KAMAL MEHTA

Summary

Affiliation: The Ohio State University
Country: USA

Publications

  1. pmc Critical role of diacylglycerol- and phospholipid-regulated protein kinase C epsilon in induction of low-density lipoprotein receptor transcription in response to depletion of cholesterol
    Kamal D Mehta
    Department of Molecular and Cellular Biochemistry, The Ohio State University College of Medicine, Columbus, Ohio 43210, USA
    Mol Cell Biol 22:3783-93. 2002
  2. ncbi request reprint Role of mitogen-activated protein kinases and protein kinase C in regulating low-density lipoprotein receptor expression
    Kamal D Mehta
    Department of Molecular and Cellular Biochemistry, Ohio State University College of Medicine and Public Health, Columbus 43210, USA
    Gene Expr 10:153-64. 2002
  3. ncbi request reprint pp90RSK- and protein kinase C-dependent pathway regulates p42/44MAPK-induced LDL receptor transcription in HepG2 cells
    Gurpreet S Kapoor
    Department of Molecular and Cellular Biochemistry, The Ohio State University College of Medicine and Public Health, 464 Hamilton Hall, 1645 Neil Ave, Columbus, OH 43210, USA
    J Lipid Res 44:584-93. 2003
  4. ncbi request reprint Activation of Raf-1/MEK-1/2/p42/44(MAPK) cascade alone is sufficient to uncouple LDL receptor expression from cell growth
    Gurpreet S Kapoor
    Department of Molecular and Cellular Biochemistry, The Ohio State University College of Medicine, Columbus 43210, USA
    Mol Cell Biochem 236:13-22. 2002
  5. ncbi request reprint Phorbol ester promotes histone H3-Ser10 phosphorylation at the LDL receptor promoter in a protein kinase C-dependent manner
    Wei Huang
    Department of Molecular and Cellular Biochemistry, The Ohio State University College of Medicine, Columbus, OH 43210, USA
    J Lipid Res 45:1519-27. 2004
  6. ncbi request reprint AICAR positively regulate glycogen synthase activity and LDL receptor expression through Raf-1/MEK/p42/44MAPK/p90RSK/GSK-3 signaling cascade
    Hsiang Ming Wang
    Department of Molecular and Cellular Biochemistry, The Dorothy M Davis Heart and Lung Research Institute, The Ohio State University College of Medicine, 464 Hamilton Hall, Columbus, OH 43210, United States
    Biochem Pharmacol 75:457-67. 2008
  7. pmc Selective repression of low-density lipoprotein receptor expression by SP600125: coupling of histone H3-Ser10 phosphorylation and Sp1 occupancy
    Wei Huang
    Department of Molecular and Cellular Biochemistry, The Ohio State University College of Medicine and Public Health, and The Dorothy M Davis Heart and Lung Research Institute, Columbus, OH 43210, USA
    Mol Cell Biol 26:1307-17. 2006
  8. ncbi request reprint Increases in intracellular calcium dephosphorylate histone H3 at serine 10 in human hepatoma cells: potential role of protein phosphatase 2A-protein kinase CbetaII complex
    Wei Huang
    Department of Molecular and Cellular Biochemistry, The Ohio State University College of Medicine and Public Health, Columbus, Ohio 43210, USA
    J Cell Physiol 205:37-46. 2005
  9. pmc Loss of protein kinase Cbeta function protects mice against diet-induced obesity and development of hepatic steatosis and insulin resistance
    Wei Huang
    Department of Molecular and Cellular Biochemistry, Dorothy M Davis Heart and Lung Research Institute, The Ohio State University College of Medicine, Columbus, OH 43210, USA
    Hepatology 49:1525-36. 2009
  10. ncbi request reprint Protein kinase C deficiency increases fatty acid oxidation and reduces fat storage
    Rishipal R Bansode
    Departments of Molecular and Cellular Biochemistry and Medicine, The Dorothy M Davis Heart and Lung Research Institute, The Ohio State University College of Medicine, 1645 Neil Avenue, Columbus, OH 43210, USA
    J Biol Chem 283:231-6. 2008

Collaborators

  • Anna Radominska-Pandya
  • Wei Huang
  • Gurpreet S Kapoor
  • Sanjay Batra
  • Madhu Mehta
  • Rishipal Bansode
  • Rishipal R Bansode
  • Hsiang Ming Wang
  • Vachaspati Mishra
  • Brett A Atkins
  • Sonya Mehta
  • Sanjit K Roy
  • V Mishra
  • Sasi Korrapati
  • Ishan Dillon
  • Carmen Golden
  • Brett Atkins

