L Jeffrey Medeiros

Summary

Affiliation: The University of Texas
Country: USA

Publications

  1. ncbi Oncocytoid renal cell carcinoma after neuroblastoma: a report of four cases of a distinct clinicopathologic entity
    L J Medeiros
    Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Am J Surg Pathol 23:772-80. 1999
  2. ncbi Z-138 cell line was derived from a patient with blastoid variant mantle cell lymphoma
    L Jeffrey Medeiros
    Department of Hematopathology, Box 72, M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA
    Leuk Res 30:497-501. 2006
  3. ncbi Expression of eukaryotic initiation factor 4E predicts clinical outcome in patients with mantle cell lymphoma treated with hyper-CVAD and rituximab, alternating with rituximab, high-dose methotrexate, and cytarabine
    Kedar V Inamdar
    Department of Hematopathology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 115:4727-36. 2009
  4. ncbi Inhibition of heat shock protein 90 function by 17-allylamino-17-demethoxy-geldanamycin in Hodgkin's lymphoma cells down-regulates Akt kinase, dephosphorylates extracellular signal-regulated kinase, and induces cell cycle arrest and cell death
    Georgios V Georgakis
    Department of Lymphoma and Myeloma, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Clin Cancer Res 12:584-90. 2006
  5. ncbi Chronic lymphocytic leukemia With t(2;14)(p16;q32) involves the BCL11A and IgH genes and is associated with atypical morphologic features and unmutated IgVH genes
    C Cameron Yin
    Department of Hematopathology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Am J Clin Pathol 131:663-70. 2009
  6. ncbi c-Jun expression and activation are restricted to CD30+ lymphoproliferative disorders
    Elias Drakos
    Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Am J Surg Pathol 31:447-53. 2007
  7. ncbi EBV-associated B- and T-cell posttransplant lymphoproliferative disorders following primary EBV infection in a kidney transplant recipient
    C Cameron Yin
    Department of Hematopathology, University of Texas M.D. Anderson Cancer Center, Houston 77030, USA
    Am J Clin Pathol 123:222-8. 2005
  8. ncbi Morphologic, cytogenetic, and molecular abnormalities in therapy-related acute promyelocytic leukemia
    C Cameron Yin
    Department of Hematopathology, The University of Texas M.D. Anderson Cancer Center, Houston, USA
    Am J Clin Pathol 123:840-8. 2005
  9. ncbi Comparative analysis of genes regulated in acute myelomonocytic leukemia with and without inv(16)(p13q22) using microarray techniques, real-time PCR, immunohistochemistry, and flow cytometry immunophenotyping
    Xiaoping Sun
    Division of Pathology and Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Mod Pathol 20:811-20. 2007
  10. ncbi HDM4 is overexpressed in mantle cell lymphoma and its inhibition induces p21 expression and apoptosis
    Mei Liang
    Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Mod Pathol 23:381-91. 2010

Collaborators

Detail Information

Publications117 found, 100 shown here

  1. ncbi Oncocytoid renal cell carcinoma after neuroblastoma: a report of four cases of a distinct clinicopathologic entity
    L J Medeiros
    Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Am J Surg Pathol 23:772-80. 1999
    ..In aggregate, these findings are distinctive, are not found in known types of RCC, and support the morphologic impression that oncocytoid RCC after neuroblastoma is a distinct clinicopathologic entity...
  2. ncbi Z-138 cell line was derived from a patient with blastoid variant mantle cell lymphoma
    L Jeffrey Medeiros
    Department of Hematopathology, Box 72, M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA
    Leuk Res 30:497-501. 2006
    ..According to the criteria of the current World Health Organization lymphoma classification, this neoplasm is best classified as mantle cell lymphoma, with blastoid transformation present in the terminal phase of disease...
  3. ncbi Expression of eukaryotic initiation factor 4E predicts clinical outcome in patients with mantle cell lymphoma treated with hyper-CVAD and rituximab, alternating with rituximab, high-dose methotrexate, and cytarabine
    Kedar V Inamdar
    Department of Hematopathology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 115:4727-36. 2009
    ..However, the clinical significance of eIF4E expression in MCL is unknown...
  4. ncbi Inhibition of heat shock protein 90 function by 17-allylamino-17-demethoxy-geldanamycin in Hodgkin's lymphoma cells down-regulates Akt kinase, dephosphorylates extracellular signal-regulated kinase, and induces cell cycle arrest and cell death
    Georgios V Georgakis
    Department of Lymphoma and Myeloma, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Clin Cancer Res 12:584-90. 2006
    ....
  5. ncbi Chronic lymphocytic leukemia With t(2;14)(p16;q32) involves the BCL11A and IgH genes and is associated with atypical morphologic features and unmutated IgVH genes
    C Cameron Yin
    Department of Hematopathology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Am J Clin Pathol 131:663-70. 2009
    ..We conclude that CLL/SLL with t(2;14) (p16;q32) and BCL11A/IgH rearrangement is characterized by atypical morphologic features and unmutated IgV(H) genes...
  6. ncbi c-Jun expression and activation are restricted to CD30+ lymphoproliferative disorders
    Elias Drakos
    Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Am J Surg Pathol 31:447-53. 2007
    ..We conclude that CD30 lymphomas are characterized by common patterns of c-Jun expression and activation suggesting a potential role of c-Jun in the pathogenesis of these tumors...
  7. ncbi EBV-associated B- and T-cell posttransplant lymphoproliferative disorders following primary EBV infection in a kidney transplant recipient
    C Cameron Yin
    Department of Hematopathology, University of Texas M.D. Anderson Cancer Center, Houston 77030, USA
    Am J Clin Pathol 123:222-8. 2005
    ..To our knowledge, only 4 cases of both B-cell and T-cell PTLDs have been reported. Only 2 cases have been proven to be monoclonal and EBV-associated, as in this case, the first following kidney transplantation...
