Funda Meric-Bernstam

Summary

Affiliation: The University of Texas
Country: USA

Publications

  1. pmc Influence of biospecimen variables on proteomic biomarkers in breast cancer
    Funda Meric-Bernstam
    Authors Affiliations Departments of Investigational Cancer Therapeutics, Surgical Oncology
    Clin Cancer Res 20:3870-83. 2014
  2. pmc Radiation dose escalation for loco-regional recurrence of breast cancer after mastectomy
    Heath D Skinner
    Department of Radiation Oncology, The University of Texas M, d, Anderson Cancer Center, Houston, TX 77030, USA
    Radiat Oncol 8:13. 2013
  3. pmc Implications of constructed biologic subtype and its relationship to locoregional recurrence following mastectomy
    Laura S Dominici
    Department of Surgical Oncology, University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Breast Cancer Res 14:R82. 2012
  4. pmc Local-regional control according to surrogate markers of breast cancer subtypes and response to neoadjuvant chemotherapy in breast cancer patients undergoing breast conserving therapy
    Abigail S Caudle
    Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, 1400 Hermann Pressler Drive, Unit 1484, Houston, TX 77030, USA
    Breast Cancer Res 14:R83. 2012
  5. doi request reprint Building a personalized medicine infrastructure at a major cancer center
    Funda Meric-Bernstam
    University of Texas MD Anderson Cancer Center, 1400 Pressler St, FCT17 5030, Houston, TX 77030, USA
    J Clin Oncol 31:1849-57. 2013
  6. doi request reprint Genotype in BRCA-associated breast cancers
    Funda Meric-Bernstam
    Departments of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Breast J 19:87-91. 2013
  7. ncbi request reprint Overcoming implementation challenges of personalized cancer therapy
    Funda Meric-Bernstam
    Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, 1400 Pressler Street, Unit 1484, Houston, TX 77030, USA
    Nat Rev Clin Oncol 9:542-8. 2012
  8. pmc PIK3CA/PTEN mutations and Akt activation as markers of sensitivity to allosteric mTOR inhibitors
    Funda Meric-Bernstam
    Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Clin Cancer Res 18:1777-89. 2012
  9. pmc The rapamycin-regulated gene expression signature determines prognosis for breast cancer
    Argun Akcakanat
    Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Mol Cancer 8:75. 2009
  10. pmc Functional proteomics can define prognosis and predict pathologic complete response in patients with breast cancer
    Ana M Gonzalez-Angulo
    Departments of Breast Medical Oncology and Systems Biology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Clin Proteomics 8:11. 2011

Research Grants

  1. Targeting mTOR for Cancer Therapy
    Funda Meric Bernstam; Fiscal Year: 2006
  2. Targeting mTOR for Cancer Therapy
    Funda Meric Bernstam; Fiscal Year: 2007
  3. Targeting mTOR for Cancer Therapy
    Funda Meric Bernstam; Fiscal Year: 2009

Detail Information

Publications121 found, 100 shown here

  1. pmc Influence of biospecimen variables on proteomic biomarkers in breast cancer
    Funda Meric-Bernstam
    Authors Affiliations Departments of Investigational Cancer Therapeutics, Surgical Oncology
    Clin Cancer Res 20:3870-83. 2014
    ..PI3K/Akt/mTOR signaling is being actively pursued as a therapeutic target for breast cancer. We sought to determine if tumor heterogeneity and biospecimen variables affect the evaluation of PI3K/Akt/mTOR pathway markers...
  2. pmc Radiation dose escalation for loco-regional recurrence of breast cancer after mastectomy
    Heath D Skinner
    Department of Radiation Oncology, The University of Texas M, d, Anderson Cancer Center, Houston, TX 77030, USA
    Radiat Oncol 8:13. 2013
    ..Radiation is a standard component of treatment for patients with locoregional recurrence (LRR) of breast cancer following mastectomy. The current study reports the results of a 10% radiation dose escalation in these patients...
  3. pmc Implications of constructed biologic subtype and its relationship to locoregional recurrence following mastectomy
    Laura S Dominici
    Department of Surgical Oncology, University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Breast Cancer Res 14:R82. 2012
    ..We examined the prognostic value of biologic subtype on locoregional recurrence (LRR) after mastectomy in a cohort of low risk women who did not receive adjuvant radiation therapy...
  4. pmc Local-regional control according to surrogate markers of breast cancer subtypes and response to neoadjuvant chemotherapy in breast cancer patients undergoing breast conserving therapy
    Abigail S Caudle
    Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, 1400 Hermann Pressler Drive, Unit 1484, Houston, TX 77030, USA
    Breast Cancer Res 14:R83. 2012
    ....
  5. doi request reprint Building a personalized medicine infrastructure at a major cancer center
    Funda Meric-Bernstam
    University of Texas MD Anderson Cancer Center, 1400 Pressler St, FCT17 5030, Houston, TX 77030, USA
    J Clin Oncol 31:1849-57. 2013
    ..This article will focus on the challenges and opportunities that accompany the building of infrastructure for personalized cancer therapy...
