Bruce McEwen

Summary

Affiliation: The Rockefeller University
Country: USA

Publications

  1. pmc The brain on stress: vulnerability and plasticity of the prefrontal cortex over the life course
    Bruce S McEwen
    Laboratory of Neuroendocrinology, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
    Neuron 79:16-29. 2013
  2. doi request reprint Lifetime experiences, the brain and personalized medicine: an integrative perspective
    Bruce S McEwen
    Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY 10065, USA
    Metabolism 62:S20-6. 2013
  3. pmc The ever-changing brain: cellular and molecular mechanisms for the effects of stressful experiences
    Bruce S McEwen
    Laboratory of Neuroendocrinology, The Rockefeller University, New York, New York 10065, USA
    Dev Neurobiol 72:878-90. 2012
  4. pmc Estrogen effects on the brain: actions beyond the hypothalamus via novel mechanisms
    Bruce S McEwen
    Laboratory of Neuroendocrinology, The Rockefeller University, Box 165, 1230 York Avenue, New York, NY 10065, USA
    Behav Neurosci 126:4-16. 2012
  5. pmc Introduction: the end of sex as we once knew it
    Bruce S McEwen
    Laboratory of Neuroendocrinology, The Rockefeller University, Box 165, 1230 York Avenue, New York, NY 10065, USA
    Physiol Behav 97:143-5. 2009
  6. ncbi request reprint Early life influences on life-long patterns of behavior and health
    Bruce S McEwen
    Laboratory of Neuroendocrinology, The Rockefeller University, New York, New York 10021, USA
    Ment Retard Dev Disabil Res Rev 9:149-54. 2003
  7. ncbi request reprint Physiology and neurobiology of stress and adaptation: central role of the brain
    Bruce S McEwen
    Harold and Margaret Milliken Hatch, Laboratory of Neuroendocrinology, The Rockefeller University, New York, New York 10021, USA
    Physiol Rev 87:873-904. 2007
  8. doi request reprint The role of corticosteroids and stress in chronic pain conditions
    Bruce S McEwen
    Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY 10065, USA
    Metabolism 59:S9-15. 2010
  9. pmc Stress and anxiety: structural plasticity and epigenetic regulation as a consequence of stress
    Bruce S McEwen
    Laboratory of Neuroendocrinology, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
    Neuropharmacology 62:3-12. 2012
  10. ncbi request reprint Protection and damage from acute and chronic stress: allostasis and allostatic overload and relevance to the pathophysiology of psychiatric disorders
    Bruce S McEwen
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, Box 165, 1230 York Avenue, New York, NY 10021, USA
    Ann N Y Acad Sci 1032:1-7. 2004

Research Grants

  1. GENE EXPRESSION IN NERVOUS TISSUE
    Bruce S McEwen; Fiscal Year: 2010
  2. GENE EXPRESSION IN NERVOUS TISSUE
    Bruce McEwen; Fiscal Year: 2000
  3. GENE EXPRESSION IN NERVOUS TISSUE
    Bruce McEwen; Fiscal Year: 2004
  4. STRESS, ADRENAL STEROIDS AND THE BRAIN
    Bruce McEwen; Fiscal Year: 2009
  5. STRESS, ADRENAL STEROIDS AND THE BRAIN
    Bruce McEwen; Fiscal Year: 2007
  6. GENE EXPRESSION IN NERVOUS TISSUE
    Bruce McEwen; Fiscal Year: 2007
  7. GENE EXPRESSION IN NERVOUS TISSUE
    Bruce McEwen; Fiscal Year: 1980
  8. STRESS, ADRENAL STEROIDS AND THE BRAIN
    Bruce McEwen; Fiscal Year: 1990
  9. STRESS, ADRENAL STEROIDS AND THE BRAIN
    Bruce McEwen; Fiscal Year: 1993
  10. GENE EXPRESSION IN NERVOUS TISSUE
    Bruce McEwen; Fiscal Year: 1993

Detail Information

Publications115 found, 100 shown here

  1. pmc The brain on stress: vulnerability and plasticity of the prefrontal cortex over the life course
    Bruce S McEwen
    Laboratory of Neuroendocrinology, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
    Neuron 79:16-29. 2013
    ....
  2. doi request reprint Lifetime experiences, the brain and personalized medicine: an integrative perspective
    Bruce S McEwen
    Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY 10065, USA
    Metabolism 62:S20-6. 2013
    ....
  3. pmc The ever-changing brain: cellular and molecular mechanisms for the effects of stressful experiences
    Bruce S McEwen
    Laboratory of Neuroendocrinology, The Rockefeller University, New York, New York 10065, USA
    Dev Neurobiol 72:878-90. 2012
    ..The result is a dynamic brain architecture that can be modified by experience. Under this view, the role of pharmaceutical agents, such as antidepressants, is to facilitate such plasticity that must also be guided by experiences...
  4. pmc Estrogen effects on the brain: actions beyond the hypothalamus via novel mechanisms
    Bruce S McEwen
    Laboratory of Neuroendocrinology, The Rockefeller University, Box 165, 1230 York Avenue, New York, NY 10065, USA
    Behav Neurosci 126:4-16. 2012
    ..This exciting and growing field involving many laboratories continues to reshape our ideas and approaches to neuroendocrinology both at the bench and the bedside...