  8. ncbi Morphologic, cytogenetic, and molecular abnormalities in therapy-related acute promyelocytic leukemia
    C Cameron Yin
    Department of Hematopathology, The University of Texas M.D. Anderson Cancer Center, Houston, USA
    Am J Clin Pathol 123:840-8. 2005
    ..Mutations of the flt3 gene were detected by PCR in 5 (42%) of 12 cases. We conclude that dysplastic features, secondary cytogenetic abnormalities, and flt3 mutations are common in tAPL...
  9. ncbi Comparative analysis of genes regulated in acute myelomonocytic leukemia with and without inv(16)(p13q22) using microarray techniques, real-time PCR, immunohistochemistry, and flow cytometry immunophenotyping
    Xiaoping Sun
    Division of Pathology and Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Mod Pathol 20:811-20. 2007
    ..These findings most likely represent the functional consequences of the abnormal chimeric protein CBFbeta-MYH11, which is unique to this disease, and suggest that NF-kappaB is a potential therapeutic target for treating M4Eo patients...
  10. ncbi HDM4 is overexpressed in mantle cell lymphoma and its inhibition induces p21 expression and apoptosis
    Mei Liang
    Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Mod Pathol 23:381-91. 2010
    ..Inhibition of HDM4 may serve as a potential approach in the design of therapy for patients with mantle cell lymphoma...
  11. ncbi Selective inhibition of STAT3 induces apoptosis and G(1) cell cycle arrest in ALK-positive anaplastic large cell lymphoma
    Hesham M Amin
    Department of Hematopathology, Box 72, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Oncogene 23:5426-34. 2004
    ..These results support the concept that STAT3 activation is pathogenetically important in ALCL cells by deregulating the expression of multiple target proteins that are involved in the control of apoptosis and cell cycle progression...
  12. ncbi Activation of mammalian target of rapamycin signaling pathway contributes to tumor cell survival in anaplastic lymphoma kinase-positive anaplastic large cell lymphoma
    Francisco Vega
    Department of Hematopathology, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Cancer Res 66:6589-97. 2006
    ..These findings suggest that the mTOR pathway contributes to nucleophosmin-ALK/PI3K/AKT-mediated tumorigenesis and that inhibition of mTOR represents a potential therapeutic strategy in ALK+ ALCL...
  13. ncbi Expression of serine 194-phosphorylated Fas-associated death domain protein correlates with proliferation in B-cell non-Hodgkin lymphomas
    Elias Drakos
    Department of Hematopathology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Hum Pathol 42:1117-24. 2011
    ..9, P < .0001). These data provide evidence that serine 194 phosphorylated Fas-associated death domain protein is involved in the proliferation of normal and neoplastic B cells and has features of a novel proliferation marker...
  14. ncbi Immunophenotypic heterogeneity of normal plasma cells: comparison with minimal residual plasma cell myeloma
    Dingsheng Liu
    Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    J Clin Pathol 65:823-9. 2012
    ..With advances in multicolour flow cytometry and application of recently validated markers, PCM MRD may still be reliably distinguished from non-neoplastic plasma cells...
  15. ncbi Nodular lymphocyte predominant Hodgkin lymphoma with clusters of LP Cells, acute inflammation, and fibrosis: a syncytial variant
    Elias Drakos
    Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Am J Surg Pathol 33:1725-31. 2009
    ..Recognition of this rare variant, facilitated by immunohistochemical studies in this case, further expands the morphologic spectrum of NLPHL...
  16. ncbi Lymphoid neoplasms associated with concurrent t(14;18) and 8q24/c-MYC translocation generally have a poor prognosis
    Anuradha Kanungo
    Department of Hematopathology, The University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA
    Mod Pathol 19:25-33. 2006
    ..However, this combination of molecular abnormalities can also rarely occur in other neoplasms, such as the cases of low-grade B-cell lymphoma and plasmablastic myeloma in this study...
  17. ncbi Proliferation predicts failure-free survival in mantle cell lymphoma patients treated with rituximab plus hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone alternating with rituximab plus high-dose methotrexate and cytarabine
    Mar Garcia
    Department of Hematopathology, Box 72, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Cancer 115:1041-8. 2009
    ....
  18. ncbi Benefit of consolidative radiation therapy in patients with diffuse large B-cell lymphoma treated with R-CHOP chemotherapy
    Jack Phan
    The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    J Clin Oncol 28:4170-6. 2010
    ..The role of consolidative radiation therapy (RT) in the setting of R-CHOP chemotherapy is not well reported. This retrospective analysis is an attempt to clarify this role...
  19. ncbi Sonic hedgehog signaling proteins and ATP-binding cassette G2 are aberrantly expressed in diffuse large B-cell lymphoma
    Ji Eun Kim
    Department of Hematopathology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Mod Pathol 22:1312-20. 2009
    ..These findings also provide evidence that dysregulation of the SHH pathway may be involved in the pathogenesis of diffuse large B-cell lymphoma...
  20. ncbi Cytoplasmic localization of nucleophosmin in bone marrow blasts of acute myeloid leukemia patients is not completely concordant with NPM1 mutation and is not predictive of prognosis
    Sergej Konoplev
    Department of Hematopathology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 115:4737-44. 2009
    ..Nucleophosmin (NPM1) gene mutations are reported to predict a favorable prognosis in acute myeloid leukemia (AML) patients. Aberrant cytoplasmic localization of nucleophosmin (NPM) protein is reported be a surrogate for NPM1 gene mutation...