  6. doi request reprint Genotype in BRCA-associated breast cancers
    Funda Meric-Bernstam
    Departments of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Breast J 19:87-91. 2013
    ..Further studies in genotype/phenotype correlation are needed to individualize prevention strategies...
  7. ncbi request reprint Overcoming implementation challenges of personalized cancer therapy
    Funda Meric-Bernstam
    Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, 1400 Pressler Street, Unit 1484, Houston, TX 77030, USA
    Nat Rev Clin Oncol 9:542-8. 2012
    ..Critically, the 'hype' surrounding personalized cancer therapy must be tempered with realistic expectations, which, today, encompass increased survival times for only a portion of patients...
  8. pmc PIK3CA/PTEN mutations and Akt activation as markers of sensitivity to allosteric mTOR inhibitors
    Funda Meric-Bernstam
    Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Clin Cancer Res 18:1777-89. 2012
    ..We sought to determine whether phosphoinositide 3-kinase (PI3K) pathway mutation or activation state and rapamycin-induced feedback loop activation of Akt is associated with rapamycin sensitivity or resistance...
  9. pmc The rapamycin-regulated gene expression signature determines prognosis for breast cancer
    Argun Akcakanat
    Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Mol Cancer 8:75. 2009
    ..In this study, we tested the hypothesis that the gene-expression signature regulated by rapamycin could predict disease outcome for patients with breast cancer...
  10. pmc Functional proteomics can define prognosis and predict pathologic complete response in patients with breast cancer
    Ana M Gonzalez-Angulo
    Departments of Breast Medical Oncology and Systems Biology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Clin Proteomics 8:11. 2011
    ..abstract:..
  11. ncbi request reprint Breast conservation in breast cancer: surgical and adjuvant considerations
    Funda Meric-Bernstam
    The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Curr Opin Obstet Gynecol 16:31-6. 2004
    ..This paper reviews the recent contributions to the literature, with special emphasis on breast-conserving surgery in the management of invasive breast cancer...
  12. ncbi request reprint Potential role of mammalian target of rapamycin inhibitors in breast cancer therapy
    Funda Meric-Bernstam
    Department of Surgical Oncology, University of Texas, M D Anderson Cancer Center, Houston, TX 77030, USA
    Clin Breast Cancer 6:357-60. 2005
  13. pmc Targeting the mTOR signaling network for cancer therapy
    Funda Meric-Bernstam
    Department of Surgical Oncology, Unit 444, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    J Clin Oncol 27:2278-87. 2009
    ..A better understanding of mTOR signaling, the mechanism of action of rapamycin, and the identification of biomarkers of response will lead to more optimal targeting of this pathway for cancer therapy...
  14. ncbi request reprint Positive surgical margins and ipsilateral breast tumor recurrence predict disease-specific survival after breast-conserving therapy
    Funda Meric
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Cancer 97:926-33. 2003
    ....
  15. ncbi request reprint Translation initiation in cancer: a novel target for therapy
    Funda Meric
    Department of Surgical Oncology, Box 444, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Mol Cancer Ther 1:971-9. 2002
    ..We review the basic principles of translational control, the alterations encountered in cancer, and selected therapies targeting translation initiation to help elucidate new therapeutic avenues...
  16. ncbi request reprint Feasibility and accuracy of sentinel lymph node biopsy after preoperative chemotherapy in breast cancer patients with documented axillary metastases
    Jeannie Shen
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Cancer 109:1255-63. 2007
    ..The objective of this study was to determine the feasibility and accuracy of SLN biopsy after preoperative chemotherapy in patients with documented axillary metastases at presentation...
  17. ncbi request reprint Improving local control with breast-conserving therapy: a 27-year single-institution experience
    Neslihan Cabioglu
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 104:20-9. 2005
    ..Correspondingly, the authors of the current study hypothesized that the contemporary multidisciplinary management of breast carcinoma would lead to an improvement in IBTR rates after BCT...
  18. pmc Impact of internal mammary lymph node drainage identified by preoperative lymphoscintigraphy on outcomes in patients with stage I to III breast cancer
    Amanda L Kong
    Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 118:6287-96. 2012
    ..Involvement of internal mammary (IM) lymph nodes is associated with a poor prognosis for patients with breast cancer. This study examined the effect of drainage to IM nodes identified by lymphoscintigraphy on oncologic outcomes...
  19. pmc Efficacy of neoadjuvant therapy with trastuzumab concurrent with anthracycline- and nonanthracycline-based regimens for HER2-positive breast cancer
    Soley Bayraktar
    Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 118:2385-93. 2012
    ....
  20. ncbi request reprint Effect of primary tumor extirpation in breast cancer patients who present with stage IV disease and an intact primary tumor
    Gildy V Babiera
    Department of Surgical Oncology, Unit 444, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA
    Ann Surg Oncol 13:776-82. 2006
    ..A recent review suggested that surgery may improve long-term survival in such patients. We evaluated the effect of surgery in such patients on long-term survival and disease progression...
  21. ncbi request reprint Radiation use and long-term survival in breast cancer patients with T1, T2 primary tumors and one to three positive axillary lymph nodes
    Thomas A Buchholz
    Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Radiat Oncol Biol Phys 71:1022-7. 2008
    ..For patients with Stage II breast cancer with one to three positive lymph nodes, controversy exists about whether radiation as a component of treatment provides a survival benefit...
