K V Morris

Summary

Affiliation: The Scripps Research Institute
Country: USA

Publications

  1. pmc An RNA targeted to the HIV-1 LTR promoter modulates indiscriminate off-target gene activation
    Marc S Weinberg
    Antiviral Gene Therapy Research Unit, Department of Molecular Medicine and Haematology, University of the Witwatersrand Medical School, 7 York Rd Parktown 2193, South Africa
    Nucleic Acids Res 35:7303-12. 2007
  2. pmc Promoter targeted small RNAs induce long-term transcriptional gene silencing in human cells
    Peter G Hawkins
    Department of Molecular and Experimental Medicine, Kellogg School of Science and Technology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Nucleic Acids Res 37:2984-95. 2009
  3. pmc A pseudogene long-noncoding-RNA network regulates PTEN transcription and translation in human cells
    Per Johnsson
    Department of Oncology and Pathology, Karolinska Institutet, Stockholm, Sweden
    Nat Struct Mol Biol 20:440-6. 2013
  4. pmc Chemically Modified Oligonucleotides Modulate an Epigenetically Varied and Transient Form of Transcription Silencing of HIV-1 in Human Cells
    Stuart Knowling
    Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California, USA
    Mol Ther Nucleic Acids 1:e16. 2012
  5. pmc Modulation of gene-specific epigenetic states and transcription by non-coding RNAs
    Kevin V Morris
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037 USA
    Clin Epigenetics 2:433-7. 2011
  6. pmc The emerging role of RNA in the regulation of gene transcription in human cells
    Kevin V Morris
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, United States
    Semin Cell Dev Biol 22:351-8. 2011
  7. pmc RNA-directed transcriptional gene silencing and activation in human cells
    Kevin V Morris
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    Oligonucleotides 19:299-306. 2009
  8. pmc Long antisense non-coding RNAs function to direct epigenetic complexes that regulate transcription in human cells
    Kevin V Morris
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    Epigenetics 4:296-301. 2009
  9. pmc Non-coding RNAs, epigenetic memory and the passage of information to progeny
    Kevin V Morris
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    RNA Biol 6:242-7. 2009
  10. ncbi request reprint RNA-mediated transcriptional gene silencing in human cells
    Kevin V Morris
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550N, Torrey Pines Road, La Jolla, CA 92037, USA
    Curr Top Microbiol Immunol 320:211-24. 2008

