Jose Luis Millan

Summary

Affiliation: The Burnham Institute
Country: USA

Publications

  1. pmc Proteoliposomes harboring alkaline phosphatase and nucleotide pyrophosphatase as matrix vesicle biomimetics
    Ana Maria S Simão
    Department of Chemistry, Faculdade de Filosofia, Ciencias e Letras de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, SP 14040 901, Brazil
    J Biol Chem 285:7598-609. 2010
  2. pmc Alkaline Phosphatases : Structure, substrate specificity and functional relatedness to other members of a large superfamily of enzymes
    Jose Luis Millan
    Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA, 92037, USA
    Purinergic Signal 2:335-41. 2006
  3. pmc Enzyme replacement therapy for murine hypophosphatasia
    Jose Luis Millan
    Burnham Institute for Medical Research, La Jolla, California 92037, USA
    J Bone Miner Res 23:777-87. 2008
  4. pmc Concerted regulation of inorganic pyrophosphate and osteopontin by akp2, enpp1, and ank: an integrated model of the pathogenesis of mineralization disorders
    Dympna Harmey
    The Burnham Institute, La Jolla, CA 92037, USA
    Am J Pathol 164:1199-209. 2004
  5. pmc Kinetic analysis of substrate utilization by native and TNAP-, NPP1-, or PHOSPHO1-deficient matrix vesicles
    Pietro Ciancaglini
    Sanford Children s Health Research Center, Sanford Burnham Medical Research Institute, La Jolla, CA, USA
    J Bone Miner Res 25:716-23. 2010
  6. pmc Effects of pH on the production of phosphate and pyrophosphate by matrix vesicles' biomimetics
    Ana Maria S Simão
    Department of Chemistry, FFCLRP USP, Av Bandeirantes, 3900, Ribeirao Preto, SP, 14040 901, Brazil
    Calcif Tissue Int 93:222-32. 2013
  7. pmc Loss of skeletal mineralization by the simultaneous ablation of PHOSPHO1 and alkaline phosphatase function: a unified model of the mechanisms of initiation of skeletal calcification
    Manisha C Yadav
    Sanford Children s Health Research Center, Sanford Burnham Medical Research Institute, La Jolla, CA 92037, USA
    J Bone Miner Res 26:286-97. 2011
  8. ncbi request reprint Elevated skeletal osteopontin levels contribute to the hypophosphatasia phenotype in Akp2(-/-) mice
    Dympna Harmey
    Burnham Institute for Medical Research, La Jolla, California 92037, USA
    J Bone Miner Res 21:1377-86. 2006
  9. pmc Pharmacological inhibition of PHOSPHO1 suppresses vascular smooth muscle cell calcification
    Tina Kiffer-Moreira
    Sanford Children s Health Research Center, Sanford Burnham Medical Research Institute, La Jolla, CA 92037, USA
    J Bone Miner Res 28:81-91. 2013
  10. ncbi request reprint Linked deficiencies in extracellular PP(i) and osteopontin mediate pathologic calcification associated with defective PC-1 and ANK expression
    Kristen Johnson
    Veterans Affairs Medical Center, University of California San Diego, La Jolla, California 92161, USA
    J Bone Miner Res 18:994-1004. 2003