  5. pmc Introduction: the end of sex as we once knew it
    Bruce S McEwen
    Laboratory of Neuroendocrinology, The Rockefeller University, Box 165, 1230 York Avenue, New York, NY 10065, USA
    Physiol Behav 97:143-5. 2009
    ....
  6. ncbi request reprint Early life influences on life-long patterns of behavior and health
    Bruce S McEwen
    Laboratory of Neuroendocrinology, The Rockefeller University, New York, New York 10021, USA
    Ment Retard Dev Disabil Res Rev 9:149-54. 2003
    ..Although prevention is clearly the preferable route, some degree of reversal of psychopathology and pathophysiology caused by early life adversity appears to be an achievable goal...
  7. ncbi request reprint Physiology and neurobiology of stress and adaptation: central role of the brain
    Bruce S McEwen
    Harold and Margaret Milliken Hatch, Laboratory of Neuroendocrinology, The Rockefeller University, New York, New York 10021, USA
    Physiol Rev 87:873-904. 2007
    ..As an adjunct to pharmaceutical therapy, social and behavioral interventions such as regular physical activity and social support reduce the chronic stress burden and benefit brain and body health and resilience...
  8. doi request reprint The role of corticosteroids and stress in chronic pain conditions
    Bruce S McEwen
    Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY 10065, USA
    Metabolism 59:S9-15. 2010
    ..We will discuss the implication of these new findings directly linking pain to steroids, stress, and key higher brain regions in the context of future therapeutic targets...
  9. pmc Stress and anxiety: structural plasticity and epigenetic regulation as a consequence of stress
    Bruce S McEwen
    Laboratory of Neuroendocrinology, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
    Neuropharmacology 62:3-12. 2012
    ..Finally, we suggest that such an approach needs to be extended to other brain areas that are also involved in anxiety and mood. This article is part of a Special Issue entitled 'Anxiety and Depression'...
  10. ncbi request reprint Protection and damage from acute and chronic stress: allostasis and allostatic overload and relevance to the pathophysiology of psychiatric disorders
    Bruce S McEwen
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, Box 165, 1230 York Avenue, New York, NY 10021, USA
    Ann N Y Acad Sci 1032:1-7. 2004
    ..Yet, these are not necessarily "damaged" and may be treatable with the right medications...
  11. pmc Central effects of stress hormones in health and disease: Understanding the protective and damaging effects of stress and stress mediators
    Bruce S McEwen
    Laboratory of Neuroendocrinology, The Rockefeller University, 1230 York Avenue Box 165, New York, NY 10065, United States
    Eur J Pharmacol 583:174-85. 2008
    ..Policies of government and the private sector play an important role in this top-down view of minimizing the burden of chronic stress and related lifestyle (i.e. allostatic overload)...
  12. pmc Understanding the potency of stressful early life experiences on brain and body function
    Bruce S McEwen
    Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY 10065, USA
    Metabolism 57:S11-5. 2008
    ..An important goal is to identify interventions that are likely to be most effective in early life and some guidelines are provided...
  13. pmc Stressed or stressed out: what is the difference?
    Bruce S McEwen
    Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY 10021, USA
    J Psychiatry Neurosci 30:315-8. 2005
    ..This framework has also helped to demystify the biology of stress by emphasizing the protective as well as the damaging effects of the body's attempts to cope with the challenges known as stressors...
  14. ncbi request reprint Estrogen actions throughout the brain
    Bruce McEwen
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, New York, New York 10021, USA
    Recent Prog Horm Res 57:357-84. 2002
    ....
  15. ncbi request reprint Establishing an agenda for translational research on PTSD
    Melinda M Miller
    Laboratory of Neuroendocrinology, The Rockefeller University, New York, New York 10021, USA
    Ann N Y Acad Sci 1071:294-312. 2006
    ....
  16. ncbi request reprint Invited review: Estrogens effects on the brain: multiple sites and molecular mechanisms
    B S McEwen
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, Rockefeller University, 1230 York Ave, New York, NY 10021, USA
    J Appl Physiol (1985) 91:2785-801. 2001
    ..In the future, estrogen actions over puberty and in pregnancy and lactation should be further explored and should be studied in both the hypothalamus and the extrahypothalamic regions...
  17. ncbi request reprint The neurobiology and neuroendocrinology of stress. Implications for post-traumatic stress disorder from a basic science perspective
    Bruce S McEwen
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, Box 165, 1230 York Avenue, Rockefeller University, New York, NY 10021, USA
    Psychiatr Clin North Am 25:469-94, ix. 2002
    ..Hormones associated with stress and allostatic load protect the body in the short run and promote adaptation, but in the long run allostatic load causes changes in the body that lead to disease...
  18. ncbi request reprint Glucocorticoids, depression, and mood disorders: structural remodeling in the brain
    Bruce S McEwen
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY 10021, USA
    Metabolism 54:20-3. 2005
    ..Yet, these are not necessarily "damaged" and may be treatable with the right medications. The mechanisms that distinguish between protection and damage of brain cells from stress are discussed in this context...
  19. ncbi request reprint Sex, stress and the hippocampus: allostasis, allostatic load and the aging process
    Bruce S McEwen
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Neurobiol Aging 23:921-39. 2002
    ..This review discusses the current status of work on underlying mechanisms for protection and damage...
