Research Topics
| William W MuirSummaryAffiliation: The Animal Medical Center Country: USA Publications
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Detail Information
Publications
Effects of intravenous administration of lactated Ringer's solution on hematologic, serum biochemical, rheological, hemodynamic, and renal measurements in healthy isoflurane-anesthetized dogsWilliam W Muir
QTest Laboratories, 6456 Fiesta Dr, Columbus, OH 43235, USA
J Am Vet Med Assoc 239:630-7. 2011..To determine the hematologic, serum biochemical, rheological, hemodynamic, and renal effects of IV administration of lactated Ringer's solution (LRS) to healthy anesthetized dogs...- NMDA receptor antagonists and pain: ketamineWilliam W Muir
Equine Anesthesia and Analgesia Consulting Services, 338 West 7th Avenue, Columbus, OH 43201, USA
Vet Clin North Am Equine Pract 26:565-78. 2010..This review focuses on the development of ketamine as an anesthetic and analgesic in horses... - Pain: mechanisms and management in horsesWilliam W Muir
Equine Anesthesia and Analgesia Consulting Services, 338 West 7th Avenue, Columbus, OH 43201, USA
Vet Clin North Am Equine Pract 26:467-80. 2010..Prospective, randomized clinical trials conducted in horses that suffer from naturally occurring pain will help to determine the current best approaches to effective pain therapy... 
Characteristics of pain and response to analgesic treatment in dogs and cats examined at a veterinary teaching hospital emergency serviceAshley J Wiese
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210-1089, USA
J Am Vet Med Assoc 226:2004-9. 2005....- Effects of intravenous administration of perzinfotel, fentanyl, and a combination of both drugs on the minimum alveolar concentration of isoflurane in dogsYukie Ueyama
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA
Am J Vet Res 70:1459-64. 2009..No adverse effects were detected. CONCLUSIONS AND CLINICAL RELEVANCE-IV administration of perzinfotel, fentanyl, or a perzinfotel-fentanyl combination reduced isoflurane MAC in dogs and increased arterial blood pressure... - Effects of perzinfotel on the minimum alveolar concentration of isoflurane in dogsTokiko Kushiro
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA
Am J Vet Res 68:1294-9. 2007..To determine the effect of IV administration of perzinfotel on the minimum alveolar concentration (MAC) of isoflurane in dogs. Animals-6 healthy sexually intact male Beagles... - Evaluation of hyperviscous fluid resuscitation in a canine model of hemorrhagic shock: a randomized, controlled studyEdward S Cooper
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio 43210, USA
J Trauma 66:1365-73. 2009..We hypothesized that resuscitation with hyperviscous lactated Ringer's solution (hyperLRS) would result in improved tissue oxygenation and acid-base values in hemorrhaged dogs... - Comparisons of the effects of acupuncture, electroacupuncture, and transcutaneous cranial electrical stimulation on the minimum alveolar concentration of isoflurane in dogsLindsey B Culp
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA
Am J Vet Res 66:1364-70. 2005..However, the reduction in isoflurane MAC by EA andTCES treatments was not considered clinically relevant... - Comparison of lactated Ringer's solution and a physiologically balanced 6% hetastarch plasma expander for the treatment of hypotension induced via blood withdrawal in isoflurane-anesthetized dogsWilliam W Muir
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA
Am J Vet Res 65:1189-94. 2004..CONCLUSIONS AND CLINICAL RELEVANCE: Compared with LRS infusion, smaller volumes of hetastarch solution normalized and maintained SAP without lowering COP in isoflurane-anesthetized dogs after blood withdrawal... 
Effect of 50% and maximal inspired oxygen concentrations on respiratory variables in isoflurane-anesthetized horsesJohn A E Hubbell
Deparment of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA
BMC Vet Res 7:23. 2011..Our hypothesis was that 0.5 FiO₂ would reduce ventilation-perfusion mismatching and increase the fraction of pulmonary blood flow that is oxygenated, thus improving arterial oxygen content and DO₂...- Effect of intravenous administration of lactated Ringer's solution or hetastarch for the treatment of isoflurane-induced hypotension in dogsTuri K Aarnes
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA
Am J Vet Res 70:1345-53. 2009..To determine the effect of IV administration of crystalloid (lactated Ringer's solution [LRS]) or colloid (hetastarch) fluid on isoflurane-induced hypotension in dogs... - Anesthetic and cardiopulmonary effects of intramuscular morphine, medetomidine, ketamine injection in dogsYukie Ueyama
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH, USA
Vet Anaesth Analg 35:480-7. 2008..To determine the quality and duration of anesthesia and the cardiopulmonary effects of a morphine, medetomidine, ketamine (MMK) combination administered intramuscularly (IM) to dogs... - Effect of medetomidine on respiration and minimum alveolar concentration in halothane- and isoflurane-anesthetized dogsPhillip Lerche
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA
Am J Vet Res 67:782-9. 2006..Relatively low doses of medetomidine decrease the MAC of halothane and isoflurane in dogs... - Use of the bispectral index as a monitor of anesthetic depth in cats anesthetized with isofluranePhilip A March
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA
Am J Vet Res 64:1534-41. 2003..The change in BIS values after a noxious somatic or visceral stimulus was a reliable measure of anesthetic depth and may be a useful measure of early arousal from the hypnotic state... - Prevalence and characteristics of pain in dogs and cats examined as outpatients at a veterinary teaching hospitalWilliam W Muir
