B S McEwen

Summary

Affiliation: The Rockefeller University
Country: USA

Publications

  1. pmc Brain on stress: how the social environment gets under the skin
    Bruce S McEwen
    Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 109:17180-5. 2012
  2. doi request reprint Stress- and allostasis-induced brain plasticity
    Bruce S McEwen
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, New York, New York 10065, USA
    Annu Rev Med 62:431-45. 2011
  3. pmc The neurobiological properties of tianeptine (Stablon): from monoamine hypothesis to glutamatergic modulation
    B S McEwen
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY, USA
    Mol Psychiatry 15:237-49. 2010
  4. pmc Hippocampal formation: shedding light on the influence of sex and stress on the brain
    Bruce S McEwen
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, Rockefeller University, 1300 York Avenue, New York, NY 10021, USA
    Brain Res Rev 55:343-55. 2007
  5. pmc Central role of the brain in stress and adaptation: links to socioeconomic status, health, and disease
    Bruce S McEwen
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY 10065, USA
    Ann N Y Acad Sci 1186:190-222. 2010
  6. ncbi request reprint Neurobiology of mood, anxiety, and emotions as revealed by studies of a unique antidepressant: tianeptine
    B S McEwen
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY 10021, USA
    Mol Psychiatry 10:525-37. 2005
  7. ncbi request reprint Molecular mechanisms of neuroplasticity and pharmacological implications: the example of tianeptine
    Bruce S McEwen
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology Rockefeller University, New York, NY 10021, USA
    Eur Neuropsychopharmacol 14:S497-502. 2004
  8. pmc Protective and damaging effects of stress mediators: central role of the brain
    Bruce S McEwen
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY 10021, USA
    Dialogues Clin Neurosci 8:367-81. 2006
  9. pmc Stress, sex, and neural adaptation to a changing environment: mechanisms of neuronal remodeling
    Bruce S McEwen
    Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY 10065, USA
    Ann N Y Acad Sci 1204:E38-59. 2010
  10. ncbi request reprint Chronic social stress reduces dendritic arbors in CA3 of hippocampus and decreases binding to serotonin transporter sites
    C R McKittrick
    Laboratory of Neuroendocrinology, The Rockefeller University, New York, New York 10021, USA
    Synapse 36:85-94. 2000

Collaborators

Detail Information

Publications160 found, 100 shown here

  1. pmc Brain on stress: how the social environment gets under the skin
    Bruce S McEwen
    Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 109:17180-5. 2012
    ....
  2. doi request reprint Stress- and allostasis-induced brain plasticity
    Bruce S McEwen
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, New York, New York 10065, USA
    Annu Rev Med 62:431-45. 2011
    ..It also considers interventions to prevent and treat chronic and prevalent health conditions via allodynamic brain mechanisms...
  3. pmc The neurobiological properties of tianeptine (Stablon): from monoamine hypothesis to glutamatergic modulation
    B S McEwen
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY, USA
    Mol Psychiatry 15:237-49. 2010
    ..Converging lines of evidences demonstrate actions of tianeptine on the glutamatergic system, and therefore offer new insights into how tianeptine may be useful in the treatment of depressive disorders...
  4. pmc Hippocampal formation: shedding light on the influence of sex and stress on the brain
    Bruce S McEwen
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, Rockefeller University, 1300 York Avenue, New York, NY 10021, USA
    Brain Res Rev 55:343-55. 2007
    ..This new view is consistent with the predictions of Cajal in his book "The Structure of Ammon's horn", 1892...
  5. pmc Central role of the brain in stress and adaptation: links to socioeconomic status, health, and disease
    Bruce S McEwen
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY 10065, USA
    Ann N Y Acad Sci 1186:190-222. 2010
    ..This review focuses specifically on the links between stress-related processes embedded within the social environment and embodied within the brain, which is viewed as the central mediator and target of allostasis and allostatic load...
  6. ncbi request reprint Neurobiology of mood, anxiety, and emotions as revealed by studies of a unique antidepressant: tianeptine
    B S McEwen
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY 10021, USA
    Mol Psychiatry 10:525-37. 2005
    ..Together with clinical data on the efficacy of tianeptine as an antidepressant, these actions offer insights into how compounds like tianeptine may be useful in the treatment of neurobiological features of depressive disorders...
  7. ncbi request reprint Molecular mechanisms of neuroplasticity and pharmacological implications: the example of tianeptine
    Bruce S McEwen
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology Rockefeller University, New York, NY 10021, USA
    Eur Neuropsychopharmacol 14:S497-502. 2004
    ..Chronic treatment with the antidepressant tianeptine may prevent these effects in hippocampus and amygdala...
  8. pmc Protective and damaging effects of stress mediators: central role of the brain
    Bruce S McEwen
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY 10021, USA
    Dialogues Clin Neurosci 8:367-81. 2006
    ....
