McEwen B. Possible mechanisms for atrophy of the human hippocampus. Mol Psychiatry. 1997;2:255-62 pubmed
..In cases where atrophy is due to cell loss, the time course of the disease process will provide much useful information about mechanism and offer the possibility of early intervention to arrest or slow the pathological process. ..
McEwen B, Magarinos A, Reagan L. Structural plasticity and tianeptine: cellular and molecular targets. Eur Psychiatry. 2002;17 Suppl 3:318-30 pubmed
..In studying these actions, we hope to better understand the molecular and cellular targets of action of tianeptine in relation to its role in influencing structural plasticity of the hippocampus. ..
McEwen B, Tanapat P, Weiland N. Inhibition of dendritic spine induction on hippocampal CA1 pyramidal neurons by a nonsteroidal estrogen antagonist in female rats. Endocrinology. 1999;140:1044-7 pubmed
..This result is consistent with an action of estradiol via intracellular estrogen receptors that are known to be expressed by interneurons within the hippocampus. ..
McEwen B. Allostasis, allostatic load, and the aging nervous system: role of excitatory amino acids and excitotoxicity. Neurochem Res. 2000;25:1219-31 pubmed
..Moreover, the brain retains considerable resilience in the face of stress, and estrogens appear to play a role in this resilience. This review discusses the current status of work on underlying mechanisms for these effects. ..