Collaborators

Detail Information

Publications36

  1. pmc Proteoliposomes harboring alkaline phosphatase and nucleotide pyrophosphatase as matrix vesicle biomimetics
    Ana Maria S Simão
    Department of Chemistry, Faculdade de Filosofia, Ciencias e Letras de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, SP 14040 901, Brazil
    J Biol Chem 285:7598-609. 2010
    ..The reconstitution of TNAP and NPP1 into proteoliposome membranes generates a phospholipid microenvironment that allows the kinetic study of phosphosubstrate catabolism in a manner that recapitulates the native MV microenvironment...
  2. pmc Alkaline Phosphatases : Structure, substrate specificity and functional relatedness to other members of a large superfamily of enzymes
    Jose Luis Millan
    Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA, 92037, USA
    Purinergic Signal 2:335-41. 2006
    ....
  3. pmc Enzyme replacement therapy for murine hypophosphatasia
    Jose Luis Millan
    Burnham Institute for Medical Research, La Jolla, California 92037, USA
    J Bone Miner Res 23:777-87. 2008
    ..Babies with the infantile form of HPP often die with severe rickets and sometimes hypercalcemia and vitamin B6-dependent seizures. There is no established medical treatment...
  4. pmc Concerted regulation of inorganic pyrophosphate and osteopontin by akp2, enpp1, and ank: an integrated model of the pathogenesis of mineralization disorders
    Dympna Harmey
    The Burnham Institute, La Jolla, CA 92037, USA
    Am J Pathol 164:1199-209. 2004
    ..The hypomineralization observed in Akp2(-/-) mice arises from the combined inhibitory effects of PP(i) and OPN. In contrast, NPP1 or ANK deficiencies cause a decrease in the PP(i) and OPN pools that leads to hypermineralization...
  5. pmc Kinetic analysis of substrate utilization by native and TNAP-, NPP1-, or PHOSPHO1-deficient matrix vesicles
    Pietro Ciancaglini
    Sanford Children s Health Research Center, Sanford Burnham Medical Research Institute, La Jolla, CA, USA
    J Bone Miner Res 25:716-23. 2010
    ..NPP1 does not have a major role in PP(i) generation from ATP at the level of MVs, in contrast to its accepted role on the surface of the osteoblasts and chondrocytes, but rather acts as a phosphatase in the absence of TNAP...
  6. pmc Effects of pH on the production of phosphate and pyrophosphate by matrix vesicles' biomimetics
    Ana Maria S Simão
    Department of Chemistry, FFCLRP USP, Av Bandeirantes, 3900, Ribeirao Preto, SP, 14040 901, Brazil
    Calcif Tissue Int 93:222-32. 2013
    ....
  7. pmc Loss of skeletal mineralization by the simultaneous ablation of PHOSPHO1 and alkaline phosphatase function: a unified model of the mechanisms of initiation of skeletal calcification
    Manisha C Yadav
    Sanford Children s Health Research Center, Sanford Burnham Medical Research Institute, La Jolla, CA 92037, USA
    J Bone Miner Res 26:286-97. 2011
    ....
  8. ncbi request reprint Elevated skeletal osteopontin levels contribute to the hypophosphatasia phenotype in Akp2(-/-) mice
    Dympna Harmey
    Burnham Institute for Medical Research, La Jolla, California 92037, USA
    J Bone Miner Res 21:1377-86. 2006
    ..We also found that extracellular OPN regulates the PP(i) output by osteoblasts...
  9. pmc Pharmacological inhibition of PHOSPHO1 suppresses vascular smooth muscle cell calcification
    Tina Kiffer-Moreira
    Sanford Children s Health Research Center, Sanford Burnham Medical Research Institute, La Jolla, CA 92037, USA
    J Bone Miner Res 28:81-91. 2013
    ..We conclude that PHOSPHO1 plays a critical role in VSMC mineralization and that "phosphatase inhibition" may be a useful therapeutic strategy to reduce MVC...
  10. ncbi request reprint Linked deficiencies in extracellular PP(i) and osteopontin mediate pathologic calcification associated with defective PC-1 and ANK expression
    Kristen Johnson
    Veterans Affairs Medical Center, University of California San Diego, La Jolla, California 92161, USA
    J Bone Miner Res 18:994-1004. 2003
    ..Thus, linked regulatory effects on extracellular PP(i) and OPN expression mediate the ability of PC-1 and ANK to regulate calcification...
  11. pmc The role of phosphatases in the initiation of skeletal mineralization
    Jose Luis Millan
    Sanford Children s Health Research Center, Sanford Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA, 92037, USA
    Calcif Tissue Int 93:299-306. 2013
    ....
  12. pmc Discovery and validation of a series of aryl sulfonamides as selective inhibitors of tissue-nonspecific alkaline phosphatase (TNAP)
    Russell Dahl
    Conrad Prebys Center for Chemical Genomics, Burnham Institute for Medical Research, La Jolla, California 92037, USA
    J Med Chem 52:6919-25. 2009
    ..A representative member of the series was also characterized in mechanistic and kinetic studies...
  13. ncbi request reprint Novel inhibitors of alkaline phosphatase suppress vascular smooth muscle cell calcification
    Sonoko Narisawa
    The Burnham Institute, La Jolla, California, USA
    J Bone Miner Res 22:1700-10. 2007
    ..e., they suppress in vitro calcification by cultured Enpp1(-/-) VSMCs and they inhibit the increased pyrophosphatase activity in a rat aortic model)...