  9. pmc Stress, sex, and neural adaptation to a changing environment: mechanisms of neuronal remodeling
    Bruce S McEwen
    Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY 10065, USA
    Ann N Y Acad Sci 1204:E38-59. 2010
    ..A better understanding of hormone-brain interactions should promote more flexible approaches to the treatment of psychiatric disorders, as well as their prevention through both behavioral and pharmaceutical interventions...
  10. ncbi request reprint Chronic social stress reduces dendritic arbors in CA3 of hippocampus and decreases binding to serotonin transporter sites
    C R McKittrick
    Laboratory of Neuroendocrinology, The Rockefeller University, New York, New York 10021, USA
    Synapse 36:85-94. 2000
    ..The mechanisms underlying dendritic remodeling in CA3 pyramidal neurons are likely to involve stress-induced changes in glucocorticoids and in 5HT and other transmitters...
  11. ncbi request reprint Effect of 5,7-dihydroxytryptamine, ovariectomy and gonadal steroids on serotonin receptor binding in rat brain
    M Frankfurt
    Rockefeller University, New York, NY 10021
    Neuroendocrinology 59:245-50. 1994
    ..The relationship of these results to the role of 5-HT in mediating lordosis behavior is discussed...
  12. ncbi request reprint Plasticity of the hippocampus: adaptation to chronic stress and allostatic load
    B S McEwen
    Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY 10021, USA
    Ann N Y Acad Sci 933:265-77. 2001
    ....
  13. pmc Estradiol acts via estrogen receptors alpha and beta on pathways important for synaptic plasticity in the mouse hippocampal formation
    J L Spencer-Segal
    Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY, USA
    Neuroscience 202:131-46. 2012
    ..By further delineating these mechanisms, we will better understand and predict the effects of endogenous and exogenous ovarian steroids on mood, cognition, and other hippocampal-dependent behaviors...
  14. ncbi request reprint Novel target sites for estrogen action in the dorsal hippocampus: an examination of synaptic proteins
    W G Brake
    Laboratory of Neuroendocrinology, The Rockefeller University, New York, New York 10021, USA
    Endocrinology 142:1284-9. 2001
    ..These results also suggest that RICC is a rapid and sensitive method for examining molecular changes in synaptic profiles in anatomically distinct brain regions...
  15. ncbi request reprint NMDA receptor antagonist treatment induces a long-lasting increase in the number of proliferating cells, PSA-NCAM-immunoreactive granule neurons and radial glia in the adult rat dentate gyrus
    J Nacher
    Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY 10021, USA
    Eur J Neurosci 13:512-20. 2001
    ..Thus, NMDA receptor antagonist treatment serves as a valuable tool to increase neurogenesis in the adult hippocampus without undesirable collateral deleterious effects...
  16. ncbi request reprint Widespread expression of rat collapsin response-mediated protein 4 in the telencephalon and other areas of the adult rat central nervous system
    J Nacher
    Laboratory of Neuroendocrinology, The Rockefeller University, New York, New York 10021, USA
    J Comp Neurol 424:628-39. 2000
    ..These cells did not express neuronal, astroglial, or microglial markers, although some of them also were immunoreactive for rip antibody, suggesting an oligodendroglial lineage...
  17. ncbi request reprint Ultrastructural evidence that hippocampal alpha estrogen receptors are located at extranuclear sites
    T A Milner
    Division of Neurobiology, Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Comp Neurol 429:355-71. 2001
    ..Collectively, these results suggest that ERalpha may serve as both a genomic and nongenomic transducer of estrogen action in the HF...
  18. ncbi request reprint Stress-induced changes in blood leukocyte distribution. Role of adrenal steroid hormones
    F S Dhabhar
    Rockefeller University, New York, NY 10021, USA
    J Immunol 157:1638-44. 1996
    ..These results suggest that CORT, acting at the type II adrenal steroid receptor, is a major mediator of the stress-induced changes in blood lymphocyte and monocyte distribution...
  19. ncbi request reprint Immunocytochemical analysis of synaptic proteins provides new insights into diabetes-mediated plasticity in the rat hippocampus
    C A Grillo
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Neuroscience 136:477-86. 2005
    ....
  20. ncbi request reprint Regulation of glucocorticoid receptor and mineralocorticoid receptor messenger ribonucleic acids by selective agonists in the rat hippocampus
    H M Chao
    The Rockefeller University, Laboratory of Neuroendocrinology, New York, New York 10021, USA
    Endocrinology 139:1810-4. 1998
    ..The extent to which a specific agonist can produce a significant change in the expression of a particular steroid receptor mRNA varies between the different subfields of the hippocampus...
  21. pmc Structural and functional alterations to rat medial prefrontal cortex following chronic restraint stress and recovery
    D S Goldwater
    Fishberg Department of Neuroscience and Kastor Neurobiology of Aging Laboratories, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Neuroscience 164:798-808. 2009
    ....
  22. ncbi request reprint Oxidative stress and HNE conjugation of GLUT3 are increased in the hippocampus of diabetic rats subjected to stress
    L P Reagan
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, Box 165, 1230 York Avenue, New York, NY, USA
    Brain Res 862:292-300. 2000
    ..In addition, increases in HNE protein conjugation of GLUT3 provide a potential mechanism for stress- and diabetes-mediated decreases in hippocampal neuronal glucose utilization...
