Research Topics
| G E MeredithSummaryAffiliation: The Chicago Medical School Country: USA Publications
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Publications
Brain-derived neurotrophic factor expression is increased in the rat amygdala, piriform cortex and hypothalamus following repeated amphetamine administrationGloria E Meredith
Department of Basic Medical Science, University of Missouri Kansas City, School of Medicine, 2411 Holmes Rd, Kansas City, MO 64108, USA
Brain Res 949:218-27. 2002..These results suggest that the upregulation of BDNF expression and protein in the basolateral nucleus of the amygdala and its targets could be an important part of the neuroadaptive response to psychostimulants...- Lysosomal malfunction accompanies alpha-synuclein aggregation in a progressive mouse model of Parkinson's diseaseG E Meredith
Department of Cellular and Molecular Pharmacology, Chicago Medical School, Finch University of Health Sciences, 3333 Green Bay Road, North Chicago, IL 60064, USA
Brain Res 956:156-65. 2002..They further suggest that defective protein degradation rather than altered gene expression underlies deposition of alpha-synuclein and that abundant lysosomal compartments are present to seal off the potentially toxic material... - A critical review of the development and importance of proteinaceous aggregates in animal models of Parkinson's disease: new insights into Lewy body formationGloria E Meredith
Department of Cellular and Molecular Pharmacology, Chicago Medical School, Finch University of Health Sciences, 3333 Green Bay Road, North Chicago, IL 60054, USA
Parkinsonism Relat Disord 10:191-202. 2004..Elucidating the common mechanisms in animal models is a first step towards understanding the role of Lewy bodies and their formation in Parkinson's disease... - Short-term, D2 receptor blockade induces synaptic degeneration, reduces levels of tyrosine hydroxylase and brain-derived neurotrophic factor, and enhances D2-mediated firing in the ventral pallidumG E Meredith
Department of Cellular and Molecular Pharmacology, The Chicago Medical School, Finch University of Health Sciences, 3333 Green Bay Rd, North Chicago, IL 60064 3095, USA
Brain Res 995:14-22. 2004..Moreover, the functional ramifications of these changes appear to include profound alterations in the way dopamine regulates neuronal activity in this region... - Persistent alterations in dendrites, spines, and dynorphinergic synapses in the nucleus accumbens shell of rats with neuroleptic-induced dyskinesiasG E Meredith
Department of Basic Medical Science, University of Missouri Kansas City, School of Medicine, Kansas City, Missouri 64108 2792, USA
J Neurosci 20:7798-806. 2000..Persistent, neuroleptic-induced oral dyskinesias could therefore be caused by incontrovertible alterations, involving terminal remodeling or sprouting, to the synaptic connectivity of the accumbal shell... 
Impaired glutamate homeostasis and programmed cell death in a chronic MPTP mouse model of Parkinson's diseaseG E Meredith
Department of Cellular and Molecular Pharmacology, Chicago Medical School, Rosalind Franklin University, 3333 Green Bay Road, North Chicago, IL 60064, USA
Exp Neurol 219:334-40. 2009..These data suggest that increased glutamate signaling could be an important mechanism for the death of dopaminergic neurons and trigger the induction of programmed cell death in the chronic MPTP/probenecid model...- Effect of amphetamine place conditioning on excitatory synaptic events in the basolateral amygdala ex vivoA Hetzel
Department of Cellular and Molecular Pharmacology, Chicago Medical School, Rosalind Franklin University, 3333 Green Bay Road, North Chicago, IL 60064, USA
Neuroscience 206:7-16. 2012..These findings may underlie increased excitatory drive of the BLA after AMPH CPP, and contribute to the animals' preference for the AMPH-paired compartment... - The ultrastructural distribution of alpha-synuclein-like protein in normal mouse brainSusan Totterdell
Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK
Brain Res 1004:61-72. 2004..Nevertheless alpha-synuclein is also found in terminals of neurons which have not been reported to accumulate the protein in neurodegenerative disorders... - Repeated amphetamine administration induces Fos in prefrontal cortical neurons that project to the lateral hypothalamus but not the nucleus accumbens or basolateral amygdalaMaud M Morshedi
Department of Cellular and Molecular Pharmacology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, IL 60064, USA
Psychopharmacology (Berl) 197:179-89. 2008..These projections are clearly important for the progressive enhancement of the behavioral response during drug administration that persists through withdrawal... - MPTP administration in mice changes the ratio of splice isoforms of fosB and rgs9Judith A Potashkin
Department of Cellular and Molecular Pharmacology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, IL 60064, USA
