D J McConkey

Summary

Affiliation: The University of Texas
Country: USA

Publications

  1. pmc Proteasome inhibitors activate autophagy as a cytoprotective response in human prostate cancer cells
    K Zhu
    Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Oncogene 29:451-62. 2010
  2. pmc Fibroblast growth factor receptors-1 and -3 play distinct roles in the regulation of bladder cancer growth and metastasis: implications for therapeutic targeting
    Tiewei Cheng
    Department of Urology, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    PLoS ONE 8:e57284. 2013
  3. pmc Inhibition of inducible heat shock protein-70 (hsp72) enhances bortezomib-induced cell death in human bladder cancer cells
    Wei Qi
    Department of Urology, U T M D Anderson Cancer Center Houston, Texas, USA
    PLoS ONE 8:e69509. 2013
  4. doi request reprint HDAC inhibitor modulation of proteotoxicity as a therapeutic approach in cancer
    David J McConkey
    Department of Urology, U T M D Anderson Cancer Center, Houston, Texas, USA
    Adv Cancer Res 116:131-63. 2012
  5. doi request reprint The molecular, the bad, and the ugly: preventing bladder cancer via mTOR inhibition
    David J McConkey
    Department of Urology, Unit 1373, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Cancer Prev Res (Phila) 2:1001-2. 2009
  6. ncbi request reprint Effects of the proteasome inhibitor, bortezomib, on apoptosis in isolated lymphocytes obtained from patients with chronic lymphocytic leukemia
    Jessica C Pahler
    Department of Cancer Biology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 9:4570-7. 2003
  7. doi request reprint Mechanisms of proteasome inhibitor action and resistance in cancer
    David J McConkey
    Department of Urology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Drug Resist Updat 11:164-79. 2008
  8. doi request reprint A novel role for a familiar protein in apoptosis induced by proteasome inhibition
    David J McConkey
    Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Cell 14:1-2. 2008
  9. ncbi request reprint Therapy-induced apoptosis in primary tumors
    David J McConkey
    Department of Cancer Biology 173, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA
    Adv Exp Med Biol 608:31-51. 2007
  10. ncbi request reprint Velcade displays promising activity in primary effusion lymphoma cells
    David McConkey
    Department of Cancer Biology, Univesity of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Biol Ther 4:491-2. 2005

Research Grants

  1. Proteasome Inhibition and ER Stress
    David McConkey; Fiscal Year: 2009
  2. Proteasome Inhibition and ER Stress
    David J McConkey; Fiscal Year: 2010
  3. Proteasome Inhibition and ER Stress
    David J McConkey; Fiscal Year: 2011

