Jowita Mikolajczyk

Summary

Affiliation: The Burnham Institute
Country: USA

Publications

  1. ncbi Small ubiquitin-related modifier (SUMO)-specific proteases: profiling the specificities and activities of human SENPs
    Jowita Mikolajczyk
    Program in Apoptosis and Cell Death Research, Burnham Institute for Medical Research, La Jolla, California 92037, USA
    J Biol Chem 282:26217-24. 2007
  2. ncbi Positional-scanning fluorigenic substrate libraries reveal unexpected specificity determinants of DUBs (deubiquitinating enzymes)
    Marcin Drag
    Apoptosis and Cell Death Research, Burnham Institute for Medical Research, La Jolla, CA 92037, USA
    Biochem J 415:367-75. 2008
  3. ncbi Activity profiling of human deSUMOylating enzymes (SENPs) with synthetic substrates suggests an unexpected specificity of two newly characterized members of the family
    Marcin Drag
    Apoptosis and Cell Death Research Program, Burnham Institute for Medical Research, La Jolla, CA 92037, USA
    Biochem J 409:461-9. 2008
  4. ncbi Activation and substrate specificity of caspase-14
    Jowita Mikolajczyk
    The Program in Apoptosis and Cell Death Research, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA
    Biochemistry 43:10560-9. 2004
  5. ncbi Early processing of Bid and caspase-6, -8, -10, -14 in the canine brain during cardiac arrest and resuscitation
    Maryla Krajewska
    The Burnham Institute, La Jolla, CA 92037, USA
    Exp Neurol 189:261-79. 2004
  6. ncbi Activity, specificity, and probe design for the smallpox virus protease K7L
    Alexander E Aleshin
    Program in Apoptosis and Cell Death Research, Sanford Burnham Medical Research Institute, La Jolla, California 92037, USA
    J Biol Chem 287:39470-9. 2012
  7. ncbi Sequential autolytic processing activates the zymogen of Arg-gingipain
    Jowita Mikolajczyk
    Burnham Institute, La Jolla, California 92037, USA
    J Biol Chem 278:10458-64. 2003
  8. ncbi Tumor-associated alterations in caspase-14 expression in epithelial malignancies
    Maryla Krajewska
    The Burnham Institute, La Jolla, California, USA
    Clin Cancer Res 11:5462-71. 2005

Collaborators

Detail Information

Publications8

  1. ncbi Small ubiquitin-related modifier (SUMO)-specific proteases: profiling the specificities and activities of human SENPs
    Jowita Mikolajczyk
    Program in Apoptosis and Cell Death Research, Burnham Institute for Medical Research, La Jolla, California 92037, USA
    J Biol Chem 282:26217-24. 2007
    ..Using these synthetic substrates we reveal that the SUMO domain enhances catalysis of SENP1, -2, -5, -6, and -7, demonstrating substrate-induced activation of SENPs by SUMOs...
  2. ncbi Positional-scanning fluorigenic substrate libraries reveal unexpected specificity determinants of DUBs (deubiquitinating enzymes)
    Marcin Drag
    Apoptosis and Cell Death Research, Burnham Institute for Medical Research, La Jolla, CA 92037, USA
    Biochem J 415:367-75. 2008
    ..Together, our results reveal the importance of the dual features of (1) substrate specificity and (2) the mechanism of ubiquitin binding in determining deubiquitination by this group of proteases...
  3. ncbi Activity profiling of human deSUMOylating enzymes (SENPs) with synthetic substrates suggests an unexpected specificity of two newly characterized members of the family
    Marcin Drag
    Apoptosis and Cell Death Research Program, Burnham Institute for Medical Research, La Jolla, CA 92037, USA
    Biochem J 409:461-9. 2008
    ..We also show that SENP6 and 7 have an unexpected specificity that distinguishes them from other members of the family, implying that, in contrast to previous predictions, their natural substrate(s) may not be SUMO conjugates...
  4. ncbi Activation and substrate specificity of caspase-14
    Jowita Mikolajczyk
    The Program in Apoptosis and Cell Death Research, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA
    Biochemistry 43:10560-9. 2004
    ..The results obtained with human caspase-14 classify this enzyme as a cytokine activator, but the mouse enzyme shows preferences similar to apical apoptotic caspases...
  5. ncbi Early processing of Bid and caspase-6, -8, -10, -14 in the canine brain during cardiac arrest and resuscitation
    Maryla Krajewska
    The Burnham Institute, La Jolla, CA 92037, USA
    Exp Neurol 189:261-79. 2004
    ....
  6. ncbi Activity, specificity, and probe design for the smallpox virus protease K7L
    Alexander E Aleshin
    Program in Apoptosis and Cell Death Research, Sanford Burnham Medical Research Institute, La Jolla, California 92037, USA
    J Biol Chem 287:39470-9. 2012
    ..Our study thus provides proof-of-concept for the design of inhibitors and probes that may contribute both to a better understanding of the role of K7L in the virus life cycle and the design of novel anti-virals...
  7. ncbi Sequential autolytic processing activates the zymogen of Arg-gingipain
    Jowita Mikolajczyk
    Burnham Institute, La Jolla, California 92037, USA
    J Biol Chem 278:10458-64. 2003
    ..Each step in activation requires the previous step, and an affinity probe reveals that incremental activity enhancements are achieved in a stepwise manner...
  8. ncbi Tumor-associated alterations in caspase-14 expression in epithelial malignancies
    Maryla Krajewska
    The Burnham Institute, La Jolla, California, USA
    Clin Cancer Res 11:5462-71. 2005
    ..We investigated caspase-14 expression in several types of human epithelial malignancy by immunohistochemistry, correlating results with stage, histologic grade, and patient survival...