Jeffrey J Molldrem

Summary

Affiliation: The University of Texas
Country: USA

Publications

  1. doi request reprint Preparing basic and translational grant proposals: thoughts from the trenches
    Jeffrey J Molldrem
    Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Hematology Am Soc Hematol Educ Program 2010:181-4. 2010
  2. pmc PR1-specific T cells are associated with unmaintained cytogenetic remission of chronic myelogenous leukemia after interferon withdrawal
    Shreya Kanodia
    Section of Transplant Immunology, Department of Blood and Marrow Transplantation, University of Texas M D Anderson Cancer Center, Houston, Texas, United States of America
    PLoS ONE 5:e11770. 2010
  3. pmc dsPIG: a tool to predict imprinted genes from the deep sequencing of whole transcriptomes
    Hua Li
    Shanghai Center for Systems Biomedicine, Key Laboratory of Systems Biomedicine, Ministry of Education, Shanghai Jiao Tong University, Shanghai, China
    BMC Bioinformatics 13:271. 2012
  4. ncbi request reprint Antithymocyte globulin for treatment of the bone marrow failure associated with myelodysplastic syndromes
    Jeffrey J Molldrem
    National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 70892, USA
    Ann Intern Med 137:156-63. 2002
  5. pmc 2E8 binds to the high affinity I-domain in a metal ion-dependent manner: a second generation monoclonal antibody selectively targeting activated LFA-1
    Roberto Carreno
    Section of Transplantation Immunology, Department of Stem Cell Transplantation and Cellular Therapy, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 285:32860-8. 2010
  6. pmc Broad cross-presentation of the hematopoietically derived PR1 antigen on solid tumors leads to susceptibility to PR1-targeted immunotherapy
    Gheath Alatrash
    Department of Stem Cell Transplantation and Cellular Therapy, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    J Immunol 189:5476-84. 2012
  7. doi request reprint Blocking LFA-1 activation with lovastatin prevents graft-versus-host disease in mouse bone marrow transplantation
    Yang Wang
    Section of Transplantation Immunology, Department of Stem Cell Transplantation and Cellular Therapy, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Biol Blood Marrow Transplant 15:1513-22. 2009
  8. pmc Chemokine receptor CCR5 mediates alloimmune responses in graft-versus-host disease
    Lisa A Palmer
    Section of Transplantation Immunology, Department of Stem Cell Transplantation and Cellular Therapy, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Biol Blood Marrow Transplant 16:311-9. 2010
  9. pmc A novel HLA-A*0201 restricted peptide derived from cathepsin G is an effective immunotherapeutic target in acute myeloid leukemia
    Mao Zhang
    Stem Cell Transplantation and Cellular Therapy, Surgical Oncology, and Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Clin Cancer Res 19:247-57. 2013
  10. doi request reprint Lovastatin inhibits T-cell proliferation while preserving the cytolytic function of EBV, CMV, and MART-1-specific CTLs
    Dan Li
    Section of Transplantation Immunology, Department of Stem Cell Transplantation and Cellular Therapy, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    J Immunother 33:975-82. 2010

Detail Information

Publications45

  1. doi request reprint Preparing basic and translational grant proposals: thoughts from the trenches
    Jeffrey J Molldrem
    Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Hematology Am Soc Hematol Educ Program 2010:181-4. 2010
    ..Rather, it is a brief overview of the grant writing process from conception to submission...
  2. pmc PR1-specific T cells are associated with unmaintained cytogenetic remission of chronic myelogenous leukemia after interferon withdrawal
    Shreya Kanodia
    Section of Transplant Immunology, Department of Blood and Marrow Transplantation, University of Texas M D Anderson Cancer Center, Houston, Texas, United States of America
    PLoS ONE 5:e11770. 2010
    ..IFN induces CCR in part by increasing cytotoxic T lymphocytes (CTL) specific for PR1, the HLA-A2-restricted 9-mer peptide from proteinase 3 and neutrophil elastase, but it is unknown how CCR persists after IFN is stopped...
  3. pmc dsPIG: a tool to predict imprinted genes from the deep sequencing of whole transcriptomes
    Hua Li
    Shanghai Center for Systems Biomedicine, Key Laboratory of Systems Biomedicine, Ministry of Education, Shanghai Jiao Tong University, Shanghai, China
    BMC Bioinformatics 13:271. 2012
    ..Here we propose a Bayesian model (dsPIG) to predict imprinted genes on the basis of allelic expression observed in mRNA-Seq data of independent human tissues...
