Research Topics
| L P MiddletonSummaryAffiliation: The University of Texas Country: USA Publications
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Publications
Implementation of American Society of Clinical Oncology/College of American Pathologists HER2 Guideline Recommendations in a tertiary care facility increases HER2 immunohistochemistry and fluorescence in situ hybridization concordance and decreases the nuLavinia P Middleton
Departments of Pathology, The University of Texas M D Anderson Cancer Center, Houston, USA
Arch Pathol Lab Med 133:775-80. 2009..The American Society of Clinical Oncology/ College of American Pathologists (ASCO/CAP) guideline recommendations from January 2007 identified many sources of immunohistochemistry (IHC) testing variation...
Expression of ERalpha and ERbeta in lobular carcinoma in situL P Middleton
Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Histopathology 50:875-80. 2007..The aim of this study was to examine ER expression in LCIS to determine the relationship of ERalpha to ERbeta and, thereby, to determine whether it is of clinical value to measure ERbeta along with ERalpha...- Breast carcinoma in pregnant women: assessment of clinicopathologic and immunohistochemical featuresLavinia P Middleton
Department of Pathology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, PO Box 85, Houston, TX 77030, USA
Cancer 98:1055-60. 2003..However, very few contemporary studies have attempted to identify the combined histopathologic and immunohistochemical features of breast carcinoma in these patients... - Lobular carcinoma in situ diagnosed by core needle biopsy: when should it be excised?Lavinia P Middleton
Department of Pathology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
Mod Pathol 16:120-9. 2003..Based on these findings, we recommend excisional biopsy of lobular carcinoma in situ, atypical lobular hyperplasia or lobular neoplasia only when it is associated with a synchronous mass lesion... - Histopathology of breast cancer among African-American womenLavinia P Middleton
Department of Pathology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Cancer 97:253-7. 2003..Furthermore, there is a need for central pathology review using accepted, published criteria for diagnosis of uncommon and controversial histologic subtypes of breast cancer... - Neovascularization in mucinous ductal carcinoma in situ suggests an alternative pathway for invasionS A Gadre
Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Histopathology 53:545-53. 2008..The aim was to characterize mucinous DCIS (mDCIS) of the breast and to describe, to our knowledge for the first time, neovascularization in mucin... - Metastases to breast simulating ductal carcinoma in situ: report of two cases and review of the literatureD Gupta
Department of Pathology and Laboratory Medicine, University of Texas-Houston Medical School, Houston, TX 77030-1501, USA
Ann Diagn Pathol 5:15-20. 2001..When there is any unusual histomorphology, a good degree of suspicion is necessary. Ann Diagn Pathol 5:15-20, 2001... - Loss of myoepithelium is variable in solid papillary carcinoma of the breastM M Nicolas
Department of Pathology, University of Texas M D Anderson Cancer Center, Houston, TX, USA
Histopathology 51:657-65. 2007..The aim was to clarify the frequency of myoepithelial loss in cases of SPC diagnosed at our institution... - Treatment and outcome of patients with intracystic papillary carcinoma of the breastCarmen C Solorzano
Department of Surgical Oncology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Am J Surg 184:364-8. 2002..Intracystic papillary carcinoma (IPC) of the breast is a rare form of noninvasive breast cancer. An appreciation of associated pathology with IPC may be critical in surgical decision-making... - Role of sonography in diagnosing and staging invasive lobular carcinomaVeronica L Selinko
Department of Diagnostic Radiology, The University of Texas M. D. Anderson Cancer Center, Unit 57, 1515 Holcombe Boulevard, Houston, Texas 77030-4009, USA
J Clin Ultrasound 32:323-32. 2004..Routine examination of node-bearing areas in patients with ILC proved useful in refining the disease staging... - Utility of ultrasound and fine-needle aspiration biopsy of the axilla in the assessment of invasive lobular carcinoma of the breastJudy C Boughey
Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, 1400 Holcombe Blvd, Houston, TX 77030, USA