  23. ncbi request reprint Induction of calcitonin gene-related peptide-like immunoreactivity in hippocampal neurons following ischemia: a putative regional modulator of the CNS injury/immune response
    K Bulloch
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
    Exp Neurol 150:195-205. 1998
    ....
  24. ncbi request reprint Adrenal steroid regulation of neurotrophic factor expression in the rat hippocampus
    H M Chao
    The Rockefeller University, Laboratory of Neuroendocrinology, New York, New York 10021, USA
    Endocrinology 139:3112-8. 1998
    ..Thus the extent to which adrenal steroids regulate hippocampal neurotrophic and growth-associated factors, appears to be dependent both on the adrenal steroid receptor subtype activated and on the hippocampal subregion examined...
  25. ncbi request reprint Serotonin receptor binding in a colony model of chronic social stress
    C R McKittrick
    Laboratory of Neuroendocrinology, Rockefeller University, New York, NY 10021, USA
    Biol Psychiatry 37:383-93. 1995
    ..No changes were observed in binding to 5-HT1B receptors. These results are discussed in the context of regulation of the serotonergic system by stress and glucocorticoids and possible relevance to the pathophysiology of depression...
  26. ncbi request reprint Stress-induced atrophy of apical dendrites of hippocampal CA3c neurons: involvement of glucocorticoid secretion and excitatory amino acid receptors
    A M Magarinos
    Laboratory of Neuroendocrinology, Rockefeller University, New York, New York 10021, USA
    Neuroscience 69:89-98. 1995
    ....
  27. ncbi request reprint Chronic stress impairs rat spatial memory on the Y maze, and this effect is blocked by tianeptine pretreatment
    C D Conrad
    Laboratory of Neuroendocrinology, Rockefeller University, New York 10021, USA
    Behav Neurosci 110:1321-34. 1996
    ..These data are consistent with the previously demonstrated ability of tianeptine to prevent chronic stress-induced atrophy of the CA3 dendrites...
  28. ncbi request reprint Role of adrenal steroid mineralocorticoid and glucocorticoid receptors in long-term potentiation in the CA1 field of hippocampal slices
    C Pavlides
    Rockefeller University, New York, NY 10021, USA
    Brain Res 738:229-35. 1996
    ..The present results are in agreement with previous studies showing that elevations in corticosterone or an acute episode of experimentally induced stress in vivo causes a suppression in LTP in the hippocampal CA1 field, in vitro...
  29. ncbi request reprint The neurobiology of stress: from serendipity to clinical relevance
    B S McEwen
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, 1230 York Avenue, Box 165, 10021, New York, NY, USA
    Brain Res 886:172-189. 2000
    ..Stress-induced structural changes in brain regions such as the hippocampus have clinical ramifications for disorders such as depression, post-traumatic stress disorder and individual differences in the aging process...
  30. ncbi request reprint Autoradiographic analyses of the effects of adrenalectomy and corticosterone on 5-HT1A and 5-HT1B receptors in the dorsal hippocampus and cortex of the rat
    S D Mendelson
    Laboratory of Neuroendocrinology, Rockefeller University, New York, N Y 10021
    Neuroendocrinology 55:444-50. 1992
    ..Such changes in binding may play important roles in the etiology of depression...
  31. ncbi request reprint Adaptation to prolonged or repeated stress--comparison between rat strains showing intrinsic differences in reactivity to acute stress
    F S Dhabhar
    Laboratory of Neuroendocrinology, The Rockefeller University, New York, N Y 10021, USA
    Neuroendocrinology 65:360-8. 1997
    ..These differences under prolonged or repeated stress conditions may consequently magnify the behavioral and immunological differences observed between strains under basal as well as challenged conditions...
  32. pmc Hippocampal dynorphin immunoreactivity increases in response to gonadal steroids and is positioned for direct modulation by ovarian steroid receptors
    A Torres-Reveron
    Division of Neurobiology, Department of Neurology and Neuroscience, Weill Cornell Medical College, 411 East 69th Street, New York, NY 10021, USA
    Neuroscience 159:204-16. 2009
    ..These studies indicate that ovarian hormones can modulate DYN in the MF pathway in a time-dependent manner, and suggest that hormonal effects on the DYN-containing MF pathway may be directly mediated by ERbeta and/or PR activation...
  33. pmc Localization and regulation of GLUTx1 glucose transporter in the hippocampus of streptozotocin diabetic rats
    L P Reagan
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 98:2820-5. 2001
    ....
  34. pmc Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior
    Zhe Yu Chen
    Department of Psychiatry, Weill Medical College of Cornell University, New York, NY 10021, USA
    Science 314:140-3. 2006
    ..A variant BDNF may thus play a key role in genetic predispositions to anxiety and depressive disorders...
  35. ncbi request reprint Brain region-specific up-regulation of mouse apolipoprotein E by pharmacological estrogen treatments
    J Levin-Allerhand
    The Rockefeller University, New York, New York 10021, USA
    J Neurochem 79:796-803. 2001
    ..Measurement of mRNA levels in estrogen versus placebo-treated wild-type mice indicated that the effect of 17 beta-estradiol on apoE was not associated with changes in apoE mRNA levels...
