Research Topics
Genomes and GenesSpecies | K V MorrisSummaryAffiliation: The Scripps Research Institute Country: USA Publications
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Detail Information
Publications
Modulation of gene-specific epigenetic states and transcription by non-coding RNAsKevin V Morris
Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037 USA
Clin Epigenetics 2:433-7. 2011..Knowledge of this emerging RNA-based epigenetic regulatory network and our ability to cognitively control gene expression has deep implications in the development of an entirely new area of pharmacopeia...- Long antisense non-coding RNAs function to direct epigenetic complexes that regulate transcription in human cellsKevin V Morris
Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
Epigenetics 4:296-301. 2009..This perspective will highlight the endogenous effector RNAs and mechanism of action whereby long antisense non-coding RNAs transcriptionally regulate gene expression in human cells... - Non-coding RNAs, epigenetic memory and the passage of information to progenyKevin V Morris
Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
RNA Biol 6:242-7. 2009.... 
Characterization of human immunodeficiency virus (HIV)-2 vector mobilization by HIV-1Kevin V Morris
Department of Molecular and Experimental Medicine, Scripps Research Institute, La Jolla, CA 92037, USA
Hum Gene Ther 16:1463-72. 2005..These data suggest that strategies employing vector mobilization for HIV-1 gene therapy should use vectors with maximal antiviral potency, despite resulting reductions in mobilization of the vector...- RNA-directed transcriptional gene silencing and activation in human cellsKevin V Morris
Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
Oligonucleotides 19:299-306. 2009.... - siRNA-mediated transcriptional gene silencing: the potential mechanism and a possible role in the histone codeK V Morris
Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, California 92037, USA
Cell Mol Life Sci 62:3057-66. 2005..e. directed control of gene expression) and biologically in understanding the evolution of the cell... - Therapeutic potential of siRNA-mediated transcriptional gene silencingKevin V Morris
Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
Biotechniques . 2006.... - Bidirectional transcription directs both transcriptional gene activation and suppression in human cellsKevin V Morris
Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, USA
PLoS Genet 4:e1000258. 2008..This imbalance allows the unchecked antisense RNA to direct silent state epigenetic marks to the sense promoter, resulting in stable transcriptional gene silencing... - RNA-mediated transcriptional gene silencing in human cellsKevin V Morris
Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550N, Torrey Pines Road, La Jolla, CA 92037, USA
Curr Top Microbiol Immunol 320:211-24. 2008.... - The emerging role of RNA in the regulation of gene transcription in human cellsKevin V Morris
Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, United States
Semin Cell Dev Biol 22:351-8. 2011..The results of these studies will be considered in detail as well as the implications that a vast array of non-coding RNA based regulatory networks may be operative in human cells... - The relationship between transcription initiation RNAs and CCCTC-binding factor (CTCF) localizationRyan J Taft
Department of Molecular and Experimental Medicine, The Kellogg School of Science and Technology, The Scripps Research Institute, La Jolla, CA 92037, USA
Epigenetics Chromatin 4:13. 2011..abstract:.. - Anti-HIV-1 gene expressing lentiviral vectors as an adjunctive therapy for HIV-1 infectionKevin V Morris
University of California San Diego, Department of Medicine, La Jolla, CA 92093-0678, USA
Curr HIV Res 2:185-91. 2004.... - Lentivirus-mediated RNA interference therapy for human immunodeficiency virus type 1 infectionKevin V Morris
Department of Molecular and Experimental Medicine, Scripps Research Institute, La Jolla, CA 92037, USA
Hum Gene Ther 17:479-86. 2006..This review focuses on the development, delivery, and potential therapeutic use of antiviral siRNAs in treating HIV-1... - Lentiviral-mediated delivery of siRNAs for antiviral therapyK V Morris
Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 91010, USA
Gene Ther 13:553-8. 2006..This review will focus on the development, lentiviral based delivery, and the potential therapeutic use of siRNAs in treating viral infections... - Small interfering RNA-induced transcriptional gene silencing in human cellsKevin V Morris
Department of Medicine 0678, Stein Clinical Research Building, Room 302, University of California San Diego, La Jolla, CA 92093 0678, USA
Science 305:1289-92. 2004..These results demonstrate that siRNA-directed transcriptional silencing is conserved in mammals, providing a means to inhibit mammalian gene function... - Transcriptional gene silencing through epigenetic changes mediated by non-coding RNAsBarbora Malecova
The Scripps Research Institute, Department of Molecular and Experimental Medicine, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Curr Opin Mol Ther 12:214-22. 2010.... - Mobilization-competent Lentiviral Vector-mediated Sustained Transcriptional Modulation of HIV-1 ExpressionAnne Marie W Turner
Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California, USA
Mol Ther 17:360-8. 2009.... 