Detail Information

Publications10

  1. pmc Critical role of diacylglycerol- and phospholipid-regulated protein kinase C epsilon in induction of low-density lipoprotein receptor transcription in response to depletion of cholesterol
    Kamal D Mehta
    Department of Molecular and Cellular Biochemistry, The Ohio State University College of Medicine, Columbus, Ohio 43210, USA
    Mol Cell Biol 22:3783-93. 2002
    ....
  2. ncbi request reprint Role of mitogen-activated protein kinases and protein kinase C in regulating low-density lipoprotein receptor expression
    Kamal D Mehta
    Department of Molecular and Cellular Biochemistry, Ohio State University College of Medicine and Public Health, Columbus 43210, USA
    Gene Expr 10:153-64. 2002
    ..This information may also provide new strategies to modulate specific gene expression with the hope to develop novel therapies for the treatment of hypercholesterolemia...
  3. ncbi request reprint pp90RSK- and protein kinase C-dependent pathway regulates p42/44MAPK-induced LDL receptor transcription in HepG2 cells
    Gurpreet S Kapoor
    Department of Molecular and Cellular Biochemistry, The Ohio State University College of Medicine and Public Health, 464 Hamilton Hall, 1645 Neil Ave, Columbus, OH 43210, USA
    J Lipid Res 44:584-93. 2003
    ..These findings identify for the first time a role for PKC beta in determining the specificity of p42/44MAPK signaling by participating with pp90RSK in regulating gene expression...
  4. ncbi request reprint Activation of Raf-1/MEK-1/2/p42/44(MAPK) cascade alone is sufficient to uncouple LDL receptor expression from cell growth
    Gurpreet S Kapoor
    Department of Molecular and Cellular Biochemistry, The Ohio State University College of Medicine, Columbus 43210, USA
    Mol Cell Biochem 236:13-22. 2002
    ..Thus, extent of p42/44(MAPK) activation may be important in transducing divergent cellular responses in human cells with implications for altered signaling resulting in hypercholesterolemia...
  5. ncbi request reprint Phorbol ester promotes histone H3-Ser10 phosphorylation at the LDL receptor promoter in a protein kinase C-dependent manner
    Wei Huang
    Department of Molecular and Cellular Biochemistry, The Ohio State University College of Medicine, Columbus, OH 43210, USA
    J Lipid Res 45:1519-27. 2004
    ....
  6. ncbi request reprint AICAR positively regulate glycogen synthase activity and LDL receptor expression through Raf-1/MEK/p42/44MAPK/p90RSK/GSK-3 signaling cascade
    Hsiang Ming Wang
    Department of Molecular and Cellular Biochemistry, The Dorothy M Davis Heart and Lung Research Institute, The Ohio State University College of Medicine, 464 Hamilton Hall, Columbus, OH 43210, United States
    Biochem Pharmacol 75:457-67. 2008
    ..Collectively, these results highlight Raf-1 signaling cascade as the critical mediator of AICAR action on glucose and lipid metabolism in HepG2 cells...
  7. pmc Selective repression of low-density lipoprotein receptor expression by SP600125: coupling of histone H3-Ser10 phosphorylation and Sp1 occupancy
    Wei Huang
    Department of Molecular and Cellular Biochemistry, The Ohio State University College of Medicine and Public Health, and The Dorothy M Davis Heart and Lung Research Institute, Columbus, OH 43210, USA
    Mol Cell Biol 26:1307-17. 2006
    ....
  8. ncbi request reprint Increases in intracellular calcium dephosphorylate histone H3 at serine 10 in human hepatoma cells: potential role of protein phosphatase 2A-protein kinase CbetaII complex
    Wei Huang
    Department of Molecular and Cellular Biochemistry, The Ohio State University College of Medicine and Public Health, Columbus, Ohio 43210, USA
    J Cell Physiol 205:37-46. 2005
    ....
  9. pmc Loss of protein kinase Cbeta function protects mice against diet-induced obesity and development of hepatic steatosis and insulin resistance
    Wei Huang
    Department of Molecular and Cellular Biochemistry, Dorothy M Davis Heart and Lung Research Institute, The Ohio State University College of Medicine, Columbus, OH 43210, USA
    Hepatology 49:1525-36. 2009
    ....
  10. ncbi request reprint Protein kinase C deficiency increases fatty acid oxidation and reduces fat storage
    Rishipal R Bansode
    Departments of Molecular and Cellular Biochemistry and Medicine, The Dorothy M Davis Heart and Lung Research Institute, The Ohio State University College of Medicine, 1645 Neil Avenue, Columbus, OH 43210, USA
    J Biol Chem 283:231-6. 2008
    ..The ability of PKCbeta deficiency to promote fat burning in adipocytes may suggest novel therapeutic strategies for obesity and obesity-related disorders...

Research Grants2

  1. Mechanisms of p42/44MAPK-induced LDL receptor expression
    KAMAL MEHTA; Fiscal Year: 2004
    ..This knowledge could be exploited to develop improved hypercholesterolemia therapies and to reduce foam cell formation. ..
  2. Molecular Mechanism of Protein Kinase Cbeta-Mediated Cholesterol Homeostasis
    Kamal D Mehta; Fiscal Year: 2010
    ..The greatest potential for arresting this epidemic is likely to come through a clearer understanding of its molecular pathogenesis to develop rational and mechanism based therapy. ..