Detail Information

Publications103 found, 100 shown here

  1. pmc Proteasome inhibitors activate autophagy as a cytoprotective response in human prostate cancer cells
    K Zhu
    Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Oncogene 29:451-62. 2010
    ..Overall, our data show that proteasome inhibition activates autophagy through a phospho-eIF2alpha-dependent mechanism to eliminate protein aggregates and alleviate proteotoxic stress...
  2. pmc Fibroblast growth factor receptors-1 and -3 play distinct roles in the regulation of bladder cancer growth and metastasis: implications for therapeutic targeting
    Tiewei Cheng
    Department of Urology, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    PLoS ONE 8:e57284. 2013
    ..The results suggest that the tumor EMT phenotype will be an important determinant of the biological effects of FGFR inhibitors in patients...
  3. pmc Inhibition of inducible heat shock protein-70 (hsp72) enhances bortezomib-induced cell death in human bladder cancer cells
    Wei Qi
    Department of Urology, U T M D Anderson Cancer Center Houston, Texas, USA
    PLoS ONE 8:e69509. 2013
    ....
  4. doi request reprint HDAC inhibitor modulation of proteotoxicity as a therapeutic approach in cancer
    David J McConkey
    Department of Urology, U T M D Anderson Cancer Center, Houston, Texas, USA
    Adv Cancer Res 116:131-63. 2012
    ....
  5. doi request reprint The molecular, the bad, and the ugly: preventing bladder cancer via mTOR inhibition
    David J McConkey
    Department of Urology, Unit 1373, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Cancer Prev Res (Phila) 2:1001-2. 2009
    ..The results not only support the clinical evaluation of mammalian target of rapamycin inhibitors in this setting, they open the door for the evaluation of additional molecular local therapies as well...
  6. ncbi request reprint Effects of the proteasome inhibitor, bortezomib, on apoptosis in isolated lymphocytes obtained from patients with chronic lymphocytic leukemia
    Jessica C Pahler
    Department of Cancer Biology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 9:4570-7. 2003
    ..The compound is being evaluated currently in Phase II and III clinical trials. Here we characterized the effects and mechanisms of action of bortezomib in cells obtained from patients with chronic lymphocytic leukemia (CLL)...
  7. doi request reprint Mechanisms of proteasome inhibitor action and resistance in cancer
    David J McConkey
    Department of Urology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Drug Resist Updat 11:164-79. 2008
    ..This review provides an overview of the current thinking about how PIs may kill cancer cells exemplified for pancreatic cancer and the possible mechanisms involved in resistance to PIs...
  8. doi request reprint A novel role for a familiar protein in apoptosis induced by proteasome inhibition
    David J McConkey
    Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Cell 14:1-2. 2008
    ..Their observations challenge current thinking about how this class of promising cancer therapies works and why they selectively kill cancer cells...
  9. ncbi request reprint Therapy-induced apoptosis in primary tumors
    David J McConkey
    Department of Cancer Biology 173, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA
    Adv Exp Med Biol 608:31-51. 2007
    ....
  10. ncbi request reprint Velcade displays promising activity in primary effusion lymphoma cells
    David McConkey
    Department of Cancer Biology, Univesity of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Biol Ther 4:491-2. 2005
  11. doi request reprint Role of epithelial-to-mesenchymal transition (EMT) in drug sensitivity and metastasis in bladder cancer
    David J McConkey
    Department of Urology, U T M D Anderson Cancer Center, P O Box 1373, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Cancer Metastasis Rev 28:335-44. 2009
    ..The results suggest that EMT coordinately regulates drug resistance and muscle invasion/metastasis in urothelial cancer and is a dominant feature of overall cancer biology...
  12. pmc Molecular genetics of bladder cancer: Emerging mechanisms of tumor initiation and progression
    David J McConkey
    Department of Urology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Urol Oncol 28:429-40. 2010
    ..This review will provide an overview of these new insights and discuss priorities for future investigation...
  13. ncbi request reprint Cardiac glycosides stimulate Ca2+ increases and apoptosis in androgen-independent, metastatic human prostate adenocarcinoma cells
    D J McConkey
    Department of Cancer Biology, University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Cancer Res 60:3807-12. 2000
    ..Our results define a novel activity for cardiac glycosides that could prove relevant to the treatment of metastatic prostate cancer...
  14. ncbi request reprint RAIDDing ER stress for oncolytic viral therapy
    David J McConkey
    Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Cell 20:416-8. 2011
    ..Results of a synthetic lethal screen described in this issue of Cancer Cell demonstrate that components of the unfolded protein response (UPR) limit virus-induced tumor cell killing and identify a strategy to utilize this knowledge...
  15. ncbi request reprint Treatment with low-dose interferon-alpha restores the balance between matrix metalloproteinase-9 and E-cadherin expression in human transitional cell carcinoma of the bladder
    J W Slaton
    Department of Cancer Biology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 7:2840-53. 2001
    ..These studies indicate that in addition to its antiproliferative and antiangiogenic effects, IFN-alpha limits tumor invasion by restoring the normal balance between MMP-9 and E-cadherin and enhances the activity of systemic chemotherapy...
