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Genomes and Genes | Jeffrey J MolldremSummaryAffiliation: The University of Texas Country: USA Publications
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Publications
Preparing basic and translational grant proposals: thoughts from the trenchesJeffrey J Molldrem
Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Hematology Am Soc Hematol Educ Program 2010:181-4. 2010..Rather, it is a brief overview of the grant writing process from conception to submission...
Antithymocyte globulin for treatment of the bone marrow failure associated with myelodysplastic syndromesJeffrey J Molldrem
National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 70892, USA
Ann Intern Med 137:156-63. 2002..Almost half of the deaths that result from myelodysplastic syndromes are due to cytopenia associated with bone marrow failure. Treatment is mostly supportive care...
2E8 binds to the high affinity I-domain in a metal ion-dependent manner: a second generation monoclonal antibody selectively targeting activated LFA-1Roberto Carreno
Section of Transplantation Immunology, Department of Stem Cell Transplantation and Cellular Therapy, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
J Biol Chem 285:32860-8. 2010..As a novel activation-specific monoclonal antibody, 2E8 is a potentially useful reagent for blocking high affinity LFA-1 and modulating T cell activation in research and therapeutics...- Broad cross-presentation of the hematopoietically derived PR1 antigen on solid tumors leads to susceptibility to PR1-targeted immunotherapyGheath Alatrash
Department of Stem Cell Transplantation and Cellular Therapy, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
J Immunol 189:5476-84. 2012.... - Blocking LFA-1 activation with lovastatin prevents graft-versus-host disease in mouse bone marrow transplantationYang Wang
Section of Transplantation Immunology, Department of Stem Cell Transplantation and Cellular Therapy, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Biol Blood Marrow Transplant 15:1513-22. 2009..In addition, treatment with lovastatin impaired donor-derived T cell proliferation in vivo. Taken together, these results indicate the important role of lovastatin in the treatment of GVHD... - Chemokine receptor CCR5 mediates alloimmune responses in graft-versus-host diseaseLisa A Palmer
Section of Transplantation Immunology, Department of Stem Cell Transplantation and Cellular Therapy, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
Biol Blood Marrow Transplant 16:311-9. 2010..Thus, CCR5 is a marker for GVHD effector cells and CCR5(+) T cells are active participants in the pathogenesis of human aGVHD... - Lovastatin inhibits T-cell proliferation while preserving the cytolytic function of EBV, CMV, and MART-1-specific CTLsDan Li
Section of Transplantation Immunology, Department of Stem Cell Transplantation and Cellular Therapy, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
J Immunother 33:975-82. 2010.... - Reduced graft-versus-host disease in C3-deficient mice is associated with decreased donor Th1/Th17 differentiationQing Ma
Section of Transplantation Immunology, Department of Stem Cell Transplantation and Cellular Therapy, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
Biol Blood Marrow Transplant 18:1174-81. 2012..We conclude that C3 regulates Th1/17 differentiation in bone marrow transplantation, and define a novel function of the complement system in GVHD... - Detection and characterization of a novel subset of CD8⁺CD57⁺ T cells in metastatic melanoma with an incompletely differentiated phenotypeRichard C Wu
Department of Melanoma Medical Oncology, University of Texas, MD Anderson Cancer Center, Houston, Texas, USA
Clin Cancer Res 18:2465-77. 2012.... - Adoptive transfer of PR1 cytotoxic T lymphocytes associated with reduced leukemia burden in a mouse acute myeloid leukemia xenograft modelQing Ma
Section of Transplantation Immunology, Department of Stem Cell Transplantation and Cellular Therapy, University of Texas, MD Anderson Cancer Center, Unit 900, 1515 Holcombe Boulevard, Houston, TX 77030, USA
Cytotherapy 12:1056-62. 2010..PR1-specific CTL elicited in vitro from healthy donors have been shown to lyse P3-expressing AML cells from patients. We investigated whether PR1-CTL can be adoptively transferred into NOD/SCID mice to eliminate human leukemia cells... - Cord-blood engraftment with ex vivo mesenchymal-cell cocultureMarcos de Lima
