R McMillan

Summary

Affiliation: The Scripps Research Institute
Country: USA

Publications

  1. ncbi request reprint Classical management of refractory adult immune (idiopathic) thrombocytopenic purpura
    R McMillan
    The Scripps Research Institute, La Jolla, CA 92037, USA
    Blood Rev 16:51-5. 2002
  2. pmc Impact of chronic Immune Thrombocytopenic Purpura (ITP) on health-related quality of life: a conceptual model starting with the patient perspective
    Susan D Mathias
    Health Outcomes Solutions, P, O, Box 2343 Winter Park, Florida 32790, USA
    Health Qual Life Outcomes 6:13. 2008
  3. pmc A disease-specific measure of health-related quality of life for use in adults with immune thrombocytopenic purpura: its development and validation
    Susan D Mathias
    Ovation Research Group, 188 Embarcadero, San Francisco, CA 94105, USA
    Health Qual Life Outcomes 5:11. 2007
  4. ncbi request reprint Long-term outcomes in adults with chronic ITP after splenectomy failure
    Robert McMillan
    Scripps Research Institute, MEM 215, 10550 North Torrey Pines Rd, La Jolla, CA 92037, USA
    Blood 104:956-60. 2004
  5. ncbi request reprint Antiplatelet antibodies in chronic adult immune thrombocytopenic purpura: assays and epitopes
    Robert McMillan
    The Scripps Research Institute, MEM 215, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Pediatr Hematol Oncol 25:S57-61. 2003
  6. ncbi request reprint Suppression of in vitro megakaryocyte production by antiplatelet autoantibodies from adult patients with chronic ITP
    Robert McMillan
    The Scripps Research Institute, MEM 215, 10550 N Torrey Pines Rd, La Jolla, CA 92037, USA
    Blood 103:1364-9. 2004
  7. ncbi request reprint Prospective evaluation of the immunobead assay for the diagnosis of adult chronic immune thrombocytopenic purpura (ITP)
    R McMillan
    The Scripps Research Institute, La Jolla, California 92037, USA
    J Thromb Haemost 1:485-91. 2003
  8. ncbi request reprint Many alphaIIbbeta3 autoepitopes in chronic immune thrombocytopenic purpura are localized to alphaIIb between amino acids L1 and Q459
    Robert McMillan
    The Scripps Research Institute, La Jolla, CA 92037, USA
    Br J Haematol 118:1132-6. 2002
  9. ncbi request reprint Clonal restriction of platelet-associated anti-GPIIb/IIIa autoantibodies in patients with chronic ITP
    R McMillan
    The Scripps Research Institute, La Jolla, California 92037, USA
    Thromb Haemost 85:821-3. 2001
  10. ncbi request reprint Autoantibodies to alpha(IIb)beta(3) in patients with chronic immune thrombocytopenic purpura bind primarily to epitopes on alpha(IIb)
    R McMillan
    Department of Molecular and Experimental Medicine, Room 215, The Scripps Research Institute, La Jolla, CA 92037, USA
    Blood 97:2171-2. 2001

Research Grants

  1. AUTOIMMUNE THROMBOCYTOPENIA
    Robert McMillan; Fiscal Year: 2002
  2. AUTOIMMUNE THROMBOCYTOPENIA
    Robert McMillan; Fiscal Year: 1999
  3. AUTOIMMUNE THROMBOCYTOPENIA
    Robert McMillan; Fiscal Year: 2000
  4. AUTOIMMUNE THROMBOCYTOPENIA
    Robert McMillan; Fiscal Year: 2001