  21. ncbi Side population of a murine mantle cell lymphoma model contains tumour-initiating cells responsible for lymphoma maintenance and dissemination
    Francisco Vega
    Department of Hematopathology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Cell Mol Med 14:1532-45. 2010
    ....
  22. ncbi High rate of durable remissions after treatment of newly diagnosed aggressive mantle-cell lymphoma with rituximab plus hyper-CVAD alternating with rituximab plus high-dose methotrexate and cytarabine
    Jorge E Romaguera
    Department of Lymphoma, Unit 429, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Clin Oncol 23:7013-23. 2005
    ..To determine the response, failure-free survival (FFS), and overall survival rates and toxicity of rituximab plus an intense chemotherapy regimen in patients with previously untreated aggressive mantle-cell lymphoma (MCL)...
  23. ncbi The helix-loop-helix protein Id2 is expressed differentially and induced by myc in T-cell lymphomas
    Claudiu V Cotta
    Department of Hematopathology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 112:552-61. 2008
    ..Recent studies have shown that Id2 is overexpressed in some types of B-cell lymphoma, including classical Hodgkin lymphoma. The authors of the current study hypothesized that Id2 also is overexpressed in T-cell lymphomas...
  24. ncbi A pathway-based gene signature correlates with therapeutic response in adult patients with Philadelphia chromosome-positive acute lymphoblastic leukemia
    Zhuang Zuo
    Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Mod Pathol 23:1524-34. 2010
    ..This unique 9-gene signature may better enable stratification of patients to proper therapeutic regimens and provides new insights into mechanisms of Ph+ ALL response to therapy...
  25. ncbi Differential expression and clinical significance of tyrosine-phosphorylated STAT3 in ALK+ and ALK- anaplastic large cell lymphoma
    Joseph D Khoury
    Department of Hematopathology, University of Texas, M. D. Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 9:3692-9. 2003
    ..CONCLUSIONS: STAT3 activation correlates with but is not strictly dependent on ALK expression in ALCL. Lack of STAT3 activation appears to correlate with a favorable clinical outcome in ALCL...
  26. ncbi Precursor B-acute lymphoblastic leukemia occurring in patients with a history of prior malignancies: is it therapy-related?
    Guilin Tang
    Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Haematologica 97:919-25. 2012
    ..Precursor B-acute lymphoblastic leukemia occurring in patients with a history of malignancies is uncommon, and this condition is not well understood...
  27. ncbi Phosphorylated CXCR4 is associated with poor survival in adults with B-acute lymphoblastic leukemia
    Sergej Konoplev
    Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, USA
    Cancer 117:4689-95. 2011
    ..Data regarding the prognostic impact of CXCR4 in patients with B-acute lymphoblastic leukemia (B-ALL) are sparse and limited to the pediatric population...
  28. ncbi NPM-ALK oncogenic kinase promotes cell-cycle progression through activation of JNK/cJun signaling in anaplastic large-cell lymphoma
    Vasiliki Leventaki
    Department of Hematopathology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Blood 110:1621-30. 2007
    ..Taken together, these findings reveal a novel function of NPM-ALK, phosphorylation and activation of JNK and cJun, which may contribute to uncontrolled cell-cycle progression and oncogenesis...
  29. ncbi The HSP90 inhibitor 17-AAG synergizes with doxorubicin and U0126 in anaplastic large cell lymphoma irrespective of ALK expression
    Georgios V Georgakis
    Departments of Lymphoma and Myeloma, The University of Texas, M.D. Anderson Cancer Center, Houston, TX 77030, USA
    Exp Hematol 34:1670-9. 2006
    ..CONCLUSION: Our data demonstrate that targeting HSP90 function by 17-AAG may offer a novel therapeutic strategy for ALCL, either as single-agent activity or by combining 17-AAG with conventional or targeted therapeutic schemes...
  30. ncbi Inhibition of Akt increases p27Kip1 levels and induces cell cycle arrest in anaplastic large cell lymphoma
    George Z Rassidakis
    Department of Hematopathology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Blood 105:827-9. 2005
    ..0076). These findings implicate that Akt activation promotes cell cycle progression through inactivation of p27 in ALCL...
  31. ncbi Elevated serum levels of IL-10 are associated with inferior progression-free survival in patients with Hodgkin's disease treated with radiotherapy
    Carlo Visco
    Department of Lymphoma and Myeloma, University of Texas, MD Anderson Cancer Center, Houston, USA
    Leuk Lymphoma 45:2085-92. 2004
    ..0001). In conclusion, high serum IL-10 is independently associated with inferior PFS in patients with HD treated with RT...
  32. ncbi Translocation (3;8)(q26;q24): a recurrent chromosomal abnormality in myelodysplastic syndrome and acute myeloid leukemia
    Pei Lin
    Department of Hematopathology, M D Anderson Cancer Center, Box 72, The University of Texas, Houston, TX 77030, USA
    Cancer Genet Cytogenet 166:82-5. 2006
    ..We conclude that the t(3;8)(q26;q24) is a recurrent translocation associated with therapy-related MDS/AML or de novo AML, and is frequently associated with monosomy 7...
  33. ncbi The t(14;19)(q32;q13)-positive small B-cell leukaemia: a clinicopathologic and cytogenetic study of seven cases
    Yang O Huh
    Department of Hematopathology, MD Anderson Cancer Centre, The University of Texas, Houston, TX 77030, USA
    Br J Haematol 136:220-8. 2007
    ..However, these neoplasms also differ from CLL cytologically and in their immunophenotype...
  34. ncbi Intrinsic apoptotic pathway in anaplastic large cell lymphoma
    Mauricio P Oyarzo
    Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Hum Pathol 37:874-82. 2006
    ..In conclusion, chemotherapy-induced cell death in ALK+ ALCL cells involves the intrinsic apoptotic pathway, and apoptosome function may be an important determinant of apoptosis in ALCL tumors...
