Research Topics
Genomes and Genes
Species | Ramkumar MenonSummaryAffiliation: The Perinatal Research Center Country: USA Publications
| Collaborators
|
Detail Information
Publications
Racial disparity in pathophysiologic pathways of preterm birth based on genetic variantsRamkumar Menon
The Perinatal Research Center, Nashville, Tennessee, USA
Reprod Biol Endocrinol 7:62. 2009..To study pathophysiologic pathways in spontaneous preterm birth and possibly the racial disparity associating with maternal and fetal genetic variations, using bioinformatics tools...
Amniotic fluid concentrations of collagenase-1 and collagenase-3 are increased in polyhydramniosStephen J Fortunato
Perinatal Research Center, The Centennial Women s Hospital, Patterson, Nashville, TN 37203, USA
J Perinat Med 32:122-5. 2004..Herein we use polyhydramnios as a model to study the association of the collagenase class of matrix metalloproteinases (MMPs) with tissue remodeling during pregnancy...- Differences in the placental membrane cytokine response: a possible explanation for the racial disparity in preterm birthRamkumar Menon
The Perinatal Research Center of The Women s Health Research and Education Foundation, Nashville, TN 37203, USA
Am J Reprod Immunol 56:112-8. 2006.... - Ethnic differences in key candidate genes for spontaneous preterm birth: TNF-alpha and its receptorsRamkumar Menon
The Perinatal Research Center, Nashville, TN 37203, USA
Hum Hered 62:107-18. 2006..The objective of this study is to examine genetic differences between African-Americans and European Americans for single nucleotide polymorphisms (SNPs) in candidate genes for PTB... - Amniotic fluid interleukin-1beta and interleukin-8 concentrations: racial disparity in preterm birthRamkumar Menon
Perinatal Research Center, Nashville, Tennessee37203, USA
Reprod Sci 14:253-9. 2007..These differences in the amniotic fluid cytokine concentration might not explain the racial disparity in the PTB rate, but they are suggestive of different processes of PTB in whites and blacks... 
Spontaneous preterm birth, a clinical dilemma: etiologic, pathophysiologic and genetic heterogeneities and racial disparityRamkumar Menon
The Perinatal Research Center, Centennial Women s Hospital, Nashville, TN 37203, USA
Acta Obstet Gynecol Scand 87:590-600. 2008..Current strategies of high risk screening and intervention measures may not be generalized, and a more individualized approach may be required to understand PTB and its prevention...- Corticotrophin-releasing hormone in lipopolysaccharide-stimulated term fetal membranes and amniotic fluid from term and preterm birth in African Americans and CaucasiansRamkumar Menon
Perinatal Research Center, Nashville, Tennessee 37203, USA
Reprod Sci 15:477-83. 2008..1). AF analysis did not document racial disparity in CRH concentrations in PTB. In fetal membranes, African Americans showed a higher expression and production of CRH in response to an in vitro stimulus... - Genetic regulation of amniotic fluid TNF-alpha and soluble TNF receptor concentrations affected by race and preterm birthRamkumar Menon
The Perinatal Research Center, 2300 Patterson Street, Nashville, TN 37203, USA
Hum Genet 124:243-53. 2008..This does not appear to be the case in Caucasians. These findings may be important in understanding disparity in rates of PTB between the two populations... - Induction of triggering receptors of myeloid cell (TREM-1) expression in fetal membranes and higher concentration of soluble TREM-1 in amniotic fluid with spontaneous preterm birthRamkumar Menon
Perinatal Research Center, Nashville, Tennessee 37203, USA
Reprod Sci 15:825-30. 2008..To document triggering receptors of myeloid cells (TREM-1) expression in fetal membranes and to estimate soluble TREM-1 (sTREM-1) concentrations in the amniotic fluid (AF) from spontaneous preterm birth (PTB)... - IL-1 beta is a better inducer of apoptosis in human fetal membranes than IL-6S J Fortunato
The Perinatal Research Center of The Women s Health Research and Education Foundation and Aquinas College, 2300 Patterson Street, Nashville, TN 37203, USA
Placenta 24:922-8. 2003..DNA fragmentation was seen in greater numbers after IL-1 beta treatment than after IL-6 treatment. This study demonstrates that IL-1 beta is a better inducer of apoptosis in normal human fetal membranes than IL-6... - Immunoreactivity of human fetal membranes to peptidoglycan polysaccharide (PGPS): cytokine responseS J Fortunato