  4. ncbi request reprint Antithymocyte globulin for treatment of the bone marrow failure associated with myelodysplastic syndromes
    Jeffrey J Molldrem
    National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 70892, USA
    Ann Intern Med 137:156-63. 2002
    ..Almost half of the deaths that result from myelodysplastic syndromes are due to cytopenia associated with bone marrow failure. Treatment is mostly supportive care...
  5. pmc 2E8 binds to the high affinity I-domain in a metal ion-dependent manner: a second generation monoclonal antibody selectively targeting activated LFA-1
    Roberto Carreno
    Section of Transplantation Immunology, Department of Stem Cell Transplantation and Cellular Therapy, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 285:32860-8. 2010
    ..As a novel activation-specific monoclonal antibody, 2E8 is a potentially useful reagent for blocking high affinity LFA-1 and modulating T cell activation in research and therapeutics...
  6. pmc Broad cross-presentation of the hematopoietically derived PR1 antigen on solid tumors leads to susceptibility to PR1-targeted immunotherapy
    Gheath Alatrash
    Department of Stem Cell Transplantation and Cellular Therapy, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    J Immunol 189:5476-84. 2012
    ....
  7. doi request reprint Blocking LFA-1 activation with lovastatin prevents graft-versus-host disease in mouse bone marrow transplantation
    Yang Wang
    Section of Transplantation Immunology, Department of Stem Cell Transplantation and Cellular Therapy, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Biol Blood Marrow Transplant 15:1513-22. 2009
    ..In addition, treatment with lovastatin impaired donor-derived T cell proliferation in vivo. Taken together, these results indicate the important role of lovastatin in the treatment of GVHD...
  8. pmc Chemokine receptor CCR5 mediates alloimmune responses in graft-versus-host disease
    Lisa A Palmer
    Section of Transplantation Immunology, Department of Stem Cell Transplantation and Cellular Therapy, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Biol Blood Marrow Transplant 16:311-9. 2010
    ..Thus, CCR5 is a marker for GVHD effector cells and CCR5(+) T cells are active participants in the pathogenesis of human aGVHD...
  9. pmc A novel HLA-A*0201 restricted peptide derived from cathepsin G is an effective immunotherapeutic target in acute myeloid leukemia
    Mao Zhang
    Stem Cell Transplantation and Cellular Therapy, Surgical Oncology, and Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Clin Cancer Res 19:247-57. 2013
    ..In this study, we characterize the role of the myeloid azurophil granule protease cathepsin G (CG) as a novel target for AML immunotherapy...
  10. doi request reprint Lovastatin inhibits T-cell proliferation while preserving the cytolytic function of EBV, CMV, and MART-1-specific CTLs
    Dan Li
    Section of Transplantation Immunology, Department of Stem Cell Transplantation and Cellular Therapy, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    J Immunother 33:975-82. 2010
    ....
  11. pmc Co-stimulation through 4-1BB/CD137 improves the expansion and function of CD8(+) melanoma tumor-infiltrating lymphocytes for adoptive T-cell therapy
    Jessica Ann Chacon
    Department of Melanoma Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    PLoS ONE 8:e60031. 2013
    ..This may greatly improve TIL persistence and anti-tumor activity in vivo after adoptive transfer into patients...
  12. pmc Reduced graft-versus-host disease in C3-deficient mice is associated with decreased donor Th1/Th17 differentiation
    Qing Ma
    Section of Transplantation Immunology, Department of Stem Cell Transplantation and Cellular Therapy, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Biol Blood Marrow Transplant 18:1174-81. 2012
    ..We conclude that C3 regulates Th1/17 differentiation in bone marrow transplantation, and define a novel function of the complement system in GVHD...
  13. pmc Detection and characterization of a novel subset of CD8⁺CD57⁺ T cells in metastatic melanoma with an incompletely differentiated phenotype
    Richard C Wu
    Department of Melanoma Medical Oncology, University of Texas, MD Anderson Cancer Center, Houston, Texas, USA
    Clin Cancer Res 18:2465-77. 2012
    ....