  22. ncbi request reprint Lymphovascular invasion and lobular histology are associated with increased incidence of isolated tumor cells in sentinel lymph nodes from early-stage breast cancer patients
    Elizabeth A Mittendorf
    Department of Surgical Oncology, Unit 444, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Ann Surg Oncol 15:3369-77. 2008
    ..Our goal was to identify clinicopathologic features associated with ITC in patients undergoing sentinel lymph node dissection (SLND)...
  23. pmc Predictors of tumor progression during neoadjuvant chemotherapy in breast cancer
    Abigail S Caudle
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    J Clin Oncol 28:1821-8. 2010
    ..Because many of these variables are also associated with response to NCT, novel molecular predictors are needed to identify patients at risk for progression on standard NCT...
  24. pmc Ten-year recurrence rates in young women with breast cancer by locoregional treatment approach
    Beth M Beadle
    Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Int J Radiat Oncol Biol Phys 73:734-44. 2009
    ..The goal of this study is to determine the impact of locoregional treatment strategy, breast-conserving therapy (BCT), mastectomy alone (M), or mastectomy with adjuvant radiation (MXRT), on LRR for patients 35 years or younger...
  25. ncbi request reprint Effect of postmastectomy radiotherapy in patients <35 years old with stage II-III breast cancer treated with doxorubicin-based neoadjuvant chemotherapy and mastectomy
    Amit K Garg
    Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Radiat Oncol Biol Phys 69:1478-83. 2007
    ..The objective of this study was to assess the benefits of PMRT in patients <35 years old treated with doxorubicin-based neoadjuvant chemotherapy for Stage II-III breast cancer...
  26. ncbi request reprint Role for intraoperative margin assessment in patients undergoing breast-conserving surgery
    Neslihan Cabioglu
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX, 77030, USA
    Ann Surg Oncol 14:1458-71. 2007
    ..We investigated whether intraoperative margin assessment aids in obtaining negative margins, and to evaluate the local control thus achieved...
  27. ncbi request reprint Comparison of risk of local-regional recurrence after mastectomy or breast conservation therapy for patients treated with neoadjuvant chemotherapy and radiation stratified according to a prognostic index score
    Eugene H Huang
    Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Radiat Oncol Biol Phys 66:352-7. 2006
    ..The purpose of this study was to compare the rates of LRR as a function of prognostic index score for patients treated with BCT or mastectomy plus radiation after neoadjuvant chemotherapy...
  28. pmc Loss of HER2 amplification following trastuzumab-based neoadjuvant systemic therapy and survival outcomes
    Elizabeth A Mittendorf
    Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 15:7381-8. 2009
    ..To evaluate HER2 status in residual tumor identified at the time of surgery in patients not achieving a pathologic complete response (pCR) and to determine the effect of alterations in HER2 status on recurrence-free survival (RFS)...
  29. ncbi request reprint Role of primary tumor characteristics in predicting positive sentinel lymph nodes in patients with ductal carcinoma in situ or microinvasive breast cancer
    Min Yi
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Am J Surg 196:81-7. 2008
    ..We determined the incidence of positive sentinel lymph nodes (SLNs) in patients with ductal carcinoma in situ (DCIS) or microinvasive breast cancer (MIC) and the predictive factors of SLN metastasis in these patients...
  30. ncbi request reprint Physician recommendations regarding tamoxifen and patient utilization of tamoxifen after surgery for ductal carcinoma in situ
    Tina W F Yen
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 100:942-9. 2004
    ..The current study was designed to evaluate the impact of NSABP B-24 on current practices at a comprehensive cancer center...
  31. doi request reprint Sentinel lymph node surgery after neoadjuvant chemotherapy is accurate and reduces the need for axillary dissection in breast cancer patients
    Kelly K Hunt
    Department of Surgical Oncology, MD Anderson Cancer Center, The University of Texas, Houston, TX 77030, USA
    Ann Surg 250:558-66. 2009
    ..This study was performed to evaluate the accuracy of SLN surgery for patients undergoing neoadjuvant chemotherapy versus patients undergoing surgery first...
  32. ncbi request reprint Accuracy of the combination of mammography and sonography in predicting tumor response in breast cancer patients after neoadjuvant chemotherapy
    Florentia Peintinger
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Ann Surg Oncol 13:1443-9. 2006
    ..Residual tumor size after neoadjuvant chemotherapy is an important consideration in surgical planning. We examined the accuracy of the combination of mammography and sonography in predicting pathologic residual tumor size...
  33. ncbi request reprint Predictors of systemic recurrence and disease-specific survival after ipsilateral breast tumor recurrence
    Jeannie Shen
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Cancer 104:479-90. 2005
    ..Therefore, the management of isolated IBTR remains controversial. The objective of the current study was to identify determinants of systemic recurrence and DSS after IBTR...
  34. doi request reprint Primary tumor extirpation in breast cancer patients who present with stage IV disease is associated with improved survival
    Julie E Lang
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Ann Surg Oncol 20:1893-9. 2013
    ..1 months median follow-up. We assessed the impact of surgery after 74.2 months median follow-up, and the effect of systemic therapy and local radiotherapy (RT)...