  36. ncbi request reprint Estradiol affects spinophilin protein differently in gonadectomized males and females
    S J Lee
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, Box 165, 1230 York Avenue, New York, NY 10021, USA
    Neuroscience 127:983-8. 2004
    ..This suggests the possibility that E regulates spinophilin protein expression and or stability within dendrites via post-transcriptional mechanisms...
  37. ncbi request reprint Doublecortin expression in the adult rat telencephalon
    J Nacher
    Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY 10021, USA
    Eur J Neurosci 14:629-44. 2001
    ..Given these results, we hypothesize that DCX expression in differentiated neurons could be related to its capacity for microtubule reorganization and that this fact could be linked to axonal outgrowth or synaptogenesis...
  38. ncbi request reprint Distribution and hormone regulation of estrogen receptor immunoreactive cells in the hippocampus of male and female rats
    N G Weiland
    Laboratory of Neuroendocrinology, Rockefeller University, New York, New York 10021, USA
    J Comp Neurol 388:603-12. 1997
    ..From this, we can conclude that estrogen can have a direct effect on hippocampal neurons and that any sex differences in estrogen responsiveness is due to something other than sex differences in ER levels or function in the hippocampus...
  39. ncbi request reprint Volumetric measurement of the hippocampus, the anterior cingulate cortex, and the retrosplenial granular cortex of the rat using structural MRI
    O T Wolf
    Center for Brain Health, Neuroimaging Laboratory, NYU School of Medicine, New York, NY 10016, USA
    Brain Res Brain Res Protoc 10:41-6. 2002
    ..93. The current protocol should facilitate future in vivo neuroimaging research using animal models of neurodegenerative diseases...
  40. pmc Chronic stress alters synaptic terminal structure in hippocampus
    A M Magarinos
    The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 94:14002-8. 1997
    ....
  41. ncbi request reprint Fear learning transiently impairs hippocampal cell proliferation
    K Pham
    Laboratory of Neuroendocrinology, Rockefeller University, New York, NY 10021, USA
    Neuroscience 130:17-24. 2005
    ..Instead, the effect of context conditioning on cell proliferation appears to be specifically due to the formation of an association between the context and shock during training, an amygdala dependent function...
  42. ncbi request reprint Mood disorders and allostatic load
    Bruce S McEwen
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, New York, New York 10021, USA
    Biol Psychiatry 54:200-7. 2003
    ..Allostatic load is seen in major depressive illness and may also be expressed in other chronic anxiety disorders such as PTSD and should be documented...
  43. pmc Uncovering the mechanisms of estrogen effects on hippocampal function
    Joanna L Spencer
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, 1300 York Avenue, New York, NY 10065, USA
    Front Neuroendocrinol 29:219-37. 2008
    ..Finally, estrogen may signal through both nuclear and extranuclear hippocampal estrogen receptors to achieve its downstream effects...
  44. ncbi request reprint Astrocytes give rise to new neurons in the adult mammalian hippocampus
    B Seri
    The Rockefeller University, New York, New York 10021, USA
    J Neurosci 21:7153-60. 2001
    ..These results reveal the origins of new neurons in the adult hippocampus...
  45. ncbi request reprint Calcitonin gene-related peptide immunoreactivity in the hippocampus and its relationship to cellular changes following exposure to trimethyltin
    K Bulloch
    Laboratory of Neuroendocrinology, Rockefeller University, New York, New York 10021, USA
    J Neurosci Res 55:441-57. 1999
    ..Given the known effects of CGRP on these cell types and on programmed cell death elsewhere, these findings are consistent with a regional immunoregulatory/injury response role for CGRP following organotin poisoning...
  46. ncbi request reprint Structural plasticity and tianeptine: cellular and molecular targets
    B S McEwen
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY 10021, USA
    Eur Psychiatry 17:318-30. 2002
    ..In studying these actions, we hope to better understand the molecular and cellular targets of action of tianeptine in relation to its role in influencing structural plasticity of the hippocampus...
  47. ncbi request reprint Immunocytochemical localization of nuclear estrogen receptors and progestin receptors within the rat dorsal raphe nucleus
    S E Alves
    Laboratory of Neuroendocrinology, The Rockefeller University, New York, New York 10021, USA
    J Comp Neurol 391:322-34. 1998
    ..These findings point to a species difference in ovarian steroid regulation of 5-HT activity between the macaque and the rat, perhaps transsynaptically via local neurons in the rat brain...
  48. ncbi request reprint Studies of hormone action in the hippocampal formation: possible relevance to depression and diabetes
    Bruce S McEwen
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, Box 165, 1230 York Avenue, New York, NY 10021, USA
    J Psychosom Res 53:883-90. 2002
    ..The hippocampus is also vulnerable to damage by stroke and head trauma and susceptible to damage during aging and repeated stress, and is sensitive to the effects of diabetes...