  16. ncbi request reprint Tyrosine kinase inhibition of multiple angiogenic growth factor receptors improves survival in mice bearing colon cancer liver metastases by inhibition of endothelial cell survival mechanisms
    R M Shaheen
    Department of Surgical Oncology, University of Texas M. D. Anderson Cancer Center, Houston 77030, USA
    Cancer Res 61:1464-8. 2001
    ....
  17. pmc Early RB94-produced cytotoxicity in cancer cells is independent of caspase activation or 50 kb DNA fragmentation
    J Zhou
    Department of Genitourinary Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Gene Ther 16:13-9. 2009
    ..As RB94 will soon be used for gene therapy further understanding the molecular basis of these early changes in killing cancer cells is one of our particularly important present goals...
  18. ncbi request reprint Endothelial cell apoptosis is inhibited by a soluble factor secreted by human colon cancer cells
    W Liu
    Department of Cancer Biology, The University of Texas M. D. Anderson Cancer Center, Houston 77030, USA
    Int J Cancer 92:26-30. 2001
    ..This factor is likely to be a protein or protein fragment because it loses its activity after heat inactivation. These studies support the hypothesis that tumor cells can alter the phenotype of endothelial cells...
  19. pmc Measuring soluble forms of extracellular cytokeratin 18 identifies both apoptotic and necrotic mechanisms of cell death produced by adenoviral-mediated interferon alpha: possible use as a surrogate marker
    M B Fisher
    Department of Urology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Gene Ther 16:567-72. 2009
    ....
  20. ncbi request reprint Increased mitochondrial biogenesis in primary leukemia cells: the role of endogenous nitric oxide and impact on sensitivity to fludarabine
    J S Carew
    Department of Molecular Pathology, The University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA
    Leukemia 18:1934-40. 2004
    ..Taken together, our results suggest that NO is a key mediator of mitochondrial biogenesis in CLL and that modulation of mitochondrial biogenesis by NO may alter cellular sensitivity to fludarabine...
  21. ncbi request reprint Apoptosis resistance increases with metastatic potential in cells of the human LNCaP prostate carcinoma line
    D J McConkey
    Department of Cell Biology, University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Cancer Res 56:5594-9. 1996
    ..Our data support the hypothesis that apoptosis resistance contributes to prostate cancer metastasis and that elevated expression of BCL-2 is involved...
  22. ncbi request reprint In vivo intracellular signaling as a marker of antiangiogenic activity
    C C Solorzano
    Department of Surgical Oncology, University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 61:7048-51. 2001
    ..Determining the activation status of the Erk and Akt signaling pathways in tumor ECs may serve as a surrogate marker for the effectiveness of antiangiogenic regimens...
  23. ncbi request reprint Calcium flux measurements in apoptosis
    D J McConkey
    Department of Cancer Biology, U.T.M.D. Anderson Cancer Center, Houston, Texas 77030, USA
    Methods Cell Biol 66:229-46. 2001
    ..However, current techniques should be considered semiquantitative at best and will remain so until specific organelle-targeted fluorescent dyes are developed and widely available...
  24. ncbi request reprint Histone deacetylase inhibitor downregulation of bcl-xl gene expression leads to apoptotic cell death in mesothelioma
    X X Cao
    Department of Thoracic and Cardiovascular Surgery, Section of Thoracic Molecular Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA
    Am J Respir Cell Mol Biol 25:562-8. 2001
    ..Additional study of the therapeutic benefit of targeting bcl-xl gene expression in mesothelioma is warranted...
  25. ncbi request reprint Adenoviral-mediated interferon alpha overcomes resistance to the interferon protein in various cancer types and has marked bystander effects
    X Zhang
    Department of Genitourinary Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Gene Ther 14:241-50. 2007
    ..Moreover, we document that a yet to be identified soluble factor(s) is responsible for causing the bystander effect observed following Ad-IFN treatment in IFN protein-resistant cancer cells...
  26. ncbi request reprint Induction of cell cycle arrest and apoptosis by the proteasome inhibitor PS-341 in Hodgkin disease cell lines is independent of inhibitor of nuclear factor-kappaB mutations or activation of the CD30, CD40, and RANK receptors
    Bei Zheng
    Departments of Lymphoma Myeloma, Bioimmunotherapy, and Cancer Biology, M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 10:3207-15. 2004
    ..Cell cycle analysis was determined by flow cytometry. Intracellular protein levels were determined by Western blot...
  27. pmc Phase II trial of imatinib mesylate in patients with metastatic melanoma
    K B Kim
    Department of Melanoma Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Br J Cancer 99:734-40. 2008
    ..However, based on the characteristics of the responding tumour in our study, clinical activity of imatinib, specifically in patients with melanoma with certain c-kit aberrations, should be examined...
  28. ncbi request reprint Apoptosis in mycobacterium tuberculosis infection in mice exhibiting varied immunopathology
    V E Watson
    University of Texas Houston Medical School, Department of Pathology, Houston, TX 77030, USA
    J Pathol 190:211-20. 2000
    ..Moreover, a failure of completion of the FAS/FAS ligand-mediated apoptosis pathway in the A/J mice may contribute to inefficient elimination of lymphocytes, thus further aggravating pulmonary pathology...
  29. ncbi request reprint Biochemical determinants of apoptosis and necrosis
    D J McConkey
    Department of Cell Biology, University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Toxicol Lett 99:157-68. 1998