  35. ncbi request reprint Clinical outcome of patients with lymph node-negative breast carcinoma who have sentinel lymph node micrometastases detected by immunohistochemistry
    Anees Chagpar
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 103:1581-6. 2005
    ....
  36. doi request reprint A prospective study comparing touch imprint cytology, frozen section analysis, and rapid cytokeratin immunostain for intraoperative evaluation of axillary sentinel lymph nodes in breast cancer
    Savitri Krishnamurthy
    Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 115:1555-62. 2009
    ....
  37. ncbi request reprint Predictors of invasive breast cancer in patients with an initial diagnosis of ductal carcinoma in situ: a guide to selective use of sentinel lymph node biopsy in management of ductal carcinoma in situ
    Tina W F Yen
    Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    J Am Coll Surg 200:516-26. 2005
    ..The purpose of our study was to determine when the risk of finding invasive disease on final pathology in patients with an initial diagnosis of DCIS was sufficiently high to justify use of SLNB...
  38. doi request reprint Impact of the american college of surgeons oncology group Z0011 criteria applied to a contemporary patient population
    Min Yi
    Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    J Am Coll Surg 216:105-13. 2013
    ..The aim of this study was to assess applicability of Z0011 results to our patient population and determine what percentage may be affected by these results...
  39. ncbi request reprint Low locoregional failure rates in selected breast cancer patients with tumor-positive sentinel lymph nodes who do not undergo completion axillary dissection
    Rosa F Hwang
    Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77230 1402, USA
    Cancer 110:723-30. 2007
    ..The objective of this study was to examine the long-term safety of avoiding CLND in selected patients with positive SLNs...
  40. ncbi request reprint Factors predicting additional disease in the axilla in patients with positive sentinel lymph nodes after neoadjuvant chemotherapy
    Jacqueline S Jeruss
    Department Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 112:2646-54. 2008
    ....
  41. ncbi request reprint Decision analysis to assess the efficacy of routine sentinel lymphadenectomy in patients undergoing prophylactic mastectomy
    Judy C Boughey
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77230 1402, USA
    Cancer 110:2542-50. 2007
    ..The objective of this study was to compare the efficacy of 2 surgical strategies, routine SLND versus directed ALND, in PM patients...
  42. ncbi request reprint Lymphatic drainage patterns on early versus delayed breast lymphoscintigraphy performed after injection of filtered Tc-99m sulfur colloid in breast cancer patients undergoing sentinel lymph node biopsy
    Gildy V Babiera
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Nucl Med 30:11-5. 2005
    ....
  43. doi request reprint Impact of progression during neoadjuvant chemotherapy on surgical management of breast cancer
    Abigail S Caudle
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Ann Surg Oncol 18:932-8. 2011
    ..The goal of this study was to determine the impact of disease progression during NCT on surgical management...
  44. ncbi request reprint Feasibility of breast-conserving surgery for patients with breast carcinoma associated with nipple discharge
    Neslihan Cabioglu
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 101:508-17. 2004
    ..The purpose of the current study was to determine the feasibility of breast-conserving surgery (BCS) for these patients...
  45. pmc Impact of preoperative versus postoperative chemotherapy on the extent and number of surgical procedures in patients treated in randomized clinical trials for breast cancer
    Judy C Boughey
    Department of Surgical Oncology, MD Anderson Cancer Center, Houston, TX 77030, USA
    Ann Surg 244:464-70. 2006
    ..To determine the effect of preoperative chemotherapy on the volume of tissue excised and the number of breast operations in patients undergoing breast-conserving therapy (BCT)...
  46. ncbi request reprint Fluorouracil, epirubicin, and cyclophosphamide (FEC-75) followed by paclitaxel plus trastuzumab versus paclitaxel plus trastuzumab followed by FEC-75 plus trastuzumab as neoadjuvant treatment for patients with HER2-positive breast cancer (Z1041): a random
    Aman U Buzdar
    Office of Vice President for Clinical Research, University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Lancet Oncol 14:1317-25. 2013
    ..We investigated the effect of the timing of trastuzumab administration with anthracycline and taxane neoadjuvant chemotherapy...
  47. ncbi request reprint The safety of breast-conserving surgery in patients who achieve a complete pathologic response after neoadjuvant chemotherapy
    Florentia Peintinger
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 107:1248-54. 2006
    ....
  48. ncbi request reprint Selective use of sentinel lymph node surgery during prophylactic mastectomy
    Judy C Boughey
    Department of Surgical Oncology, University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Cancer 107:1440-7. 2006
    ..The current study investigates the invasive cancer rate in PM and evaluates factors associated with invasive cancer to guide SLN surgery use...
  49. ncbi request reprint Intramammary lymph node metastases are an independent predictor of poor outcome in patients with breast carcinoma
    Jeannie Shen
    Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston 77030, USA
    Cancer 101:1330-7. 2004
    ..The goals of the current retrospective analysis were to elucidate the clinical relevance of intraMLN metastases and to assess the relation between such metastases and outcome in patients with breast carcinoma...