Collaborators

Detail Information

Publications38

  1. pmc An RNA targeted to the HIV-1 LTR promoter modulates indiscriminate off-target gene activation
    Marc S Weinberg
    Antiviral Gene Therapy Research Unit, Department of Molecular Medicine and Haematology, University of the Witwatersrand Medical School, 7 York Rd Parktown 2193, South Africa
    Nucleic Acids Res 35:7303-12. 2007
    ..These data suggest caution when using short antisense RNAs or siRNAs designed to target promoter sequences, since promoter-targeted RNAs may have unintended inhibitory effects against factors with suppressive gene activity...
  2. pmc Promoter targeted small RNAs induce long-term transcriptional gene silencing in human cells
    Peter G Hawkins
    Department of Molecular and Experimental Medicine, Kellogg School of Science and Technology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Nucleic Acids Res 37:2984-95. 2009
    ..Taken together the data presented here highlight the cellular pathway with which noncoding RNAs interact to epigenetically regulate gene expression in human cells...
  3. pmc A pseudogene long-noncoding-RNA network regulates PTEN transcription and translation in human cells
    Per Johnsson
    Department of Oncology and Pathology, Karolinska Institutet, Stockholm, Sweden
    Nat Struct Mol Biol 20:440-6. 2013
    ..Disruption of this asRNA-regulated network induces cell-cycle arrest and sensitizes cells to doxorubicin, which suggests a biological function for the respective PTENpg1 expressed asRNAs...
  4. pmc Chemically Modified Oligonucleotides Modulate an Epigenetically Varied and Transient Form of Transcription Silencing of HIV-1 in Human Cells
    Stuart Knowling
    Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California, USA
    Mol Ther Nucleic Acids 1:e16. 2012
    ..These data suggest that chemically modified oligonucleotide based approaches could be implemented as a means to regulate gene transcription in an epigenetically independent manner...
  5. pmc Modulation of gene-specific epigenetic states and transcription by non-coding RNAs
    Kevin V Morris
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037 USA
    Clin Epigenetics 2:433-7. 2011
    ..Knowledge of this emerging RNA-based epigenetic regulatory network and our ability to cognitively control gene expression has deep implications in the development of an entirely new area of pharmacopeia...
  6. pmc The emerging role of RNA in the regulation of gene transcription in human cells
    Kevin V Morris
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, United States
    Semin Cell Dev Biol 22:351-8. 2011
    ..The results of these studies will be considered in detail as well as the implications that a vast array of non-coding RNA based regulatory networks may be operative in human cells...
  7. pmc RNA-directed transcriptional gene silencing and activation in human cells
    Kevin V Morris
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    Oligonucleotides 19:299-306. 2009
    ....
  8. pmc Long antisense non-coding RNAs function to direct epigenetic complexes that regulate transcription in human cells
    Kevin V Morris
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    Epigenetics 4:296-301. 2009
    ..This perspective will highlight the endogenous effector RNAs and mechanism of action whereby long antisense non-coding RNAs transcriptionally regulate gene expression in human cells...
  9. pmc Non-coding RNAs, epigenetic memory and the passage of information to progeny
    Kevin V Morris
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    RNA Biol 6:242-7. 2009
    ....
  10. ncbi request reprint RNA-mediated transcriptional gene silencing in human cells
    Kevin V Morris
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550N, Torrey Pines Road, La Jolla, CA 92037, USA
    Curr Top Microbiol Immunol 320:211-24. 2008
    ....
  11. pmc The relationship between transcription initiation RNAs and CCCTC-binding factor (CTCF) localization
    Ryan J Taft
    Department of Molecular and Experimental Medicine, The Kellogg School of Science and Technology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Epigenetics Chromatin 4:13. 2011
    ..abstract:..
  12. ncbi request reprint Therapeutic potential of siRNA-mediated transcriptional gene silencing
    Kevin V Morris
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    Biotechniques . 2006
    ....
  13. ncbi request reprint Characterization of human immunodeficiency virus (HIV)-2 vector mobilization by HIV-1
    Kevin V Morris
    Department of Molecular and Experimental Medicine, Scripps Research Institute, La Jolla, CA 92037, USA
    Hum Gene Ther 16:1463-72. 2005
