Peter M Moyle

Summary

Affiliation: The Rockefeller University
Country: USA

Publications

  1. ncbi request reprint Method for the synthesis of multi-epitopic Streptococcus pyogenes lipopeptide vaccines using native chemical ligation
    Peter M Moyle
    School of Pharmacy and School of Molecular and Microbial Sciences SMMS, University of Queensland, St Lucia, QLD, Australia
    J Org Chem 71:6846-50. 2006
  2. ncbi request reprint Self-adjuvanting lipopeptide vaccines
    Peter M Moyle
    School of Molecular and Microbial Sciences and School of Pharmacy, The University of Queensland, St Lucia 4072, QLD, Australia
    Curr Med Chem 15:506-16. 2008
  3. doi request reprint Development of a liposaccharide-based delivery system and its application to the design of group A streptococcal vaccines
    Pavla Simerska
    School of Molecular and Microbial Sciences, The University of Queensland, St Lucia 4072, Queensland, Australia
    J Med Chem 51:1447-52. 2008
  4. ncbi request reprint Method for the synthesis of highly pure vaccines using the lipid core peptide system
    Peter M Moyle
    School of Molecular and Microbial Biosciences, The University of Queensland, St Lucia, Queensland, Australia
    J Pept Sci 12:800-7. 2006
  5. ncbi request reprint Structure-activity relationship of a series of synthetic lipopeptide self-adjuvanting group a streptococcal vaccine candidates
    Abu Baker M Abdel-Aal
    School of Molecular and Microbial Sciences, The University of Queensland, St Lucia 4072, Queensland, Australia
    J Med Chem 51:167-72. 2008
  6. ncbi request reprint Synthesis of a highly pure lipid core peptide based self-adjuvanting triepitopic group A streptococcal vaccine, and subsequent immunological evaluation
    Peter M Moyle
    School of Pharmacy, The University of Queensland, St Lucia 4072, Queensland, Australia
    J Med Chem 49:6364-70. 2006
  7. ncbi request reprint Toward the development of prophylactic and therapeutic human papillomavirus type-16 lipopeptide vaccines
    Peter M Moyle
    School of Pharmacy, The University of Queensland, St Lucia 4072, Queensland, Australia
    J Med Chem 50:4721-7. 2007
  8. doi request reprint Investigation toward multi-epitope vaccine candidates using native chemical ligation
    Yoshio Fujita
    School of Molecular and Microbial Sciences SMMS, The University of Queensland, Brisbane QLD 4072, Australia
    Biopolymers 90:624-32. 2008
  9. ncbi request reprint An efficient, chemically-defined semisynthetic lipid-adjuvanted nanoparticulate vaccine development system
    Peter M Moyle
    School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia 4072, QLD, Australia Institute for Molecular Biosciences, The University of Queensland, St Lucia 4072, QLD, Australia Electronic address
    Nanomedicine 9:935-44. 2013
  10. ncbi request reprint Oral vaccine delivery--new strategies and technologies
    Pavla Simerska
    The University of Queensland, School of Chemistry and Molecular Biosciences, St Lucia, 4072, Queensland, Australia
    Curr Drug Deliv 6:347-58. 2009