Department of Stem Cell Transplantation and Cellular Therapy, University of Texas M D Anderson Cancer Center, Houston, USA
N Engl J Med 367:2305-15. 2012..We hypothesized that engraftment would be improved by transplanting cord blood that was expanded ex vivo with mesenchymal stromal cells... - Breast cancer cell uptake of the inflammatory mediator neutrophil elastase triggers an anticancer adaptive immune responseElizabeth A Mittendorf
Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
Cancer Res 72:3153-62. 2012..Taken together, our findings reveal a previously unknown mechanism of antitumor adaptive immunity that links cancer cell uptake of an inflammatory mediator to an effective cytolytic response against an important breast cancer antigen... - Functionally active virus-specific T cells that target CMV, adenovirus, and EBV can be expanded from naive T-cell populations in cord blood and will target a range of viral epitopesPatrick J Hanley
Department of Immunology, Baylor College of Medicine, Texas Children s Hospital and The Methodist Hospital, Center for Cell and Gene Therapy, Houston, TX 77030, USA
Blood 114:1958-67. 2009..This study is registered at www.clinicaltrials.gov as NCT00078533... - A novel HLA-A*0201 restricted peptide derived from cathepsin G is an effective immunotherapeutic target in acute myeloid leukemiaMao Zhang
Stem Cell Transplantation and Cellular Therapy, Surgical Oncology, and Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
Clin Cancer Res 19:247-57. 2013..In this study, we characterize the role of the myeloid azurophil granule protease cathepsin G (CG) as a novel target for AML immunotherapy... - The role of antigen cross-presentation from leukemia blasts on immunity to the leukemia-associated antigen PR1Gheath Alatrash
Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
J Immunother 35:309-20. 2012..Our data demonstrate distinct mechanisms for cross-presentation of soluble and cell-associated NE and P3, which may be valuable in understanding immunity to PR1 in leukemia... - LFA-1 affinity regulation is necessary for the activation and proliferation of naive T cellsYang Wang
Section of Transplantation Immunology, Department of Stem Cell Transplantation and Cellular Therapy, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
J Biol Chem 284:12645-53. 2009..This implicates LFA-1 activation as a novel regulatory mechanism for the modulation of T cell activation and proliferation... - An anti-PR1/HLA-A2 T-cell receptor-like antibody mediates complement-dependent cytotoxicity against acute myeloid leukemia progenitor cellsAnna Sergeeva
Section of Transplantation Immunology, Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Blood 117:4262-72. 2011..Therefore, this antibody warrants further study as a novel approach to targeting leukemia-initiating cells in patients with AML... - Delayed immune reconstitution after cord blood transplantation is characterized by impaired thymopoiesis and late memory T-cell skewingKrishna V Komanduri
Department of Stem Cell Transplantation and Cellular Therapy, M D Anderson Cancer Center, Houston, TX 77030, USA
Blood 110:4543-51. 2007..Strategies that improve the engraftment of lymphoid precursors, protect the thymus during pretransplant conditioning, and/or augment the recovery of thymopoiesis may improve outcomes after CBT... - A novel strategy for rapid and efficient isolation of human tumor-specific CD4(+) and CD8(+) T-cell clonesSeung Tae Lee
Department of Lymphoma and Myeloma, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
J Immunol Methods 331:13-26. 2008..The method was simple, efficient, and reproducible, and may have potential application for the development of adoptive immunotherapeutic strategies... - Vaccines as consolidation therapy for myeloid leukemiaGheath Alatrash
Department of Stem Cell Transplantation and Cellular Therapy, University of Texas, MD Anderson Cancer Center, 1515 Holcombe Blvd, Unit 900, Houston, TX 77030, USA
Expert Rev Hematol 4:37-50. 2011..Although not yet considered the standard of care, leukemia vaccines continue to show promising results in the management of the myeloid leukemias... - Immunotherapy of AMLGheath Alatrash