  20. doi request reprint Hippocampal structural changes across the menstrual cycle
    Xenia Protopopescu
    Functional Neuroimaging Laboratory, Weill Medical College of Cornell University, New York, New York 10021, USA
    Hippocampus 18:985-8. 2008
    ....
  21. pmc Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior
    Zhe Yu Chen
    Department of Psychiatry, Weill Medical College of Cornell University, New York, NY 10021, USA
    Science 314:140-3. 2006
    ..A variant BDNF may thus play a key role in genetic predispositions to anxiety and depressive disorders...
  22. ncbi request reprint Mood disorders and allostatic load
    Bruce S McEwen
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, New York, New York 10021, USA
    Biol Psychiatry 54:200-7. 2003
    ..Allostatic load is seen in major depressive illness and may also be expressed in other chronic anxiety disorders such as PTSD and should be documented...
  23. pmc Uncovering the mechanisms of estrogen effects on hippocampal function
    Joanna L Spencer
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, 1300 York Avenue, New York, NY 10065, USA
    Front Neuroendocrinol 29:219-37. 2008
    ..Finally, estrogen may signal through both nuclear and extranuclear hippocampal estrogen receptors to achieve its downstream effects...
  24. doi request reprint Frontolimbic function and cortisol reactivity in response to emotional stimuli
    James C Root
    Functional Neuroimaging Laboratory, Department of Psychiatry, PO Box 140, Weill Medical College of Cornell University, 1300 York Avenue, NY 10021, USA
    Neuroreport 20:429-34. 2009
    ..Cortisol reactivity to the paradigm was positively associated with amygdalar and hippocampal activity and negatively associated with ventromedial prefrontal cortex activity in conditions involving emotional imagery...
  25. ncbi request reprint Behavioral and biological effects of chronic S18986, a positive AMPA receptor modulator, during aging
    Erik B Bloss
    The Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY 10021, USA
    Exp Neurol 210:109-17. 2008
    ..These results provide a framework for further studies of the potentially beneficial effects of AMPAR modulators on brain aging...
  26. ncbi request reprint Age-specific threats induce CRF expression in the paraventricular nucleus of the hypothalamus and hippocampus of young rats
    Christoph P Wiedenmayer
    Department of Psychiatry, Columbia University, New York, NY 10032, USA
    Horm Behav 47:139-50. 2005
    ..Hippocampal CRF mRNA expression levels did not parallel cat odor or male-induced immobility, indicating that CRF is not involved in this response in young rats but may be involved in aspects of learning and memory...
  27. ncbi request reprint Estrogen levels regulate the subcellular distribution of phosphorylated Akt in hippocampal CA1 dendrites
    Vladimir Znamensky
    Division of Neurobiology, Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Neurosci 23:2340-7. 2003
    ..These findings suggest that estrogens may regulate spine formation in CA1 pyramidal neurons via Akt-mediated signaling events...
  28. ncbi request reprint Studies of hormone action in the hippocampal formation: possible relevance to depression and diabetes
    Bruce S McEwen
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, Box 165, 1230 York Avenue, New York, NY 10021, USA
    J Psychosom Res 53:883-90. 2002
    ..The hippocampus is also vulnerable to damage by stroke and head trauma and susceptible to damage during aging and repeated stress, and is sensitive to the effects of diabetes...
  29. pmc Cellular and subcellular localization of estrogen and progestin receptor immunoreactivities in the mouse hippocampus
    Katherine L Mitterling
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, New York, New York 10065, USA
    J Comp Neurol 518:2729-43. 2010
    ....
  30. pmc Interactive effects of stress and aging on structural plasticity in the prefrontal cortex
    Erik B Bloss
    Fishberg Department of Neuroscience and Kastor Neurobiology of Aging Laboratories, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Neurosci 30:6726-31. 2010
    ..The data presented here provide evidence that aging is accompanied by selective impairments in long-term neocortical morphological plasticity...
  31. doi request reprint Diurnal cortisol amplitude and fronto-limbic activity in response to stressful stimuli
    Amy C Cunningham-Bussel
    Functional Neuroimaging Laboratory, Department of Psychiatry, Box 140, Rm 1302, Weill Cornell Medical College, 1300 York Avenue, New York, NY 10065, United States
    Psychoneuroendocrinology 34:694-704. 2009
    ....
  32. ncbi request reprint Biphasic effects of stress upon GLUT8 glucose transporter expression and trafficking in the diabetic rat hippocampus
    Gerardo G Piroli
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Brain Res 1006:28-35. 2004
    ....
  33. ncbi request reprint Estrogen and aging affect the subcellular distribution of estrogen receptor-alpha in the hippocampus of female rats
    Michelle M Adams
    Kastor Neurobiology of Aging Laboratories, Fishberg Research Center for Neurobiology, and Henry L Schwartz Department of Geriatrics and Adult Development, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    J Neurosci 22:3608-14. 2002
    ..Such a role for spinous ER-alpha has important implications for age-related attenuation of estrogen-induced hippocampal plasticity...
  34. pmc Estrogen alters hippocampal dendritic spine shape and enhances synaptic protein immunoreactivity and spatial memory in female mice
    Chenjian Li
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 101:2185-90. 2004
    ....