  35. ncbi Aberrant EVI1 expression in acute myeloid leukemias associated with the t(3;8)(q26;q24)
    Patrick A Lennon
    School of Health Sciences, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, Texas 77030, USA
    Cancer Genet Cytogenet 177:37-42. 2007
    ..Western blot analysis detected EVI1 in one case analyzed. We conclude that the t(3;8)(q26;q24) results in deregulated EVI1 expression, similar to other balanced or unbalanced chromosomal translocations involving chromosome 3q26...
  36. ncbi Residual monotypic plasma cells in patients with waldenstrom macroglobulinemia after therapy
    Fareed H Barakat
    Dept of Hematopathology, The University of Texas M D Anderson Cancer Center, Houston, 77030, USA
    Am J Clin Pathol 135:365-73. 2011
    ..This finding has implications for the immunophenotypic assessment of WM after therapy and may explain persistent IgM paraproteinemia in patients with WM with no evidence of a clonal B-lymphocyte population...
  37. ncbi Immunohistochemical detection of ZAP70 in chronic lymphocytic leukemia predicts immunoglobulin heavy chain gene mutation status and time to progression
    Joan H Admirand
    Department of Hematopathology, University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Mod Pathol 23:1518-23. 2010
    ..03). These results show that ZAP70 expression assessed by immunohistochemistry is a reliable surrogate marker of the somatic mutation status of the IGHV genes, and predicts time to progression...
  38. ncbi Apoptotic rate in peripheral T-cell lymphomas. A study using a tissue microarray with validation on full tissue sections
    George Z Rassidakis
    Department of Hematopathology, University of Texas M.D. Anderson Cancer Center, Houston 77030, USA
    Am J Clin Pathol 118:328-34. 2002
    ..We conclude that the highest ARs in PTCLs are found in enteropathy-type T-cell lymphoma and ALK-positive ALCL, and that AR can be assessed reliably by using a tissue microarray...
  39. ncbi Pure erythroid leukemia: a reassessment of the entity using the 2008 World Health Organization classification
    Wei Liu
    Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030 4009, USA
    Mod Pathol 24:375-83. 2011
    ..These new assigned categories fail to capture the distinct features of PEL, where the phenotype of PEL correlates with a very complex karyotype and an extremely aggressive clinical course...
  40. ncbi Acute myeloid leukemia with t(6;9)(p23;q34) is associated with dysplasia and a high frequency of flt3 gene mutations
    Mauricio P Oyarzo
    Department of Hematopathology, The University of Texas M.D. Anderson Cancer Center, Houston 77030, USA
    Am J Clin Pathol 122:348-58. 2004
    ..We conclude that t(6;9)-positive AML cases have distinctive morphologic features, an immunophenotype suggesting origin from an early hematopoietic progenitor cell, and a high frequency of flt3 gene mutations...
  41. ncbi Dicarbonyl/L-xylulose reductase: a potential biomarker identified by laser-capture microdissection-micro serial analysis of gene expression of human prostate adenocarcinoma
    Jeong Hee Cho-Vega
    Department of Pathology, The Methodist Hospital, Houston, TX, USA
    Cancer Epidemiol Biomarkers Prev 16:2615-22. 2007
    ..In all samples, the stromal cells were completely devoid of DCXR expression. Based on these findings, we suggest that DCXR overexpression has the potential to be an additional useful biomarker for prostate cancer...
  42. ncbi Nuclear BCL-10 expression is common in lymphoplasmacytic lymphoma/Waldenström macroglobulinemia and does not correlate with p65 NF-kappaB activation
    Mihai Merzianu
    Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Mod Pathol 19:891-8. 2006
    ..These results indicate that nuclear BCL-10 expression is common in LPL/WM and does not correlate with MALT lymphoma-associated translocations or p65 NF-kappaB nuclear staining...
  43. ncbi Eight-year experience with allogeneic stem cell transplantation for relapsed follicular lymphoma after nonmyeloablative conditioning with fludarabine, cyclophosphamide, and rituximab
    Issa F Khouri
    Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Blood 111:5530-6. 2008
    ..Only 5 patients were still undergoing immunosuppressive therapy at the time of last follow-up. We believe that the described results are a step forward toward developing a curative strategy for recurrent follicular lymphoma...
  44. ncbi Clusterin expression correlates with stage and presence of large cells in mycosis fungoides
    Pranil Chandra
    Department of Hematopathology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Box 85, Houston, TX 77030, USA
    Am J Clin Pathol 131:511-5. 2009
    ..Clusterin expression was not specific for MF as it also was positive in 3 of 3 cases of LyP, 2 of 2 systemic ALCL cases involving skin, 7 of 16 cutaneous ALCLs, and 1 of 6 PTCLs...
  45. ncbi Sonic hedgehog signaling pathway is activated in ALK-positive anaplastic large cell lymphoma
    Rajesh R Singh
    Department of Hematopathology and School of Health Sciences, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Cancer Res 69:2550-8. 2009
    ..There is a positive synergistic effect between the SHH/GLI1 and PI3K/AKT pathways that contributes to the lymphomagenic effect of NPM-ALK...
  46. ncbi De novo acute myeloid leukemia with inv(3)(q21q26.2) or t(3;3)(q21;q26.2): a clinicopathologic and cytogenetic study of an entity recently added to the WHO classification
    Jianlan Sun
    Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Mod Pathol 24:384-9. 2011
    ..Allogeneic stem cell transplantation seems to improve outcome in patients with this disease...