  14. pmc Adoptive transfer of PR1 cytotoxic T lymphocytes associated with reduced leukemia burden in a mouse acute myeloid leukemia xenograft model
    Qing Ma
    Section of Transplantation Immunology, Department of Stem Cell Transplantation and Cellular Therapy, University of Texas, MD Anderson Cancer Center, Unit 900, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Cytotherapy 12:1056-62. 2010
    ..PR1-specific CTL elicited in vitro from healthy donors have been shown to lyse P3-expressing AML cells from patients. We investigated whether PR1-CTL can be adoptively transferred into NOD/SCID mice to eliminate human leukemia cells...
  15. pmc Cord-blood engraftment with ex vivo mesenchymal-cell coculture
    Marcos de Lima
    Department of Stem Cell Transplantation and Cellular Therapy, University of Texas M D Anderson Cancer Center, Houston, USA
    N Engl J Med 367:2305-15. 2012
    ..We hypothesized that engraftment would be improved by transplanting cord blood that was expanded ex vivo with mesenchymal stromal cells...
  16. pmc Breast cancer cell uptake of the inflammatory mediator neutrophil elastase triggers an anticancer adaptive immune response
    Elizabeth A Mittendorf
    Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 72:3153-62. 2012
    ..Taken together, our findings reveal a previously unknown mechanism of antitumor adaptive immunity that links cancer cell uptake of an inflammatory mediator to an effective cytolytic response against an important breast cancer antigen...
  17. pmc Functionally active virus-specific T cells that target CMV, adenovirus, and EBV can be expanded from naive T-cell populations in cord blood and will target a range of viral epitopes
    Patrick J Hanley
    Department of Immunology, Baylor College of Medicine, Texas Children s Hospital and The Methodist Hospital, Center for Cell and Gene Therapy, Houston, TX 77030, USA
    Blood 114:1958-67. 2009
    ..This study is registered at www.clinicaltrials.gov as NCT00078533...
  18. pmc The role of antigen cross-presentation from leukemia blasts on immunity to the leukemia-associated antigen PR1
    Gheath Alatrash
    Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    J Immunother 35:309-20. 2012
    ..Our data demonstrate distinct mechanisms for cross-presentation of soluble and cell-associated NE and P3, which may be valuable in understanding immunity to PR1 in leukemia...
  19. pmc LFA-1 affinity regulation is necessary for the activation and proliferation of naive T cells
    Yang Wang
    Section of Transplantation Immunology, Department of Stem Cell Transplantation and Cellular Therapy, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    J Biol Chem 284:12645-53. 2009
    ..This implicates LFA-1 activation as a novel regulatory mechanism for the modulation of T cell activation and proliferation...
  20. doi request reprint Immunotherapy of AML
    Gheath Alatrash
    Division of Cancer Medicine, University of Texas MD, Anderson Cancer Center, Houston, TX, USA
    Cancer Treat Res 145:237-55. 2010
    ..This chapter will discuss the role of the immune system and recent advances in immunotherapy for the treatment of AML, focusing on cellular and non-cellular approaches...
  21. pmc An anti-PR1/HLA-A2 T-cell receptor-like antibody mediates complement-dependent cytotoxicity against acute myeloid leukemia progenitor cells
    Anna Sergeeva
    Section of Transplantation Immunology, Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Blood 117:4262-72. 2011
    ..Therefore, this antibody warrants further study as a novel approach to targeting leukemia-initiating cells in patients with AML...
  22. pmc Delayed immune reconstitution after cord blood transplantation is characterized by impaired thymopoiesis and late memory T-cell skewing
    Krishna V Komanduri
    Department of Stem Cell Transplantation and Cellular Therapy, M D Anderson Cancer Center, Houston, TX 77030, USA
    Blood 110:4543-51. 2007
    ..Strategies that improve the engraftment of lymphoid precursors, protect the thymus during pretransplant conditioning, and/or augment the recovery of thymopoiesis may improve outcomes after CBT...
  23. pmc A novel strategy for rapid and efficient isolation of human tumor-specific CD4(+) and CD8(+) T-cell clones
    Seung Tae Lee
    Department of Lymphoma and Myeloma, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Immunol Methods 331:13-26. 2008
    ..The method was simple, efficient, and reproducible, and may have potential application for the development of adoptive immunotherapeutic strategies...
  24. pmc Vaccines as consolidation therapy for myeloid leukemia
    Gheath Alatrash
    Department of Stem Cell Transplantation and Cellular Therapy, University of Texas, MD Anderson Cancer Center, 1515 Holcombe Blvd, Unit 900, Houston, TX 77030, USA
    Expert Rev Hematol 4:37-50. 2011
    ..Although not yet considered the standard of care, leukemia vaccines continue to show promising results in the management of the myeloid leukemias...
