Lindsey Miles

Summary

Affiliation: The Scripps Research Institute
Country: USA

Publications

  1. pmc The plasminogen receptor, Plg-R(KT), and macrophage function
    Lindsey A Miles
    Department of Cell Biology, The Scripps Research Institute, 10550 N Torrey Pines Road, SP30 3020, La Jolla, CA 92037, USA
    J Biomed Biotechnol 2012:250464. 2012
  2. pmc New insights into the role of Plg-RKT in macrophage recruitment
    Lindsey A Miles
    Department of Cell and Molecular Biology, The Scripps Research Institute, La Jolla, California, USA Electronic address
    Int Rev Cell Mol Biol 309:259-302. 2014
  3. pmc Plasminogen receptors: the first quarter century
    Lindsey A Miles
    Department of Cell and Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Semin Thromb Hemost 39:329-37. 2013
  4. ncbi request reprint Plasminogen receptors: the sine qua non of cell surface plasminogen activation
    Lindsey A Miles
    Department of Cell Biology, Division of Vascular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Front Biosci 10:1754-62. 2005
  5. ncbi request reprint Critical role for conversion of glu-plasminogen to Lys-plasminogen for optimal stimulation of plasminogen activation on cell surfaces
    Lindsey A Miles
    Department of Cell Biology, Division of Vascular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Trends Cardiovasc Med 13:21-30. 2003
  6. pmc Plasminogen inhibits TNFalpha-induced apoptosis in monocytes
    Jennifer W Mitchell
    Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Blood 107:4383-90. 2006
  7. ncbi request reprint Plasmin-induced migration of endothelial cells. A potential target for the anti-angiogenic action of angiostatin
    Takehiko Tarui
    Department of Cell Biology, VB 6, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    J Biol Chem 277:33564-70. 2002
  8. pmc Proteomics-based discovery of a novel, structurally unique, and developmentally regulated plasminogen receptor, Plg-RKT, a major regulator of cell surface plasminogen activation
    Nicholas M Andronicos
    Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Blood 115:1319-30. 2010
  9. ncbi request reprint Localization of regulatory elements mediating constitutive and cytokine-stimulated plasminogen gene expression
    Felizabel Garcia Bannach
    Department of Cell Biology, Division of Vascular Biology, Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 277:38579-88. 2002
  10. ncbi request reprint Chromaffin cell plasminogen receptors
    Lindsey A Miles
    Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Ann N Y Acad Sci 971:454-9. 2002

Research Grants

  1. 18th International Congress on Fibrinolysis and Proteolysis
    Lindsey Miles; Fiscal Year: 2006
  2. Proteomic Analysis of Plasminogen Receptors
    Lindsey A Miles; Fiscal Year: 2010
  3. REGULATION OF FIBRINOLYSIS BY CELL SURFACE
    Lindsey Miles; Fiscal Year: 2002
  4. Proteomic Analysis of Plasminogen Receptors
    Lindsey Miles; Fiscal Year: 2009
  5. REGULATION OF THE PLASMINOGEN SYSTEM
    Lindsey Miles; Fiscal Year: 2000
  6. Proteomic Analysis of Plasminogen Receptors
    Lindsey Miles; Fiscal Year: 2009
  7. Proteomic Analysis of Plasminogen Receptors
    Lindsey Miles; Fiscal Year: 2007
  8. PLASMINOGEN ACTIVATOR ASSEMBLY SYSTEMS ON CELL SURFACES
    Lindsey Miles; Fiscal Year: 1990
  9. PLASMINOGEN ACTIVATOR ASSEMBLY SYSTEMS ON CELL SURFACES
    Lindsey Miles; Fiscal Year: 1991
  10. PLASMINOGEN ACTIVATOR ASSEMBLY SYSTEMS ON CELL SURFACES
    Lindsey Miles; Fiscal Year: 1992