  47. ncbi Differential expression of cyclin D3 in ALK+ and ALK- anaplastic large cell lymphoma
    Rory R Dalton
    Department of Hematopathology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Hum Pathol 36:806-11. 2005
    ..35, P = .036). We conclude that cyclin D3 is differentially expressed in ALK+ and ALK- ALCL and that high expression levels of cyclin D3 in ALK+ ALCL may be attributable to STAT3 activation...
  48. ncbi Aurora-A kinase nuclear expression in chronic lymphocytic leukemia
    Kedar V Inamdar
    Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Mod Pathol 21:1428-35. 2008
    ..Thus, Aurora-A kinase overexpression in chronic lymphocytic leukemia may be involved in the genesis of chromosomal abnormalities and is a potential target for therapeutic intervention...
  49. ncbi Characterization of 4 mantle cell lymphoma cell lines
    Hesham M Amin
    Department of Hematopathology, The University of Texas M. D. Anderson Cancer Center, Houston 77030, USA
    Arch Pathol Lab Med 127:424-31. 2003
    ..The susceptibility of these cell lines to gene transfer provides opportunities to evaluate the importance of various oncogenes and tumor suppressor genes that may have an impact on developing effective therapeutic regimens for MCL...
  50. ncbi Rapid and reliable confirmation of acute promyelocytic leukemia by immunofluorescence staining with an antipromyelocytic leukemia antibody: the M. D. Anderson Cancer Center experience of 349 patients
    Nikolay D Dimov
    Department of Hematopathology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 116:369-76. 2010
    ....
  51. ncbi MALT1 gene rearrangements and NF-kappaB activation involving p65 and p50 are absent or rare in primary MALT lymphomas of the breast
    Sameer S Talwalkar
    Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Mod Pathol 19:1402-8. 2006
    ..In contrast, breast diffuse large B-cell lymphomas are heterogeneous. Weak cytoplasmic BCL-10 staining in most cases and evidence of NF-kappaB p50 activation in a subset differs from breast MALT lymphomas...
  52. ncbi Angioimmunoblastic T-cell lymphoma in bone marrow: a morphologic and immunophenotypic study
    Faisal A Khokhar
    Department of Hematopathology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Hum Pathol 41:79-87. 2010
    ..By contrast, programed death-1 immunohistochemical staining and double labeling using antibodies specific for BCL-6 and CD3 were helpful in appreciating the follicular T-helper cell immunophenotype of angioimmunoblastic T-cell lymphoma...
  53. ncbi Expression of Mcl-1 in mantle cell lymphoma is associated with high-grade morphology, a high proliferative state, and p53 overexpression
    Joseph D Khoury
    Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston 77030, USA
    J Pathol 199:90-7. 2003
    ..002). It is concluded that expression of Mcl-1 in MCL is heterogeneous. A relatively high level of Mcl-1 expression correlates with high-grade morphology, a high proliferative state, and p53 overexpression...
  54. ncbi Activation of mammalian target of rapamycin signaling promotes cell cycle progression and protects cells from apoptosis in mantle cell lymphoma
    Evangelia Peponi
    Department of Hematopathology, Unit 72, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Am J Pathol 169:2171-80. 2006
    ..These findings suggest that the mTOR signaling pathway is activated and may contribute to cell cycle progression and tumor cell survival in MCL...
  55. ncbi Cuplike nuclei (prominent nuclear invaginations) in acute myeloid leukemia are highly associated with FLT3 internal tandem duplication and NPM1 mutation
    Weina Chen
    Department of Pathology, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA
    Cancer 115:5481-9. 2009
    ..A small subset of patients with acute myeloid leukemia (AML) have cuplike nuclei. Other investigators have demonstrated that these neoplasms have distinctive clinicopathologic and molecular features...
  56. ncbi Sequence analysis proves clonal identity in five patients with typical and blastoid mantle cell lymphoma
    C Cameron Yin
    Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Mod Pathol 20:1-7. 2007
    ..These results support the concept that blastoid MCL arising in patients with typical MCL represents histologic transformation of the original neoplastic clone...
  57. ncbi Constitutive BR3 receptor signaling in diffuse, large B-cell lymphomas stabilizes nuclear factor-κB-inducing kinase while activating both canonical and alternative nuclear factor-κB pathways
    Lan V Pham
    Department of Hematopathology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Blood 117:200-10. 2011
    ..These results further elucidate mechanisms involved in abnormal NF-κB activation in DLBCL, and should contribute to better future therapeutic approaches for patients with DLBCL...
  58. ncbi T-cell prolymphocytic leukemia involving extramedullary sites
    Jose R Valbuena
    Department of Hematopathology, The University of Texas M.D. Anderson Cancer Center, Houston 77030, USA
    Am J Clin Pathol 123:456-64. 2005
    ..We conclude that the prolymphocytoid features of T-PLL cells can be difficult to detect in routinely stained sections of extramedullary biopsy specimens. TCL-1 expression can aid in diagnosis at extramedullary sites...
  59. ncbi Outcome of patients with diffuse large B-cell lymphoma of the testis by era of treatment: the M. D. Anderson Cancer Center experience
    Ali Mazloom
    Division of Epidemiology, The University of Texas School of Public Health, Houston, TX 77030, USA
    Leuk Lymphoma 51:1217-24. 2010
    ..019 for OS and p = 0.138 for PFS). Advanced stage, elevated serum LDH, B-symptoms, and high IPI are poor prognostic markers. R-CHOP based chemotherapy with intrathecal chemotherapy and scrotal RT is associated with an improved OS...
  60. ncbi Survivin expression predicts poorer prognosis in anaplastic large-cell lymphoma
    Ellen J Schlette
    Department of Hematopathology, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA
    J Clin Oncol 22:1682-8. 2004
    ..Modulation of survivin expression or function may provide a novel target for experimental therapy in patients with ALCL...