Maternal Fetal Medicine and Perinatal Research Center, Women s Health Research and Education Foundation, Nashville, TN, USA
J Perinat Med 26:442-7. 1998.... - MMP/TIMP imbalance in amniotic fluid during PROM: an indirect support for endogenous pathway to membrane ruptureS J Fortunato
Perinatal Research Center, Women s Health Research and Education Foundation, Nashville, TN, USA
J Perinat Med 27:362-8. 1999..This study examines the levels of the gelatinases and their natural inhibitors (tissue inhibitor of matrix metalloproteinases-TIMPs) in the amniotic fluid during PROM, preterm labor (PTL) and at term... - Amniochorion gelatinase-gelatinase inhibitor imbalance in vitro: a possible infectious pathway to ruptureS J Fortunato
Maternal Fetal Group and Perinatal Research Center of the Women s Health Research and Education Foundation and Aquinas College, Nashville, Tennessee 37203, USA
Obstet Gynecol 95:240-4. 2000..To estimate the effect of lipopolysaccharide on gelatinases and tissue inhibitors of matrix metalloproteinase 2 (gelatinase inhibitor) balance in human fetal membranes... - Stromelysins in placental membranes and amniotic fluid with premature rupture of membranesS J Fortunato
Maternal Fetal Group, Perinatal Research Center, Nashville, Tennessee 37203, USA
Obstet Gynecol 94:435-40. 1999..To determine the expression and site of production of stromelysins in fetal membranes and to measure stromelysin 1 levels in amniotic fluid and amniochorion culture media... - Interleukin-10 inhibition of gelatinases in fetal membranes: therapeutic implications in preterm premature rupture of membranesS J Fortunato
The Perinatal Research Center of The Women s Health Research and Education Foundation, The Maternal Fetal Group and Aquinas College, Department of Preventive Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37203, USA
Obstet Gynecol 98:284-8. 2001..To examine the effect of interleukin-10 on production and regulation of gelatinases by amniochorion in an in vitro model of infection... - Screening of novel matrix metalloproteinases (MMPs) in human fetal membranesStephen J Fortunato
The Perinatal Research Center of The Women s Health Research and Education Foundation, Nashville, Tennessee 37203, USA
J Assist Reprod Genet 19:483-6. 2002..The objective of this study is to document the expression pattern of most of the MMPs cloned and sequenced so far in amniochorion during preterm premature rupture of membranes (pPROM), at term not in labor and during term labor... - Role of tumor necrosis factor-alpha in the premature rupture of membranes and preterm labor pathwaysSephen J Fortunato
Perinatal Research Center of the Women s Health Research and Education Foundation, Nashville, TN 37203, USA
Am J Obstet Gynecol 187:1159-62. 2002.... - Collagenase-3 (MMP-13) in fetal membranes and amniotic fluid during pregnancyStephen J Fortunato
Perinatal Research Center, Women s Health Research and Education Foundation, Aquinas College, Nashville, TN 37203, USA
Am J Reprod Immunol 49:120-5. 2003..To examine the expression, site of production and a role of collagenase-3 in human fetal membranes and amniotic fluid (AF)... - Racial disparity in membrane response to infectious stimuli: a possible explanation for observed differences in the incidence of prematurity. Community Award PaperStephen J Fortunato
The Perinatal Research Center of The Women s Health Research and Education Foundation, The Women s Hospital at Centennial Medical Center, Nashville, TN 37203, USA
Am J Obstet Gynecol 190:1557-62; discussion 1562-3. 2004..This study compares the immune responsiveness of amniochorionic membranes (AC) derived from African American (AA) and white (C) women to an infectious stimulus ex vivo... - Racial disparity in maternal-fetal genetic epistasis in spontaneous preterm birthStephen J Fortunato
Perinatal Research Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA
Am J Obstet Gynecol 198:666.e1-9; discussion 666.e9-10. 2008..To understand the differences in genetic interactions among tumor necrosis factor-alpha, interleukin-6 and their receptor gene variants between black and white patients in spontaneous preterm birth... - Patterns of cytokine profiles differ with pregnancy outcome and ethnicityDigna R Velez