Collaborators

Detail Information

Publications11

  1. ncbi request reprint Method for the synthesis of multi-epitopic Streptococcus pyogenes lipopeptide vaccines using native chemical ligation
    Peter M Moyle
    School of Pharmacy and School of Molecular and Microbial Sciences SMMS, University of Queensland, St Lucia, QLD, Australia
    J Org Chem 71:6846-50. 2006
    ..Intranasal immunization of the described tri-epitopic GAS lipopeptide with the mucosal adjuvant cholera toxin B subunit induced high serum IgG antibody titers specific for each of the incorporated peptide epitopes...
  2. ncbi request reprint Self-adjuvanting lipopeptide vaccines
    Peter M Moyle
    School of Molecular and Microbial Sciences and School of Pharmacy, The University of Queensland, St Lucia 4072, QLD, Australia
    Curr Med Chem 15:506-16. 2008
    ..g. monophosphoryl lipid A). The review also discusses the potential mechanisms of action for lipopeptide and glycolipopeptide vaccines, as well as structure activity relationships, and provides examples of studies utilising each system...
  3. doi request reprint Development of a liposaccharide-based delivery system and its application to the design of group A streptococcal vaccines
    Pavla Simerska
    School of Molecular and Microbial Sciences, The University of Queensland, St Lucia 4072, Queensland, Australia
    J Med Chem 51:1447-52. 2008
    ..High serum IgG antibody titers against each of the incorporated peptide epitopes were detected following subcutaneous immunization of B10.BR (H-2 (k)) mice with the liposaccharide vaccine candidates...
  4. ncbi request reprint Method for the synthesis of highly pure vaccines using the lipid core peptide system
    Peter M Moyle
    School of Molecular and Microbial Biosciences, The University of Queensland, St Lucia, Queensland, Australia
    J Pept Sci 12:800-7. 2006
    ..Subcutaneous immunization of B10.BR (H-2(k)) mice with one of these vaccines, without the addition of any adjuvant, elicited high levels of systemic IgG antibodies against each of the incorporated peptides...
  5. ncbi request reprint Structure-activity relationship of a series of synthetic lipopeptide self-adjuvanting group a streptococcal vaccine candidates
    Abu Baker M Abdel-Aal
    School of Molecular and Microbial Sciences, The University of Queensland, St Lucia 4072, Queensland, Australia
    J Med Chem 51:167-72. 2008
    ..Overall, the best vaccines featured a C-terminal lipid moiety, conjugated through a lysine residue to P25 at the N-terminus, and J14 on the lysine side chain...
  6. ncbi request reprint Synthesis of a highly pure lipid core peptide based self-adjuvanting triepitopic group A streptococcal vaccine, and subsequent immunological evaluation
    Peter M Moyle
    School of Pharmacy, The University of Queensland, St Lucia 4072, Queensland, Australia
    J Med Chem 49:6364-70. 2006
    ..Subcutaneous immunization of B10.BR (H-2(k)) mice with the synthesized vaccine, with or without the addition of complete Freund's adjuvant, elicited high serum IgG antibody titers against each of the incorporated peptide epitopes...
  7. ncbi request reprint Toward the development of prophylactic and therapeutic human papillomavirus type-16 lipopeptide vaccines
    Peter M Moyle
    School of Pharmacy, The University of Queensland, St Lucia 4072, Queensland, Australia
    J Med Chem 50:4721-7. 2007
    ....
  8. doi request reprint Investigation toward multi-epitope vaccine candidates using native chemical ligation
    Yoshio Fujita
    School of Molecular and Microbial Sciences SMMS, The University of Queensland, Brisbane QLD 4072, Australia
    Biopolymers 90:624-32. 2008
    ..It was found that the difficulty in NCL of first two peptide antigen was associated with the steric hindrance. Using Thz instead of Cys(Acm) and Msc-Cys was important to reduce the steric hindrance and improve NCL yield...
  9. ncbi request reprint An efficient, chemically-defined semisynthetic lipid-adjuvanted nanoparticulate vaccine development system
    Peter M Moyle
    School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia 4072, QLD, Australia Institute for Molecular Biosciences, The University of Queensland, St Lucia 4072, QLD, Australia Electronic address
    Nanomedicine 9:935-44. 2013
    ..pyogenes strains represented within the polytope sequence, with higher antibody levels observed where a dendritic cell targeting peptide (DCpep) was incorporated within the LCP adjuvant...
  10. ncbi request reprint Oral vaccine delivery--new strategies and technologies
    Pavla Simerska
    The University of Queensland, School of Chemistry and Molecular Biosciences, St Lucia, 4072, Queensland, Australia
    Curr Drug Deliv 6:347-58. 2009
    ..Approaches to overcome these obstacles aim to provide new vaccines and delivery systems that are capable of eliciting protective immune responses, and are making an impact on current vaccine development...
  11. ncbi request reprint Site-specific incorporation of three toll-like receptor 2 targeting adjuvants into semisynthetic, molecularly defined nanoparticles: application to group a streptococcal vaccines
    Peter M Moyle
    School of Pharmacy, The University of Queensland, Woolloongabba 4102, Queensland, Australia
    Bioconjug Chem 25:965-78. 2014
    ....