  50. ncbi request reprint Margin assessment after neoadjuvant chemotherapy in invasive lobular cancer
    Jamie Wagner
    Department of Surgical Oncology, The University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA
    Am J Surg 198:387-91. 2009
    ..Optimal surgical management of patients with invasive lobular carcinoma (ILC) who undergo neoadjuvant chemotherapy (NAC) is unknown. We evaluated optimal margin distance and local recurrence (LR) rates for these patients...
  51. pmc Accuracy of physical examination, ultrasonography, and mammography in predicting residual pathologic tumor size in patients treated with neoadjuvant chemotherapy
    Anees B Chagpar
    Department of Surgical Oncology, University of Texas M D Anderson Cancer Center, Houston, TX 77030 4095, USA
    Ann Surg 243:257-64. 2006
    ..To assess the accuracy of physical examination, ultrasonography, and mammography in predicting residual size of breast tumors following neoadjuvant chemotherapy...
  52. ncbi request reprint Locoregional treatment outcomes for breast cancer patients with ipsilateral supraclavicular metastases at diagnosis
    Eugene H Huang
    Department of Radiation Oncology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Radiat Oncol Biol Phys 67:490-6. 2007
    ..To evaluate the locoregional efficacy of multimodality treatment for breast cancer patients who present with ipsilateral supraclavicular (SCV) disease without systemic metastases...
  53. ncbi request reprint Comparative analysis of sentinel lymph node operation in male and female breast cancer patients
    Judy C Boughey
    Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    J Am Coll Surg 203:475-80. 2006
    ..The purpose of this study was to determine whether SLN operation is as feasible and accurate in male patients compared with female patients...
  54. ncbi request reprint Predictors of contralateral breast cancer in patients with unilateral breast cancer undergoing contralateral prophylactic mastectomy
    Min Yi
    Department of Surgical Oncology, Unit 444, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Cancer 115:962-71. 2009
    ..The objective of this study was to identify the clinicopathologic factors that predict contralateral breast cancer and thereby inform decisions regarding performing CPM in unilateral breast cancer patients...
  55. pmc Age and survival estimates in patients who have node-negative T1ab breast cancer by breast cancer subtype
    Rachel L Theriault
    Department of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Clin Breast Cancer 11:325-31. 2011
    ..This article evaluates the risk of recurrence for patients who have small node-negative breast cancer by age and tumor subtype...
  56. doi request reprint Triple-negative breast cancer is not a contraindication for breast conservation
    Farrell C Adkins
    Department of Surgical Oncology, The University of Texas, M D Anderson Cancer Center, Houston, TX, USA
    Ann Surg Oncol 18:3164-73. 2011
    ..Triple-negative breast cancer (TNBC) is an aggressive subtype shown to have a high risk of locoregional recurrence (LRR). The purpose of this study was to determine the impact of operation type on LRR in TNBC patients...
  57. doi request reprint Trends in and outcomes from sentinel lymph node biopsy (SLNB) alone vs. SLNB with axillary lymph node dissection for node-positive breast cancer patients: experience from the SEER database
    Min Yi
    Department of Surgical Oncology, Unit 444, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Ann Surg Oncol 17:343-51. 2010
    ..The purpose of this study was to examine differences in survival for patients undergoing SLNB alone versus SLNB with complete ALND...
  58. doi request reprint Neoadjuvant chemotherapy in invasive lobular carcinoma may not improve rates of breast conservation
    Judy C Boughey
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, USA
    Ann Surg Oncol 16:1606-11. 2009
    ..This study was intended to evaluate the impact of neoadjuvant chemotherapy in ILC on breast-conserving surgery (BCS) rates...
  59. doi request reprint Among women who experience a recurrence after postmastectomy radiation therapy irradiation is not associated with more aggressive local recurrence or reduced survival
    Wendy A Woodward
    Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Breast Cancer Res Treat 123:597-605. 2010
    ..These data do not support the hypothesis that irradiation promotes biologically aggressive local recurrences...
  60. doi request reprint Factors affecting the decision of breast cancer patients to undergo contralateral prophylactic mastectomy
    Min Yi
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, 77030, USA
    Cancer Prev Res (Phila) 3:1026-34. 2010
    ..Evidence-driven models are needed to better inform women of their absolute risk of contralateral breast cancer as well as their competing risk of recurrence from the primary breast cancer to empower them in their active decision making...
  61. ncbi request reprint Validation of a breast cancer nomogram for predicting nonsentinel lymph node metastases after a positive sentinel node biopsy
    Laura A Lambert
    Department of Surgical Oncology, Unit 444, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA
    Ann Surg Oncol 13:310-20. 2006
    ..To assess the generalizable use of this nomogram, validation analysis was performed by using an external database...
  62. ncbi request reprint Impact of concurrent proliferative high-risk lesions on the risk of ipsilateral breast carcinoma recurrence and contralateral breast carcinoma development in patients with ductal carcinoma in situ treated with breast-conserving therapy
    Linda J Adepoju
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 106:42-50. 2006
    ....
  63. ncbi request reprint Breast conservation after neoadjuvant chemotherapy
    Allen M Chen
    Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 103:689-95. 2005
    ..The purpose of the current report was to develop a prognostic index to help refine selection criteria and to serve as a general framework for clinical decision-making for patients treated by this multimodality approach...