Division of Cardiovascular Medicine, Vanderbilt University, Nashville, TN, USA
Hum Reprod 23:1902-9. 2008..Preterm birth (PTB) is hypothesized to be an inflammatory response disease. However, no single factor alone is likely to explain PTB risk. It is more probable that coordinated networks of cytokines affect risk... - Multilocus interactions at maternal tumor necrosis factor-alpha, tumor necrosis factor receptors, interleukin-6 and interleukin-6 receptor genes predict spontaneous preterm labor in European-American womenRamkumar Menon
The Perinatal Research Center, Nashville, TN 37203, USA
Am J Obstet Gynecol 194:1616-24. 2006..In this study we examine the allelic and genotypic variations and the gene-gene interactions in the TNF-alpha, TNFRs, IL-6, and IL-6R genes in maternal DNA samples by using a case-control model... - An evolutionary genomic approach to identify genes involved in human birth timingJevon Plunkett
Department of Pediatrics, Vanderbilt University School of Medicine and Monroe Carell Jr Children s Hospital at Vanderbilt, Nashville, Tennessee, United States of America
PLoS Genet 7:e1001365. 2011..We anticipate other human accelerated genes will similarly be associated with preterm birth risk and elucidate essential pathways for human parturition... - Racial disparity in amniotic fluid concentrations of tumor necrosis factor (TNF)-alpha and soluble TNF receptors in spontaneous preterm birthRamkumar Menon
Perinatal Research Center, Nashville, TN 37203, USA
Am J Obstet Gynecol 198:533.e1-10. 2008..The objective of this study is to examine the inflammatory cytokine, tumor necrosis factor (TNF)-alpha and soluble TNF receptor concentrations (sTNFR1 and sTNFR2) in the amniotic fluid of black and white women at delivery... - Amniotic fluid interleukin-6 increase is an indicator of spontaneous preterm birth in white but not black AmericansRamkumar Menon
Perinatal Research Center of the Women s Health Research and Education Foundation, Women s Hospital at the Centennial Medical Center, Nashville, TN 37203, USA
Am J Obstet Gynecol 198:77.e1-7. 2008..This study examined the differences in the inflammatory cytokine interleukin (IL)-6 and the immunoinhibitory cytokine IL-10 in the amniotic fluid of black and white women in spontaneous preterm birth... - Interleukin-6 (IL-6) and receptor (IL6-R) gene haplotypes associate with amniotic fluid protein concentrations in preterm birthDigna R Velez
Division of Cardiovascular Medicine, Vanderbilt University, Nashville, TN, USA
Hum Mol Genet 17:1619-30. 2008..In conclusion, our results suggest that IL-6 AF concentration, in situations of PTB, result from variation in IL-6 and more importantly IL-6R... - Maternal and fetal genetic associations of PTGER3 and PON1 with preterm birthKelli K Ryckman
Department of Molecular Physiology and Biophysics and Center for Human Genetics Research, Vanderbilt University, Nashville, Tennessee, United States of America
PLoS ONE 5:e9040. 2010.... - Preterm birth in Caucasians is associated with coagulation and inflammation pathway gene variantsDigna R Velez
Center for Human Genetics Research, Vanderbilt University, Nashville, TN, USA
PLoS ONE 3:e3283. 2008..001). These results support a role for genes in both the coagulation and inflammation pathways, and potentially different maternal and fetal genetic risks for PTB... - Association of genetic variants, ethnicity and preterm birth with amniotic fluid cytokine concentrationsRamkumar Menon
The Perinatal Research Center, Nashville, TN, USA
Ann Hum Genet 74:165-83. 2010..AF cytokine concentrations were associated with interactions between genotype and PTB in African Americans, but less so in Caucasians... - Analysis of association between maternal tumor necrosis factor-alpha promoter polymorphism (-308), tumor necrosis factor concentration, and preterm birthRamkumar Menon
The Perinatal Research Center, Nashville, TN 37203, USA
Am J Obstet Gynecol 195:1240-8. 2006..In addition, association between this variant and TNF-alpha concentration in amniotic fluid (AF) in preterm birth was also investigated... - Human fetal membrane expression of IL-19 and IL-20 and its differential effect on inflammatory cytokine productionRamkumar Menon