Am J Surg 194:450-5. 2007..Whether it similarly limits lymph node staging by ultrasound (US) and fine-needle aspiration (FNA) biopsy was the subject of the current study... - Intracystic papillary carcinoma of the breast with invasionA Elizabeth Wagner
Division of Diagnostic Imaging, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd, Box 57, Houston, TX 77030, USA
AJR Am J Roentgenol 183:1516. 2004 - E-cadherin immunohistochemical analysis of histiocytoid carcinoma of the breastDeepali Gupta
Department of Pathology and Laboratory Medicine, The University of Texas Health Science Center, Houston, TX, USA
Ann Diagn Pathol 6:141-7. 2002..Moreover, the lack of consistent morphologic features, a specific clinical profile, and a distinct immunohistochemical pattern lead us to hypothesize that histiocytoid carcinoma is not a special type of breast cancer... - HER-2/neu and p53 overexpression as biomarkers of breast carcinoma in women age 30 years and youngerDipen Maru
Department of Pathology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA
Cancer 103:900-5. 2005..HER-2/neu overexpression was associated significantly with lymph node involvement and, thus, may be a marker for aggressive clinical behavior in patients with breast carcinoma age < or = 30 years... - Clinical outcome of patients with lymph node-negative breast carcinoma who have sentinel lymph node micrometastases detected by immunohistochemistryAnees Chagpar
Department of Surgical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA
Cancer 103:1581-6. 2005..543 and P = 0.540, respectively). CONCLUSIONS: Although the finding of SLN micrometastases by IHC may change management in > 12% of patients, preliminary results suggested that such micrometastases do not affect outcomes significantly... - Adjuvant systemic therapy for male breast carcinomaSharon H Giordano
Department of Breast Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Cancer 104:2359-64. 2005..In the current study, the authors describe the M. D. Anderson experience with adjuvant systemic therapy in male breast carcinoma patients... - Expression of c-kit proto-oncogene product in breast tissueMarwan A Yared
Department of Pathology, University of Texas-M.D. Anderson Cancer Center, Houston, Texas 77030, USA
Breast J 10:323-7. 2004..These data suggest that c-kit may play a role in breast tumor progression and may therefore have diagnostic, prognostic, and therapeutic implications... - Assessment of histologic features and expression of biomarkers in predicting pathologic response to anthracycline-based neoadjuvant chemotherapy in patients with breast carcinomaJianzhou Wang
Department of Pathology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA
Cancer 94:3107-14. 2002.... - Myolipoma of the breast: mammographic, sonographic, and pathologic correlationDavid K McGregor
Department of Pathology, University of Texas, M.D. Anderson Cancer Center, Houston, Texas 77030-5816, USA
Breast J 10:259-60. 2004 - Accuracy of core needle biopsy diagnosis in assessing papillary breast lesions: histologic predictors of malignancyDoina Ivan
Department of Pathology, The University of Texas-Houston, Houston, TX, USA
Mod Pathol 17:165-71. 2004..0001) than is the presence of mitoses (P<0.053). A diagnosis of carcinoma or atypical papilloma by CNB should warrant an EB, whereas benign papillomas may be followed if imaging findings are concordant... - Diagnostic pitfalls in fine needle aspiration cytology of atypical apocrine metaplasia in a breast lesion. A case reportDeepali Gupta
Department of Pathology and Laboratory Medicine, University of Texas Houston Medical School, Department of Pathology, M D Anderson Cancer Center, Houston, Texas, USA
Acta Cytol 46:749-52. 2002..Atypical apocrine metaplastic cells with signet ring features can also occur, and their presence may present a diagnostic dilemma in the differentiation of benign versus malignant lesions... - IGFBP2 and IGFBP5 overexpression correlates with the lymph node metastasis in T1 breast carcinomasHuamin Wang
Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
Breast J 14:261-7. 2008..Our data suggest that IGFBP2 and IGFBP5 play a role in the development of metastasis and may serve as useful markers to predict lymph node metastasis in patients with small (T1) invasive breast carcinomas... - Invasive micropapillary carcinoma of the breast metastatic to the urinary bladder and endometrium: diagnostic pitfalls and review of the literature of tumors with micropapillary featuresPreetha Ramalingam
