Research Topics
Species | Edward MonosovSummaryAffiliation: The Scripps Research Institute Country: USA Publications
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Detail Information
Publications
Large scale protein profiling by combination of protein fractionation and multidimensional protein identification technology (MudPIT)Emily I Chen
Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA
Mol Cell Proteomics 5:53-6. 2006..As a result, we were able to reduce sample complexity by protein fractionation and increase the possibility of detecting proteins with lower abundance in the complex protein mixture...
Maspin alters the carcinoma proteomeEmily I Chen
Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
FASEB J 19:1123-4. 2005..These observations reveal for the first time the far reaching effects of maspin on multiple protein networks and a new hypothesis of maspin function based on the regulation of proteasome function...
Maspin and tumor metastasisEmily I Chen
Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA
IUBMB Life 58:25-9. 2006....
Adaptation of energy metabolism in breast cancer brain metastasesEmily I Chen
Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
Cancer Res 67:1472-86. 2007....
Rational design and real time, in-cell detection of the proapoptotic activity of a novel compound targeting Bcl-X(L)Barbara Becattini
The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
Chem Biol 11:389-95. 2004..Finally, preliminary data on cells freshly isolated from patients affected by chronic lymphocytic leukemia strongly suggest potential applications of Bcl-2 antagonists as chemosensitizers in cancer therapy...
BI-1 regulates an apoptosis pathway linked to endoplasmic reticulum stressHan Jung Chae
The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
Mol Cell 15:355-66. 2004..Thus, BI-1 regulates a cell death pathway important for cytopreservation during ER stress...
Mammalian dap3 is an essential gene required for mitochondrial homeostasis in vivo and contributing to the extrinsic pathway for apoptosisHyung Ryong Kim
Burnham Institute for Medical Research, 10901 N Torrey Pines Road, La Jolla, CA 92037, USA
FASEB J 21:188-96. 2007..Thus, DAP3 joins a growing list of bifunctional proteins that play roles in normal mitochondrial physiology and in apoptosis...