  49. ncbi request reprint Behavioral and biological effects of chronic S18986, a positive AMPA receptor modulator, during aging
    Erik B Bloss
    The Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY 10021, USA
    Exp Neurol 210:109-17. 2008
    ..These results provide a framework for further studies of the potentially beneficial effects of AMPAR modulators on brain aging...
  50. ncbi request reprint Estrogen levels regulate the subcellular distribution of phosphorylated Akt in hippocampal CA1 dendrites
    Vladimir Znamensky
    Division of Neurobiology, Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Neurosci 23:2340-7. 2003
    ..These findings suggest that estrogens may regulate spine formation in CA1 pyramidal neurons via Akt-mediated signaling events...
  51. pmc Cellular and subcellular localization of estrogen and progestin receptor immunoreactivities in the mouse hippocampus
    Katherine L Mitterling
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, New York, New York 10065, USA
    J Comp Neurol 518:2729-43. 2010
    ....
  52. ncbi request reprint Age-specific threats induce CRF expression in the paraventricular nucleus of the hypothalamus and hippocampus of young rats
    Christoph P Wiedenmayer
    Department of Psychiatry, Columbia University, New York, NY 10032, USA
    Horm Behav 47:139-50. 2005
    ..Hippocampal CRF mRNA expression levels did not parallel cat odor or male-induced immobility, indicating that CRF is not involved in this response in young rats but may be involved in aspects of learning and memory...
  53. pmc Interactive effects of stress and aging on structural plasticity in the prefrontal cortex
    Erik B Bloss
    Fishberg Department of Neuroscience and Kastor Neurobiology of Aging Laboratories, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Neurosci 30:6726-31. 2010
    ..The data presented here provide evidence that aging is accompanied by selective impairments in long-term neocortical morphological plasticity...
  54. ncbi request reprint Serotonin modulation of sensory inputs to the lateral amygdala: dependency on corticosterone
    G E Stutzmann
    New York University, Center for Neural Science, New York, New York 10003, USA
    J Neurosci 18:9529-38. 1998
    ..Via this mechanism, 5-HT modulates the processing of sensory information within the LA and thus may regulate amygdala-related functions...
  55. pmc Effect of brain-derived neurotrophic factor haploinsufficiency on stress-induced remodeling of hippocampal neurons
    A M Magarinos
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, Rockefeller University, New York, USA
    Hippocampus 21:253-64. 2011
    ..The inability of CRS to modify the dendritic structure of CA3 pyramidal neurons in BDNF(±) mice suggests an indirect, perhaps permissive, role of BDNF in mediating hippocampal dendritic remodeling...
  56. ncbi request reprint Impaired adaptation of the hypothalamic-pituitary-adrenal axis to chronic ethanol stress in aged rats
    R L Spencer
    Department of Neuroendocrinology, Rockefeller University, New York, N Y, USA
    Neuroendocrinology 65:353-9. 1997
    ..This study suggests that in aged rats there are changes in the adaptive mechanisms contributing to tolerance of the HPA axis response to ethanol...
  57. ncbi request reprint The effects of type I and type II corticosteroid receptor agonists on exploratory behavior and spatial memory in the Y-maze
    C D Conrad
    Laboratory of Neuroendocrinology, Rockefeller University, New York, NY 10021, USA
    Brain Res 759:76-83. 1997
    ..These data are discussed along with other evidence to suggest that Type II receptors may require the simultaneous occupancy of Type I receptors to affect learning and memory processes...
  58. ncbi request reprint Chronic restraint stress and chronic corticosterone treatment modulate differentially the expression of molecules related to structural plasticity in the adult rat piriform cortex
    J Nacher
    Laboratory of Neuroendocrinology, Rockefeller University, New York, NY 10021, USA
    Neuroscience 126:503-9. 2004
    ..This is a potential mechanism by which stress and corticosterone modulate functions of this limbic region, such as its participation in olfactory memory...
  59. ncbi request reprint Differential expression of suppressors of cytokine signaling-1, -2, and -3 in the rat hippocampus after seizure: implications for neuromodulation by gp130 cytokines
    D R Rosell
    Laboratory of Neuroendocrinology, The Rockefeller University, 1230 York Avenue, Box 165, New York, NY 10021, USA
    Neuroscience 122:349-58. 2003
    ..Since in our previous study we did not detect cytokine receptor expression in non-principal cells, it is unclear what elicits SOCS-3 expression in this population...
  60. ncbi request reprint Changes in interneuronal phenotypes regulated by estradiol in the adult rat hippocampus: a potential role for neuropeptide Y
    N H Nakamura
    Laboratory of Neuroendocrinology, The Rockefeller University, Box 165, 1230 York Avenue, New York, NY 10021 6399, USA
    Neuroscience 136:357-69. 2005
    ....
  61. pmc Estrous cycle regulates activation of hippocampal Akt, LIM kinase, and neurotrophin receptors in C57BL/6 mice
    J L Spencer
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY 10065, USA
    Neuroscience 155:1106-19. 2008
    ..The findings suggest that endogenous estradiol and progesterone produced by the ovaries modulate specific signaling pathways governing actin remodeling, cell excitability, and synapse formation...