Division of Cancer Medicine, University of Texas MD, Anderson Cancer Center, Houston, TX, USA
Cancer Treat Res 145:237-55. 2010..This chapter will discuss the role of the immune system and recent advances in immunotherapy for the treatment of AML, focusing on cellular and non-cellular approaches... - Co-Stimulation through 4-1BB/CD137 Improves the Expansion and Function of CD8(+) Melanoma Tumor-Infiltrating Lymphocytes for Adoptive T-Cell TherapyJessica Ann Chacon
Department of Melanoma Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas, United States of America The Immunology Program of the University of Texas Health Science Center, Graduate School of Biomedical Sciences, The University of Texas M D Anderson Cancer Center, Houston, Texas, United States of America
PLoS ONE 8:e60031. 2013..This may greatly improve TIL persistence and anti-tumor activity in vivo after adoptive transfer into patients... - Immunotherapeutic peptide vaccination with leukemia-associated antigensSylvie Rusakiewicz
Section of Transplantation Immunology, Department of Blood and Marrow Transplantation, University of Texas MD Anderson Cancer Center, Houston, Texas, USA
Curr Opin Immunol 18:599-604. 2006..The results of these vaccine trials, although still preliminary, provide some evidence that vaccination with LAAs might confer protective immunity to leukemia and offer great prospect as part of the future treatment of leukemia... - Targeting human B-cell malignancies through Ig light chain-specific cytotoxic T lymphocytesJinsheng Weng
Department of Lymphoma and Myeloma, Stem Cell Transplantation and Cellular Therapy, and Center for Cancer Immunology Research, MD Anderson Cancer Center, Houston, Texas, USA
Clin Cancer Res 17:5945-52. 2011..However, epitopes derived from Id that stimulate human CD8(+) T-cell immunity are incompletely characterized... - LFA-1 regulates CD8+ T cell activation via T cell receptor-mediated and LFA-1-mediated Erk1/2 signal pathwaysDan Li
Section of Transplantation Immunology, Department of Stem Cell Transplantation and Cellular Therapy, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
J Biol Chem 284:21001-10. 2009..We demonstrated that the function of LFA-1 is to enhance TCR signaling through the immunological synapse and deliver distinct signals in CD8+ T cell activation... - Vaccination for leukemiaJeffrey J Molldrem
Transplantation Immunology Section, Blood and Marrow Transplantation Department, University of Texas MD Anderson Cancer Center, Houston, 77030, USA
Biol Blood Marrow Transplant 12:13-8. 2006..Although these studies are still early, they offer evidence that effective immunity to leukemia is possible after vaccination, thus setting the stage for future combined therapies... - Functional assessment and specific depletion of alloreactive human T cells using flow cytometrySergio L R Martins
Transplant Immunology Section, Department of Blood and Marrow Transplantation, MD Anderson Cancer Center, SCRB 3.3019, Unit 900, 7455 Fannin St, Houston, TX 77030, USA
Blood 104:3429-36. 2004..This approach also was applied to specifically enrich or deplete human virus-specific T cells... - Donor-specific anti-HLA Abs and graft failure in matched unrelated donor hematopoietic stem cell transplantationStefan O Ciurea
Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
Blood 118:5957-64. 2011..1%; P < .0001) and higher in women with 1 (P = .008) and 2 or more pregnancies (P = .0003) than in men. We conclude that the presence of anti-DPB1 DSAs is associated with graft failure in MUD hematopoietic stem cell transplantation... - Vascular ligand-receptor mapping by direct combinatorial selection in cancer patientsFernanda I Staquicini
David H Koch Center, Department of Genitourinary Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Proc Natl Acad Sci U S A 108:18637-42. 2011..These findings provide vascular molecular markers for biotechnology and medical applications... - Assembly of the kappa preB receptor requires a V kappa-like protein encoded by a germline transcriptRoberto Rangel
Department of Immunology, M D Anderson Cancer Center, The University of Texas, Houston, Texas 77054, USA
J Biol Chem 280:17807-14. 2005..In addition, the present study confirms the co-existence of surrogate lambda and kappa receptors that are proposed to work in concert to promote B lymphocyte maturation... - Immune-induced cytopenia: bone marrow failure syndromeYukio Kondo