Controlling transcription with noncoding RNAs in mammalian cellsAnne Marie W Turner
Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
Biotechniques 48:ix-xvi. 2010..Furthermore, the potential for therapeutic applications based on ncRNA regulation will also be discussed...- Promoter targeted small RNAs induce long-term transcriptional gene silencing in human cellsPeter G Hawkins
Department of Molecular and Experimental Medicine, Kellogg School of Science and Technology, The Scripps Research Institute, La Jolla, CA 92037, USA
Nucleic Acids Res 37:2984-95. 2009..Taken together the data presented here highlight the cellular pathway with which noncoding RNAs interact to epigenetically regulate gene expression in human cells... - RNA and transcriptional modulation of gene expressionPeter G Hawkins
Department of Molecular and Experimental Medicine and Kellogg School of Science and Technology, The Scripps Research Institute, La Jolla, California 92037, USA
Cell Cycle 7:602-7. 2008..Several recent findings have shed light on this newly discovered link between small RNA molecules and epigenetic regulatory machinery, notably in human cells... - The effects of HHV-8 vMIP-II on SIVmac251 infection and replication competent and incompetent SIVmac239Delta3 vectorsKevin V Morris
Department of Medicine 0678, Stein Clinical Research Building, Room 402, University of California, La Jolla, San Diego, CA 92093 0678, USA
Virus Res 94:103-12. 2003..These data suggest that replication defective SIV vectors expressing immunobiolgic genes such as vMIP-II may prove useful in gene therapies, particularly in augmenting immune responses in chronically infected individuals... - Characterization of a mobilization-competent simian immunodeficiency virus (SIV) vector containing a ribozyme against SIV polymeraseKevin V Morris
Department of Medicine, Stein Clinical Research Building Room 402, University of California San Diego, La Jolla, CA 92093 0665, USA
J Gen Virol 85:1489-96. 2004..These findings provide direct evidence that mobilization of an anti-retroviral SIV gene therapy vector is feasible in the SIV/macaque model... - Transduction of cell lines and primary cells by FIV-packaged HIV vectorsKevin V Morris
Department of Medicine, University of California at San Diego, La Jolla, CA, USA
Mol Ther 10:181-90. 2004..Upon challenge with cell-free HIV-1 (m.o.i. = 0.1) a significant reduction in replication was observed. These findings demonstrate that packaging HIV vectors with FIV is a viable alternative, which avoids use of HIV structural proteins... - Promoter-associated RNA is required for RNA-directed transcriptional gene silencing in human cellsJiang Han
Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Proc Natl Acad Sci U S A 104:12422-7. 2007.... - Antiviral applications of RNAiKevin V Morris
The Scripps Research Institute, Division of Rheumatology, Department of Molecular and Experimental Medicine, 10550 N Torrey Pines Road, MEM 131, La Jolla, CA 92037, USA
Curr Opin Mol Ther 8:115-21. 2006..The development, delivery and potential therapeutic use of antiviral siRNAs in treating viral infections and emerging viral threats are reviewed... - siRNA induced transcriptional gene silencing in mammalian cellsHiroaki Kawasaki
Department of Chemistry and Biotechnology, School of Engineering, The University of Tokyo, Tokyo, Japan
Cell Cycle 4:442-8. 2005..e., directed control of a genes expression) and biologically in understanding the evolution of the cell... - Are viral-encoded microRNAs mediating latent HIV-1 infection?Marc S Weinberg