  62. pmc Experimental diabetes in rats causes hippocampal dendritic and synaptic reorganization and increased glucocorticoid reactivity to stress
    A M Magarinos
    The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 97:11056-61. 2000
    ....
  63. ncbi request reprint Stress and the aging hippocampus
    B S McEwen
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, Rockefeller University, 1230 York Avenue, New York, New York, 10021, USA
    Front Neuroendocrinol 20:49-70. 1999
    ....
  64. ncbi request reprint Effects of antidepressants and benzodiazepine treatments on the dendritic structure of CA3 pyramidal neurons after chronic stress
    A M Magarinos
    The Rockefeller University, New York, NY 10021, USA
    Eur J Pharmacol 371:113-22. 1999
    ..These findings suggest that the synaptic availability of 5-HT is involved in the mechanism leading to stress-induced dendritic remodeling and supports the idea that the hippocampal inhibitory GABAergic tone may play a regulatory role...
  65. ncbi request reprint Volumetric structural magnetic resonance imaging (MRI) of the rat hippocampus following kainic acid (KA) treatment
    O T Wolf
    Center for Brain Health, Neuroimaging Lab, NYU School of Medicine New York, New York, NY 10016, USA
    Brain Res 934:87-96. 2002
    ..These data demonstrate a reliable and valid method for the measurement of the rat hippocampus in vivo using MRI with a high field magnet, thereby providing a useful tool for future studies of rodent models of neuro-degenerative diseases...
  66. pmc Estrogen alters hippocampal dendritic spine shape and enhances synaptic protein immunoreactivity and spatial memory in female mice
    Chenjian Li
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 101:2185-90. 2004
    ....
  67. ncbi request reprint Estrogen and aging affect the subcellular distribution of estrogen receptor-alpha in the hippocampus of female rats
    Michelle M Adams
    Kastor Neurobiology of Aging Laboratories, Fishberg Research Center for Neurobiology, and Henry L Schwartz Department of Geriatrics and Adult Development, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    J Neurosci 22:3608-14. 2002
    ..Such a role for spinous ER-alpha has important implications for age-related attenuation of estrogen-induced hippocampal plasticity...
  68. ncbi request reprint Biphasic effects of stress upon GLUT8 glucose transporter expression and trafficking in the diabetic rat hippocampus
    Gerardo G Piroli
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Brain Res 1006:28-35. 2004
    ....
  69. ncbi request reprint Protective and damaging effects of mediators of stress. Elaborating and testing the concepts of allostasis and allostatic load
    B S McEwen
    Laboratory of Neuroendocrinology, Rockefeller University, New York, New York 10021, USA
    Ann N Y Acad Sci 896:30-47. 1999
    ....
  70. ncbi request reprint Selective regulation of T-cell development and function by calcitonin gene-related peptide in thymus and spleen. An example of differential regional regulation of immunity by the neuroendocrine system
    K Bulloch
    Laboratory of Neuroendocrinology, Rokefeller University, New York, NY 10021, USA
    Ann N Y Acad Sci 840:551-62. 1998
    ..These effects of a neuropeptide exemplify the phenomenon of differential regional regulation of immunity by the autonomic and neuroendocrine systems...
  71. ncbi request reprint Chronic treatment with pentazocine or SFK 10047 decrease proenkephalin mRNA levels in the rat striatum and nucleus accumbens
    J A Angulo
    Laboratory of Neuroendocrinology, Rockefeller University, New York, NY 10021
    Neurosci Lett 122:47-9. 1991
    ..The results demonstrate that sigma-receptor activity can exert tonic effects on proenkephalin mRNA expression in the striatum and the nucleus accumbens of the rat...
  72. ncbi request reprint Chronic behavioral stress induces apical dendritic reorganization in pyramidal neurons of the medial prefrontal cortex
    J J Radley
    Kastor Neurobiology of Aging Laboratories and Fishberg Research Center for Neurobiology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Neuroscience 125:1-6. 2004
    ....
  73. ncbi request reprint Peritoneal implantation of macroencapsulated porcine pancreatic islets in diabetic rats ameliorates severe hyperglycemia and prevents retraction and simplification of hippocampal dendrites
    A M Magarinos
    Laboratory of Neuroendocrinology, The Rockefeller University, 1230 York Avenue, 10021, New York, NY, USA
    Brain Res 902:282-7. 2001
    ....
  74. ncbi request reprint Activation of the type 2 adrenal steroid receptor can rescue granule cells from death during development
    E Gould
    Laboratory of Neuroendocrinology, Rockefeller University, New York, NY 10021, USA
    Brain Res Dev Brain Res 101:265-8. 1997
    ..RU28362 administration decreased the numbers of degenerating granule cells suggesting that type 2 receptor activation can rescue granule cells from degeneration...
  75. ncbi request reprint Inhibition of dendritic spine induction on hippocampal CA1 pyramidal neurons by a nonsteroidal estrogen antagonist in female rats
    B S McEwen
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, Rockefeller University, New York, New York 10021, USA
    Endocrinology 140:1044-7. 1999
    ..This result is consistent with an action of estradiol via intracellular estrogen receptors that are known to be expressed by interneurons within the hippocampus...