  35. pmc Diurnal regulation of the gastrin-releasing peptide receptor in the mouse circadian clock
    Ilia N Karatsoreos
    Department of Psychology, Columbia University, New York, NY 10027, USA
    Eur J Neurosci 23:1047-53. 2006
    ..Together, the present findings reveal that changes in GRPr are light driven and not endogenously organized. Diurnal variation in GRPr activity probably underlies intra-SCN signaling important for entrainment and phase shifting...
  36. ncbi request reprint Involvement of AMPA receptor phosphorylation in antidepressant actions with special reference to tianeptine
    Per Svenningsson
    Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, New York 10021, USA
    Eur J Neurosci 26:3509-17. 2007
    ....
  37. ncbi request reprint NMDA receptor antagonist treatment increases the production of new neurons in the aged rat hippocampus
    Juan Nacher
    Laboratory of Neuroendocrinology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Neurobiol Aging 24:273-84. 2003
    ..Injection of the NMDA receptor antagonist to aged rats increases significantly the number of proliferating cells, new neurons and radial glia-like cells in the hippocampus...
  38. pmc Ovarian steroids alter mu opioid receptor trafficking in hippocampal parvalbumin GABAergic interneurons
    Annelyn Torres-Reveron
    Division of Neurobiology, Department of Neurology and Neuroscience, Weill Cornell Medical College, 407 East 61st Street, New York, NY 10065, USA
    Exp Neurol 219:319-27. 2009
    ....
  39. ncbi request reprint Estrogen stimulates postsynaptic density-95 rapid protein synthesis via the Akt/protein kinase B pathway
    Keith T Akama
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, New York, New York 10021 6399, USA
    J Neurosci 23:2333-9. 2003
    ....
  40. ncbi request reprint Tissue plasminogen activator in the amygdala is critical for stress-induced anxiety-like behavior
    Robert Pawlak
    Laboratory of Neurobiology and Genetics, The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
    Nat Neurosci 6:168-74. 2003
    ..These studies support the idea that tPA is critical for the development of anxiety-like behavior after stress...
  41. doi request reprint Chronic immobilization stress alters aspects of emotionality and associative learning in the rat
    Gwendolyn E Wood
    The Laboratory of Neuroendocrinology The Rockefeller University, New York, NY 10065, USA
    Behav Neurosci 122:282-92. 2008
    ..e., struggling and helplessness). These results emphasize the emotional and learned responses to CIS evident during and after the stress treatment, as well as the importance of individual differences...
  42. ncbi request reprint Regulation of neurotransmitter release by synapsin III
    Jian Feng
    Laboratory of Molecular and Cellular Neuroscience and Laboratory of Endocrinology, The Rockefeller University, New York, New York 10021, USA
    J Neurosci 22:4372-80. 2002
    ..Our data indicate that synapsin III plays unique roles both in early axon outgrowth and in the regulation of synaptic vesicle trafficking...
  43. ncbi request reprint Glucocorticoid receptor mRNA expression in the hippocampal formation of male rats before and after pubertal development in response to acute or repeated stress
    Russell D Romeo
    Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY, USA
    Neuroendocrinology 87:160-7. 2008
    ..These data point to a dissociation between differential stress-induced corticosterone responses and regulation of hippocampal GR levels in prepubertal and adult animals...
  44. ncbi request reprint Diabetes, but not stress, reduces neuronal nitric oxide synthase expression in rat hippocampus: implications for hippocampal synaptic plasticity
    Lawrence P Reagan
    Haroldand Margaret Milliken Hatch Laboratory of Neuroendocrinology, Rockefeller University, New York, NY 10021, USA
    Neuroreport 13:1801-4. 2002
    ....
  45. doi request reprint Steroid hormone receptor expression and function in microglia
    Amanda Sierra
    Laboratory of Neuroendocrinology, Rockefeller University, New York, New York 10021, USA
    Glia 56:659-74. 2008
    ....
  46. ncbi request reprint Mother lowers glucocorticoid levels of preweaning rats after acute threat
    Christoph P Wiedenmayer
    Department of Psychiatry, Columbia University, 1051 Riverside Drive, Unit 40, New York, NY 10032, USA
    Ann N Y Acad Sci 1008:304-7. 2003
    ..The endocrine stress response was decreased when the pups were reunited with their mother immediately after exposure. These findings demonstrate that social variables can reduce the consequences of an aversive experience...
  47. ncbi request reprint Cognitive effects of intravenous hydrocortisone in subjects with PTSD and healthy control subjects
    Robert Grossman
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    Ann N Y Acad Sci 1071:410-21. 2006
    ....
  48. ncbi request reprint Chronic stress alters amphetamine effects on behavior and synaptophysin levels in female rats
    Veronica Bisagno
    Department of Psychology, Hunter College, 695 Park Avenue, New York, NY 10021, USA
    Pharmacol Biochem Behav 78:541-50. 2004
    ..Stress may counteract AMPH effects on the memory task by blocking both the induction of AMPH anxiety-like effects and neuroplastic changes in the caudate nucleus of female rats...
  49. ncbi request reprint Age- and stress-induced changes in corticotropin-releasing hormone mRNA expression in the paraventricular nucleus of the hypothalamus
    Russell D Romeo
    Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY 10021, USA
    Neuroendocrinology 85:199-206. 2007
    ..Interestingly, in response to repeated restraint, neither age nor stress significantly influence CRH expression. Together, these data indicate that both age and experience with stress interact to modulate CRH expression in the PVN...