  14. pmc Design and synthesis of pyrazole derivatives as potent and selective inhibitors of tissue-nonspecific alkaline phosphatase (TNAP)
    Shyama Sidique
    Burnham Center for Chemical Genomics, Burnham Institute for Medical Research, La Jolla, CA 92037, USA
    Bioorg Med Chem Lett 19:222-5. 2009
    ..A representative of the series was characterized in kinetic studies and determined to have a mode of inhibition not previously observed for TNAP inhibitors...
  15. doi request reprint Ablation of osteopontin improves the skeletal phenotype of phospho1(-/-) mice
    Manisha C Yadav
    Sanford Children s Health Research Center, Sanford Burnham Medical Research Institute, La Jolla, CA, USA
    J Bone Miner Res 29:2369-81. 2014
    ....
  16. pmc In vivo overexpression of tissue-nonspecific alkaline phosphatase increases skeletal mineralization and affects the phosphorylation status of osteopontin
    Sonoko Narisawa
    Sanford Children s Health Research Center, Sanford Burnham Medical Research Institute, La Jolla, CA, USA
    J Bone Miner Res 28:1587-98. 2013
    ..Our data suggest that the promineralization role of TNAP may be related not only to its accepted pyrophosphatase activity but also to its ability to modify the phosphorylation status of OPN...
  17. ncbi request reprint Kinetic characterization of hypophosphatasia mutations with physiological substrates
    Sonia Di Mauro
    The Burnham Institute, La Jolla, California 92037, USA
    J Bone Miner Res 17:1383-91. 2002
    ..Because abnormalities in PLP metabolism have been shown to cause epileptic seizures in mice null for the TNAP gene, these kinetic data help explain the variable expressivity of epileptic seizures in hypophosphatasia patients...
  18. pmc Enzyme replacement prevents enamel defects in hypophosphatasia mice
    Manisha C Yadav
    Sanford Children s Health Research Center, Sanford Burnham Medical Research Institute, La Jolla, CA 92037, USA
    J Bone Miner Res 27:1722-34. 2012
    ..2 mg/kg/day for up to 44 days. These data reveal an important role for TNAP in enamel mineralization and demonstrate the efficacy of mineral-targeted TNAP to prevent enamel defects in HPP...
  19. ncbi request reprint A novel phosphatase upregulated in Akp3 knockout mice
    Sonoko Narisawa
    Burnham Institute for Medical Research, La Jolla, CA 92037, USA
    Am J Physiol Gastrointest Liver Physiol 293:G1068-77. 2007
    ....
  20. pmc Dose response of bone-targeted enzyme replacement for murine hypophosphatasia
    Manisha C Yadav
    Sanford Children s Health Research Center, Sanford Burnham Medical Research Institute, La Jolla, CA 92037, USA
    Bone 49:250-6. 2011
    ..These dose-response relationships strongly support the pharmacological efficacy of ENB-0040 for HPP, and provide the experimental basis for the therapeutic range of ENB-0040 chosen for clinical trials...
  21. pmc Pathophysiological role of vascular smooth muscle alkaline phosphatase in medial artery calcification
    Campbell R Sheen
    Sanford Children s Health Research Center, Sanford Burnham Medical Research Institute, La Jolla, CA, USA
    J Bone Miner Res 30:824-36. 2015
    ..This study shows that TNAP in the vasculature contributes to the pathology of MVC and that it is a druggable target. © 2015 American Society for Bone and Mineral Research. ..
  22. pmc Assay format as a critical success factor for identification of novel inhibitor chemotypes of tissue-nonspecific alkaline phosphatase from high-throughput screening
    Thomas D Y Chung
    Conrad Prebys Center for Chemical Genomics, Sanford Burnham Medical Research Institute, La Jolla, CA 92037, USA
    Molecules 15:3010-37. 2010
    ..This illustrates the underappreciated impact of the underlying fundamental assay configuration on screening success, beyond mere signal generation and detection formats...
  23. pmc Improvement of the skeletal and dental hypophosphatasia phenotype in Alpl-/- mice by administration of soluble (non-targeted) chimeric alkaline phosphatase
    Kellen C S Gasque
    Sanford Children s Health Research Center, Sanford Burnham Medical Research Institute, La Jolla, CA 92037, USA
    Bone 72:137-47. 2015
    ..This study provides the first evidence for the pharmacological efficacy of ChimAP for use in the treatment of skeletal and dental manifestations of HPP...
  24. pmc High-throughput screening of tissue-nonspecific alkaline phosphatase for identification of effectors with diverse modes of action
    Eduard A Sergienko
    Conrad Prebys Center for Chemical Genomics, Sanford Burnham Medical Research Institute, La Jolla, California, USA
    Nat Protoc 5:1431-9. 2010
    ..This protocol provides a method of screening TNAP that is 1,000-fold more sensitive and 10-fold faster than a conventional colorimetric assay with p-nitrophenyl phosphate...
  25. ncbi request reprint Three novel spermatogenesis-specific zinc finger genes
    Helge Weissig
    The Burnham Institute, La Jolla, CA 92037, USA
    FEBS Lett 547:61-8. 2003
    ....
  26. pmc Identification and characterization of novel tissue-nonspecific alkaline phosphatase inhibitors with diverse modes of action
