Robert A Mitchell

Summary

Affiliation: The Picower Institute for Medical Research
Country: USA

Publications

  1. ncbi request reprint Inhibition of MIF bioactivity by rational design of pharmacological inhibitors of MIF tautomerase activity
    Angeles Dios
    The Picower Institute for Medical Research, Manhasset, NY 11030, USA
    J Med Chem 45:2410-6. 2002
  2. pmc A Leishmania ortholog of macrophage migration inhibitory factor modulates host macrophage responses
    Daniela Kamir
    Yale University School of Medicine, New Haven, CT 06520, USA
    J Immunol 180:8250-61. 2008
  3. pmc Macrophage migration inhibitory factor (MIF) sustains macrophage proinflammatory function by inhibiting p53: regulatory role in the innate immune response
    Robert A Mitchell
    Picower Institute for Medical Research, New York, NY 11030, USA
    Proc Natl Acad Sci U S A 99:345-50. 2002
  4. ncbi request reprint IFN-gamma induces high mobility group box 1 protein release partly through a TNF-dependent mechanism
    Beatriz Rendon-Mitchell
    Center of Immunology and Inflammation, North Shore Long Island Jewish Research Institute, Manhasset, NY 11030, USA
    J Immunol 170:3890-7. 2003
  5. ncbi request reprint Macrophage migration inhibitory factor deficiency is associated with altered cell growth and reduced susceptibility to Ras-mediated transformation
    Oleksi Petrenko
    Picower Institute for Medical Research, Manhasset, New York 11030, USA
    J Biol Chem 278:11078-85. 2003
  6. pmc Rho GTPase-dependent signaling is required for macrophage migration inhibitory factor-mediated expression of cyclin D1
    James D Swant
    Department of Biochemistry and Molecular Biology, University of Louisville, KY 40202, USA
    J Biol Chem 280:23066-72. 2005
  7. ncbi request reprint Adhesion-dependent signaling by macrophage migration inhibitory factor (MIF)
    Hong Liao
    North Shore Long Island Jewish Health System, Manhasset, New York 11030, USA
    J Biol Chem 278:76-81. 2003
  8. pmc Inhibition of macrophage migration inhibitory factor (MIF) tautomerase and biological activities by acetaminophen metabolites
    Peter D Senter
    The Picower Institute for Medical Research, 350 Community Drive, Manhasset, New York 11030, USA
    Proc Natl Acad Sci U S A 99:144-9. 2002
  9. pmc Cooperative regulation of non-small cell lung carcinoma angiogenic potential by macrophage migration inhibitory factor and its homolog, D-dopachrome tautomerase
    Arlixer M Coleman
    Microbiology and Immunology Program, School of Medicine, University of Louisville, Louisville, KY 40202, USA
    J Immunol 181:2330-7. 2008
  10. pmc Macrophage migration inhibitory factor manipulation and evaluation in tumoral hypoxic adaptation
    Millicent Winner
    Molecular Targets Program, JG Brown Cancer Center, University of Louisville, Louisville, Kentucky, USA
    Methods Enzymol 435:355-69. 2007