  50. pmc Stress, sex, and neural adaptation to a changing environment: mechanisms of neuronal remodeling
    Bruce S McEwen
    Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY 10065, USA
    Ann N Y Acad Sci 1204:E38-59. 2010
    ..A better understanding of hormone-brain interactions should promote more flexible approaches to the treatment of psychiatric disorders, as well as their prevention through both behavioral and pharmaceutical interventions...
  51. ncbi request reprint Dihydrotestosterone increases hippocampal N-methyl-D-aspartate binding but does not affect choline acetyltransferase cell number in the forebrain or choline transporter levels in the CA1 region of adult male rats
    Russell D Romeo
    Laboratory of Neuroendocrinology, The Rockefeller University, Box 165, New York, New York 10021, USA
    Endocrinology 146:2091-7. 2005
    ..However, unlike E-treated females, these data suggest that DHT does not influence cholinergic inputs to the hippocampus...
  52. ncbi request reprint Molecular mechanisms of neuroplasticity and pharmacological implications: the example of tianeptine
    Bruce S McEwen
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology Rockefeller University, New York, NY 10021, USA
    Eur Neuropsychopharmacol 14:S497-502. 2004
    ..Chronic treatment with the antidepressant tianeptine may prevent these effects in hippocampus and amygdala...
  53. ncbi request reprint Site and time dependent effects of acute stress on hippocampal long-term potentiation in freely behaving rats
    Kazuo Yamada
    The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Exp Brain Res 152:52-9. 2003
    ..The present results suggest that stress affects synaptic plasticity differently at the two hippocampal subfields and that the effects are time-dependent and involve the stress-induced surge of glucocorticoids...
  54. doi request reprint Stress- and allostasis-induced brain plasticity
    Bruce S McEwen
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, New York, New York 10065, USA
    Annu Rev Med 62:431-45. 2011
    ..It also considers interventions to prevent and treat chronic and prevalent health conditions via allodynamic brain mechanisms...
  55. ncbi request reprint Acute and chronic restraint stress alter the incidence of social conflict in male rats
    Gwendolyn E Wood
    Laboratory of Neuroendocrinology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Horm Behav 43:205-13. 2003
    ..These results indicate that acute and chronic restraint stress alter the incidence of aggression, and emphasize the relevance of this model of chronic stress to studies of stress-responsive disorders characterized by aggressive behavior...
  56. pmc Involvement of the endocannabinoid system in the neurobehavioural effects of stress and glucocorticoids
    Matthew N Hill
    Laboratory of Neuroendocrinology, Rockefeller University, New York, NY 10065, USA
    Prog Neuropsychopharmacol Biol Psychiatry 34:791-7. 2010
    ..Collectively, these studies reveal a complex interplay between endocannabinoids and the HPA axis, and further identify endocannabinoid signaling as a critical regulator of the stress response...
  57. ncbi request reprint Testosterone cannot activate an adult-like stress response in prepubertal male rats
    Russell D Romeo
    Laboratory of Neuroendocrinology, Rockefeller University, New York, NY, USA
    Neuroendocrinology 79:125-32. 2004
    ..Thus, we conclude that the HPA neuroendocrine axis is further shaped during pubertal development to allow for the emergence of a more tightly regulated stress response in adulthood...
  58. pmc Endocrine and physiological changes in response to chronic corticosterone: a potential model of the metabolic syndrome in mouse
    Ilia N Karatsoreos
    Laboratory of Neuroendocrinology, The Rockefeller University, New York, New York 10065, USA
    Endocrinology 151:2117-27. 2010
    ....
  59. pmc Ovarian steroids modulate leu-enkephalin levels and target leu-enkephalinergic profiles in the female hippocampal mossy fiber pathway
    Annelyn Torres-Reveron
    Division of Neurobiology, Department of Neurology and Neuroscience, Weill Cornell Medical College, 411 East 69th Street, New York, NY 10021, USA
    Brain Res 1232:70-84. 2008
    ..The present studies indicate that estrogen can modulate LENK in subregions of the MF pathway in a dose-and time-dependent manner. These effects might be triggered by direct activation of ERbeta or PR in LENK-containing terminals...
  60. pmc Chronic restraint stress up-regulates GLT-1 mRNA and protein expression in the rat hippocampus: reversal by tianeptine
    Lawrence P Reagan
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 101:2179-84. 2004
    ....
  61. pmc Ultrastructural localization of extranuclear progestin receptors in the rat hippocampal formation
    Elizabeth M Waters
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, New York, New York 10065, USA
    J Comp Neurol 511:34-46. 2008
    ....
  62. pmc Stress-induced dendritic remodeling in the prefrontal cortex is circuit specific
    Rebecca M Shansky
    Department of Neuroscience Mount Sinai School of Medicine, New York, NY 10029, USA
    Cereb Cortex 19:2479-84. 2009
    ..Such region- and circuit-specificity in response to stress could contribute to the development of stress-related mental illnesses...
  63. ncbi request reprint Subcellular relationships between cholinergic terminals and estrogen receptor-alpha in the dorsal hippocampus
    Laura A Towart
    Division of Neurobiology, Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Comp Neurol 463:390-401. 2003
    ....