    ..These data suggest that strategies employing vector mobilization for HIV-1 gene therapy should use vectors with maximal antiviral potency, despite resulting reductions in mobilization of the vector...
  14. pmc Bidirectional transcription directs both transcriptional gene activation and suppression in human cells
    Kevin V Morris
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, USA
    PLoS Genet 4:e1000258. 2008
    ..This imbalance allows the unchecked antisense RNA to direct silent state epigenetic marks to the sense promoter, resulting in stable transcriptional gene silencing...
  15. ncbi request reprint siRNA-mediated transcriptional gene silencing: the potential mechanism and a possible role in the histone code
    K V Morris
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, California 92037, USA
    Cell Mol Life Sci 62:3057-66. 2005
    ..e. directed control of gene expression) and biologically in understanding the evolution of the cell...
  16. ncbi request reprint Anti-HIV-1 gene expressing lentiviral vectors as an adjunctive therapy for HIV-1 infection
    Kevin V Morris
    University of California San Diego, Department of Medicine, La Jolla, CA 92093 0678, USA
    Curr HIV Res 2:185-91. 2004
    ....
  17. ncbi request reprint Lentivirus-mediated RNA interference therapy for human immunodeficiency virus type 1 infection
    Kevin V Morris
    Department of Molecular and Experimental Medicine, Scripps Research Institute, La Jolla, CA 92037, USA
    Hum Gene Ther 17:479-86. 2006
    ..This review focuses on the development, delivery, and potential therapeutic use of antiviral siRNAs in treating HIV-1...
  18. ncbi request reprint Lentiviral-mediated delivery of siRNAs for antiviral therapy
    K V Morris
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 91010, USA
    Gene Ther 13:553-8. 2006
    ..This review will focus on the development, lentiviral based delivery, and the potential therapeutic use of siRNAs in treating viral infections...
  19. ncbi request reprint Small interfering RNA-induced transcriptional gene silencing in human cells
    Kevin V Morris
    Department of Medicine 0678, Stein Clinical Research Building, Room 302, University of California San Diego, La Jolla, CA 92093 0678, USA
    Science 305:1289-92. 2004
    ..These results demonstrate that siRNA-directed transcriptional silencing is conserved in mammals, providing a means to inhibit mammalian gene function...
  20. pmc Transcriptional gene silencing through epigenetic changes mediated by non-coding RNAs
    Barbora Malecova
    The Scripps Research Institute, Department of Molecular and Experimental Medicine, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Curr Opin Mol Ther 12:214-22. 2010
    ....
  21. doi request reprint Controlling transcription with noncoding RNAs in mammalian cells
    Anne Marie W Turner
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    Biotechniques 48:ix-xvi. 2010
    ..Furthermore, the potential for therapeutic applications based on ncRNA regulation will also be discussed...
  22. pmc Mobilization-competent Lentiviral Vector-mediated Sustained Transcriptional Modulation of HIV-1 Expression
    Anne Marie W Turner
    Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California, USA
    Mol Ther 17:360-8. 2009
    ....
  23. ncbi request reprint Transduction of cell lines and primary cells by FIV-packaged HIV vectors
    Kevin V Morris
    Department of Medicine, University of California at San Diego, La Jolla, CA, USA
    Mol Ther 10:181-90. 2004
    ..Upon challenge with cell-free HIV-1 (m.o.i. = 0.1) a significant reduction in replication was observed. These findings demonstrate that packaging HIV vectors with FIV is a viable alternative, which avoids use of HIV structural proteins...
  24. ncbi request reprint Characterization of a mobilization-competent simian immunodeficiency virus (SIV) vector containing a ribozyme against SIV polymerase
    Kevin V Morris
    Department of Medicine, Stein Clinical Research Building Room 402, University of California San Diego, La Jolla, CA 92093 0665, USA
    J Gen Virol 85:1489-96. 2004
    ..These findings provide direct evidence that mobilization of an anti-retroviral SIV gene therapy vector is feasible in the SIV/macaque model...
  25. ncbi request reprint The effects of HHV-8 vMIP-II on SIVmac251 infection and replication competent and incompetent SIVmac239Delta3 vectors
    Kevin V Morris
    Department of Medicine 0678, Stein Clinical Research Building, Room 402, University of California, La Jolla, San Diego, CA 92093 0678, USA
    Virus Res 94:103-12. 2003
    ..These data suggest that replication defective SIV vectors expressing immunobiolgic genes such as vMIP-II may prove useful in gene therapies, particularly in augmenting immune responses in chronically infected individuals...
