K Mrozek

Summary

Affiliation: The Ohio State University
Country: USA

Publications

  1. ncbi Prognostic value of cytogenetic findings in adults with acute myeloid leukemia
    K Mrozek
    Division of Hematology and Oncology and the Comprehensive Cancer Center, The Authur G James Cancer Hospital, The Ohio State University, Columbus 43210 1228, USA
    Int J Hematol 72:261-71. 2000
  2. ncbi Cytogenetics in acute leukemia
    Krzysztof Mrozek
    Division of Hematology and Oncology, The Comprehensive Cancer Center, The Arthur G James Cancer Hospital and Richard J Solove Research Institute, Room 1248B, The Ohio State University, Columbus, OH 43210 1228, USA
    Blood Rev 18:115-36. 2004
  3. ncbi Molecular cytogenetic characterization of the KG-1 and KG-1a acute myeloid leukemia cell lines by use of spectral karyotyping and fluorescence in situ hybridization
    Krzysztof Mrozek
    Division of Hematology and Oncology, and the Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA
    Genes Chromosomes Cancer 38:249-52. 2003
  4. ncbi Spectral karyotyping in patients with acute myeloid leukemia and a complex karyotype shows hidden aberrations, including recurrent overrepresentation of 21q, 11q, and 22q
    Krzysztof Mrozek
    Division of Hematology and Oncology and the Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210 1228, USA
    Genes Chromosomes Cancer 34:137-53. 2002
  5. ncbi Comparison of cytogenetic and molecular genetic detection of t(8;21) and inv(16) in a prospective series of adults with de novo acute myeloid leukemia: a Cancer and Leukemia Group B Study
    K Mrozek
    Division of Hematology and Oncology, Comprehensive Cancer Center, Ohio State University, Columbus, OH 43210 1228, USA
    J Clin Oncol 19:2482-92. 2001
  6. ncbi Spectral karyotyping reveals 17;22 fusions in a cytogenetically atypical dermatofibrosarcoma protuberans with a large marker chromosome as a sole abnormality
    K Mrozek
    Division of Hematology and Oncology, and the Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA
    Genes Chromosomes Cancer 31:182-6. 2001
  7. pmc GAS6 expression identifies high-risk adult AML patients: potential implications for therapy
    S P Whitman
    The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA
    Leukemia 28:1252-8. 2014
  8. ncbi Core binding factor acute myeloid leukemia. Cancer and Leukemia Group B (CALGB) Study 8461
    C D Bloomfield
    The Ohio State University, Columbus, OH, USA
    Ann Hematol 83:S84-5. 2004
  9. ncbi Clinical importance of cytogenetics in acute myeloid leukaemia
    K Mrozek
    Division of Hematology and Oncology and the Comprehensive Cancer Center, The Arthur G James Cancer Hospital and Richard J Solove Research Institute, The Ohio State University, Room 1248B, Columbus, OH, 43210 1228, USA
    Best Pract Res Clin Haematol 14:19-47. 2001
  10. pmc BAALC, the human member of a novel mammalian neuroectoderm gene lineage, is implicated in hematopoiesis and acute leukemia
    S M Tanner
    Human Cancer Genetics Program, Ohio State University, 646 Medical Research Facility, 420 West 12th Avenue, Columbus, OH 43210, USA
    Proc Natl Acad Sci U S A 98:13901-6. 2001