  64. pmc Chronic stress differentially regulates cannabinoid CB1 receptor binding in distinct hippocampal subfields
    Matthew N Hill
    Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY 10065, USA
    Eur J Pharmacol 614:66-9. 2009
    ....
  65. doi request reprint CD11c/EYFP transgene illuminates a discrete network of dendritic cells within the embryonic, neonatal, adult, and injured mouse brain
    Karen Bulloch
    Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York, New York 10065, USA
    J Comp Neurol 508:687-710. 2008
    ..Collectively, these findings suggest a new member of the dendritic cell family residing among the heterogeneous microglia population...
  66. pmc Regulation of kainate receptor subunit mRNA by stress and corticosteroids in the rat hippocampus
    Richard G Hunter
    Laboratory of Neuroendocrinology, The Rockefeller University, New York, New York, United States of America
    PLoS ONE 4:e4328. 2009
    ....
  67. ncbi request reprint Differential stress reactivity in intact and ovariectomized prepubertal and adult female rats
    Russell D Romeo
    Laboratory of Neuroendocrinology, Rockefeller University, New York, NY 10021, USA
    Neuroendocrinology 80:387-93. 2004
    ..Furthermore, these data demonstrate additional development of the HPA axis during pubertal maturation, resulting in a more quickly terminated stress response in adulthood...
  68. ncbi request reprint Sex differences in hippocampal estradiol-induced N-methyl-D-aspartic acid binding and ultrastructural localization of estrogen receptor-alpha
    Russell D Romeo
    Laboratory of Neuroendocrinology, The Rockefeller University, Box 165, New York, NY 10021, USA
    Neuroendocrinology 81:391-9. 2005
    ....
  69. pmc Rapid and reversible changes in intrahippocampal connectivity during the course of hibernation in European hamsters
    Ana Maria Magarinos
    The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 103:18775-80. 2006
    ..The reported reductions in morphological connectivity between the dentate gyrus and the CA3 subregions could underlie the cessation of exploratory activity and spatial navigation skills during hibernation...
  70. ncbi request reprint Stress-induced alterations in prefrontal cortical dendritic morphology predict selective impairments in perceptual attentional set-shifting
    Conor Liston
    Laboratory of Neuroendocrinology, The Rockefeller University, New York, New York 10021, USA
    J Neurosci 26:7870-4. 2006
    ..This study provides the first direct evidence that dendritic remodeling in the prefrontal cortex may underlie the functional deficits in attentional control that are symptomatic of stress-related mental illnesses...
  71. pmc Protective and damaging effects of stress mediators: central role of the brain
    Bruce S McEwen
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY 10021, USA
    Dialogues Clin Neurosci 8:367-81. 2006
    ....
  72. ncbi request reprint Stress and the adolescent brain
    Russell D Romeo
    Laboratory of Neuroendocrinology, The Rockefeller University, Box 165, New York, NY 10021, USA
    Ann N Y Acad Sci 1094:202-14. 2006
    ....
  73. ncbi request reprint Decreases in neurokinin-3 tachykinin receptor-immunoreactive and -mRNA levels are associated with salt appetite in the deoxycorticosterone-treated rat
    Louis R Lucas
    Laboratory of Neuroendocrinology, The Rockefeller University, P O Box 165, 1230 York Avenue, New York, NY 10021, USA
    Brain Res 960:252-8. 2003
    ....
  74. pmc Regulation of CART mRNA by stress and corticosteroids in the hippocampus and amygdala
    Richard G Hunter
    Laboratory of Neuroendocrinology, Rockefeller University, New York, New York, NY 10021, USA
    Brain Res 1152:234-40. 2007
    ..Our data establish that CART expression is regulated by stress in a regionally and time specific manner and that CART is regulated by corticosteroid actions in the hippocampus...
  75. ncbi request reprint Effects of chronic stress on hippocampal long-term potentiation
    Constantine Pavlides
    The Rockefeller University, New York, New York 10021, USA
    Hippocampus 12:245-57. 2002
    ..Furthermore, they suggest that chronic stress produces changes in the input-output relationship in the hippocampal trisynaptic circuit which could affect information flow through this structure...
  76. pmc Estrogen and aging affect the synaptic distribution of estrogen receptor β-immunoreactivity in the CA1 region of female rat hippocampus
    Elizabeth M Waters
    Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY 10065, USA
    Brain Res 1379:86-97. 2011
    ..This suggests that synaptic ERβ may be a more responsive target to E, particularly in aged females...
  77. ncbi request reprint Pubertal maturation and time of day differentially affect behavioral and neuroendocrine responses following an acute stressor
    Russell D Romeo
    Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY 10021, USA
    Horm Behav 50:463-8. 2006
    ..These data indicate that pubertal development and time of day interact to modulate post-stress behavior and demonstrate a dissociation between post-stress hormonal and behavioral responses...
  78. pmc Hippocampal formation: shedding light on the influence of sex and stress on the brain
    Bruce S McEwen
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, Rockefeller University, 1300 York Avenue, New York, NY 10021, USA
    Brain Res Rev 55:343-55. 2007
    ..This new view is consistent with the predictions of Cajal in his book "The Structure of Ammon's horn", 1892...