  64. ncbi request reprint Antitumor activity of rapamycin and octreotide as single agents or in combination in neuroendocrine tumors
    Amy Moreno
    Department of Surgical Oncology, Division of Quantitative Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Endocr Relat Cancer 15:257-66. 2008
    ..Further study is needed in order to determine whether octreotide or other somatostatin analogs enhance the efficacy of mTOR inhibitors in other models...
  65. ncbi request reprint Use of lymphoscintigraphy defines lymphatic drainage patterns before sentinel lymph node biopsy for breast cancer
    Kazumi Kawase
    Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    J Am Coll Surg 203:64-72. 2006
    ..We assessed whether drainage patterns seen on LSG were associated with histologic findings in axillary SLNs recovered at SLN biopsy...
  66. pmc Other primary malignancies in breast cancer patients treated with breast conserving surgery and radiation therapy
    Min Yi
    Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Ann Surg Oncol 20:1514-21. 2013
    ..Our purpose was to examine the incidence and impact on survival of other primary malignancies (OPM) outside of the breast in breast cancer patients and to identify risk factors associated with OPM...
  67. ncbi request reprint American College of Surgeons Oncology Group (ACOSOG) Z0011: impact on surgeon practice patterns
    Abigail S Caudle
    Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Ann Surg Oncol 19:3144-51. 2012
    ..The ACOSOG Z0011 trial has been described as practice-changing. The goal of this study was to determine the impact of the trial on surgeon practice patterns at our institution...
  68. ncbi request reprint Effective local control and long-term survival in patients with T4 locally advanced breast cancer treated with breast conservation therapy
    Jeannie Shen
    Department of Surgical Oncology, Unit 444, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Ann Surg Oncol 11:854-60. 2004
    ..This study was conducted to assess the outcome of a carefully selected group of patients who presented with breast cancer involving the skin and who had breast conservation therapy (BCT) following neoadjuvant chemotherapy...
  69. doi request reprint Impact of chemotherapy sequencing on local-regional failure risk in breast cancer patients undergoing breast-conserving therapy
    Elizabeth A Mittendorf
    Department of Surgical Oncology, Unit 1484, The University of TexasMDAnderson Cancer Center, 1400 Pressler St, Houston, TX 77030, USA
    Ann Surg 257:173-9. 2013
    ..This study was performed to evaluate long-term local-regional control rates after breast-conserving therapy (BCT) for patients undergoing surgery before or after neoadjuvant chemotherapy...
  70. pmc Gene expression, molecular class changes, and pathway analysis after neoadjuvant systemic therapy for breast cancer
    Ana M Gonzalez-Angulo
    Departments of Breast Medical Oncology, Systems Biology, Biostatistics, Surgical Oncology, and Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Clin Cancer Res 18:1109-19. 2012
    ..To examine gene expression differences between pre- and post-neoadjuvant systemic therapy (NST) specimens of breast cancers and identify biologic changers that may lead to new therapeutic insights...
  71. pmc Evaluation of a breast cancer nomogram for predicting risk of ipsilateral breast tumor recurrences in patients with ductal carcinoma in situ after local excision
    Min Yi
    Department of Surgical Oncology, Unit 1484, The University of Texas MD Anderson Cancer Center, 1400 Pressler St, Houston, TX 77030, USA
    J Clin Oncol 30:600-7. 2012
    ..The aim of our study was to evaluate a published nomogram from Memorial Sloan-Kettering Cancer Center to predict for risk of IBTR in patients with DCIS from our institution...
  72. doi request reprint Incorporation of sentinel lymph node metastasis size into a nomogram predicting nonsentinel lymph node involvement in breast cancer patients with a positive sentinel lymph node
    Elizabeth A Mittendorf
    Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Ann Surg 255:109-15. 2012
    ..The goal of this study was to construct a nomogram incorporating SLN metastasis size to accurately predict non-SLN involvement in patients with SLN-positive disease...
  73. pmc High risk of recurrence for patients with breast cancer who have human epidermal growth factor receptor 2-positive, node-negative tumors 1 cm or smaller
    Ana M Gonzalez-Angulo
    Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030 4009, USA
    J Clin Oncol 27:5700-6. 2009
    ..To evaluate the risk of recurrence in women diagnosed with T1a and T1b, node-negative, human epidermal growth factor receptor 2 (HER2) -positive breast cancer...
  74. doi request reprint Does blue dye contribute to success of sentinel node mapping for breast cancer?
    Taewoo Kang
    Department of Surgical Oncology, M D Anderson Cancer Center, The University of Texas, Houston, TX, USA
    Ann Surg Oncol 17:280-5. 2010
    ..We sought to evaluate the utilization of blue dye in addition to radioisotope and its relative contribution to sentinel lymph node (SLN) mapping at a high-volume institution...
  75. doi request reprint Sentinel lymph node dissection is technically feasible in older breast cancer patients
    Vicente Valero
    Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Clin Breast Cancer 10:477-82. 2010
    ..This study was undertaken to compare identification rates in patients 70 years of age and older versus those younger than 70 years in a large cohort undergoing sentinel lymph node dissection (SLND)...