Department of Pathology, The University of Texas M. D. Anderson Cancer Center, Houston 77030, USA
Ann Diagn Pathol 7:112-9. 2003..Carcinomas with micropapillary features have a propensity for lymph node metastases and advanced stage disease. This article discusses the differential diagnosis of carcinomas with micropapillary features in different organs... - Comparison of fluorescence and chromogenic in situ hybridization for detection of HER-2/neu oncogene in breast cancerDeepali Gupta
Department of Pathology, University of Texas Medical School, Houston, USA
Am J Clin Pathol 119:381-7. 2003..If a probe for chromosome 17 (now available for CISH) is used in cases of questionable HER-2/neu amplification, CISH seems to be as accurate and more practical than FISH... - Multicentric mammary carcinoma: evidence of monoclonal proliferationLavinia P Middleton
Department of Pathology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
Cancer 94:1910-6. 2002..We also compared the clinical outcomes of the patients in the current study with stage-matched and treatment-matched groups of patients with unicentric mammary carcinoma... - Clinical, histopathologic, and biologic features of pleomorphic lobular (ductal-lobular) carcinoma in situ of the breast: a report of 24 casesNour Sneige
Division of Pathology and Laboratory Medicine, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Mod Pathol 15:1044-50. 2002..Long-term follow-up studies are needed to further define the natural history of PL/DLCIS and its optimal management... 
Accuracy of physical examination, ultrasonography, and mammography in predicting residual pathologic tumor size in patients treated with neoadjuvant chemotherapyAnees B Chagpar
Department of Surgical Oncology, University of Texas M.D. Anderson Cancer Center, Houston, TX 77030-4095, USA
Ann Surg 243:257-64. 2006..CONCLUSION: Physical examination, ultrasonography, and mammography were only moderately useful for predicting residual pathologic tumor size after neoadjuvant chemotherapy...- Specimen radiography in confirmation of MRI-guided needle localization and surgical excision of breast lesionsBasak Erguvan-Dogan
Department of Diagnostic Radiology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Unit 1350, Houston, TX 77230, USA
AJR Am J Roentgenol 187:339-44. 2006..Specimen radiography has the additional advantage of facilitating immediate assessment of surgical margins... - Serous carcinoma of the ovary and peritoneum with metastases to the breast and axillary lymph nodes: a potential pitfallMonica A Recine
Department of Pathology, University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA
Am J Surg Pathol 28:1646-51. 2004..Clinical history, the presence of papillary architecture, and WT-1 expression are useful in establishing the correct diagnosis... - Lymphoepithelioma-like carcinoma of the breast: report of a case mimicking lymphomaSouzan Sanati
The University of Texas Medical Branch, Galveston, TX 77030-4009, USA
Ann Diagn Pathol 8:309-15. 2004..In summary, lymphoepithelioma-like carcinoma of the breast is a tumor with a good prognosis that should be considered as a possible diagnosis in breast tumors with an intense lymphocytic infiltrate... - Breast cancer in menGeorge H Perkins
BMJ 327:239-40. 2003 - Intracystic papillary carcinoma of the breastBasak Erguvan Dogan
Division of Diagnostic Imaging, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd, Box 57, Houston, TX 77030, USA
AJR Am J Roentgenol 181:186. 2003 - Histologic localization of sentinel lymph node metastases in breast cancerLeslie K Diaz
Department of Pathology, M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
Am J Surg Pathol 27:385-9. 2003..This information may be useful in determining the optimal method for evaluating axillary sentinel lymph node specimens from breast cancer patients... - Factors predictive of having four or more positive axillary lymph nodes in patients with positive sentinel lymph nodes: implications for selection of radiation fieldsKaren H Shahar
Department of Radiation Oncology, University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 97, Houston, TX 77030, USA
Int J Radiat Oncol Biol Phys 59:1074-9. 2004..The remaining patients have a greater risk of having four or more positive lymph nodes, and, therefore, the high axilla/supraclavicular fossa should also be included in the radiation fields...