Collaborators

  • Gunter Fingerle Rowson
  • Elias Lolis
  • Hong Wang
  • Yousef Al-Abed
  • Huan Yang
  • Jianhua Li
  • Oleksi Petrenko
  • Thierry Calandra
  • Shin Onodera
  • Huabao Xiong
  • Ming Zhao
  • Richard Bucala
  • Millicent Winner
  • Beatriz E Rendon
  • Lin Leng
  • Hong Liao
  • Arlixer M Coleman
  • Daniela Kamir
  • Peter D Senter
  • Swen Zierow
  • Courtney McDonald
  • Toshiya Atsumi
  • Wayne Zundel
  • Yibang Chen
  • James D Swant
  • Christine Metz
  • Beatriz Rendon-Mitchell
  • Christine N Metz
  • Angeles Dios
  • Jason Griffith
  • John Trent
  • Dan Xin
  • Michael Cappello
  • Melanie Merk
  • John Walker
  • Yuen Kwan Amy Kwong
  • Jason Meier
  • Ming Wei Qian
  • Yira Diaz
  • Jon Vermeire
  • Diane McMahon-Pratt
  • Jurgen Bernhagen
  • Yoonsang Cho
  • Ned Smith
  • John O Trent
  • Gregg V Crichlow
  • Randall Riggs
  • Thierry Roger
  • Tim Yu
  • Jason K Kim
  • You Ree Cho
  • Narihito Yoshioka
  • Hirokatsu Niwa
  • Takao Koike
  • Eun Gyoung Hong
  • Albert C Koong
  • Tomomi Umino
  • Ivo Teneng
  • Cheryl Danton
  • Jun Takeuchi
  • Marc Symons
  • Mahendar Ochani
  • Jing Xu
  • John Baugh
  • Guoqian Chen
  • Thomas Delohery
  • Andrew E Sama
  • Seamas Donnelly
  • Jialian Han
  • Seenu Susarla
  • Christopher Czura
  • Kevin J Tracey
  • Yan Fang
  • Carlos G Gartner
  • J Chesney
  • Bayan Aljabari
  • KerryAnn O'Connor
  • Jodi Lubetsky
  • Sidney D Nelson
  • Fabio Benigni
  • Kirk R Manogue
  • George J Todaro
  • David J E Callaway
  • Jianlin Han