    Eduard Sergienko
    Conrad Prebys Center for Chemical Genomics, Burnham Institute for Medical Research, La Jolla, California 92037, USA
    J Biomol Screen 14:824-37. 2009
    ....
  27. pmc Tissue-nonspecific alkaline phosphatase and plasma cell membrane glycoprotein-1 are central antagonistic regulators of bone mineralization
    Lovisa Hessle
    The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 99:9445-9. 2002
    ..Our results suggest that inhibiting PC-1 function may be a viable therapeutic strategy for hypophosphatasia. Conversely, interfering with TNAP activity may correct pathological hyperossification because of PP(i) insufficiency...
  28. pmc Design, synthesis and evaluation of benzoisothiazolones as selective inhibitors of PHOSPHO1
    Yalda Bravo
    Cell Death and Survival Networks Research Program, NCI Designated Cancer Center, Sanford Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA Conrad Prebys Center for Chemical Genomics, Sanford Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Bioorg Med Chem Lett 24:4308-11. 2014
    ..On the basis of its overall profile the benzoisothiazolone analogue 2q was selected as MLPCN probe ML086. ..
  29. pmc Accelerated fat absorption in intestinal alkaline phosphatase knockout mice
    Sonoko Narisawa
    The Burnham Institute, La Jolla, California 92037, USA
    Mol Cell Biol 23:7525-30. 2003
    ..Our study suggests that IAP participates in a rate-limiting step regulating fat absorption...
  30. ncbi request reprint Mammalian alkaline phosphatase catalysis requires active site structure stabilization via the N-terminal amino acid microenvironment
    Marc F Hoylaerts
    Burnham Institute for Medical Research, La Jolla, California 92037, USA
    Biochemistry 45:9756-66. 2006
    ..These findings provide a mechanistic interpretation for loss-of-function mutations of N-terminal TNAP residues in cases of hypophosphatasia...
  31. pmc Testis-specific cytochrome c-null mice produce functional sperm but undergo early testicular atrophy
    Sonoko Narisawa
    The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Mol Cell Biol 22:5554-62. 2002
    ..Our data indicate that the Cyt c(T)-null testes undergo early atrophy equivalent to that which occurs during aging as a consequence of a reduction in oxidative phosphorylation...
  32. doi request reprint Upregulation of IGF2 expression during vascular calcification
    Dongxing Zhu
    The Roslin Institute and Royal Dick School of Veterinary Studies, The University of Edinburgh, Easter Bush, Roslin, Midlothian, EH25 9RG Scotland, UK Sanford Burnham Medical Research Institute, Sanford Children s Health Research Center, La Jolla, California 92037, USA
    J Mol Endocrinol 52:77-85. 2014
    ..A full understanding of the importance of IGF2 in this pathological process will lead to a better understanding of the aetiology of vascular calcification...
  33. pmc Refined structures of placental alkaline phosphatase show a consistent pattern of interactions at the peripheral site
    Boguslaw Stec
    Sanford Burnham Medical Research Institute, La Jolla, CA 92037, USA
    Acta Crystallogr Sect F Struct Biol Cryst Commun 66:866-70. 2010
    ..Comparison of the re-refined models shows a consistent pattern of interactions at the peripheral site...
  34. pmc Molecular characterisation of the Hyp deletion and an improved assay for its detection
    Campbell R Sheen
    Sanford Children s Health Research Center, Sanford Burnham Medical Research Institute, La Jolla, California, USA
    Bone 50:592-5. 2012
    ..This study provides confirmation of the Hyp phenotype as a single gene defect, a potential mechanism for its formation and an improved method for genotyping that will make working with this strain significantly easier...
  35. ncbi request reprint Structural evidence of functional divergence in human alkaline phosphatases
    Marie Helene Le Du
    Département d Ingénierie et d Etudes des Protéines DIEP, CEA, Bat 152 C E Saclay, 91191 Gif sur Yvette Cedex, France
    J Biol Chem 277:49808-14. 2002
    ..This analysis led to a structural fingerprint of the active site of each AP isozyme that suggests a diversification in substrate specificity for this isozyme family...
  36. ncbi request reprint Cutaneous metabolism of vitamin B-6
    Stephen P Coburn
    Fort Wayne State Developmental Center, Fort Wayne, Indiana 46835, USA
    J Invest Dermatol 120:292-300. 2003
    ..This suggests that an enzyme different from the classical tissue-nonspecific alkaline phosphatase may perform cutaneous pyridoxal 5'-phosphate hydrolase activity...

Research Grants3

  1. CANCER RELATED PLACENTAL TYPE ALKALINE PHOSPHATASES
    Jose Luis Millan; Fiscal Year: 2003
    ..These bispecific antibodies will be useful in the treatment of metastatic lesions and residual masses after surgical resection of the bulk of the tumors. ..
  2. Activators of the Pyrophosphatase Activity of Alkaline Phosphatase
    Jose Luis Millan; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  3. The Role of PHOSPHO1 in the Initiation of Skeletal Calcification
    Jose Luis Millan; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..