Detail Information

Publications22

  1. ncbi request reprint Classical management of refractory adult immune (idiopathic) thrombocytopenic purpura
    R McMillan
    The Scripps Research Institute, La Jolla, CA 92037, USA
    Blood Rev 16:51-5. 2002
    ..Patients undergoing these treatments may require concomitant intravenous gammaglobulin, high-dose corticosteroids or platelets, to maintain the platelet count in the setting of mucosal bleeding or severe thrombocytopenia...
  2. pmc Impact of chronic Immune Thrombocytopenic Purpura (ITP) on health-related quality of life: a conceptual model starting with the patient perspective
    Susan D Mathias
    Health Outcomes Solutions, P, O, Box 2343 Winter Park, Florida 32790, USA
    Health Qual Life Outcomes 6:13. 2008
    ..The aim of this research is to develop a conceptual model to describe the impact of ITP and its treatment on patients' health-related quality of life (HRQoL)...
  3. pmc A disease-specific measure of health-related quality of life for use in adults with immune thrombocytopenic purpura: its development and validation
    Susan D Mathias
    Ovation Research Group, 188 Embarcadero, San Francisco, CA 94105, USA
    Health Qual Life Outcomes 5:11. 2007
    ..Therefore, we sought to develop and validate the ITP-Patient Assessment Questionnaire (ITP-PAQ) for adult subjects with ITP...
  4. ncbi request reprint Long-term outcomes in adults with chronic ITP after splenectomy failure
    Robert McMillan
    Scripps Research Institute, MEM 215, 10550 North Torrey Pines Rd, La Jolla, CA 92037, USA
    Blood 104:956-60. 2004
    ..We conclude that most patients with refractory ITP attain stable remission, though on average this occurs slowly. However, a subpopulation with severe, resistant disease experiences significant morbidity and mortality...
  5. ncbi request reprint Antiplatelet antibodies in chronic adult immune thrombocytopenic purpura: assays and epitopes
    Robert McMillan
    The Scripps Research Institute, MEM 215, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Pediatr Hematol Oncol 25:S57-61. 2003
    ....
  6. ncbi request reprint Suppression of in vitro megakaryocyte production by antiplatelet autoantibodies from adult patients with chronic ITP
    Robert McMillan
    The Scripps Research Institute, MEM 215, 10550 N Torrey Pines Rd, La Jolla, CA 92037, USA
    Blood 103:1364-9. 2004
    ..These results show that plasma autoantibody from some adult patients with ITP inhibits in vitro megakaryocyte production, suggesting that a similar effect may occur in vivo...
  7. ncbi request reprint Prospective evaluation of the immunobead assay for the diagnosis of adult chronic immune thrombocytopenic purpura (ITP)
    R McMillan
    The Scripps Research Institute, La Jolla, California 92037, USA
    J Thromb Haemost 1:485-91. 2003
    ..1%. We conclude that the presence of immune thrombocytopenia is highly probable if the immunobead assay is positive and that antigen-specific assays are diagnostically useful in adult chronic ITP...
  8. ncbi request reprint Many alphaIIbbeta3 autoepitopes in chronic immune thrombocytopenic purpura are localized to alphaIIb between amino acids L1 and Q459
    Robert McMillan
    The Scripps Research Institute, La Jolla, CA 92037, USA
    Br J Haematol 118:1132-6. 2002
    ..We conclude that the binding of many anti-alphaIIbbeta3 autoantibodies is dependent on the presence of alphaIIb amino acids L1-Q459...
  9. ncbi request reprint Clonal restriction of platelet-associated anti-GPIIb/IIIa autoantibodies in patients with chronic ITP
    R McMillan
    The Scripps Research Institute, La Jolla, California 92037, USA
    Thromb Haemost 85:821-3. 2001
    ..These results are consistent with other studies in ITP suggesting a limited antigenic repertoire...
  10. ncbi request reprint Autoantibodies to alpha(IIb)beta(3) in patients with chronic immune thrombocytopenic purpura bind primarily to epitopes on alpha(IIb)
    R McMillan
    Department of Molecular and Experimental Medicine, Room 215, The Scripps Research Institute, La Jolla, CA 92037, USA
    Blood 97:2171-2. 2001
    ..Because these 2 integrins have the same beta chain (beta(3)), these results show that most epitopes in chronic ITP are dependent on the presence of glycoprotein alpha(IIb.) (Blood. 2001;97:2171-2172)..
  11. doi request reprint The pathogenesis of chronic immune thrombocytopenic purpura
    Robert McMillan
    The Scripps Research Institute, La Jolla, CA
    Semin Hematol 44:S3-S11. 2007
    ..In summary, activation of the immune system by platelet autoantigens in ITP may result in platelet destruction and/or inhibition of platelet production. The importance of each mechanism in the individual patient probably varies...
  12. ncbi request reprint Mobilized peripheral blood progenitor cells (PBPC) in support of tandem cycles of high-dose chemotherapy (HDC)
    B R Meisenberg
    Division of Hematology Oncology, Scripps Clinic and Research Foundation, La Jolla, CA, USA
    Bone Marrow Transplant 18:1087-93. 1996
    ..Tandem cycles of high-dose chemotherapy supported by PBPC are feasible and safe, although many patients fail to receive the second treatment. Preliminary evaluation shows evidence of further antitumor efficacy following cycle 2...