Collaborators

Detail Information

Publications18

  1. pmc The plasminogen receptor, Plg-R(KT), and macrophage function
    Lindsey A Miles
    Department of Cell Biology, The Scripps Research Institute, 10550 N Torrey Pines Road, SP30 3020, La Jolla, CA 92037, USA
    J Biomed Biotechnol 2012:250464. 2012
    ....
  2. pmc New insights into the role of Plg-RKT in macrophage recruitment
    Lindsey A Miles
    Department of Cell and Molecular Biology, The Scripps Research Institute, La Jolla, California, USA Electronic address
    Int Rev Cell Mol Biol 309:259-302. 2014
    ....
  3. pmc Plasminogen receptors: the first quarter century
    Lindsey A Miles
    Department of Cell and Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Semin Thromb Hemost 39:329-37. 2013
    ....
  4. ncbi request reprint Plasminogen receptors: the sine qua non of cell surface plasminogen activation
    Lindsey A Miles
    Department of Cell Biology, Division of Vascular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Front Biosci 10:1754-62. 2005
    ..This issue includes chapters on the well studied plasminogen receptor functions...
  5. ncbi request reprint Critical role for conversion of glu-plasminogen to Lys-plasminogen for optimal stimulation of plasminogen activation on cell surfaces
    Lindsey A Miles
    Department of Cell Biology, Division of Vascular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Trends Cardiovasc Med 13:21-30. 2003
    ....
  6. pmc Plasminogen inhibits TNFalpha-induced apoptosis in monocytes
    Jennifer W Mitchell
    Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Blood 107:4383-90. 2006
    ..Because apoptosis of monocytes plays a key role in inflammation and atherosclerosis, these results provide insight into a novel role of plasminogen in these processes...
  7. ncbi request reprint Plasmin-induced migration of endothelial cells. A potential target for the anti-angiogenic action of angiostatin
    Takehiko Tarui
    Department of Cell Biology, VB 6, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    J Biol Chem 277:33564-70. 2002
    ..These results suggest that plasmin-induced migration of endothelial cells requires alphavbeta(3) and the catalytic activity of plasmin and that this process is a potential target for the inhibitory activity of angiostatin...
  8. pmc Proteomics-based discovery of a novel, structurally unique, and developmentally regulated plasminogen receptor, Plg-RKT, a major regulator of cell surface plasminogen activation
    Nicholas M Andronicos
    Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Blood 115:1319-30. 2010
    ..This structurally unique plasminogen receptor represents a novel control point for regulating cell surface proteolysis...
  9. ncbi request reprint Localization of regulatory elements mediating constitutive and cytokine-stimulated plasminogen gene expression
    Felizabel Garcia Bannach
    Department of Cell Biology, Division of Vascular Biology, Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 277:38579-88. 2002
    ..These results indicate the presence of regulatory elements in the 5'-flanking region of the murine plasminogen promoter that may regulate murine plasminogen gene expression and, hence, plasmin activity...
  10. ncbi request reprint Chromaffin cell plasminogen receptors
    Lindsey A Miles
    Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Ann N Y Acad Sci 971:454-9. 2002
  11. ncbi request reprint Cell-surface actin binds plasminogen and modulates neurotransmitter release from catecholaminergic cells
    Lindsey A Miles
    Department of Cell Biology, Division of Vascular Biology, The Scripps Research Institute, La Jolla, California, 92037, USA
    J Neurosci 26:13017-24. 2006
    ..Our results suggest that cell-surface-expressed forms of actin bind plasminogen, thereby promoting plasminogen activation and increased prohormone processing leading to inhibition of neurotransmitter release...
  12. pmc Plasminogen enhances neuritogenesis on laminin-1
    Ana Gutierrez-Fernandez
    Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Neurosci 29:12393-400. 2009
    ..This study provides the first direct evidence that plasminogen participates in neurite outgrowth and also suggests that laminin-1 degradation by plasmin contributes to the process of neuritogenesis...
  13. ncbi request reprint Plasminogen has a broad extrahepatic distribution
    Lu Zhang
    The Scripps Research Institute, Department of Vascular Biology, La Jolla, CA 92037, USA
    Thromb Haemost 87:493-501. 2002
    ..Thus, tissues separated by local anatomic barriers as well as tissues accessible to circulating plasminogen have the capacity to provide local sources of plasminogen...
  14. ncbi request reprint Inhibition of cell surface mediated plasminogen activation by a monoclonal antibody against alpha-Enolase
    Roser Lopez-Alemany
    Centre d Oncologia Molecular C O M, Institut de Recerca Oncolgica IRO, Barcelona, Spain
    Am J Hematol 72:234-42. 2003
    ..These data suggest that, although leukocytic cells display several molecules that bind plasminogen, alpha-enolase is responsible for the majority of the promotion of plasminogen activation on the surfaces of leukocytic cells...
  15. ncbi request reprint Alpha-enolase comes muscling in on plasminogen activation
    Lindsey A Miles
    Thromb Haemost 90:564-6. 2003
  16. ncbi request reprint The local chromaffin cell plasminogen/plasmin system and the regulation of catecholamine secretion
    Qijiao Jiang
    Department of Medicine, University of California, and San Diego VA Healthcare System, San Diego, California 92161, USA
    Ann N Y Acad Sci 971:445-9. 2002
    ..These results suggest the presence of a local, functionally active, chromaffin cell plasminogen/plasmin system that plays a major role in the regulation of catecholamine release from catecholaminergic cells...
  17. ncbi request reprint Reduction of myocardial infarct size by doxycycline: a role for plasmin inhibition
    Michael O Griffin
    Department of Medicine, University of California, San Diego, CA 2103 8412, USA
    Mol Cell Biochem 270:1-11. 2005
    ....