  79. ncbi request reprint Stress history and pubertal development interact to shape hypothalamic-pituitary-adrenal axis plasticity
    Russell D Romeo
    Laboratory of Neuroendocrinology, Rockefeller University, New York, New York 10021, USA
    Endocrinology 147:1664-74. 2006
    ..These data indicate that experience-dependent plasticity of the hypothalamic-pituitary-adrenal neuroendocrine axis is significantly influenced by pubertal maturation...
  80. ncbi request reprint Involvement of mesolimbic structures in short-term sodium depletion: in situ hybridization and ligand-binding analyses
    Louis R Lucas
    Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY 10021, USA
    Neuroendocrinology 77:406-15. 2003
    ..Only the naltrindole-treated rats showed a blunted intake of salt solution. Thus, these findings along with our neurochemical results suggest that mesolimbic enkephalin might impact salt intake through dopaminergic systems...
  81. pmc Regulation of hippocampal H3 histone methylation by acute and chronic stress
    Richard G Hunter
    Laboratory of Neuroendocrinology, Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 106:20912-7. 2009
    ....
  82. pmc Regulation of the nicotinic receptor alpha7 subunit by chronic stress and corticosteroids
    Richard G Hunter
    Laboratory of Neuroendocrinology, Rockefeller University, New York, New York 10065, USA
    Brain Res 1325:141-6. 2010
    ..While the mechanism behind these observations is as yet unclear, they may be neuroprotective against the damaging effects of CRS or an example of adaptation to the allostatic load produced by CRS...
  83. pmc Central role of the brain in stress and adaptation: links to socioeconomic status, health, and disease
    Bruce S McEwen
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY 10065, USA
    Ann N Y Acad Sci 1186:190-222. 2010
    ..This review focuses specifically on the links between stress-related processes embedded within the social environment and embodied within the brain, which is viewed as the central mediator and target of allostasis and allostatic load...
  84. pmc Estrogen receptor alpha and beta specific agonists regulate expression of synaptic proteins in rat hippocampus
    Elizabeth M Waters
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
    Brain Res 1290:1-11. 2009
    ..Moreover, the effects of estradiol treatment on PSD-95 expression are consistent with a growing body of evidence that this postsynaptic protein is a key marker of estrogen action related to spine synapse formation...
  85. ncbi request reprint Stress-induced progesterone secretion and progesterone receptor immunoreactivity in the paraventricular nucleus are modulated by pubertal development in male rats
    Russell D Romeo
    The Rockefeller University, Laboratory of Neuroendocrinology, New York, NY 10021, USA
    Stress 8:265-71. 2005
    ..However, given the pleiotropic effects of progesterone on male physiology and behaviour, it is likely that the disparate post-stress exposure to progesterone affects the prepubertal and adult male differently...
  86. ncbi request reprint GLUT8 glucose transporter is localized to excitatory and inhibitory neurons in the rat hippocampus
    Lawrence P Reagan
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, Box 165, 1230 York Avenue, New York, NY 10021, USA
    Brain Res 932:129-34. 2002
    ..These results demonstrate that GLUT8 is a neuron-specific glucose transporter expressed in the neuronal cell bodies of excitatory and inhibitory neurons in the rat hippocampus...
  87. ncbi request reprint Steroid-induced hippocampal synaptic plasticity: sex differences and similarities
    Russell D Romeo
    Laboratory of Neuroendocrinology, The Rockefeller University, Box 165, New York, NY 10021, USA
    Neuron Glia Biol 1:219-29. 2004
    ....
  88. ncbi request reprint The effects of acute stress and pubertal development on metabolic hormones in the rat
    Russell D Romeo
    Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY 10021, USA
    Stress 10:101-6. 2007
    ..Furthermore, though stage of development significantly affects the levels of peripheral metabolic hormones such as insulin, T4 and T3, acute stress does not appreciably influence their secretion before or after puberty...
  89. pmc Rapid elevations in limbic endocannabinoid content by glucocorticoid hormones in vivo
    Matthew N Hill
    Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY 10065, USA
    Psychoneuroendocrinology 35:1333-8. 2010
    ..These data provide in vivo support for non-genomic steroid effects in mammals and suggest that AEA is a mediator of these effects...
  90. ncbi request reprint The concept of allostasis in biology and biomedicine
    Bruce S McEwen
    Laboratory of Neuroendocrinology, The Rockefeller University, Box 165, 1230 York Avenue, New York, NY 10021, USA
    Horm Behav 43:2-15. 2003
    ..If allostatic load is chronically high, then pathologies develop. Type 2 allostatic overload does not trigger an escape response, and can only be counteracted through learning and changes in the social structure...
  91. ncbi request reprint Anxiety and fear behaviors in adult male and female C57BL/6 mice are modulated by maternal separation
    Russell D Romeo
    Laboratory of Neuroendocrinology, Rockefeller University, New York, NY 10021, USA
    Horm Behav 43:561-7. 2003
    ..These results indicate that the emotionality of adult male and female mice can be modulated by maternal separation. However, this effect is dependent on the sex of the offspring and the phase of the estrous cycle of the female...
  92. ncbi request reprint Trends of reproductive hormones in male rats during psychosocial stress: role of glucocorticoid metabolism in behavioral dominance
    Matthew P Hardy
    Population Council Rockefeller University, New York, New York 10021, USA
    Biol Reprod 67:1750-5. 2002
    ....