  25. pmc Targeting human B-cell malignancies through Ig light chain-specific cytotoxic T lymphocytes
    Jinsheng Weng
    Department of Lymphoma and Myeloma, Stem Cell Transplantation and Cellular Therapy, and Center for Cancer Immunology Research, MD Anderson Cancer Center, Houston, Texas, USA
    Clin Cancer Res 17:5945-52. 2011
    ..However, epitopes derived from Id that stimulate human CD8(+) T-cell immunity are incompletely characterized...
  26. ncbi request reprint Immunotherapeutic peptide vaccination with leukemia-associated antigens
    Sylvie Rusakiewicz
    Section of Transplantation Immunology, Department of Blood and Marrow Transplantation, University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    Curr Opin Immunol 18:599-604. 2006
    ..The results of these vaccine trials, although still preliminary, provide some evidence that vaccination with LAAs might confer protective immunity to leukemia and offer great prospect as part of the future treatment of leukemia...
  27. pmc CD13-positive bone marrow-derived myeloid cells promote angiogenesis, tumor growth, and metastasis
    Eleonora Dondossola
    David H Koch Center, The University of Texas MD Anderson Cancer Center, Houston, TX 77030
    Proc Natl Acad Sci U S A 110:20717-22. 2013
    ..Thus, CD11b(+)CD13(+) myeloid cells constitute a population of bone marrow-derived cells that promote tumor progression and metastasis and are potential candidates for the development of targeted antiangiogenic drugs. ..
  28. ncbi request reprint Monoculture-derived T lymphocytes specific for multiple viruses expand and produce clinically relevant effects in immunocompromised individuals
    Ann M Leen
    Center for Cell and Gene Therapy, Baylor College of Medicine, The Methodist Hospital and Texas Children s Hospital, Houston, Texas 77030, USA
    Nat Med 12:1160-6. 2006
    ..Monoculture-derived multispecific CTL infusion could provide a safe and efficient means to restore virus-specific immunity in the immunocompromised host...
  29. pmc Mitochondrial DNA sequence variation in single cells from leukemia patients
    Yong Gang Yao
    Hematology Branch and Flow Cytometry Core Facility, National Heart, Lung, and Blood Institute, NIH Bldg 10 CRC, Rm 3E 5216, 10 Center Dr Bethesda, MD 20892, USA
    Blood 109:756-62. 2007
    ..Our results suggest that the somatic mutation process in leukemia is complex, leading to diverse levels of genetic alterations due to either intrinsic aspects of leukemia pathophysiology or chemotherapy effects...
  30. ncbi request reprint Functional assessment and specific depletion of alloreactive human T cells using flow cytometry
    Sergio L R Martins
    Transplant Immunology Section, Department of Blood and Marrow Transplantation, MD Anderson Cancer Center, SCRB 3 3019, Unit 900, 7455 Fannin St, Houston, TX 77030, USA
    Blood 104:3429-36. 2004
    ..This approach also was applied to specifically enrich or deplete human virus-specific T cells...
  31. ncbi request reprint Vaccination for leukemia
    Jeffrey J Molldrem
    Transplantation Immunology Section, Blood and Marrow Transplantation Department, University of Texas MD Anderson Cancer Center, Houston, 77030, USA
    Biol Blood Marrow Transplant 12:13-8. 2006
    ..Although these studies are still early, they offer evidence that effective immunity to leukemia is possible after vaccination, thus setting the stage for future combined therapies...
  32. pmc LFA-1 regulates CD8+ T cell activation via T cell receptor-mediated and LFA-1-mediated Erk1/2 signal pathways
    Dan Li
    Section of Transplantation Immunology, Department of Stem Cell Transplantation and Cellular Therapy, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 284:21001-10. 2009
    ..We demonstrated that the function of LFA-1 is to enhance TCR signaling through the immunological synapse and deliver distinct signals in CD8+ T cell activation...
  33. pmc Donor-specific anti-HLA Abs and graft failure in matched unrelated donor hematopoietic stem cell transplantation
    Stefan O Ciurea
    Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Blood 118:5957-64. 2011
    ..1%; P < .0001) and higher in women with 1 (P = .008) and 2 or more pregnancies (P = .0003) than in men. We conclude that the presence of anti-DPB1 DSAs is associated with graft failure in MUD hematopoietic stem cell transplantation...
