Research Topics
Genomes and GenesSpecies | Robert A MitchellSummaryAffiliation: The Picower Institute for Medical Research Country: USA Publications
| Collaborators
|
Detail Information
Publications
Inhibition of MIF bioactivity by rational design of pharmacological inhibitors of MIF tautomerase activityAngeles Dios
The Picower Institute for Medical Research, Manhasset, NY 11030, USA
J Med Chem 45:2410-6. 2002..The inhibitory activity of amino acid-benzaldehyde Schiff base-type MIF antagonists is the first step toward a meaningful structure/function analysis of inhibitors of MIF cellular bioactivities...
A Leishmania ortholog of macrophage migration inhibitory factor modulates host macrophage responsesDaniela Kamir
Yale University School of Medicine, New Haven, CT 06520, USA
J Immunol 180:8250-61. 2008..The ability of Lm1740MIF to inhibit apoptosis may facilitate the persistence of Leishmania within the macrophage and contribute to its evasion from immune destruction...- Macrophage migration inhibitory factor (MIF) sustains macrophage proinflammatory function by inhibiting p53: regulatory role in the innate immune responseRobert A Mitchell
Picower Institute for Medical Research, New York, NY 11030, USA
Proc Natl Acad Sci U S A 99:345-50. 2002.... - IFN-gamma induces high mobility group box 1 protein release partly through a TNF-dependent mechanismBeatriz Rendon-Mitchell
Center of Immunology and Inflammation, North Shore-Long Island Jewish Research Institute, Manhasset, NY 11030, USA
J Immunol 170:3890-7. 2003..These data suggest that IFN-gamma plays an important role in the regulation of HMGB1 release through a TNF- and Janus kinase 2-dependent mechanism... - Macrophage migration inhibitory factor deficiency is associated with altered cell growth and reduced susceptibility to Ras-mediated transformationOleksi Petrenko
Picower Institute for Medical Research, Manhasset, New York 11030, USA
J Biol Chem 278:11078-85. 2003..Our results demonstrate that MIF plays a role in an E2F/p53 pathway that operates downstream of Rb regulation and implicate MIF as a mediator of normal and malignant cell growth... - Rho GTPase-dependent signaling is required for macrophage migration inhibitory factor-mediated expression of cyclin D1James D Swant
Department of Biochemistry and Molecular Biology, University of Louisville, KY 40202, USA
J Biol Chem 280:23066-72. 2005..These results suggest that MIF is an integral autocrine mediator of Rho GTPase-dependent signaling events and provide mechanistic insight into how MIF regulates proliferative, migratory, and oncogenic processes... - Adhesion-dependent signaling by macrophage migration inhibitory factor (MIF)Hong Liao
North Shore Long Island Jewish Health System, Manhasset, New York 11030, USA
J Biol Chem 278:76-81. 2003..These results suggest that MIF is an important autocrine mediator of adhesion-dependent signaling events and may provide mechanistic insight into how MIF regulates proliferative and oncogenic processes... - Inhibition of macrophage migration inhibitory factor (MIF) tautomerase and biological activities by acetaminophen metabolitesPeter D Senter
The Picower Institute for Medical Research, 350 Community Drive, Manhasset, New York 11030, USA
Proc Natl Acad Sci U S A 99:144-9. 2002.... - Cooperative regulation of non-small cell lung carcinoma angiogenic potential by macrophage migration inhibitory factor and its homolog, D-dopachrome tautomeraseArlixer M Coleman
Microbiology and Immunology Program, School of Medicine, University of Louisville, Louisville, KY 40202, USA
J Immunol 181:2330-7. 2008..This is the first demonstration of a biological role for D-DT, and its synergism with MIF suggests that the combined therapeutic targeting of both family members may enhance current anti-MIF-based therapies... - Macrophage migration inhibitory factor manipulation and evaluation in tumoral hypoxic adaptationMillicent Winner
Molecular Targets Program, JG Brown Cancer Center, University of Louisville, Louisville, Kentucky, USA
Methods Enzymol 435:355-69. 2007..As the importance of MIF in hypoxic adaptation of human tumors is now becoming fully realized, we review protocols designed to evaluate MIF expression, activity, and functional consequences in hypoxic environments... - The proinflammatory cytokine macrophage migration inhibitory factor regulates glucose metabolism during systemic inflammationToshiya Atsumi
Graduate School of Medicine, Hokkaido University, Sapporo, Japan
J Immunol 179:5399-406. 2007..Genetic MIF deficiency also promotes adipogenesis, which is in accord with a downstream role for MIF in the action of TNF-alpha. These studies support an important role for MIF in host glucose metabolism during sepsis... - Regulation of human lung adenocarcinoma cell migration and invasion by macrophage migration inhibitory factorBeatriz E Rendon
Molecular Targets Program, J G Brown Cancer Center, University of Louisville, Louisville, Kentucky 40202, USA
J Biol Chem 282:29910-8. 2007.... - Amplification of tumor hypoxic responses by macrophage migration inhibitory factor-dependent hypoxia-inducible factor stabilizationMillicent Winner
Molecular Targets Program, James Graham Brown Cancer Center and Department of Radiation Oncology, University of Louisville, 580 South Preston Street, Louisville, KY, USA
Cancer Res 67:186-93. 2007..This functional interdependence between HIF-1alpha and MIF may represent an important and previously unrecognized pro-tumorigenic axis... - Mechanisms and effectors of MIF-dependent promotion of tumourigenesisRobert A Mitchell
James Graham Brown Cancer Center, University of Louisville, Baxter II Research Building, 580 S Preston Street, Louisville, KY 40202, USA
Cell Signal 16:13-9. 2004..This review will focus on recently characterized phenotypes and mechanistic effectors thought to be associated with MIF-dependent promotion of neoplastic processes and discuss their relative importance in carcinogenesis... 
MIF signal transduction initiated by binding to CD74Lin Leng
Department of Internal Medicine, Section of Rheumatology, Yale University School of Medicine, 333 Cedar St, P O Box 208031, New Haven, CT 06520 8031, USA
J Exp Med 197:1467-76. 2003..These data provide a molecular basis for MIF's interaction with target cells and identify it as a natural ligand for CD74, which has been implicated previously in signaling and accessory functions for immune cell activation...- A novel, macrophage migration inhibitory factor suicide substrate inhibits motility and growth of lung cancer cellsMillicent Winner
Molecular Targets Program, University of Louisville, KY, USA
Cancer Res 68:7253-7. 2008..Finally, using an in silico combinatorial optimization strategy, we have identified four unique congeners of 4-IPP that exhibit MIF inhibitory activity at concentrations 10x to 20x lower than that of parental 4-IPP...