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA
J Am Vet Med Assoc 224:1459-63. 2004..Older, heavier dogs and older cats were more likely to have evidence of pain... - Investigation of escalating and large bolus doses of a novel, nano-droplet, aqueous 1% propofol formulation in catsAshley J Wiese
Department of Veterinary Clinical Sciences, The Ohio State University, Columbus, OH 43210, USA
Vet Anaesth Analg 37:250-7. 2010..Identify, describe, and quantitate effects of an escalating dose of a nano-droplet formulation of 1% w/v propofol in telemetered cats... - Vital organ tissue oxygenation after serial normovolemic exchange transfusion with HBOC-201 in anesthetized swineWilliam W Muir
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, Ohio, USA
Shock 35:597-603. 2011..Heart rate and left ventricular end-diastolic pressure were not different among treatment groups. In conclusion, the administration of HBOC-201 maintained tPO2 in three vital organs after profound hemodilution... - Bispectral analysis of the electroencephalogram: a review of its development and use in anesthesiaPhilip A March
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH, USA
Vet Anaesth Analg 32:241-55. 2005..However, application of this technique during the use of various drug combinations (i.e. clinical anesthesia) will require further research and understanding... - Analgesic, behavioral, and hemodynamic and respiratory effects of midsacral subarachnoidally administered ropivacaine hydrochloride in maresRoman T Skarda
Department of Veterinary Clinical Sciences, The Ohio State University, 601 Vernon L Tharp Street, Columbus, OH 43210 1089, USA
Vet Anaesth Analg 30:37-50. 2003..To determine the analgesic, behavioral, hemodynamic and respiratory effects of midsacral subarachnoid administration of ropivacaine hydrochloride solution in mares... - Minimum alveolar concentration measures of central nervous system activation in cats anesthetized with isofluranePhilip A March
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA
Am J Vet Res 64:1528-33. 2003..Bispectral index values obtained after somatic or visceral stimulation were sensitive for the detection of early changes in cortical excitability... - Prevention of central sensitization and pain by N-methyl-D-aspartate receptor antagonistsAntonio Pozzi
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA
J Am Vet Med Assoc 228:53-60. 2006 - Pain management in cattleDavid E Anderson
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA
Vet Clin North Am Food Anim Pract 21:623-35, v-vi. 2005 - Effects of morphine, lidocaine, ketamine, and morphine-lidocaine-ketamine drug combination on minimum alveolar concentration in dogs anesthetized with isofluraneWilliam W Muir
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA
Am J Vet Res 64:1155-60. 2003..The BIS can be used to monitor depth of anesthesia... - Effect of medetomidine on breathing and inspiratory neuromuscular drive in conscious dogsPhillip Lerche
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA
Am J Vet Res 65:720-4. 2004..v. administration of medetomidine decreases RR, V(M), and central respiratory drive in conscious dogs. Medetomidine should be used cautiously and with careful monitoring in dogs with CNS depression or respiratory compromise... - Comparison of the effect of propofol and sevoflurane on the urethral pressure profile in healthy female dogsJulie K Byron
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA
Am J Vet Res 64:1288-92. 2003..Titration of anesthetic depth is a critical component of urodynamic testing... - Continuous cardiac output monitoring via arterial pressure waveform analysis following severe hemorrhagic shock in dogsEdward S Cooper
College of Veterinary Medicine, Department of Veterinary Clinical Sciences, The Ohio State University, Columbus, OH, USA
Crit Care Med 35:1724-9. 2007.... - Pain management in ruminantsDavid E Anderson
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, 601 Tharp Street, Columbus, OH 43210, USA
Vet Clin North Am Food Anim Pract 21:19-31. 2005.... - Evaluation of a commercial ultrasonographic hemodynamic recording system for the measurement of cardiac output in dogsBrian A Scansen
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA
Am J Vet Res 70:862-8. 2009..To evaluate the accuracy of a commercial ultrasonographic cardiac output (CO) monitoring system (UCOMS) in anesthetized Beagles as assessed by comparison with thermodilution CO (TDCO)... - Sodium nitroprusside-induced deliberate hypotension to facilitate patent ductus arteriosus ligation in dogsSuzanne L Hunter
Section of Surgery, Department of Veterinary Clinical Sciences, The Ohio State University Veterinary Teaching Hospital, Columbus, OH, USA
Vet Surg 32:336-40. 2003..CLINICAL RELEVANCE: Sodium nitroprusside infusion produces hypotension within 5 to 10 minutes and is easy to control, rapidly abates, and should help to facilitate surgical ligation of PDA... - Hemoglobin solutions and tissue oxygenationWilliam W Muir
Department of Veterinary Clinical Sciences College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210 1089, USA
J Vet Intern Med 17:127-35. 2003..However, mechanisms responsible for HBOC-facilitated, O2-dependent autoregulatory changes in the microcirculation have not been completely elucidated... - Comparison of electroacupuncture and butorphanol on respiratory and cardiovascular effects and rectal pain threshold after controlled rectal distention in maresRoman T Skarda
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA
Am J Vet Res 64:137-44. 2003..CONCLUSIONS AND CLINICAL RELEVANCE: Electroacupuncture and butorphanol (0.1 mg/kg, IV) may provide useful rectal analgesia in horses...