Perinatal Research Center of the Women's Health Research and Education Foundation, 2300 Patterson Street, Nashville, TN 37203, USA
J Matern Fetal Neonatal Med 19:209-14. 2006..The effect of IL-19 and IL-20 in pregnancy will be dependent on their concentrations and other environmental factors such as infection... - Diversity in cytokine response to bacteria associated with preterm birth by fetal membranesRamkumar Menon
Perinatal Research Center, Centennial Women s Hospital, Nashville, TN, USA
Am J Obstet Gynecol 201:306.e1-6. 2009..This study compared cytokine and prostaglandin (PG) responses by fetal membranes stimulated with 4 different bacterial species associated with preterm birth (PTB)... - Investigation of genetic risk factors for chronic adult diseases for association with preterm birthNadia Falah
Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN, USA
Hum Genet 132:57-67. 2013..Given the limited sample size in his study, we suggest larger studies to further investigate possible HLA genetic involvement in PTB... - Distinct pathophysiologic pathways induced by in vitro infection and cigarette smoke in normal human fetal membranesRamkumar Menon
Perinatal Research Center, Centennial Women s Hospital, 2300 Patterson St, Nashville, TN 37203, USA
Am J Obstet Gynecol 200:334.e1-8. 2009..The purpose of this study was to document distinct pathways that are initiated by lipopolysaccharide and cigarette smoke stimulation of normal term fetal membranes... - Salivary proteinase activity: a potential biomarker for preterm premature rupture of the membranesRamkumar Menon
The Perinatal Research Center, Nashville, TN 37203, USA
Am J Obstet Gynecol 194:1609-15; discussion 1615. 2006.... - TNF-alpha promotes caspase activation and apoptosis in human fetal membranesRamkumar Menon
The Perinatal Research Center, Women s Health Research and Education Foundation, The Women s Hospital, Nashville, Tennessee, USA
J Assist Reprod Genet 19:201-4. 2002..We have noted increased apoptosis in membranes derived from women with PROM. This study examines the role of TNF in promoting fetal membrane apoptosis... - The expression pattern of two novel cytokines (IL-24 and IL-29) in human fetal membranesJudith Nace
The Perinatal Research Center, Centennial Women s Hospital, Nashville, TN 37203, USA
J Perinat Med 38:665-70. 2010..The functions of these cytokines in the reproductive system are unknown. We examined the expression pattern of IL-24 and IL-29 in human fetal membranes from preterm and term births and in in vitro in response to microbial antigens... - An overview of racial disparities in preterm birth rates: caused by infection or inflammatory response?Ramkumar Menon
Department of Epidemiology, Women and Children s Center, Emory University Rollins School of Public Health, Atlanta, GA 30322, USA
Acta Obstet Gynecol Scand 90:1325-31. 2011.... - Mitochondrial DNA variant A4917G, smoking and spontaneous preterm birthDigna R Velez
Division of Cardiovascular Medicine, Department of Medicine and Center for Human Genetics Research, 519 Light Hall, Vanderbilt University, Nashville, TN 37232, USA
Mitochondrion 8:130-5. 2008..Our data, although preliminary, support the hypothesis that mitochondrial genome polymorphisms may play a significant role in PTB through an interaction with smoking... - Geographic ancestry and markers of preterm birthScott M Williams
Department of Molecular Physiology and Biophysics, Center for Human Genetics Research, Vanderbilt University, Nashville, TN 37232, USA
Expert Rev Mol Diagn 10:27-32. 2010..An alternative is presented that, although not yet proven, may make it possible to use a common set of biomarkers and their relationships to assess risk... - Genetic associations in preterm birth: a primer of marker selection, study design, and data analysisRamkumar Menon
The Perinatal Research Center, Nashville, TN 37203, USA
J Soc Gynecol Investig 13:531-41. 2006..We also introduce how the concept of gene-gene interactions (biologic epistasis) and gene-environment interactions may affect the predisposition to PTB... - Fetal membrane inflammatory cytokines: a switching mechanism between the preterm premature rupture of the membranes and preterm labor pathwaysRamkumar Menon
The Perinatal Research Center, Women s Health Research and Education Foundation, University of Phoenix, Nashville Campus, Nashville, TN 37203, U S A