Department of Blood and Marrow Transplantation, University of Texas MD Anderson Cancer Center, 7455 Fannin SCRB-Unit 900, PO Box 301402, Houston, TX 77230, USA
Curr Hematol Rep 3:178-83. 2004..Recent studies suggest that dominant clonal T cells, which may be driven to expand by hematopoietic antigenic stimuli, result in the T-cell-mediated inhibition of hematopoietic progenitors, thus contributing to cytopenia... - Immunity to chronic myelogenous leukemiaDax Kurbegov
Division of Cancer Medicine, University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Box 10, Houston, TX 77030, USA
Hematol Oncol Clin North Am 18:733-52, xi-xii. 2004..Finally,the authors discuss how advances in the understanding of the molecular and cellular nature of immunity are being translated into new therapeutic strategies for the treatment of CML... - Mitochondrial DNA sequence variation in single cells from leukemia patientsYong Gang Yao
Hematology Branch and Flow Cytometry Core Facility, National Heart, Lung, and Blood Institute, NIH Bldg 10 CRC, Rm 3E 5216, 10 Center Dr Bethesda, MD 20892, USA
Blood 109:756-62. 2007..Our results suggest that the somatic mutation process in leukemia is complex, leading to diverse levels of genetic alterations due to either intrinsic aspects of leukemia pathophysiology or chemotherapy effects... - Monoculture-derived T lymphocytes specific for multiple viruses expand and produce clinically relevant effects in immunocompromised individualsAnn M Leen
Center for Cell and Gene Therapy, Baylor College of Medicine, The Methodist Hospital and Texas Children's Hospital, Houston, Texas 77030, USA
Nat Med 12:1160-6. 2006..Monoculture-derived multispecific CTL infusion could provide a safe and efficient means to restore virus-specific immunity in the immunocompromised host... - The basis of T-cell-mediated immunity to chronic myelogenous leukemiaJeffrey J Molldrem
Transplantation Immunology Section, Department of Blood and Marrow Transplantation, University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA
Oncogene 21:8668-73. 2002 - Vaccines in leukemiaSijie Lu
The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA
Adv Pharmacol 51:255-70. 2004 - A human Mix-like homeobox gene MIXL shows functional similarity to Xenopus Mix.1Wei Guo
Department of Molecular Genetics, University of Texas M D Anderson Cancer Center, Houston, 77030, USA
Blood 100:89-95. 2002..Isolation of the MIXL gene is the first step toward understanding novel regulatory circuits in early hematopoietic differentiation and malignant transformation... - CD25 expression on donor CD4+ or CD8+ T cells is associated with an increased risk for graft-versus-host disease after HLA-identical stem cell transplantation in humansMarta Stanzani
Transplant Immunology Laboratory, MD Anderson Cancer Center, SCRB 3.3019, 7455 Fannin St, Houston, TX 77030, USA
Blood 103:1140-6. 2004.... - Overexpressed differentiation antigens as targets of graft-versus-leukemia reactionsJeffrey J Molldrem
Transplantation Immunology Section, Department of Blood and Marrow Transplantation, University of Texas M D Anderson Cancer Center, Houston, 77030, USA
Curr Opin Hematol 9:503-8. 2002..By altering T-cell receptor affinity, peptide specificity can be maintained and the potency of immunity can be enhanced in the MHC-mismatched setting... - Loss of T-lymphocyte clonal dominance in patients with myelodysplastic syndrome responsive to immunosuppressionJames N Kochenderfer
Section of Transplantation Immunology, Department of Blood and Marrow Transplantation, University of Texas M. D. Anderson Cancer Center, Houston 77030, USA
Blood 100:3639-45. 2002..Our results demonstrate that predominant clonal T cells that appear to be antigen-driven persist in patients with MDS unresponsive to immunosuppression, but predominant clones regress in responders to immunosuppression... - Vaccinating transplant recipientsJeffrey J Molldrem
Nat Med 11:1162-3. 2005 - Selective depletion of donor alloreactive T cells without loss of antiviral or antileukemic responsesPersis J Amrolia
Department of Bone Marrow Transplantation, Great Ormond Street Children s Hospital, London, United Kingdom
Blood 102:2292-9. 2003..Based on these data, we have embarked on a phase 1 clinical trial of addback of allo-LCL-depleted donor T cells in the haplo-identical setting...