Brain Res 1182:1-10. 2007..The data indicate that the pattern of splice isoforms of fosB and rgs9 reflects the brain's immediate and long-term responses to the physiological stress associated with Parkinsonism... - 'Rejuvenation' protects neurons in mouse models of Parkinson's diseaseC Savio Chan
Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
Nature 447:1081-6. 2007..Such blocking ('rejuvenation') protects these neurons in both in vitro and in vivo models of Parkinson's disease, pointing to a new strategy that could slow or stop the progression of the disease... - BDNF heterozygous mice demonstrate age-related changes in striatal and nigral gene expressionAlicia J Saylor
Department of Neurosciences, Medical University of South Carolina, 173 Ashley Avenue, Charleston, SC 29425, USA
Exp Neurol 199:362-72. 2006.... - Relationship of orofacial movements to behavioural repertoire as assessed topographically over the course of 6-month haloperidol treatment followed by 4-month withdrawalIan E J De Souza
Department of Anatomy, Royal College of Surgeons in Ireland, St. Stephen's Green, Dublin 2, Ireland
Psychopharmacology (Berl) 169:28-34. 2003.... - Elevated neuronal nitric oxide synthase expression in chronic haloperidol-treated ratsYuen Sum Lau
Division of Pharmacology, School of Pharmacy, University of Missouri Kansas City, 2411 Holmes St M3 111, Kansas City, MO, USA
Neuropharmacology 45:986-94. 2003..Furthermore, the toxic effect of chronic haloperidol on NOS system selectivity takes place in the neostriatum... - Astroglial plasticity and glutamate function in a chronic mouse model of Parkinson's diseaseAdrian G Dervan
Department of Cellular and Molecular Pharmacology, Rosalind Franklin University of Medicine and Science, The Chicago Medical School, 3333 Green Bay Road, North Chicago, IL 60064, USA
Exp Neurol 190:145-56. 2004.... - Quantitative proteomic analysis of mitochondrial proteins: relevance to Lewy body formation and Parkinson's diseaseJinghua Jin
Department of Pathology, School of Medicine, University of Washington, Seattle, WA 98104, USA
Brain Res Mol Brain Res 134:119-38. 2005..In addition, DJ-1 was present in the halo but not in the core of classical LBs in patients with PD. Our findings suggested that DJ-1 might play an important role in mitochondrial dysfunction, as well as LB formation in PD... - Amphetamine increases tyrosine kinase-B receptor expression in the dorsal striatumGloria E Meredith
Department of Cellular and Molecular Pharmacology, Chicago Medical School Rosalind Franklin University of Medicine and Science, North Chicago, Illinois 60064, USA
Neuroreport 17:75-8. 2006..These findings indicate that changes in striatal tyrosine kinase-B signaling could play a role in neuroadaptations and behavioral changes induced by amphetamine treatment... - Differential laminar effects of amphetamine on prefrontal parvalbumin interneuronsM M Morshedi
Department of Cellular and Molecular Pharmacology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, IL 60064, USA
Neuroscience 149:617-24. 2007..They also suggest that a sensitizing amphetamine regimen directs medial prefrontal cortex (mPFC) outflow, via changes in inhibitory neuron activation, toward subcortical centers important in reward... - The neural substrates of amphetamine conditioned place preference: implications for the formation of conditioned stimulus-reward associationsDavid J Rademacher
Department of Cellular and Molecular Pharmacology, Rosalind Franklin University of Medicine and Science, Chicago Medical School, 3333 Green Bay Road, North Chicago, IL 60064, USA
Eur J Neurosci 24:2089-97. 2006..These data therefore suggest that the formation of conditioned stimulus-reward associations requires, at least in part, activation of amygdalar-hippocampal circuits... - Context modulates the expression of conditioned motor sensitization, cellular activation and synaptophysin immunoreactivityDavid J Rademacher
Department of Cellular and Molecular Pharmacology, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, IL 60064, USA
Eur J Neurosci 26:2661-8. 2007..These data indicate that the basolateral amygdala-nucleus accumbens core pathway is necessary for the context-elicited conditioned motor responses, while the hippocampus encodes the spatial context... - The role of oxidative stress in the dysregulation of gene expression and protein metabolism in neurodegenerative diseaseJudith A Potashkin
Department of Cellular and Molecular Pharmacology, The Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois, USA
Antioxid Redox Signal 8:144-51. 2006.... - Animal models of Parkinson's disease progressionGloria E Meredith
Department of Cellular and Molecular Pharmacology, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, IL 60064, USA
Acta Neuropathol 115:385-98. 2008..This review critically evaluates these in vivo models and the roles they play in mimicking the progression of PD... - From drugs of abuse to parkinsonism. The MPTP mouse model of Parkinson's diseaseYuen-Sum Lau
Division of Pharmacology, University of Missouri-Kansas City, School of Pharmacy, Kansas City, MO, USA
Methods Mol Med 79:103-16. 2003