J Perinat Med 32:391-9. 2004..Inflammatory cytokines are involved in both preterm labor and preterm premature of the membranes pathways; however, the interaction between TNF-alpha and its receptors may dictate the clinical outcome of pregnancy... - A single-nucleotide polymorphism in the fetal catechol-O-methyltransferase gene is associated with spontaneous preterm birth in African AmericansChandrasekhar Thota
Department of Obstetrics and Gynecology, Center for Women s Health Research, Meharry Medical College, Nashville, TN 37208, USA
Reprod Sci 19:135-42. 2012..01) association between rs4818 and PTB. In conclusion, our study demonstrated that a synonymous polymorphism, rs4818 in the fetal COMT gene, is associated with PTB in AA... - Common polymorphisms in human lysyl oxidase genes are not associated with the adolescent idiopathic scoliosis phenotypeTracy L McGregor
Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
BMC Med Genet 12:92. 2011..We hypothesized that common polymorphisms in the five human lysyl oxidase genes (LOX, LOXL1, LOXL2, LOXL3, and LOXL4) may be associated with the phenotype of adolescent idiopathic scoliosis... - Infection and the role of inflammation in preterm premature rupture of the membranesRamkumar Menon
Perinatal Research Center of the Women s Health Research and Education Foundation, Centennial Medical Center, 2300 Patterson Street, Nashville, TN, USA
Best Pract Res Clin Obstet Gynaecol 21:467-78. 2007.... - Vitamin D elicits anti-inflammatory response, inhibits contractile-associated proteins, and modulates Toll-like receptors in human myometrial cellsChandrasekhar Thota
Department of Obstetrics and Gynecology, Center for Women s Health Research, Meharry Medical College, Nashville, TN 37208, USA
Reprod Sci 20:463-75. 2013..Our results suggest that vitamin D can potentially decrease infection-induced increases in cytokines and contractile-associated proteins in the myometrium... - The role of matrix degrading enzymes and apoptosis in rupture of membranesRamkumar Menon
The Perinatal Research Center of the Women's Health Research and Education Foundation and The University of Phoenix, Nashville Campus, Nashville, Tennessee, USA
J Soc Gynecol Investig 11:427-37. 2004.... - Polymorphisms in maternal and fetal genes encoding for proteins involved in extracellular matrix metabolism alter the risk for small-for-gestational-ageDigna R Velez Edwards
Department of Obstetrics and Gynecology, Vanderbilt Epidemiology Center, Institute of Medicine and Public Health, Vanderbilt University, Nashville, Tennessee, USA
J Matern Fetal Neonatal Med 24:362-80. 2011..To examine the association between maternal and fetal genetic variants and small-for-gestational-age (SGA)... - Primate-specific evolution of noncoding element insertion into PLA2G4C and human preterm birthJevon Plunkett
Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
BMC Med Genomics 3:62. 2010..We hypothesize that higher primate-specific gene evolution may lead to these differences and target genes involved in human preterm birth, an area of global health significance... - Proteinase activity in human and murine saliva as a biomarker for proteinase inhibitor efficacyBarbara Fingleton
Department of Cancer Biology, Vanderbilt University Medical Center, 771 PRB 2220 Pierce Avenue, Nashville, TN 37232-6840, USA
Clin Cancer Res 10:7865-74. 2004.... - Quantitation and localization of inflammatory cytokines interleukin-6 and interleukin-8 in the lower uterine segment during cervical dilatationBirgit Kemp
Department of Obstetrics and Gynecology, University Hospital, Technical University, Aachen, Germany
J Assist Reprod Genet 19:215-9. 2002..In situ hybridization localized IL-6 and IL-8 mRNA to the glandular epithelium. CONCLUSIONS: The increase in the inflammatory cytokines (IL-6 and IL-8) during parturition is associated with cervical effacement... - Single nucleotide polymorphisms in the human progesterone receptor gene and spontaneous preterm birth- Guoyang Luo
Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut, USA
Reprod Sci 15:147-55. 2008..5 kg/m(2) (relative risk, 10.8; 95% confidence interval, 1.4-82.6; P = .02). Maternal carriage of minor alleles of +331(G>A), +770(C>T), and +660(G> T) SNPs in the PR gene is not associated with spontaneous preterm birth...