  76. ncbi request reprint Neuroendocrine-related effects of long-term, 'binge' cocaine administration: diminished individual differences in stress-induced corticosterone response
    Z Sarnyai
    Laboratory of Neuroendocrinology, The Rockefeller University, New York, N Y, 10021, USA
    Neuroendocrinology 68:334-44. 1998
    ..These results indicate that chronic binge cocaine administration leads to sustained activation of the HPA axis and alters processes underlying individual vulnerability to stress...
  77. ncbi request reprint Effect of chronic restraint stress and tianeptine on growth factors, growth-associated protein-43 and microtubule-associated protein 2 mRNA expression in the rat hippocampus
    Y Kuroda
    Laboratory of Neuroendocrinology, Rockefeller University, New York, NY, USA
    Brain Res Mol Brain Res 59:35-9. 1998
    ..We conclude that these neurotrophins, GAP-43 and MAP2 are not likely to be directly related to the chronic stress-induced dendritic atrophy or the prevention of the atrophy by tianeptine...
  78. ncbi request reprint Acute stress enhances while chronic stress suppresses cell-mediated immunity in vivo: a potential role for leukocyte trafficking
    F S Dhabhar
    Rockefeller University, New York, NY 10021, USA
    Brain Behav Immun 11:286-306. 1997
    ..These results suggest that stress-induced alterations in lymphocyte redeployment may play an important role in mediating the bi-directional effects of acute versus chronic stress on cell-mediated immunity in vivo...
  79. ncbi request reprint NMDA receptor antagonist treatment increases the production of new neurons in the aged rat hippocampus
    Juan Nacher
    Laboratory of Neuroendocrinology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Neurobiol Aging 24:273-84. 2003
    ..Injection of the NMDA receptor antagonist to aged rats increases significantly the number of proliferating cells, new neurons and radial glia-like cells in the hippocampus...
  80. pmc Diurnal regulation of the gastrin-releasing peptide receptor in the mouse circadian clock
    Ilia N Karatsoreos
    Department of Psychology, Columbia University, New York, NY 10027, USA
    Eur J Neurosci 23:1047-53. 2006
    ..Together, the present findings reveal that changes in GRPr are light driven and not endogenously organized. Diurnal variation in GRPr activity probably underlies intra-SCN signaling important for entrainment and phase shifting...
  81. ncbi request reprint Involvement of AMPA receptor phosphorylation in antidepressant actions with special reference to tianeptine
    Per Svenningsson
    Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, New York 10021, USA
    Eur J Neurosci 26:3509-17. 2007
    ....
  82. ncbi request reprint Estrogen stimulates postsynaptic density-95 rapid protein synthesis via the Akt/protein kinase B pathway
    Keith T Akama
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, New York, New York 10021 6399, USA
    J Neurosci 23:2333-9. 2003
    ....
  83. pmc Ovarian steroids alter mu opioid receptor trafficking in hippocampal parvalbumin GABAergic interneurons
    Annelyn Torres-Reveron
    Division of Neurobiology, Department of Neurology and Neuroscience, Weill Cornell Medical College, 407 East 61st Street, New York, NY 10065, USA
    Exp Neurol 219:319-27. 2009
    ....
  84. ncbi request reprint Spatiotemporal distribution of gp130 cytokines and their receptors after status epilepticus: comparison with neuronal degeneration and microglial activation
    D R Rosell
    Laboratory of Neuroendocrinology, The Rockefeller University, 1230 York Avenue, Box 165, New York, NY 10021, USA
    Neuroscience 122:329-48. 2003
    ..Furthermore, we suggest that activity-dependent mechanisms may be involved in the regulation of cytokines expressed early, and that relatively late occurring cytokine expression may be elicited by injury-related stimuli...
  85. pmc Impaired hippocampal-dependent learning and functional abnormalities in the hippocampus in mice lacking serotonin(1A) receptors
    Z Sarnyai
    Laboratory of Neuroendocrinology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 97:14731-6. 2000
    ....
  86. ncbi request reprint Mother lowers glucocorticoid levels of preweaning rats after acute threat
    Christoph P Wiedenmayer
    Department of Psychiatry, Columbia University, 1051 Riverside Drive, Unit 40, New York, NY 10032, USA
    Ann N Y Acad Sci 1008:304-7. 2003
    ..The endocrine stress response was decreased when the pups were reunited with their mother immediately after exposure. These findings demonstrate that social variables can reduce the consequences of an aversive experience...
  87. doi request reprint Chronic immobilization stress alters aspects of emotionality and associative learning in the rat
    Gwendolyn E Wood
    The Laboratory of Neuroendocrinology The Rockefeller University, New York, NY 10065, USA
    Behav Neurosci 122:282-92. 2008
    ..e., struggling and helplessness). These results emphasize the emotional and learned responses to CIS evident during and after the stress treatment, as well as the importance of individual differences...