Collaborators

Detail Information

Publications11

  1. ncbi Prognostic value of cytogenetic findings in adults with acute myeloid leukemia
    K Mrozek
    Division of Hematology and Oncology and the Comprehensive Cancer Center, The Authur G James Cancer Hospital, The Ohio State University, Columbus 43210 1228, USA
    Int J Hematol 72:261-71. 2000
    ..In this review, we present an overview of major cytogenetic findings in AML and discuss associations between karyotype and clinical outcome of adults with AML...
  2. ncbi Cytogenetics in acute leukemia
    Krzysztof Mrozek
    Division of Hematology and Oncology, The Comprehensive Cancer Center, The Arthur G James Cancer Hospital and Richard J Solove Research Institute, Room 1248B, The Ohio State University, Columbus, OH 43210 1228, USA
    Blood Rev 18:115-36. 2004
    ..This review summarizes current views on clinical relevance of major cytogenetic findings in adult AML and ALL...
  3. ncbi Molecular cytogenetic characterization of the KG-1 and KG-1a acute myeloid leukemia cell lines by use of spectral karyotyping and fluorescence in situ hybridization
    Krzysztof Mrozek
    Division of Hematology and Oncology, and the Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA
    Genes Chromosomes Cancer 38:249-52. 2003
    ....
  4. ncbi Spectral karyotyping in patients with acute myeloid leukemia and a complex karyotype shows hidden aberrations, including recurrent overrepresentation of 21q, 11q, and 22q
    Krzysztof Mrozek
    Division of Hematology and Oncology and the Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210 1228, USA
    Genes Chromosomes Cancer 34:137-53. 2002
    ..We conclude that SKY considerably enhances the accuracy of karyotype interpretation, and that amplification of chromosomal material may play a greater role in leukemogenesis than has been recognized...
  5. ncbi Comparison of cytogenetic and molecular genetic detection of t(8;21) and inv(16) in a prospective series of adults with de novo acute myeloid leukemia: a Cancer and Leukemia Group B Study
    K Mrozek
    Division of Hematology and Oncology, Comprehensive Cancer Center, Ohio State University, Columbus, OH 43210 1228, USA
    J Clin Oncol 19:2482-92. 2001
    ....
  6. ncbi Spectral karyotyping reveals 17;22 fusions in a cytogenetically atypical dermatofibrosarcoma protuberans with a large marker chromosome as a sole abnormality
    K Mrozek
    Division of Hematology and Oncology, and the Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA
    Genes Chromosomes Cancer 31:182-6. 2001
    ..Furthermore, our case demonstrates the usefulness of SKY in detection of a diagnostically relevant 17;22 fusion in DFSP patients who have unusual karyotypic features...
  7. pmc GAS6 expression identifies high-risk adult AML patients: potential implications for therapy
    S P Whitman
    The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA
    Leukemia 28:1252-8. 2014
    ....
  8. ncbi Core binding factor acute myeloid leukemia. Cancer and Leukemia Group B (CALGB) Study 8461
    C D Bloomfield
    The Ohio State University, Columbus, OH, USA
    Ann Hematol 83:S84-5. 2004
  9. ncbi Clinical importance of cytogenetics in acute myeloid leukaemia
    K Mrozek
    Division of Hematology and Oncology and the Comprehensive Cancer Center, The Arthur G James Cancer Hospital and Richard J Solove Research Institute, The Ohio State University, Room 1248B, Columbus, OH, 43210 1228, USA
    Best Pract Res Clin Haematol 14:19-47. 2001
    ..This review presents current information on chromosome abnormalities in AML, and on associations between karyotype and clinical characteristics and outcome of AML patients...
  10. pmc BAALC, the human member of a novel mammalian neuroectoderm gene lineage, is implicated in hematopoiesis and acute leukemia
    S M Tanner
    Human Cancer Genetics Program, Ohio State University, 646 Medical Research Facility, 420 West 12th Avenue, Columbus, OH 43210, USA
    Proc Natl Acad Sci U S A 98:13901-6. 2001
    ..Our data suggest that BAALC is a gene implicated in both neuroectodermal and hematopoietic cell functions...
  11. pmc A stem cell-like gene expression signature associates with inferior outcomes and a distinct microRNA expression profile in adults with primary cytogenetically normal acute myeloid leukemia
    K H Metzeler
    The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA
    Leukemia 27:2023-31. 2013
    ..Fifteen miRs were upregulated in both younger and older CE(high) patients, including miRs relevant for stem cell function. Our results support the clinical relevance of LSCs and improve risk stratification in AML. ..