  61. ncbi Acute erythroid leukemia as defined in the World Health Organization classification is a rare and pathogenetically heterogeneous disease
    Armen Kasyan
    Department of Hematopathology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Mod Pathol 23:1113-26. 2010
    ..The prognosis of this patient subset is relatively good. The other subset has cytogenetic abnormalities similar to those in myelodysplastic syndromes and a poor prognosis...
  62. ncbi Lymphomas involving the pleura: a clinicopathologic study of 34 cases diagnosed by pleural biopsy
    Francisco Vega
    Department of Hematopathology, The University of Texas M.D. Anderson Cancer Center, Houston, Tex 77030, USA
    Arch Pathol Lab Med 130:1497-502. 2006
    ..The most frequent type is diffuse large B-cell lymphoma, followed by follicular lymphoma. Cytologic examination can have negative results in patients with pleural involvement by lymphoma...
  63. ncbi Peripheral T-cell lymphoma with a "follicular" pattern and the perifollicular sinus phenotype
    Liuyan Jiang
    Department of Pathology and Laboratory Medicine, The University of Texas-Houston Medical School, Houston, USA
    Am J Clin Pathol 123:448-55. 2005
    ..We suggest that the follicular growth pattern in this case of PTCL arose secondarily to tumor spread via the perifollicular sinus...
  64. ncbi Activating FLT3 mutations are detectable in chronic and blast phase of chronic myeloproliferative disorders other than chronic myeloid leukemia
    Pei Lin
    Department of Hematopathology, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA
    Am J Clin Pathol 126:530-3. 2006
    ..By contrast, no FLT3 mutations were detected in CML, including 108 chronic and 11 blast phase cases. FLT3 mutations occur in approximately 10% of CMPD and CMPD/MDS but are not observed in JAK2+ CMPD or in CML...
  65. ncbi Differential expression of CKS-1B in typical and blastoid variants of mantle cell lymphoma
    Nalan Akyurek
    Department of Hematopathology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Hum Pathol 41:1448-55. 2010
    ..We conclude that CKS-1B is commonly expressed in mantle cell lymphoma, particularly in aggressive histologic variants, and may be involved in pathogenesis...
  66. ncbi Inhibition of the phosphatidylinositol-3 kinase/Akt promotes G1 cell cycle arrest and apoptosis in Hodgkin lymphoma
    Georgios V Georgakis
    Department of Lymphoma and Myeloma, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA
    Br J Haematol 132:503-11. 2006
    ..Our data suggest that PTEN phosphorylation and activation of CD30, CD40 and RANK may play a role in activating Akt in HRS cells...
  67. ncbi MCL-1 expression in B-cell non-Hodgkin's lymphomas
    Jeong Hee Cho-Vega
    Department of Pathology, University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA
    Hum Pathol 35:1095-100. 2004
    ..MCL-1 expression also correlates with grade and may contribute to transformation in follicular lymphomas...
  68. ncbi TCL1 expression in plasmacytoid dendritic cells (DC2s) and the related CD4+ CD56+ blastic tumors of skin
    Marco Herling
    Department of Hematopathology, University of Texas MD Anderson Cancer Center, Houston 77030, USA
    Blood 101:5007-9. 2003
    ..These results further support derivation of BTs from DC2s, and demonstrate that TCL1 expression in this tumor is common to the immature blastoid, lymphoid-appearing, and subsequent myelomonocytic phases of this disease...
  69. ncbi Biological validation of differentially expressed genes in chronic lymphocytic leukemia identified by applying multiple statistical methods to oligonucleotide microarrays
    Lynne V Abruzzo
    Department of Hematopathology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, USA
    J Mol Diagn 7:337-45. 2005
    ..A comprehensive list of all differentially expressed genes can only be obtained by combining the results of multiple statistical tests...
  70. ncbi Mantle cell lymphoma involving skin: cutaneous lesions may be the first manifestation of disease and tumors often have blastoid cytologic features
    Filiz Sen
    Division of Pathology and Loboratory Medicine, University of Texas M.D. Anderson Center, Houston, Texas 77030, USA
    Am J Surg Pathol 26:1312-8. 2002
    ..We conclude that mantle cell lymphoma can involve skin, usually as a manifestation of disseminated disease, and is often associated with blastoid cytologic features. Rare cases of mantle cell lymphoma may arise in skin...
  71. ncbi CD20 expression in Hodgkin and Reed-Sternberg cells of classical Hodgkin's disease: associations with presenting features and clinical outcome
    George Z Rassidakis
    Department of Lymphoma-Myeloma, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA
    J Clin Oncol 20:1278-87. 2002
    ..CONCLUSION: CD20 is expressed by HRS cells in 22% of patients with classical HD but is not associated with different FFS after treatment with equivalent regimens...
  72. ncbi Acute lymphoblastic leukemia in elderly patients the Philadelphia chromosome may not be a significant adverse prognostic factor
    Mihaela Onciu
    Department of Hematopathology, University of Taxas M. D. Anderson Cancer Center, Houston 77030, USA
    Am J Clin Pathol 117:716-20. 2002
    ..Ph+ and Ph- groups did not differ significantly in median survival (13.4 months vs 19.0 months) or other variables studied. The Ph may not be a significant adverse prognostic factor in ALL in elderly patients...
  73. ncbi Determination of cyclin D1 and CD20 mRNA levels by real-time quantitative RT-PCR from archival tissue sections of mantle cell lymphoma and other non-Hodgkin's lymphomas
    Vilmos A Thomazy
    Department of Pathology and Laboratory Medicine, The University of Texas Houston Medical School, Houston, USA
    J Mol Diagn 4:201-8. 2002
    ..Normalization of cyclin D1 to a B-cell-specific marker more accurately reflects overexpression by MCL than other methods that normalize using constitutively expressed mRNA species...
