MARK K MERCOLA

Summary

Affiliation: The Burnham Institute
Country: USA

Publications

  1. ncbi A Nodal-to-TGFβ cascade exerts biphasic control over cardiopoiesis
    Wenqing Cai
    Muscle Development and Regeneration Program, Sanford Burnham Medical Research Institute, 10901 N Torrey Pines Rd, La Jolla, CA 92037, USA
    Circ Res 111:876-81. 2012
  2. ncbi Left-right asymmetry: nodal points
    Mark Mercola
    Stem Cell and Regeneration Program, The Burnham Institute, 10901 N Torrey Pines Road, La Jolla, CA 92037, USA
    J Cell Sci 116:3251-7. 2003
  3. ncbi Cardiac muscle regeneration: lessons from development
    Mark Mercola
    Muscle Development and Regeneration Program, Sanford Burnham Medical Research Institute, La Jolla, California 92037, USA
    Genes Dev 25:299-309. 2011
  4. ncbi Heart induction by Wnt antagonists depends on the homeodomain transcription factor Hex
    Ann C Foley
    Stem Cell and Regeneration Program, Burnham Institute, La Jolla, California 92037, USA
    Genes Dev 19:387-96. 2005
  5. ncbi Developmental patterning of the cardiac atrioventricular canal by Notch and Hairy-related transcription factors
    Joshua B Rutenberg
    Burnham Institute for Medical Research, 10901 N Torrey Pines Road, La Jolla, CA 92037, USA
    Development 133:4381-90. 2006
  6. ncbi Heart induction: embryology to cardiomyocyte regeneration
    Ann Foley
    Ann Foley and Mark Mercola are at the Stem Cell and Regeneration Program, The Burnham Institute, La Jolla, California, USA
    Trends Cardiovasc Med 14:121-5. 2004
  7. ncbi A novel activity of the Dickkopf-1 amino terminal domain promotes axial and heart development independently of canonical Wnt inhibition
    Oksana Korol
    Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Dev Biol 324:131-8. 2008
  8. ncbi Multiple functions of Cerberus cooperate to induce heart downstream of Nodal
    Ann C Foley
    Burnham Institute for Medical Research, 10901 N Torrey Pines Road, La Jolla, CA 92037, USA
    Dev Biol 303:57-65. 2007
  9. ncbi Non-cardiomyocytes influence the electrophysiological maturation of human embryonic stem cell-derived cardiomyocytes during differentiation
    Changsung Kim
    Center for Neuroscience, Aging and Stem Cell Research, Burnham Institute for Medical Research, La Jolla, California 92037, USA
    Stem Cells Dev 19:783-95. 2010

Research Grants

  1. Cardiomyocyte Regeneration from Multipotent precursor c*
    Mark Mercola; Fiscal Year: 2004
  2. Q3DM/Beckman Coulter IC 100 Automated Microscope System
    Mark Mercola; Fiscal Year: 2005
  3. MOLECULAR BIOLOGY OF HEART INDUCTION
    Mark Mercola; Fiscal Year: 2005
  4. Small Molecule Regulators of Beta-Cell Differentiation
    Mark Mercola; Fiscal Year: 2005
  5. MOLECULAR BIOLOGY OF HEART INDUCTION
    Mark Mercola; Fiscal Year: 2007
  6. Notch function in myocardial development and homeostasis
    Mark Mercola; Fiscal Year: 2007
  7. Reconstruction & Modeling of Networks Involved in Cardiomyocyte Differentiation
    Mark Mercola; Fiscal Year: 2007
  8. Notch function in myocardial development and homeostasis
    Mark Mercola; Fiscal Year: 2009
  9. Notch function in heart and kidney organogenesis
    Mark Mercola; Fiscal Year: 2004
  10. MOLECULAR BIOLOGY OF HEART INDUCTION
    Mark Mercola; Fiscal Year: 2000

Collaborators

  • Huei Sheng Vincent Chen
  • Ann C Foley
  • Oksana Korol
  • Wenqing Cai
  • Changsung Kim
  • Joshua B Rutenberg
  • Ann Foley
  • Ke Wei
  • Erik Willems
  • Herman Davidovics
  • Rosa M Guzzo
  • Brandon Nelson
  • Karen A Wei
  • Maryam Majdi
  • Sean Spiering
  • Peng Xia
  • Maria Talantova
  • Ruchika W Gupta
  • Anjuli M Timmer
  • Tao P Zhong
  • Andreas Fischer
  • Haibo Jia
  • Manfred Gessler