  26. pmc RNA and transcriptional modulation of gene expression
    Peter G Hawkins
    Department of Molecular and Experimental Medicine and Kellogg School of Science and Technology, The Scripps Research Institute, La Jolla, California 92037, USA
    Cell Cycle 7:602-7. 2008
    ..Several recent findings have shed light on this newly discovered link between small RNA molecules and epigenetic regulatory machinery, notably in human cells...
  27. pmc Promoter-associated RNA is required for RNA-directed transcriptional gene silencing in human cells
    Jiang Han
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 104:12422-7. 2007
    ....
  28. ncbi request reprint Antiviral applications of RNAi
    Kevin V Morris
    The Scripps Research Institute, Division of Rheumatology, Department of Molecular and Experimental Medicine, 10550 N Torrey Pines Road, MEM 131, La Jolla, CA 92037, USA
    Curr Opin Mol Ther 8:115-21. 2006
    ..The development, delivery and potential therapeutic use of antiviral siRNAs in treating viral infections and emerging viral threats are reviewed...
  29. pmc The efficacy of generating three independent anti-HIV-1 siRNAs from a single U6 RNA Pol III-expressed long hairpin RNA
    Sheena Saayman
    Antiviral Gene Therapy Research Unit, Department of Molecular Medicine and Haematology, University of Witwatersrand, Johannesburg, South Africa
    PLoS ONE 3:e2602. 2008
    ..Although lhRNAs offer advantages for combinatorial RNAi, we show that good silencing efficacy across the span of the lhRNA duplex is difficult to achieve with sequences that encode more than two adjacent independent siRNAs...
  30. pmc Are viral-encoded microRNAs mediating latent HIV-1 infection?
    Marc S Weinberg
    Department of Molecular Medicine and Haematology, University of the Witwatersrand Medical School, Parktown, South Africa
    DNA Cell Biol 25:223-31. 2006
    ..Thus, HIV-1 may have evolved mechanisms to exploit the RNAi pathway at both the transcriptional and posttranscriptional level to affect and/or maintain a latent infection...
  31. ncbi request reprint siRNA induced transcriptional gene silencing in mammalian cells
    Hiroaki Kawasaki
    Department of Chemistry and Biotechnology, School of Engineering, The University of Tokyo, Tokyo, Japan
    Cell Cycle 4:442-8. 2005
    ..e., directed control of a genes expression) and biologically in understanding the evolution of the cell...
  32. ncbi request reprint Inhibition of HIV-1 replication by siRNA targeting conserved regions of gag/pol
    Kevin V Morris
    Division of Molecular Medicine, Beckman Research Institute at the City of Hope, Duarte, California 91010 3011, USA
    RNA Biol 2:17-20. 2005
    ..Requirements for target sequence conservation and activity over a range of concentrations may severely limit the number of siRNA candidates for therapeutic development...
  33. ncbi request reprint The inhibitory efficacy of RNA POL III-expressed long hairpin RNAs targeted to untranslated regions of the HIV-1 5' long terminal repeat
    Samantha Barichievy
    Antiviral Gene Therapy Unit, Department of Molecular Medicine and Haematology, University of Witwatersrand, Johannesburg, South Africa
    Oligonucleotides 17:419-31. 2007
    ..Although lhRNAs themselves require further manipulation to improve their overall efficacy in generating multiple functioning siRNAs, they may prove useful in any combinatorial-based approach to treating HIV-1 infection...
  34. doi request reprint Profiling microRNA expression with microarrays
    James Q Yin
    National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Beijing 100101, China
    Trends Biotechnol 26:70-6. 2008
    ....
  35. pmc The antisense strand of small interfering RNAs directs histone methylation and transcriptional gene silencing in human cells
    Marc S Weinberg
    Department of Molecular Medicine and Hematology, University of the Witwatersrand Medical School, Parktown, South Africa
    RNA 12:256-62. 2006
    ....
  36. ncbi request reprint VRX-496(VIRxSYS)
    Kevin V Morris
    Division of Molecular Medicine, Beckman Research Institute at the City of Hope, 1450 East Duarte Road, Duarte, CA 91010 3011, USA
    Curr Opin Investig Drugs 6:209-15. 2005
    ..In July 2003, VIRxSYS undertook the initial dosing of an HIV-positive patient in a phase I/IIa trial...
  37. ncbi request reprint Argonaute-1 directs siRNA-mediated transcriptional gene silencing in human cells
    Daniel H Kim
    Graduate School of Biological Sciences, Beckman Research Institute of the City of Hope, 1450 E Duarte Road, Duarte, California 91010, USA
    Nat Struct Mol Biol 13:793-7. 2006
    ..These results establish a connection between RNAi components AGO1 and TRBP2, RNAPII transcription and Polycomb-regulated control of gene expression...