  34. pmc Vascular ligand-receptor mapping by direct combinatorial selection in cancer patients
    Fernanda I Staquicini
    David H Koch Center, Department of Genitourinary Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 108:18637-42. 2011
    ..These findings provide vascular molecular markers for biotechnology and medical applications...
  35. ncbi request reprint Assembly of the kappa preB receptor requires a V kappa-like protein encoded by a germline transcript
    Roberto Rangel
    Department of Immunology, M D Anderson Cancer Center, The University of Texas, Houston, Texas 77054, USA
    J Biol Chem 280:17807-14. 2005
    ..In addition, the present study confirms the co-existence of surrogate lambda and kappa receptors that are proposed to work in concert to promote B lymphocyte maturation...
  36. ncbi request reprint Immunity to chronic myelogenous leukemia
    Dax Kurbegov
    Division of Cancer Medicine, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Box 10, Houston, TX 77030, USA
    Hematol Oncol Clin North Am 18:733-52, xi-xii. 2004
    ..Finally,the authors discuss how advances in the understanding of the molecular and cellular nature of immunity are being translated into new therapeutic strategies for the treatment of CML...
  37. ncbi request reprint Immune-induced cytopenia: bone marrow failure syndrome
    Yukio Kondo
    Department of Blood and Marrow Transplantation, University of Texas MD Anderson Cancer Center, 7455 Fannin SCRB Unit 900, PO Box 301402, Houston, TX 77230, USA
    Curr Hematol Rep 3:178-83. 2004
    ..Recent studies suggest that dominant clonal T cells, which may be driven to expand by hematopoietic antigenic stimuli, result in the T-cell-mediated inhibition of hematopoietic progenitors, thus contributing to cytopenia...
  38. ncbi request reprint Vaccines in leukemia
    Sijie Lu
    The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Adv Pharmacol 51:255-70. 2004
  39. ncbi request reprint The basis of T-cell-mediated immunity to chronic myelogenous leukemia
    Jeffrey J Molldrem
    Transplantation Immunology Section, Department of Blood and Marrow Transplantation, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Oncogene 21:8668-73. 2002
  40. ncbi request reprint Overexpressed differentiation antigens as targets of graft-versus-leukemia reactions
    Jeffrey J Molldrem
    Transplantation Immunology Section, Department of Blood and Marrow Transplantation, University of Texas M D Anderson Cancer Center, Houston, 77030, USA
    Curr Opin Hematol 9:503-8. 2002
    ..By altering T-cell receptor affinity, peptide specificity can be maintained and the potency of immunity can be enhanced in the MHC-mismatched setting...
  41. ncbi request reprint A human Mix-like homeobox gene MIXL shows functional similarity to Xenopus Mix.1
    Wei Guo
    Department of Molecular Genetics, University of Texas M D Anderson Cancer Center, Houston, 77030, USA
    Blood 100:89-95. 2002
    ..Isolation of the MIXL gene is the first step toward understanding novel regulatory circuits in early hematopoietic differentiation and malignant transformation...
  42. ncbi request reprint CD25 expression on donor CD4+ or CD8+ T cells is associated with an increased risk for graft-versus-host disease after HLA-identical stem cell transplantation in humans
    Marta Stanzani
    Transplant Immunology Laboratory, MD Anderson Cancer Center, SCRB 3 3019, 7455 Fannin St, Houston, TX 77030, USA
    Blood 103:1140-6. 2004
    ....
  43. ncbi request reprint Loss of T-lymphocyte clonal dominance in patients with myelodysplastic syndrome responsive to immunosuppression
    James N Kochenderfer
    Section of Transplantation Immunology, Department of Blood and Marrow Transplantation, University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Blood 100:3639-45. 2002
    ..Our results demonstrate that predominant clonal T cells that appear to be antigen-driven persist in patients with MDS unresponsive to immunosuppression, but predominant clones regress in responders to immunosuppression...
  44. ncbi request reprint Selective depletion of donor alloreactive T cells without loss of antiviral or antileukemic responses
    Persis J Amrolia
    Department of Bone Marrow Transplantation, Great Ormond Street Children s Hospital, London, United Kingdom
    Blood 102:2292-9. 2003
    ..Based on these data, we have embarked on a phase 1 clinical trial of addback of allo-LCL-depleted donor T cells in the haplo-identical setting...
  45. ncbi request reprint Vaccinating transplant recipients
    Jeffrey J Molldrem
    Nat Med 11:1162-3. 2005