  88. doi request reprint Steroid hormone receptor expression and function in microglia
    Amanda Sierra
    Laboratory of Neuroendocrinology, Rockefeller University, New York, New York 10021, USA
    Glia 56:659-74. 2008
    ....
  89. ncbi request reprint Regulation of neurotransmitter release by synapsin III
    Jian Feng
    Laboratory of Molecular and Cellular Neuroscience and Laboratory of Endocrinology, The Rockefeller University, New York, New York 10021, USA
    J Neurosci 22:4372-80. 2002
    ..Our data indicate that synapsin III plays unique roles both in early axon outgrowth and in the regulation of synaptic vesicle trafficking...
  90. ncbi request reprint Diabetes, but not stress, reduces neuronal nitric oxide synthase expression in rat hippocampus: implications for hippocampal synaptic plasticity
    Lawrence P Reagan
    Haroldand Margaret Milliken Hatch Laboratory of Neuroendocrinology, Rockefeller University, New York, NY 10021, USA
    Neuroreport 13:1801-4. 2002
    ....
  91. ncbi request reprint Glucocorticoid receptor mRNA expression in the hippocampal formation of male rats before and after pubertal development in response to acute or repeated stress
    Russell D Romeo
    Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY, USA
    Neuroendocrinology 87:160-7. 2008
    ..These data point to a dissociation between differential stress-induced corticosterone responses and regulation of hippocampal GR levels in prepubertal and adult animals...
  92. ncbi request reprint Morphological changes in the hippocampal CA3 region induced by non-invasive glucocorticoid administration: a paradox
    A M Magarinos
    Department of Biology, Arizona State University, Tempe, USA
    Brain Res 809:314-8. 1998
    ....
  93. pmc Differential colocalization of estrogen receptor beta (ERbeta) with oxytocin and vasopressin in the paraventricular and supraoptic nuclei of the female rat brain: an immunocytochemical study
    S E Alves
    Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 95:3281-6. 1998
    ..These findings suggest that estrogen can directly modulate specific OT and AVP systems through an ERbeta-mediated mechanism, in a tissue-specific manner...
  94. ncbi request reprint Novelty-induced locomoter activity in Long-Evans rats pre- and post-chronic 'binge'-pattern cocaine treatment
    L R Lucas
    Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY 10021, USA
    Neurosci Lett 237:25-8. 1997
    ..These findings suggest that behavioral sensitization, as a result of CBP cocaine treatment, changes novelty-stress induced behavior which may reflect altered individual vulnerability to drugs of abuse...
  95. ncbi request reprint Estrogen-regulated progestin receptors are found in the midbrain raphe but not hippocampus of estrogen receptor alpha (ER alpha) gene-disrupted mice
    S E Alves
    Laboratory of Neuroendocrinology, The Rockefeller University, New York, New York 10021, USA
    J Comp Neurol 427:185-95. 2000
    ..Collectively, these findings suggest that estrogen can regulate the expression of one gene (the PR) via multiple mechanisms, based upon brain region...
  96. ncbi request reprint Stress, adaptation, and disease. Allostasis and allostatic load
    B S McEwen
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, Rockefeller University, New York, New York 10021, USA
    Ann N Y Acad Sci 840:33-44. 1998
    ..The relationship of allostatic load to genetic and developmental predispositions to disease is also considered...
  97. ncbi request reprint Effects of mineralocorticoid and glucocorticoid receptors on long-term potentiation in the CA3 hippocampal field
    C Pavlides
    Rockefeller University, New York, NY 10021, USA
    Brain Res 851:204-14. 1999
    ..These results indicate that adrenal steroids may modulate LTP induction in the hippocampus via an interaction with glutamatergic NMDAR...
  98. ncbi request reprint Stress and hippocampal plasticity
    B S McEwen
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, Rockefeller University, New York, New York 10021, USA
    Annu Rev Neurosci 22:105-22. 1999
    ..It is important, from a therapeutic standpoint, to distinguish between a permanent loss of cells and a reversible atrophy...
  99. pmc Enhancing versus suppressive effects of stress hormones on skin immune function
    F S Dhabhar
    The Rockefeller University, 1230 York Avenue, Box 165, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 96:1059-64. 1999
    ..g., wounding or infection) for which stress perception by the brain may serve as an early warning signal...
  100. ncbi request reprint Neurochemical characterization of individual vulnerability to addictive drugs in rats
    L R Lucas
    Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY 10021, USA
    Eur J Neurosci 10:3153-63. 1998
    ..These results enhance our knowledge of the neurobiological correlates of individual rats' propensities to develop drug-intake and provide some putative mechanisms for the dopaminergic hyperactivity that characterizes drug-prone animals...
  101. ncbi request reprint Allostasis, allostatic load, and the aging nervous system: role of excitatory amino acids and excitotoxicity
    B S McEwen
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, Rockfeller University, New York, NY 10021, USA
    Neurochem Res 25:1219-31. 2000
    ..Moreover, the brain retains considerable resilience in the face of stress, and estrogens appear to play a role in this resilience. This review discusses the current status of work on underlying mechanisms for these effects...