  74. ncbi Quantitative PCR detection of t(14;18) bcl-2/JH fusion sequences in follicular lymphoma patients: comparison of peripheral blood and bone marrow aspirate samples
    Alex Bowman
    Department of Hematopathology, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77054, USA
    J Mol Diagn 6:396-400. 2004
    ....
  75. ncbi Precursor T-cell acute lymphoblastic leukemia in adults: age-related immunophenotypic, cytogenetic, and molecular subsets
    Mihaela Onciu
    Department of Hematopathology, The University of Texas M.D. Anderson Cancer Center, Houston 77030, USA
    Am J Clin Pathol 117:252-8. 2002
    ..Within this group, CD1a expression correlated with age 28 to 60 years. These results illustrate considerable age-related heterogeneity in adult T-ALL, which may reflect differences in tumor cell maturation...
  76. ncbi Primary T-cell lymphoblastic lymphoma of the cavernous sinus
    Sarfaraz Sadruddin
    Departments of Neurosurgery and Hematopathology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Neurosurg Pediatr 5:94-7. 2010
    ..The patient achieved complete remission and is currently completing the 2-year maintenance phase of chemotherapy...
  77. ncbi Discrepancies in the immunophenotype of lymphoma cells in samples obtained simultaneously from different anatomic sites
    Mihaela Onciu
    Department of Hematopathology, University of Texas, M.D. Anderson Cancer Center, Houston 77030, USA
    Am J Clin Pathol 117:644-50. 2002
    ..Differences in immunophenotype may relate to mechanisms of disease dissemination, influence of the microenvironment, or differential response to therapy...
  78. ncbi Quantitative real-time polymerase chain reaction for monitoring minimal residual disease in patients with advanced indolent lymphomas treated with rituximab, fludarabine, mitoxantrone, and dexamethasone
    Andreas H Sarris
    Department of Lymphoma and Myeloma, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA
    Semin Oncol 29:48-55. 2002
    ..The presence of cells with t(14;18) and their numbers are prospectively quantitated in blood and marrow of patients treated with FND plus rituximab to determine their clinical significance both at presentation and during therapy...
  79. ncbi Molecular genetic methods in the diagnosis of hematologic neoplasms
    Filiz Sen
    Department of Hematopathology, The University of Texas M.D. Anderson Cancer Center, Houston 77030, USA
    Semin Diagn Pathol 19:72-93. 2002
    ..In this review, we focus on chromosomal translocations in hematologic neoplasms and the techniques used for their detection. We also briefly discuss tumor suppressor genes and assessment of clonality in lymphoid neoplasms...
  80. ncbi Mantle cell lymphoma with 8q24 chromosomal abnormalities: a report of 5 cases with blastoid features
    Suyang Hao
    Department of Hematopathology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, USA
    Mod Pathol 15:1266-72. 2002
    ..C-myc gene abnormalities are associated with blastoid cytologic features and also may be associated with leukemic involvement...
  81. ncbi Expression of STAT3 and its phosphorylated forms in mantle cell lymphoma cell lines and tumours
    Raymond Lai
    Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    J Pathol 199:84-9. 2003
    ..In conclusion, these findings provide evidence that STAT3 is constitutively activated in MCL, supporting the concept that STAT3 signalling may be important in the pathogenesis of these tumours...
  82. ncbi Diffuse large B-cell lymphoma occurring in patients with lymphoplasmacytic lymphoma/Waldenström macroglobulinemia. Clinicopathologic features of 12 cases
    Pei Lin
    Department of Hematopathology, University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Am J Clin Pathol 120:246-53. 2003
    ..DLBCL, most likely as a result of histologic transformation, occurs in a subset of patients with LPL/WM and is associated with aggressive clinical course and poor outcome. EBV is unlikely to be involved in transformation...
  83. ncbi Germinal centre-like versus undifferentiated stromal immunophenotypes in follicular lymphoma
    Kong-Chao Chang
    Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    J Pathol 201:404-12. 2003
    ..The pattern of FDC antigen loss in stroma of FL is a readily assessable biological feature that appears independent of architectural growth pattern and may serve as a useful surrogate marker of tumour progression...
  84. ncbi Immunomodulator agent-related lymphoproliferative disorders
    Robert P Hasserjian
    Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA
    Mod Pathol 22:1532-40. 2009
    ..Further study is warranted to evaluate how these therapies interact with other immunosuppressive agents and the underlying abnormal immune system to enhance the development of lymphomas and atypical lymphoid proliferations...
  85. ncbi Lack of c-kit (CD117) expression in CD30+ lymphomas and lymphomatoid papulosis
    George Z Rassidakis
    Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Mod Pathol 17:946-53. 2004
    ....
  86. ncbi Myeloid sarcoma involving the breast
    Jose R Valbuena
    Department of Hematopathology, The University of Texas M. D. Anderson Cancer Center, Houston 77030, USA
    Arch Pathol Lab Med 129:32-8. 2005
    ..Immunohistochemical studies are extremely helpful for recognizing isolated myeloid sarcoma...
  87. ncbi Myeloid sarcoma of the urinary bladder and epididymis as a primary manifestation of acute myeloid leukemia with inv(16)
    Samer Z Al-Quran
    Department of Anatomic Pathology, University of Texas M. D. Anderson Cancer Center, Houston, TX 77030-4095, USA
    Arch Pathol Lab Med 130:862-6. 2006
    ..A high index of suspicion is required to establish the diagnosis of MS involving bladder. Cytogenetic analysis is useful for both demonstrating minimal marrow disease and classifying MS in paraffin-embedded tissue sections...