Detail Information

Publications16

  1. ncbi request reprint Inhibition of MIF bioactivity by rational design of pharmacological inhibitors of MIF tautomerase activity
    Angeles Dios
    The Picower Institute for Medical Research, Manhasset, NY 11030, USA
    J Med Chem 45:2410-6. 2002
    ..The inhibitory activity of amino acid-benzaldehyde Schiff base-type MIF antagonists is the first step toward a meaningful structure/function analysis of inhibitors of MIF cellular bioactivities...
  2. pmc A Leishmania ortholog of macrophage migration inhibitory factor modulates host macrophage responses
    Daniela Kamir
    Yale University School of Medicine, New Haven, CT 06520, USA
    J Immunol 180:8250-61. 2008
    ..The ability of Lm1740MIF to inhibit apoptosis may facilitate the persistence of Leishmania within the macrophage and contribute to its evasion from immune destruction...
  3. pmc Macrophage migration inhibitory factor (MIF) sustains macrophage proinflammatory function by inhibiting p53: regulatory role in the innate immune response
    Robert A Mitchell
    Picower Institute for Medical Research, New York, NY 11030, USA
    Proc Natl Acad Sci U S A 99:345-50. 2002
    ....
  4. ncbi request reprint IFN-gamma induces high mobility group box 1 protein release partly through a TNF-dependent mechanism
    Beatriz Rendon-Mitchell
    Center of Immunology and Inflammation, North Shore Long Island Jewish Research Institute, Manhasset, NY 11030, USA
    J Immunol 170:3890-7. 2003
    ..These data suggest that IFN-gamma plays an important role in the regulation of HMGB1 release through a TNF- and Janus kinase 2-dependent mechanism...
  5. ncbi request reprint Macrophage migration inhibitory factor deficiency is associated with altered cell growth and reduced susceptibility to Ras-mediated transformation
    Oleksi Petrenko
    Picower Institute for Medical Research, Manhasset, New York 11030, USA
    J Biol Chem 278:11078-85. 2003
    ..Our results demonstrate that MIF plays a role in an E2F/p53 pathway that operates downstream of Rb regulation and implicate MIF as a mediator of normal and malignant cell growth...
  6. pmc Rho GTPase-dependent signaling is required for macrophage migration inhibitory factor-mediated expression of cyclin D1
    James D Swant
    Department of Biochemistry and Molecular Biology, University of Louisville, KY 40202, USA
    J Biol Chem 280:23066-72. 2005
    ..These results suggest that MIF is an integral autocrine mediator of Rho GTPase-dependent signaling events and provide mechanistic insight into how MIF regulates proliferative, migratory, and oncogenic processes...
  7. ncbi request reprint Adhesion-dependent signaling by macrophage migration inhibitory factor (MIF)
    Hong Liao
    North Shore Long Island Jewish Health System, Manhasset, New York 11030, USA
    J Biol Chem 278:76-81. 2003
    ..These results suggest that MIF is an important autocrine mediator of adhesion-dependent signaling events and may provide mechanistic insight into how MIF regulates proliferative and oncogenic processes...
  8. pmc Inhibition of macrophage migration inhibitory factor (MIF) tautomerase and biological activities by acetaminophen metabolites
    Peter D Senter
    The Picower Institute for Medical Research, 350 Community Drive, Manhasset, New York 11030, USA
    Proc Natl Acad Sci U S A 99:144-9. 2002
    ....
  9. pmc Cooperative regulation of non-small cell lung carcinoma angiogenic potential by macrophage migration inhibitory factor and its homolog, D-dopachrome tautomerase
    Arlixer M Coleman
    Microbiology and Immunology Program, School of Medicine, University of Louisville, Louisville, KY 40202, USA
    J Immunol 181:2330-7. 2008
    ..This is the first demonstration of a biological role for D-DT, and its synergism with MIF suggests that the combined therapeutic targeting of both family members may enhance current anti-MIF-based therapies...
  10. pmc Macrophage migration inhibitory factor manipulation and evaluation in tumoral hypoxic adaptation
    Millicent Winner
    Molecular Targets Program, JG Brown Cancer Center, University of Louisville, Louisville, Kentucky, USA
    Methods Enzymol 435:355-69. 2007
    ..As the importance of MIF in hypoxic adaptation of human tumors is now becoming fully realized, we review protocols designed to evaluate MIF expression, activity, and functional consequences in hypoxic environments...
  11. ncbi request reprint The proinflammatory cytokine macrophage migration inhibitory factor regulates glucose metabolism during systemic inflammation
    Toshiya Atsumi
    Graduate School of Medicine, Hokkaido University, Sapporo, Japan
    J Immunol 179:5399-406. 2007
    ..Genetic MIF deficiency also promotes adipogenesis, which is in accord with a downstream role for MIF in the action of TNF-alpha. These studies support an important role for MIF in host glucose metabolism during sepsis...
  12. ncbi request reprint Regulation of human lung adenocarcinoma cell migration and invasion by macrophage migration inhibitory factor
    Beatriz E Rendon
    Molecular Targets Program, J G Brown Cancer Center, University of Louisville, Louisville, Kentucky 40202, USA
    J Biol Chem 282:29910-8. 2007
    ....
  13. pmc Amplification of tumor hypoxic responses by macrophage migration inhibitory factor-dependent hypoxia-inducible factor stabilization
    Millicent Winner
    Molecular Targets Program, James Graham Brown Cancer Center and Department of Radiation Oncology, University of Louisville, 580 South Preston Street, Louisville, KY, USA
    Cancer Res 67:186-93. 2007
    ..This functional interdependence between HIF-1alpha and MIF may represent an important and previously unrecognized pro-tumorigenic axis...
  14. ncbi request reprint Mechanisms and effectors of MIF-dependent promotion of tumourigenesis
    Robert A Mitchell
    James Graham Brown Cancer Center, University of Louisville, Baxter II Research Building, 580 S Preston Street, Louisville, KY 40202, USA
    Cell Signal 16:13-9. 2004
    ..This review will focus on recently characterized phenotypes and mechanistic effectors thought to be associated with MIF-dependent promotion of neoplastic processes and discuss their relative importance in carcinogenesis...
  15. pmc MIF signal transduction initiated by binding to CD74
    Lin Leng
    Department of Internal Medicine, Section of Rheumatology, Yale University School of Medicine, 333 Cedar St, P O Box 208031, New Haven, CT 06520 8031, USA
    J Exp Med 197:1467-76. 2003
    ..These data provide a molecular basis for MIF's interaction with target cells and identify it as a natural ligand for CD74, which has been implicated previously in signaling and accessory functions for immune cell activation...
  16. pmc A novel, macrophage migration inhibitory factor suicide substrate inhibits motility and growth of lung cancer cells
    Millicent Winner
    Molecular Targets Program, University of Louisville, KY, USA
    Cancer Res 68:7253-7. 2008
    ..Finally, using an in silico combinatorial optimization strategy, we have identified four unique congeners of 4-IPP that exhibit MIF inhibitory activity at concentrations 10x to 20x lower than that of parental 4-IPP...