  93. ncbi request reprint Allostatic load: when protection gives way to damage
    Bruce McEwen
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology Rockefeller University, New York, USA
    Adv Mind Body Med 19:28-33. 2003
  94. pmc Impact of genetic variant BDNF (Val66Met) on brain structure and function
    Zhe Yu Chen
    Department of Psychiatry, Weill Medical College of Cornell University, New York, NY 10021, USA
    Novartis Found Symp 289:180-8; discussion 188-95. 2008
    ..A genetic variant BDNF may thus play a key role in genetic predispositions to anxiety and depressive disorders...
  95. ncbi request reprint Toward a functional neuroanatomy of premenstrual dysphoric disorder
    Xenia Protopopescu
    Functional Neuroimaging Laboratory, Department of Psychiatry, Weill Medical College of Cornell University, New York, NY 10021, United States
    J Affect Disord 108:87-94. 2008
    ..The neurobiology of this underdiagnosed and undertreated illness is poorly understood. A functional magnetic resonance imaging (fMRI) probe of fronto-limbic function was used to advance understanding of PMDD pathophysiology...
  96. ncbi request reprint Reversibility of apical dendritic retraction in the rat medial prefrontal cortex following repeated stress
    Jason J Radley
    Department of Neuroscience, Mount Sinai School of Medicine, New York, NY 10029, USA
    Exp Neurol 196:199-203. 2005
    ..These results suggest that stress-induced dendritic plasticity in the medial PFC is reversible and may have implications for the functional recovery of medial PFC function following prolonged psychological stress...
  97. ncbi request reprint Serotonin mediates CA1 spine density but is not crucial for ovarian steroid regulation of synaptic plasticity in the adult rat dorsal hippocampus
    Stephen E Alves
    Atherosclerosis and Endocrinology, Merck Research Laboratories, Rahway, New Jersey 07065, USA
    Synapse 45:143-51. 2002
    ..5-HT-regulated spines/synapses may represent distinct populations from those modulated by estradiol and progesterone in dorsal hippocampus...
  98. ncbi request reprint Neurobiological and clinical effects of the antidepressant tianeptine
    Siegfried Kasper
    Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria
    CNS Drugs 22:15-26. 2008
    ..The neurobiological properties of tianeptine may provide an explanation not only for its antidepressant activity, but also for its anxiolytic effects in depressed patients and its lack of adverse effects on cognitive function and memory...
  99. ncbi request reprint Deficient hippocampal c-fos expression results in reduced anxiety and altered response to chronic stress in female mice
    Jill M Slane McQuade
    Department of Cell Biology, Neurobiology and Anatomy, University of Cincinnati College of Medicine, OH 45267, USA
    Neurosci Lett 403:125-30. 2006
    ..These findings suggest that hippocampal c-fos plays a role in gender-dependent response to stress...
  100. pmc Stress duration modulates the spatiotemporal patterns of spine formation in the basolateral amygdala
    Rupshi Mitra
    National Centre for Biological Sciences, Bangalore 560065, India
    Proc Natl Acad Sci U S A 102:9371-6. 2005
    ..Our results also suggest that stress may facilitate symptoms of chronic anxiety disorders like post-traumatic stress disorder by enhancing synaptic connectivity in the BLA...

Research Grants46

  1. GENE EXPRESSION IN NERVOUS TISSUE
    Bruce S McEwen; Fiscal Year: 2010
    ..abstract_text> ..
  2. GENE EXPRESSION IN NERVOUS TISSUE
    Bruce McEwen; Fiscal Year: 2000
    ..Finally, the sexual differentiation of synapse formation and the role of androgen as well as estrogens in males will be investigated. ..
  3. GENE EXPRESSION IN NERVOUS TISSUE
    Bruce McEwen; Fiscal Year: 2004
    ..We plan to use the power of mouse genetics by employing mice lacking ERa and ERb to provide more definitive information regarding the role of the two known intracellular ER types in these E effects. ..
  4. STRESS, ADRENAL STEROIDS AND THE BRAIN
    Bruce McEwen; Fiscal Year: 2009
    ..abstract_text> ..
  5. STRESS, ADRENAL STEROIDS AND THE BRAIN
    Bruce McEwen; Fiscal Year: 2007
    ..abstract_text> ..
  6. GENE EXPRESSION IN NERVOUS TISSUE
    Bruce McEwen; Fiscal Year: 2007
    ....
  7. GENE EXPRESSION IN NERVOUS TISSUE
    Bruce McEwen; Fiscal Year: 1980
    ..These effects may take the form of permanent differences in brain circuitry, levels of steroid receptors, of inducibility of gene products by steroids and other agents. ..
  8. STRESS, ADRENAL STEROIDS AND THE BRAIN
    Bruce McEwen; Fiscal Year: 1990
    ..hostages, prisoners of war)...
  9. STRESS, ADRENAL STEROIDS AND THE BRAIN
    Bruce McEwen; Fiscal Year: 1993
    ..Better understanding of the beneficial as well as destructive aspects of GC actions on neuronal survival may aid in developing treatment strategies to slow the rate of progress of neural degenerative diseases...
  10. GENE EXPRESSION IN NERVOUS TISSUE
    Bruce McEwen; Fiscal Year: 1993
    ....