Affiliation: The Rockefeller University
EsterhÃ¡zy D, Mucida D. Serum amyloid A proteins take retinol for a ride. Trends Immunol. 2014;35:505-6 pubmed publisher
Reis B, Lee K, Fanok M, Mascaraque C, Amoury M, Cohn L, et al
. Leptin receptor signaling in T cells is required for Th17 differentiation. J Immunol. 2015;194:5253-60 pubmed publisher
..This study establishes cell-intrinsic roles for LepR signaling in the immune system and suggests that leptin signaling during T cell differentiation plays a crucial role in T cell peripheral effector function. ..
Rogoz A, Reis B, Karssemeijer R, Mucida D. A 3-D enteroid-based model to study T-cell and epithelial cell interaction. J Immunol Methods. 2015;421:89-95 pubmed publisher
Pedicord V, Mucida D. "A Sledgehammer Breaks Glass but Forges Steel": Bacteria Adhesion Shapes Gut Immunity. Cell. 2015;163:273-4 pubmed publisher
..Two studies by Atarashi et al. and Sano et al. shed light on how bacterial adhesion can cue intestinal epithelial cells to direct differentiation of gut T cells. ..
Veiga Fernandes H, Mucida D. Neuro-Immune Interactions at Barrier Surfaces. Cell. 2016;165:801-11 pubmed publisher
Muller P, Mucida D. Spineless Behavior of CX3CR1+ Monocytes in Response to Infection. Immunity. 2017;47:12-14 pubmed publisher
..In a recent Nature Medicine article, GarrÃ© etÂ al. (2017) report that sickness-induced cortical dendritic spine loss and impaired memory formation is mediated by CX3CR1+ monocyte-derived TNF-Î±. ..
Hoytema van Konijnenburg D, Reis B, Pedicord V, Farache J, Victora G, Mucida D. Intestinal Epithelial and Intraepithelial T Cell Crosstalk Mediates a Dynamic Response to Infection. Cell. 2017;171:783-794.e13 pubmed publisher
..Our results uncover a coordinated EC-IEL response to enteric infections that modulates lymphocyte energy utilization and dynamics and supports maintenance of the intestinal epithelial barrier. VIDEO ABSTRACT. ..
Muller P, Mucida D. Can U Turn ILC2s Up?. Cell. 2017;171:742-744 pubmed publisher
..Innate lymphoid cells (ILCs) are tuned to quickly respond to and amplify tissue-specific signals. Work of three independent groups in Nature uncovers a novel mode of inflammatory communication between ILC2s and neurons at mucosal surfaces. ..
Reis B, Hoytema van Konijnenburg D, Grivennikov S, Mucida D. Transcription factor T-bet regulates intraepithelial lymphocyte functional maturation. Immunity. 2014;41:244-56 pubmed publisher
..We conclude that the gut environment provides cues for IEL maturation through the interplay between T-bet and Runx3, allowing tissue-specific adaptation of mature T lymphocytes. ..