CLARE MCGOWAN

Summary

Affiliation: The Scripps Research Institute
Country: USA

Publications

  1. pmc Cleavage mechanism of human Mus81-Eme1 acting on Holliday-junction structures
    Ewan R Taylor
    Departments of Molecular Biology and Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 105:3757-62. 2008
  2. ncbi Checking in on Cds1 (Chk2): A checkpoint kinase and tumor suppressor
    Clare H McGowan
    Department of Molecular Biology, The Scripps Research Institute, 10550, Torrey Pines Road, La Jolla, California 92037, USA
    Bioessays 24:502-11. 2002
  3. ncbi The DNA damage response: sensing and signaling
    Clare H McGowan
    Department of Molecular Biology, The Scripps Research Institute, 10550, North Torrey Pines Road, La Jolla, California 92037, USA
    Curr Opin Cell Biol 16:629-33. 2004
  4. ncbi CHK2: a tumor suppressor or not?
    Clare H McGowan
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Cell Cycle 1:401-3. 2002
  5. ncbi Running into problems: how cells cope with replicating damaged DNA
    Clare H McGowan
    Department of Molecular Biology and Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Mutat Res 532:75-84. 2003
  6. pmc Disruption of murine Mus81 increases genomic instability and DNA damage sensitivity but does not promote tumorigenesis
    Najoua Dendouga
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Mol Cell Biol 25:7569-79. 2005
  7. pmc Mus81 endonuclease localizes to nucleoli and to regions of DNA damage in human S-phase cells
    Hui Gao
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Mol Biol Cell 14:4826-34. 2003
  8. pmc RNA interference inhibition of Mus81 reduces mitotic recombination in human cells
    Veronique Blais
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Mol Biol Cell 15:552-62. 2004
  9. pmc A conserved proliferating cell nuclear antigen-interacting protein sequence in Chk1 is required for checkpoint function
    Jennifer Scorah
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 283:17250-9. 2008
  10. pmc SUMO-targeted ubiquitin ligases in genome stability
    John Prudden
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    EMBO J 26:4089-101. 2007

Research Grants

Collaborators

  • W Edelmann
  • Hui Gao
  • PAUL R RUSSELL
  • JOHN ROBERT contact YATES
  • J Jefferson P Perry
  • Stephen C West
  • Peter Stambrook
  • C C Harris
  • Ann MacLaren
  • Jennifer Scorah
  • Veronique Blais
  • J Kim Holloway
  • Ewan R Taylor
  • John Prudden
  • Victoria Martin
  • Michael N Boddy
  • Ran Zhang
  • Najoua Dendouga
  • El Mustapha Bahassi
  • Angelos Constantinou
  • David Gillespie
  • James Booth
  • Mary Scott
  • Meng Qiu Dong
  • Paula E Cohen
  • John A Tainer
  • Daniela A Slavin
  • Stephanie Pebernard
  • Grazia Raffa
  • Charly Chahwan
  • James Wohlschlegel
  • Dieder Moechars
  • Qin Yang
  • Nozomu Yanaihara
  • John Bradsher
  • Jorge Vialard
  • Sagar Sengupta
  • Michel Janicot
  • Steven P Linke
  • Pierre Henri L Gaillard
  • Cherilyn A Elwell
  • Xiao Bo Chen
  • Christopher W Conn
  • Robert F Hennigan
  • Yolanda Sanchez
  • David L Myer

