Marc R Montminy
Affiliation: The Salk Institute
Sonntag T, Ostojic J, Vaughan J, Moresco J, Yoon Y, Yates J, et al
. Mitogenic Signals Stimulate the CREB Coactivator CRTC3 through PP2A Recruitment. iScience. 2019;11:134-145 pubmed publisher
Yoon Y, Tsai W, Van de Velde S, Chen Z, Lee K, Morgan D, et al
. cAMP-inducible coactivator CRTC3 attenuates brown adipose tissue thermogenesis. Proc Natl Acad Sci U S A. 2018;115:E5289-E5297 pubmed publisher
Tsai W, Matsumura S, Liu W, Phillips N, Sonntag T, Hao E, et al
. ATF3 mediates inhibitory effects of ethanol on hepatic gluconeogenesis. Proc Natl Acad Sci U S A. 2015;112:2699-704 pubmed publisher
..These results illustrate how the induction of transcription factors with overlapping specificity can lead to cross-coupling between stress and hormone-sensitive pathways. ..
Paz J, Park S, Phillips N, Matsumura S, Tsai W, Kasper L, et al
. Combinatorial regulation of a signal-dependent activator by phosphorylation and acetylation. Proc Natl Acad Sci U S A. 2014;111:17116-21 pubmed publisher
Ravnskjaer K, Madiraju A, Montminy M. Role of the cAMP Pathway in Glucose and Lipid Metabolism. Handb Exp Pharmacol. 2016;233:29-49 pubmed publisher
..Here we review current understanding of the mechanisms by which the cAMP signaling pathway triggers metabolic programs in insulin-responsive tissues. ..
Shen R, Wang B, Giribaldi M, Ayres J, Thomas J, Montminy M. Neuronal energy-sensing pathway promotes energy balance by modulating disease tolerance. Proc Natl Acad Sci U S A. 2016;113:E3307-14 pubmed publisher
..Our results reveal a previously unidentified tolerance defense strategy involving a brain-gut pathway that maintains homeostasis through its effects on epithelial integrity. ..
Blanchet E, Van de Velde S, Matsumura S, Hao E, LeLay J, KAESTNER K, et al
. Feedback inhibition of CREB signaling promotes beta cell dysfunction in insulin resistance. Cell Rep. 2015;10:1149-57 pubmed publisher
..Indeed, disruption of the PKIB gene improved islet function in the setting of obesity. These results demonstrate how crosstalk between nutrient and hormonal pathways contributes to loss of pancreatic islet function. ..
Hogan M, Ravnskjaer K, Matsumura S, Huising M, Hull R, Kahn S, et al
. Hepatic Insulin Resistance Following Chronic Activation of the CREB Coactivator CRTC2. J Biol Chem. 2015;290:25997-6006 pubmed publisher
Kim J, Hedrick S, Tsai W, Wiater E, Le Lay J, Kaestner K, et al
. CREB coactivators CRTC2 and CRTC3 modulate bone marrow hematopoiesis. Proc Natl Acad Sci U S A. 2017;114:11739-11744 pubmed publisher