Department of Molecular Medicine and Haematology, University of the Witwatersrand Medical School, Parktown, South Africa
DNA Cell Biol 25:223-31. 2006..Thus, HIV-1 may have evolved mechanisms to exploit the RNAi pathway at both the transcriptional and posttranscriptional level to affect and/or maintain a latent infection... - Inhibition of HIV-1 replication by siRNA targeting conserved regions of gag/polKevin V Morris
Division of Molecular Medicine, Beckman Research Institute at the City of Hope, Duarte, California 91010 3011, USA
RNA Biol 2:17-20. 2005..Requirements for target sequence conservation and activity over a range of concentrations may severely limit the number of siRNA candidates for therapeutic development... - The efficacy of generating three independent anti-HIV-1 siRNAs from a single U6 RNA Pol III-expressed long hairpin RNASheena Saayman
Antiviral Gene Therapy Research Unit, Department of Molecular Medicine and Haematology, University of Witwatersrand, Johannesburg, South Africa
PLoS ONE 3:e2602. 2008..Although lhRNAs offer advantages for combinatorial RNAi, we show that good silencing efficacy across the span of the lhRNA duplex is difficult to achieve with sequences that encode more than two adjacent independent siRNAs... - The inhibitory efficacy of RNA POL III-expressed long hairpin RNAs targeted to untranslated regions of the HIV-1 5' long terminal repeatSamantha Barichievy
Antiviral Gene Therapy Unit, Department of Molecular Medicine and Haematology, University of Witwatersrand, Johannesburg, South Africa
Oligonucleotides 17:419-31. 2007..Although lhRNAs themselves require further manipulation to improve their overall efficacy in generating multiple functioning siRNAs, they may prove useful in any combinatorial-based approach to treating HIV-1 infection... - An RNA targeted to the HIV-1 LTR promoter modulates indiscriminate off-target gene activationMarc S Weinberg
Antiviral Gene Therapy Research Unit, Department of Molecular Medicine and Haematology, University of the Witwatersrand Medical School, 7 York Rd Parktown 2193, South Africa
Nucleic Acids Res 35:7303-12. 2007..These data suggest caution when using short antisense RNAs or siRNAs designed to target promoter sequences, since promoter-targeted RNAs may have unintended inhibitory effects against factors with suppressive gene activity... - Argonaute-1 directs siRNA-mediated transcriptional gene silencing in human cellsDaniel H Kim
Graduate School of Biological Sciences, Beckman Research Institute of the City of Hope, 1450 E Duarte Road, Duarte, California 91010, USA
Nat Struct Mol Biol 13:793-7. 2006..These results establish a connection between RNAi components AGO1 and TRBP2, RNAPII transcription and Polycomb-regulated control of gene expression... - The antisense strand of small interfering RNAs directs histone methylation and transcriptional gene silencing in human cellsMarc S Weinberg
Department of Molecular Medicine and Hematology, University of the Witwatersrand Medical School, Parktown, South Africa
RNA 12:256-62. 2006.... - VRX-496(VIRxSYS)Kevin V Morris
Division of Molecular Medicine, Beckman Research Institute at the City of Hope, 1450 East Duarte Road, Duarte, CA 91010 3011, USA
Curr Opin Investig Drugs 6:209-15. 2005..In July 2003, VIRxSYS undertook the initial dosing of an HIV-positive patient in a phase I/IIa trial... - Profiling microRNA expression with microarraysJames Q Yin
National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Beijing 100101, China
Trends Biotechnol 26:70-6. 2008....