  88. ncbi Immunohistochemical detection of ZAP-70 in 341 cases of non-Hodgkin and Hodgkin lymphoma
    Joan H Admirand
    Department of Hematopathology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Mod Pathol 17:954-61. 2004
    ..In summary, ZAP-70 is expressed by many lymphoma types, correlates with immunoglobulin heavy-chain variable region gene mutational status in CLL/SLL, and can be detected reliably using immunohistochemical methods...
  89. ncbi Signal transducer and activator of transcription-3 activation contributes to high tissue inhibitor of metalloproteinase-1 expression in anaplastic lymphoma kinase-positive anaplastic large cell lymphoma
    Raymond Lai
    Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    Am J Pathol 164:2251-8. 2004
    ..TIMP1, as a downstream target of STAT3, may mediate the anti-apoptotic effects of STAT3...
  90. ncbi Metastasis-associated protein 1 transgenic mice: a new model of spontaneous B-cell lymphomas
    Rozita Bagheri Yarmand
    Department of Molecular and Cellular Oncology, M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Res 67:7062-7. 2007
    ..These observations suggest that MTA1-TG mice represent a new model of spontaneous DLBCL associated with high tumor incidence and could be used for therapeutic intervention studies...
  91. ncbi Clonal heterogeneity in mycosis fungoides and its relationship to clinical course
    Francisco Vega
    Division of Pathology and Laboratory Medicine, University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Blood 100:3369-73. 2002
    ..Demonstration of identical clonal GRs in multiple biopsy specimens at the time of diagnosis may provide prognostic information related to disease progression...
  92. ncbi Expression of B cell-specific activator protein/PAX5 in acute myeloid leukemia with t(8;21)(q22;q22)
    Jose R Valbuena
    Department of Hematopathology, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA
    Am J Clin Pathol 126:235-40. 2006
    ..These results indicate that silencing of PAX5 is not required for commitment to myeloid differentiation and that BSAP expression in AML is found mainly in cases with t(8;21)...
  93. ncbi The role of the perifollicular sinus in determining the complex immunoarchitecture of angioimmunoblastic T-cell lymphoma
    Giulia Ottaviani
    Department of Hematopathology, University of Texas-MD Anderson Cancer Center, Houston TX, USA
    Am J Surg Pathol 28:1632-40. 2004
    ..Patterns of sinus drainage largely explain the useful changes in B-cell distribution that occur in nodal T-cell lymphomas and represent an important tool in classification and diagnosis of these tumors...
  94. ncbi Expression of p27(Kip1) and c-Jun activation binding protein 1 are inversely correlated in systemic anaplastic large cell lymphoma
    George Z Rassidakis
    Department of Hematopathology, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Clin Cancer Res 9:1121-8. 2003
    ..These findings suggest that JAB1-mediated degradation of p27, allowing cell cycle progression, may play a role in the pathogenesis of ALCL...
  95. ncbi Retinoblastoma protein is frequently absent or phosphorylated in anaplastic large-cell lymphoma
    George Z Rassidakis
    Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Am J Pathol 164:2259-67. 2004
    ..In conclusion, Rb is absent or phosphorylated in most ALCL cell lines and tumors and absence of Rb expression is associated with better clinical outcome in patients with ALCL...
  96. ncbi The stromal composition of malignant lymphoid aggregates in bone marrow: variations in architecture and phenotype in different B-cell tumours
    Francisco Vega
    Division of Pathology and Laboratory Medicine, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Br J Haematol 117:569-76. 2002
    ..In FL, expression of follicular dendritic cell-associated markers is modulated in pre-existing marrow stromal cells...
  97. ncbi Suppressor of cytokine signaling 3 expression in anaplastic large cell lymphoma
    J H Cho-Vega
    Department of Molecular Pathology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Leukemia 18:1872-8. 2004
    ..However, SOCS3 is also expressed in tumors that lack STAT3 and ALK suggesting alternative mechanisms of upregulation...
  98. ncbi Activation status of the JAK/STAT3 pathway in mantle cell lymphoma
    Marwan A Yared
    Department of Hematopathology, The University of Texas, M. D. Anderson Cancer Center, Houston, USA
    Arch Pathol Lab Med 129:990-6. 2005
    ..STAT3 activation in the small cell but not the blastoid variant of MCL is likely mediated by JAK3...
  99. ncbi Expression of constitutively active nuclear-kappa B RelA transcription factor in blasts of acute myeloid leukemia
    Carlos E Bueso-Ramos
    Department of Hematopathology, MD Anderson Cancer Center, Houston, TX 77030, USA
    Hum Pathol 35:246-53. 2004
    ..These results suggest that suppression of NF-kappa B may be a useful therapeutic strategy for a subset of patients with AML...
  100. ncbi T-cell large granular lymphocyte leukemia associated with myelodysplastic syndrome: a clinicopathologic study of nine cases
    Yang O Huh
    Department of Hematopathology, Unit 72, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Am J Clin Pathol 131:347-56. 2009
    ..The median hemoglobin level and absolute lymphocyte count were lower in patients with T-LGL/MDS (P < .05). The frequency of coexistent T-LGL and MDS at our institution suggests an etiologic relationship rather than simple coincidence...
  101. ncbi Lymphoplasmacytic lymphoma/waldenstrom macroglobulinemia: an evolving concept
    Pei Lin
    From the Department of Hematopathology, UTMD Anderson Cancer Center, Houston, Texas 77030, USA
    Adv Anat Pathol 12:246-55. 2005
    ..In some cases, in our opinion, distinguishing LPL/WM from marginal zone B-cell lymphomas seems arbitrary using currently recommended criteria...