Research Grants29

  1. 18th International Congress on Fibrinolysis and Proteolysis
    Lindsey Miles; Fiscal Year: 2006
    ....
  2. Proteomic Analysis of Plasminogen Receptors
    Lindsey A Miles; Fiscal Year: 2010
    ..Furthermore, because monocyte/macrophage recruitment and infiltration is a key feature of the atherosclerotic lesion, our results should apply to the understanding of atherosclerosis. ..
  3. REGULATION OF FIBRINOLYSIS BY CELL SURFACE
    Lindsey Miles; Fiscal Year: 2002
    ..Accomplishment of these aims should provide broad insights into the interactions of plasminogen and plasminogen domains with cells, an essential feature of fibrinolysis and angiogenesis. ..
  4. Proteomic Analysis of Plasminogen Receptors
    Lindsey Miles; Fiscal Year: 2009
    ..Furthermore, because monocyte/macrophage recruitment and infiltration is a key feature of the atherosclerotic lesion, our results should apply to the understanding of atherosclerosis. ..
  5. REGULATION OF THE PLASMINOGEN SYSTEM
    Lindsey Miles; Fiscal Year: 2000
    ....
  6. Proteomic Analysis of Plasminogen Receptors
    Lindsey Miles; Fiscal Year: 2009
    ..Furthermore, because monocyte/macrophage recruitment and infiltration is a key feature of the atherosclerotic lesion, our results should apply to the understanding of atherosclerosis. ..
  7. Proteomic Analysis of Plasminogen Receptors
    Lindsey Miles; Fiscal Year: 2007
    ..Furthermore, because monocyte/macrophage recruitment and infiltration is a key feature of the atherosclerotic lesion, our results should apply to the understanding of atherosclerosis. ..
  8. PLASMINOGEN ACTIVATOR ASSEMBLY SYSTEMS ON CELL SURFACES
    Lindsey Miles; Fiscal Year: 1990
  9. PLASMINOGEN ACTIVATOR ASSEMBLY SYSTEMS ON CELL SURFACES
    Lindsey Miles; Fiscal Year: 1991
  10. PLASMINOGEN ACTIVATOR ASSEMBLY SYSTEMS ON CELL SURFACES
    Lindsey Miles; Fiscal Year: 1992
  11. REGULATION OF THE PLASMINOGEN SYSTEM
    Lindsey Miles; Fiscal Year: 2004
    ..g. stroke and Alzheimer's disease) ..
  12. REGULATION OF FIBRINOLYSIS BY CELL SURFACE
    Lindsey Miles; Fiscal Year: 2000
    ..Accomplishment of these aims should provide broad insights into the interactions of plasminogen and plasminogen domains with cells, an essential feature of fibrinolysis and angiogenesis. ..
  13. REGULATION OF THE PLASMINOGEN SYSTEM
    Lindsey Miles; Fiscal Year: 2003
    ..g. stroke and Alzheimer's disease) ..
  14. REGULATION OF THE PLASMINOGEN SYSTEM
    Lindsey Miles; Fiscal Year: 2001
    ....
  15. REGULATION OF THE PLASMINOGEN SYSTEM
    Lindsey Miles; Fiscal Year: 1999
    ....
  16. REGULATION OF THE PLASMINOGEN SYSTEM
    Lindsey Miles; Fiscal Year: 2006
    ..g. stroke and Alzheimer's disease) ..
  17. REGULATION OF THE PLASMINOGEN SYSTEM
    Lindsey Miles; Fiscal Year: 2000
    ....
  18. PLASMINOGEN ACTIVATOR ASSEMBLY SYSTEMS ON CELL SURFACES
    Lindsey Miles; Fiscal Year: 1993
  19. REGULATION OF FIBRINOLYSIS BY CELL SURFACE
    Lindsey Miles; Fiscal Year: 1999
    ..Accomplishment of these aims should provide broad insights into the interactions of plasminogen and plasminogen domains with cells, an essential feature of fibrinolysis and angiogenesis. ..
  20. REGULATION OF FIBRINOLYSIS BY CELL SURFACE
    Lindsey Miles; Fiscal Year: 2001
    ..Accomplishment of these aims should provide broad insights into the interactions of plasminogen and plasminogen domains with cells, an essential feature of fibrinolysis and angiogenesis. ..
  21. REGULATION OF THE PLASMINOGEN SYSTEM
    Lindsey Miles; Fiscal Year: 2005
    ..g. stroke and Alzheimer's disease) ..