Detail Information

Publications9

  1. ncbi A Nodal-to-TGFβ cascade exerts biphasic control over cardiopoiesis
    Wenqing Cai
    Muscle Development and Regeneration Program, Sanford Burnham Medical Research Institute, 10901 N Torrey Pines Rd, La Jolla, CA 92037, USA
    Circ Res 111:876-81. 2012
    ..The transforming growth factor-β (TGFβ) family member Nodal promotes cardiogenesis, but the mechanism is unclear despite the relevance of TGFβ family proteins for myocardial remodeling and regeneration...
  2. ncbi Left-right asymmetry: nodal points
    Mark Mercola
    Stem Cell and Regeneration Program, The Burnham Institute, 10901 N Torrey Pines Road, La Jolla, CA 92037, USA
    J Cell Sci 116:3251-7. 2003
    ....
  3. ncbi Cardiac muscle regeneration: lessons from development
    Mark Mercola
    Muscle Development and Regeneration Program, Sanford Burnham Medical Research Institute, La Jolla, California 92037, USA
    Genes Dev 25:299-309. 2011
    ..Here we discuss commonalities of development and regeneration, and the application of the rich developmental biology heritage to achieve therapeutic regeneration of the human heart...
  4. ncbi Heart induction by Wnt antagonists depends on the homeodomain transcription factor Hex
    Ann C Foley
    Stem Cell and Regeneration Program, Burnham Institute, La Jolla, California 92037, USA
    Genes Dev 19:387-96. 2005
    ..This novel function for Hex suggests an etiology for the cardiac malformations in Hex mutant mice and will make possible the isolation of factors that induce heart directly in the mesoderm...
  5. ncbi Developmental patterning of the cardiac atrioventricular canal by Notch and Hairy-related transcription factors
    Joshua B Rutenberg
    Burnham Institute for Medical Research, 10901 N Torrey Pines Road, La Jolla, CA 92037, USA
    Development 133:4381-90. 2006
    ....
  6. ncbi Heart induction: embryology to cardiomyocyte regeneration
    Ann Foley
    Ann Foley and Mark Mercola are at the Stem Cell and Regeneration Program, The Burnham Institute, La Jolla, California, USA
    Trends Cardiovasc Med 14:121-5. 2004
    ..These proteins may also prove to be useful to stimulate progenitor cells to differentiate into cardiomyocytes within the damaged heart...
  7. ncbi A novel activity of the Dickkopf-1 amino terminal domain promotes axial and heart development independently of canonical Wnt inhibition
    Oksana Korol
    Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Dev Biol 324:131-8. 2008
    ..We conclude that this new activity is also likely to synergize with canonical Wnt inhibitory in the numerous developmental and disease processes that involve Dkk1...
  8. ncbi Multiple functions of Cerberus cooperate to induce heart downstream of Nodal
    Ann C Foley
    Burnham Institute for Medical Research, 10901 N Torrey Pines Road, La Jolla, CA 92037, USA
    Dev Biol 303:57-65. 2007
    ..Both pathways operate in endoderm to initiate cardiogenesis in overlying mesoderm...
  9. ncbi Non-cardiomyocytes influence the electrophysiological maturation of human embryonic stem cell-derived cardiomyocytes during differentiation
    Changsung Kim
    Center for Neuroscience, Aging and Stem Cell Research, Burnham Institute for Medical Research, La Jolla, California 92037, USA
    Stem Cells Dev 19:783-95. 2010
    ..Defining the nature of these extrinsic signals will aid in the directed maturation of immature hESC-CMs to mitigate arrhythmogenic risks of cell-based therapies...

Research Grants32

  1. Cardiomyocyte Regeneration from Multipotent precursor c*
    Mark Mercola; Fiscal Year: 2004
    ..To carry out Aim 4 concurrently with the other aims, embryonic stem cells will be used initially as they proliferate well in culture and differentiate into cardiomyocytes in response to known inducers (preliminary data). ..
  2. Q3DM/Beckman Coulter IC 100 Automated Microscope System
    Mark Mercola; Fiscal Year: 2005
    ....
  3. MOLECULAR BIOLOGY OF HEART INDUCTION
    Mark Mercola; Fiscal Year: 2005
    ..Factors that reside in the embryonic heart-forming region, such as Dkk1, Crescent and novel proteins secreted by the endoderm, will be tested for the ability to enhance myocardial differentiation of these cells in vivo. ..
  4. Small Molecule Regulators of Beta-Cell Differentiation
    Mark Mercola; Fiscal Year: 2005
    ..abstract_text> ..
  5. MOLECULAR BIOLOGY OF HEART INDUCTION
    Mark Mercola; Fiscal Year: 2007
    ..The signals that control embryonic cardiogenesis have been demonstrated to function in stem cell cardiogenesis; thus, elucidation of signaling molecules that act directly on competent mesoderm should enable regenerative technologies. ..
  6. Notch function in myocardial development and homeostasis
    Mark Mercola; Fiscal Year: 2007
    ....
  7. Reconstruction & Modeling of Networks Involved in Cardiomyocyte Differentiation
    Mark Mercola; Fiscal Year: 2007
    ....
  8. Notch function in myocardial development and homeostasis
    Mark Mercola; Fiscal Year: 2009
    ....
  9. Notch function in heart and kidney organogenesis
    Mark Mercola; Fiscal Year: 2004
    ..Knowledge of Notch function and the key downstream regulatory proteins should provide molecular insights that may be of therapeutic benefit for disease and congenital disorders. ..
  10. MOLECULAR BIOLOGY OF HEART INDUCTION
    Mark Mercola; Fiscal Year: 2000
    ..Aim 4) is to overexpress notch or a domininant-negative form of notch, by injection into blastomeres in the heart-forming region, and see if the amount of heart-forming tissue is altered. ..
  11. GAP JUNCTIONAL COMMUNICATION AND LEFT/RIGHT ASYMMETRY
    Mark Mercola; Fiscal Year: 2002
    ..abstract_text> ..