  76. ncbi request reprint Histologic changes associated with false-negative sentinel lymph nodes after preoperative chemotherapy in patients with confirmed lymph node-positive breast cancer before treatment
    Alexandra S Brown
    Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Cancer 116:2878-83. 2010
    ....
  77. ncbi request reprint Cytologically proven axillary lymph node metastases are eradicated in patients receiving preoperative chemotherapy with concurrent trastuzumab for HER2-positive breast cancer
    Laura S Dominici
    Department of Surgical Oncology, Brigham and Women s Hospital, Boston, MA, USA
    Cancer 116:2884-9. 2010
    ..To the authors' knowledge, the rate of eradication of biopsy-proven axillary lymph node metastases with trastuzumab-containing neoadjuvant chemotherapy regimens has not been previously reported...
  78. ncbi request reprint Outcomes of breast-conservation therapy for invasive lobular carcinoma are equivalent to those for invasive ductal carcinoma
    Thao N Vo
    Department of Surgical Oncology, Unit 444, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Am J Surg 192:552-5. 2006
    ..We evaluated our institutional experience with BCT and compared treatment outcomes for ILC with those for IDC...
  79. doi request reprint Triple receptor-negative breast cancer: the effect of race on response to primary systemic treatment and survival outcomes
    Shaheenah Dawood
    Department of Breast Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    J Clin Oncol 27:220-6. 2009
    ..The goal of this study was to describe the effect of race on pathologic complete response (pCR) rates and survival outcomes in women with triple receptor-negative (TN) breast cancers...
  80. doi request reprint How many sentinel lymph nodes are enough during sentinel lymph node dissection for breast cancer?
    Min Yi
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer 113:30-7. 2008
    ..The objective of this study was to determine how many SLNs need to be removed for accurate lymph node staging and which patient and tumor characteristics influence this number...
  81. ncbi request reprint Breast conservation after neoadjuvant chemotherapy: the MD Anderson cancer center experience
    Allen M Chen
    Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    J Clin Oncol 22:2303-12. 2004
    ..To determine patterns of local-regional recurrence (LRR) and ipsilateral breast tumor recurrence (IBTR) among patients treated with breast conservation therapy after neoadjuvant chemotherapy...
  82. ncbi request reprint Promoter polymorphism (-786t>C) in the endothelial nitric oxide synthase gene is associated with risk of sporadic breast cancer in non-Hispanic white women age younger than 55 years
    Jiachun Lu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 107:2245-53. 2006
    ..Most breast cancers develop from mammary epithelial cells; therefore, NO may play a role in their development. It was hypothesized that eNOS polymorphisms are associated with risk of breast cancer...
  83. pmc Coordinated prophylactic surgical management for women with hereditary breast-ovarian cancer syndrome
    Larissa I Batista
    Department of Surgical Oncology, The University of Texas M, d, Anderson Cancer Center, Houston, TX, USA
    BMC Cancer 8:101. 2008
    ..We aimed to assess the feasibility of coordinated PM and BSO in hereditary breast-ovarian cancer syndrome...
  84. ncbi request reprint Lower and central tumor location correlates with lymphoscintigraphy drainage to the internal mammary lymph nodes in breast carcinoma
    Karen H Shahar
    Department of Radiation Oncology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 103:1323-9. 2005
    ..The purpose of this study was to identify predictors of IMC drainage in patients with positive axillary SLNs...
  85. ncbi request reprint Immediate breast reconstruction can impact postmastectomy irradiation
    Naomi R Schechter
    Departments of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Am J Clin Oncol 28:485-94. 2005
    ..The purpose of this study was to qualitatively assess the effect of immediate reconstruction on the design of postmastectomy radiotherapy fields at our institution...
  86. doi request reprint Response to neoadjuvant systemic therapy for breast cancer in BRCA mutation carriers and noncarriers: a single-institution experience
    Banu Arun
    Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Unit 1354, Houston, TX 77030 4009, USA
    J Clin Oncol 29:3739-46. 2011
    ....
  87. ncbi request reprint Paget's disease of the breast: there is a role for breast-conserving therapy
    Kazumi Kawase
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 444, Houston, Texas 77030, USA
    Ann Surg Oncol 12:391-7. 2005
    ..In an effort to develop rational treatment guidelines, we examined our institutional experience with Paget's disease of the breast...
  88. ncbi request reprint Potential applicability of balloon catheter-based accelerated partial breast irradiation after conservative surgery for breast carcinoma
    Timothy M Pawlik
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 100:490-8. 2004
    ..The objective of the current study was to evaluate the percentage of patients who would be eligible for balloon catheter-based APBI based on the selection criteria of the American Society of Breast Surgeons and the surgical VR...
  89. ncbi request reprint Sentinel lymph node dissection provides axillary control equal to complete axillary node dissection in breast cancer patients with lobular histology and a negative sentinel node
    Nazanin Khakpour
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Am J Surg 190:598-601. 2005
    ....
  90. ncbi request reprint Chest wall recurrence after mastectomy does not always portend a dismal outcome
    Anees Chagpar
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Ann Surg Oncol 10:628-34. 2003
    ..Chest wall recurrence (CWR) after mastectomy often forecasts a grim prognosis. Predictors of outcome after CWR, however, are not clear...