Detail Information

Publications18

  1. pmc Cleavage mechanism of human Mus81-Eme1 acting on Holliday-junction structures
    Ewan R Taylor
    Departments of Molecular Biology and Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 105:3757-62. 2008
    ....
  2. ncbi Checking in on Cds1 (Chk2): A checkpoint kinase and tumor suppressor
    Clare H McGowan
    Department of Molecular Biology, The Scripps Research Institute, 10550, Torrey Pines Road, La Jolla, California 92037, USA
    Bioessays 24:502-11. 2002
    ..This review focuses on the many questions generated by recent progress in understanding the function and regulation of human Cds1...
  3. ncbi The DNA damage response: sensing and signaling
    Clare H McGowan
    Department of Molecular Biology, The Scripps Research Institute, 10550, North Torrey Pines Road, La Jolla, California 92037, USA
    Curr Opin Cell Biol 16:629-33. 2004
    ..These advances have provided a more detailed understanding of the interface between damaged DNA and the checkpoint sensor proteins...
  4. ncbi CHK2: a tumor suppressor or not?
    Clare H McGowan
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Cell Cycle 1:401-3. 2002
  5. ncbi Running into problems: how cells cope with replicating damaged DNA
    Clare H McGowan
    Department of Molecular Biology and Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Mutat Res 532:75-84. 2003
    ..Thus, genome duplication necessarily involves replication of damaged DNA. The many mechanism cells use to avoid or overcome the problems of replicating an imperfect DNA template are discussed...
  6. pmc Disruption of murine Mus81 increases genomic instability and DNA damage sensitivity but does not promote tumorigenesis
    Najoua Dendouga
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Mol Cell Biol 25:7569-79. 2005
    ..Despite these defects, Mus81(-/-) mice do not show increased predisposition to lymphoma or any other malignancy in the first year of life...
  7. pmc Mus81 endonuclease localizes to nucleoli and to regions of DNA damage in human S-phase cells
    Hui Gao
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Mol Biol Cell 14:4826-34. 2003
    ..Together these data support a role for Mus81 in recombination repair in higher eukaryotes...
  8. pmc RNA interference inhibition of Mus81 reduces mitotic recombination in human cells
    Veronique Blais
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Mol Biol Cell 15:552-62. 2004
    ..These data provide direct evidence for a role of Mus81-Eme1 in mitotic recombination in higher eukaryotes and support the hypothesis that Mus81-Eme1 resolves Holliday junctions in vivo...
  9. pmc A conserved proliferating cell nuclear antigen-interacting protein sequence in Chk1 is required for checkpoint function
    Jennifer Scorah
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Biol Chem 283:17250-9. 2008
    ..These findings suggest an additional mechanism by which essential components of the DNA replication machinery interact with the replication checkpoint apparatus...
  10. pmc SUMO-targeted ubiquitin ligases in genome stability
    John Prudden
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    EMBO J 26:4089-101. 2007
    ..The DNA repair factor Rad60 and its human homolog NIP45, which contain SLDs, are candidate STUbL targets. Consistently, Rad60 and Slx8-Rfp mutants have similar DNA repair defects...
  11. ncbi Regulation of the eukaryotic cell cycle
    Clare H McGowan
    Department of Molecular Biology, Department of Cell Biology, Scripps Research Institute, La Jolla, California 92037, USA
    Prog Cell Cycle Res 5:1-4. 2003
    ..The mechanisms that coordinate cell cycle progression under favorable and adverse conditions are reviewed...
  12. pmc Claspin and Chk1 regulate replication fork stability by different mechanisms
    Jennifer Scorah
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Cell Cycle 8:1036-43. 2009
    ..The findings support a model in which Claspin plays a role regulating replication fork stability that is independent of its function in mediating Chk1 phosphorylation...
  13. pmc Sws1 is a conserved regulator of homologous recombination in eukaryotic cells
    Victoria Martin
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    EMBO J 25:2564-74. 2006
    ..A SWS1 homolog exists in human cells. It associates with RAD51D and ablating its expression reduces the number of RAD51 foci. These studies unveil a conserved pathway for the initiation and control of HR in eukaryotic cells...
  14. doi Chk2 protects against radiation-induced genomic instability
    Ann MacLaren
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Radiat Res 172:463-72. 2009
    ..The data demonstrate that Chk2 functions to maintain genome integrity after radiation-induced damage and has important implications for the use of Chk2 inhibitors as adjuvant cancer therapy...
  15. pmc Holliday junction resolution in human cells: two junction endonucleases with distinct substrate specificities
    Angelos Constantinou
    Cancer Research UK, London Research Institute, Clare Hall Laboratories, South Mimms, Hertfordshire EN6 3LD, UK
    EMBO J 21:5577-85. 2002
    ..However, the Mus81-associated endonuclease may play a more direct role in replication fork collapse by catalysing the cleavage of stalled fork structures...
  16. ncbi Mammalian Polo-like kinase 3 (Plk3) is a multifunctional protein involved in stress response pathways
    El Mustapha Bahassi
    Department of Cell Biology, University of Cincinnati College of Medicine, Cincinnati, Ohio, OH 45267, USA
    Oncogene 21:6633-40. 2002
    ..In aggregate, the data argue that Plk3 is a multifunctional protein that associates with multiple complexes and that contributes to response to stress incurred by DNA damage and mitotic spindle disruption, albeit via different pathways...
  17. ncbi BLM helicase facilitates Mus81 endonuclease activity in human cells
    Ran Zhang
    Laboratory of Human Carcinogenesis, National Cancer Institute, NIH, Bethesda, Maryland 20892 4255, USA
    Cancer Res 65:2526-31. 2005
    ..This stimulation is due to enhanced binding of Mus81 to the DNA substrates. These data suggest a new function of BLM in cooperating with Mus81 during processing and restoration of stalled replication forks...
  18. pmc MUS81 generates a subset of MLH1-MLH3-independent crossovers in mammalian meiosis
    J Kim Holloway
    Department of Biomedical Sciences, Cornell University, Ithaca, New York, United States of America
    PLoS Genet 4:e1000186. 2008
    ..This study is the first in-depth analysis of meiotic progression in Mus81-nullizygous mice, and our results implicate the MUS81 pathway as a regulator of crossover frequency and placement in mammals...

Research Grants16

  1. DNA Repair and Checkpoint Interactions in Mammals
    CLARE MCGOWAN; Fiscal Year: 2007
    ..abstract_text> ..
  2. G2 CHECKPOINT CONTROL IN TRANSFORMED HUMAN CELLS
    CLARE MCGOWAN; Fiscal Year: 2007
    ..abstract_text> ..
  3. G2 CHECKPOINT CONTROL IN TRANSFORMED HUMAN CELLS
    CLARE MCGOWAN; Fiscal Year: 2003
    ..The primary objective of this proposal is therefore to provide a detailed understanding of the regulation of Cdc25, Wee1, Myt1 and Chk1 in human checkpoint control responses. ..