  13. pmc Molecular cloning and preliminary characterization of a novel cytoplasmic antigen recognized by myasthenia gravis sera
    T Gordon
    Department of Basic and Clinical Research, Research Institute of Scripps Clinic, La Jolla, California 92037
    J Clin Invest 90:992-9. 1992
    ..These data indicate that gravin is an inducible, cell type-specific cytoplasmic protein and that auto-antibodies to gravin may be highly specific for MG...
  14. doi request reprint Antiplatelet antibodies in chronic immune thrombocytopenia and their role in platelet destruction and defective platelet production
    Robert McMillan
    Division of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Hematol Oncol Clin North Am 23:1163-75. 2009
    ..This article reviews the role of antiplatelet autoantibody in adult chronic ITP...
  15. ncbi request reprint The effect of antiplatelet autoantibodies on megakaryocytopoiesis
    Robert McMillan
    The Scripps Research Institute, La Jolla, California 92037, USA
    Int J Hematol 81:94-9. 2005
    ..In view of these findings, both platelet destruction and suppression of platelet production seem likely to be involved in the pathogenesis of ITP...
  16. ncbi request reprint The role of antiplatelet autoantibody assays in the diagnosis of immune thrombocytopenic purpura
    Robert McMillan
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, MEM 215, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Curr Hematol Rep 4:160-5. 2005
    ..Incubation of patient plasma, IgG or eluate with normal platelet-rich plasma reproduces the patient's aggregation abnormalities...
  17. ncbi request reprint Immune thrombocytopenic purpura in patients with chronic hepatitis C virus infection
    Paul J Pockros
    Division of Gastroenterology and Hepatology, Scripps Clinic, La Jolla, California 92037, USA
    Am J Gastroenterol 97:2040-5. 2002
    ..Immune thrombocytopenic purpura (ITP) is an immune-mediated syndrome of unknown etiology characterized by the presence of autoantibodies against platelet membrane proteins...
  18. ncbi request reprint Pathogenesis of chronic immune thrombocytopenic purpura
    Douglas B Cines
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Curr Opin Hematol 14:511-4. 2007
    ..This article summarizes recent insights into the pathophysiology of immune thrombocytopenic purpura, a disorder in which autoantibodies against cell-specific glycoproteins (GPIIb-IIIa, GPIb-IX and others) accelerate platelet destruction...
  19. ncbi request reprint Management of adult idiopathic thrombocytopenic purpura
    Douglas B Cines
    Department of Pathology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Annu Rev Med 56:425-42. 2005
    ..This article focuses on the management of primary ITP in adults. We discuss criteria for treatment, the roles of splenectomy and other treatment options along with their side effects, and the management of ITP during pregnancy...
  20. ncbi request reprint AMG 531, a thrombopoiesis-stimulating protein, for chronic ITP
    James B Bussel
    New York Presbyterian Hospital, New York, USA
    N Engl J Med 355:1672-81. 2006
    ..Most current treatments for chronic immune thrombocytopenic purpura (ITP) act by decreasing platelet destruction. In a phase 1-2 study, we administered a thrombopoiesis-stimulating protein, AMG 531, to patients with ITP...
  21. ncbi request reprint A disease-specific measure of health-related quality of life in adults with chronic immune thrombocytopenic purpura: psychometric testing in an open-label clinical trial
    Susan D Mathias
    Ovation Research Group, San Francisco, CA 94105, USA
    Clin Ther 29:950-62. 2007
    ..A previous study reported preliminary evidence of its reliability and validity...
  22. doi request reprint Immune-mediated thrombocytopenias: focus on chronic immune thrombocytopenic purpura
    Robert McMillan
    Semin Hematol 44:S1-2. 2007

Research Grants5

  1. AUTOIMMUNE THROMBOCYTOPENIA
    Robert McMillan; Fiscal Year: 2002
    ..Results of these studies will be correlated with the patients' clinical course and thrombopoietin levels. In addition, the effect of immune thrombocytopenia on the patients' quality of life will be studied. ..
  2. AUTOIMMUNE THROMBOCYTOPENIA
    Robert McMillan; Fiscal Year: 1999
    ..Results of these studies will be correlated with the patients' clinical course and thrombopoietin levels. In addition, the effect of immune thrombocytopenia on the patients' quality of life will be studied. ..
  3. AUTOIMMUNE THROMBOCYTOPENIA
    Robert McMillan; Fiscal Year: 2000
    ..Results of these studies will be correlated with the patients' clinical course and thrombopoietin levels. In addition, the effect of immune thrombocytopenia on the patients' quality of life will be studied. ..
  4. AUTOIMMUNE THROMBOCYTOPENIA
    Robert McMillan; Fiscal Year: 2001
    ..Results of these studies will be correlated with the patients' clinical course and thrombopoietin levels. In addition, the effect of immune thrombocytopenia on the patients' quality of life will be studied. ..