protein clearance pathways in tumor cells
    J I Ju Leu
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Mol Cancer Res 9:936-47. 2011
    ..Overall, PES simultaneously disrupts several cancer critical survival pathways, supporting the idea of targeting HSP70 as a potential approach for cancer therapeutics...
  8. pmc A small molecule inhibitor of inducible heat shock protein 70
    J I Ju Leu
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6145, USA
    Mol Cell 36:15-27. 2009
    ....
  9. pmc A modified HSP70 inhibitor shows broad activity as an anticancer agent
    Gregor M Balaburski
    Program in Molecular and Cellular Oncogenesis, The Wistar Institute, Philadelphia, PA 19104, USA
    Mol Cancer Res 11:219-29. 2013
    ..PES-Cl is thus a promising new anticancer compound with several notable mechanisms of action...
  10. ncbi request reprint The tetramerization domain of p53 is required for efficient BAK oligomerization
    E Christine Pietsch
    Program in Cell and Developmental Biology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Cancer Biol Ther 6:1576-83. 2007
    ..These data indicate that pro-apoptotic BAK, unlike other BCL2 family members, may serve as a major receptor for p53 on the mitochondria...
  11. pmc The ARF tumor suppressor can promote the progression of some tumors
    Olivier Humbey
    Division of Medical Sciences, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Cancer Res 68:9608-13. 2008
    ..These data are the first to show that ARF can act in a p53-independent manner to promote the progression of some tumors...
  12. pmc The codon 72 polymorphism of p53 regulates interaction with NF-{kappa}B and transactivation of genes involved in immunity and inflammation
    Amanda K Frank
    Fox Chase Cancer Center, W209, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Mol Cell Biol 31:1201-13. 2011
    ..Consistent with this, we show that P72 mice have a markedly enhanced response to inflammatory challenge compared to that of R72 mice. Our data indicate that the codon 72 polymorphism impacts p53's role in inflammation...
  13. pmc ARF, autophagy and tumor suppression
    Julia Pimkina
    Division of Medical Sciences, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Autophagy 5:397-9. 2009
    ..Rather, ARF-silencing enhances sarcoma development. These data suggest that the survival-benefit of ARF, and possibly also of autophagy, may be restricted to certain tumor types...
  14. ncbi request reprint The ARF/oncogene pathway activates p53 acetylation within the DNA binding domain
    Hestia Mellert
    Biomedical Graduate Studies, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Cell Cycle 6:1304-6. 2007
    ..We demonstrate here that both the DNA damage response pathway and the p19ARF/oncogene stress pathway induce the acetylation of p53 at lysine 120...
  15. ncbi request reprint A novel cancer therapy approach targeting microtubule function
    Maureen E Murphy
    Program in Cell and Developmental Biology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Cancer Biol Ther 5:1721-3. 2006
  16. ncbi request reprint Regulation of cell death in oncogenesis
    Maureen E Murphy
    Department of Pharmacology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Cancer Res 65:8069-71. 2005
  17. ncbi request reprint p53 moves to mitochondria: a turn on the path to apoptosis
    Maureen E Murphy
    Department of Pharmacology, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA
    Cell Cycle 3:836-9. 2004
    ..New data, however, suggest that p53 itself also has a direct role in accomplishing cell death, at the mitochondria...