  91. ncbi request reprint Is intraoperative touch imprint cytology of sentinel lymph nodes in patients with breast cancer cost effective?
    Jacqueline S Jeruss
    Department of Surgical Oncology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 107:2328-36. 2006
    ..The authors hypothesized that TIC, when compared with standard postoperative SLN assessment alone, would permit a cost-effective evaluation of SLNs in patients with clinically node-negative breast cancer...
  92. pmc PI3K pathway mutations and PTEN levels in primary and metastatic breast cancer
    Ana M Gonzalez-Angulo
    Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Unit 1354, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Mol Cancer Ther 10:1093-101. 2011
    ..There is a high level of discordance in PTEN level, PIK3CA mutations, and receptor status between primary tumors and metastases that may influence patient selection and response to PI3K-targeted therapies...
  93. ncbi request reprint Determinants of mastectomy in breast conservation therapy candidates
    Waddah Al-Refaie
    Department of Surgical Oncology, Unit 444, University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Am J Surg 190:602-5. 2005
    ..The purpose of this analysis was to identify factors associated with receiving mastectomy when eligible for BCT...
  94. pmc Biologic and immunologic effects of preoperative trastuzumab for ductal carcinoma in situ of the breast
    Henry M Kuerer
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Cancer 117:39-47. 2011
    ..Through this study, the authors sought to investigate the biologic and immunologic effects of preoperative trastuzumab in patients with ductal carcinoma in situ (DCIS) of the breast...
  95. doi request reprint High prevalence of preinvasive lesions adjacent to BRCA1/2-associated breast cancers
    Banu Arun
    Department of Breast Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Prev Res (Phila) 2:122-7. 2009
    ..These findings suggest that BRCA1/2-associated breast cancers progress through the same intermediate steps as sporadic breast cancers, and that DCIS should be considered as a part of the BRCA1/2 tumor spectrum...
  96. pmc The impact of pregnancy on breast cancer outcomes in women<or=35 years
    Beth M Beadle
    Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 115:1174-84. 2009
    ..The purpose of the current study was to compare locoregional recurrence (LRR), distant metastases (DM), and overall survival (OS) in young patients with PABC and non-PABC...
  97. pmc Efficacy of RAD001 (everolimus) and octreotide LAR in advanced low- to intermediate-grade neuroendocrine tumors: results of a phase II study
    James C Yao
    Department of Gastrointestinal Medical Oncology, Unit 426, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    J Clin Oncol 26:4311-8. 2008
    ..Evaluate the activity of everolimus (RAD001) in combination with octreotide long-acting repeatable (LAR) in patients with advanced low- to intermediate-grade neuroendocrine tumors...
  98. doi request reprint Decreased TGFbeta signaling and increased COX2 expression in high risk women with increased mammographic breast density
    Wei Tse Yang
    University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Breast Cancer Res Treat 119:305-14. 2010
    ..These results strongly suggest that COX2 inhibition should be investigated for breast cancer prevention despite possible increase in cardiovascular risk...
  99. doi request reprint Cyclooxygenase-2 expression in primary breast cancers predicts dissemination of cancer cells to the bone marrow
    Anthony Lucci
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, 77030, USA
    Breast Cancer Res Treat 117:61-8. 2009
    ....
  100. pmc Rak functions as a tumor suppressor by regulating PTEN protein stability and function
    Eun Kyoung Yim
    Department of Systems Biology, The University of Texas M D Anderson Cancer Center, Houston, TX 77054, USA
    Cancer Cell 15:304-14. 2009
    ..Furthermore, Rak knockdown was sufficient to transform normal mammary epithelial cells. Therefore, Rak acts as a bona fide tumor suppressor gene through the mechanism of regulating PTEN protein stability and function...
  101. ncbi request reprint Dual targeting of AKT and mammalian target of rapamycin: a potential therapeutic approach for malignant peripheral nerve sheath tumor
    Changye Y Zou
    Department of Surgical Oncology, The University of Texas M D AndersonCancer Center, Houston, Texas 77030, USA
    Mol Cancer Ther 8:1157-68. 2009
    ..PI-103 did not elicit apoptosis but significantly induced autophagy in MPNST cells. These results suggest further study of combined PI3K/AKT and mTOR inhibition as a novel therapy for patients harboring MPNST...

Research Grants4

  1. Targeting mTOR for Cancer Therapy
    Funda Meric Bernstam; Fiscal Year: 2006
    ..With this study, we not only expect to identify pharmacodynamic markers of response for mTOR inhibitors but also to significantly enhance our understanding of mTOR inhibitors' mechanism of action. ..
  2. Targeting mTOR for Cancer Therapy
    Funda Meric Bernstam; Fiscal Year: 2007
    ..With this study, we not only expect to identify pharmacodynamic markers of response for mTOR inhibitors but also to significantly enhance our understanding of mTOR inhibitors' mechanism of action. ..
  3. Targeting mTOR for Cancer Therapy
    Funda Meric Bernstam; Fiscal Year: 2009
    ..With this study, we not only expect to identify pharmacodynamic markers of response for mTOR inhibitors but also to significantly enhance our understanding of mTOR inhibitors' mechanism of action. ..