Meredith G, Totterdell S, Petroske E, Santa Cruz K, Callison R, Lau Y. Lysosomal malfunction accompanies alpha-synuclein aggregation in a progressive mouse model of Parkinson's disease. Brain Res. 2002;956:156-65 pubmed
..They further suggest that defective protein degradation rather than altered gene expression underlies deposition of alpha-synuclein and that abundant lysosomal compartments are present to seal off the potentially toxic material. ..
Meredith G, Halliday G, Totterdell S. A critical review of the development and importance of proteinaceous aggregates in animal models of Parkinson's disease: new insights into Lewy body formation. Parkinsonism Relat Disord. 2004;10:191-202 pubmed
..Elucidating the common mechanisms in animal models is a first step towards understanding the role of Lewy bodies and their formation in Parkinson's disease. ..
Meredith G, Switzer R, Napier T. Short-term, D2 receptor blockade induces synaptic degeneration, reduces levels of tyrosine hydroxylase and brain-derived neurotrophic factor, and enhances D2-mediated firing in the ventral pallidum. Brain Res. 2004;995:14-22 pubmed
..Moreover, the functional ramifications of these changes appear to include profound alterations in the way dopamine regulates neuronal activity in this region. ..