    ....
  30. ncbi request reprint Spontaneous regression of cutaneous melanoma in sinclair swine is associated with defective telomerase activity and extensive telomere erosion
    S Pathak
    Cellular Genetics Laboratory, M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Int J Oncol 17:1219-24. 2000
    ..Such abnormal chromosome configurations are lost, following the breakage-fusion-bridge-cycles, and result in extensive DNA fragmentation, as shown by laddering experiments, and, finally, cell death...
  31. ncbi request reprint p53 and Fas ligand are required for psoralen and UVA-induced apoptosis in mouse epidermal cells
    A B Santamaria
    Department of Immunology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cell Death Differ 9:549-60. 2002
    ..This implies that similar mechanisms may be involved in the elimination of psoriatic keratinocytes from human skin following PUVA therapy...
  32. ncbi request reprint Adenoviral mediated interferon-alpha 2b gene therapy suppresses the pro-angiogenic effect of vascular endothelial growth factor in superficial bladder cancer
    Liana Adam
    Department of Urology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Urol 177:1900-6. 2007
    ..We determined whether the inhibition of angiogenesis might contribute to the antitumor effect...
  33. ncbi request reprint Phase I study of bortezomib in refractory or relapsed acute leukemias
    Jorge Cortes
    Department of Leukemia, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 10:3371-6. 2004
    ..The in vitro evidence of antileukemia and transient hematological improvements observed in some patients warrants further investigation of bortezomib in acute leukemias, probably in combination with other agents...
  34. ncbi request reprint miR-200 expression regulates epithelial-to-mesenchymal transition in bladder cancer cells and reverses resistance to epidermal growth factor receptor therapy
    Liana Adam
    The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 15:5060-72. 2009
    ..The aims of this study were to determine the potential role of microRNAs (miRNA) in controlling EMT and the role of EMT in inducing the sensitivity of human bladder cancer cells to the inhibitory effects of the anti-EGFR therapy...
  35. pmc Surrogate markers in antiangiogenesis clinical trials
    D W Davis
    1Department of Cancer Biology, Unit 173, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Br J Cancer 89:8-14. 2003
    ..This review summarises the currently available clinical data on the development of surrogate markers of angiogenesis inhibitors...
  36. ncbi request reprint Adenoviral-mediated retinoblastoma 94 produces rapid telomere erosion, chromosomal crisis, and caspase-dependent apoptosis in bladder cancer and immortalized human urothelial cells but not in normal urothelial cells
    Xinqiao Zhang
    Department of Genitourinary Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 63:760-5. 2003
    ..The lack of cytotoxicity to normal cells should also provide a high therapeutic index when used in gene therapy protocols for the treatment of bladder and other cancers...
  37. ncbi request reprint The proteasome inhibitor NPI-0052 is a more effective inducer of apoptosis than bortezomib in lymphocytes from patients with chronic lymphocytic leukemia
    Stacey Ruiz
    Department of Cancer Biology, The University of Texas M D Anderson Cancer Center, Box 173, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Mol Cancer Ther 5:1836-43. 2006
    ..Our results show that NPI-0052 is a more effective proapoptotic agent than bortezomib in isolated CLL cells and suggest that the chemical properties of NPI-0052 might also make it an effective therapeutic agent in CLL patients...
  38. ncbi request reprint Protease activation and glucocorticoid-induced apoptosis in chronic lymphocytic leukemia
    D J McConkey
    Department of Cell Biology, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Leuk Lymphoma 33:421-31. 1999
    ..and leads to many of the familiar characteristics of apoptosis. Here we will examine the role of apoptotic proteases in CLL and speculate on their contribution to disease emergence and drug resistance...
  39. ncbi request reprint The role of calcium in the regulation of apoptosis
    D J McConkey
    Department of Cell Biology 173, University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Scanning Microsc 10:777-93; discussion 793-4. 1996
    ..This review will summarize what is known about the role of Ca2+ in the regulation of apoptosis and discuss how Ca2+ might interact with some of the other biochemical signals implicated in cell death...
  40. pmc Nitric oxide-dependent activation of p53 suppresses bleomycin-induced apoptosis in the lung
    D W Davis
    Program in Toxicology, University of Texas Houston Graduate School of Biomedical Sciences, Houston, Texas 77030, USA
    J Exp Med 192:857-69. 2000
    ..Together, our results demonstrate that iNOS and p53 mediate a novel apoptosis-suppressing pathway in the lung...
  41. ncbi request reprint The role of calcium in the regulation of apoptosis
    D J McConkey
    Department of Cell Biology, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Biochem Biophys Res Commun 239:357-66. 1997
    ..This review will summarize the role of Ca2+ in apoptosis within the context of what is known about the core components of the effector machinery for apoptosis...
  42. ncbi request reprint Novel therapies for pancreatic adenocarcinoma
    Simona M Pino
    Department of Gastrointestinal Medical Oncology, The University of Texas M D Anderson Cancer Center, Unit 426, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Curr Oncol Rep 6:199-206. 2004
    ..The scientific rationale, mechanism of action, and clinical trial data for these novel agents are discussed...
  43. ncbi request reprint Novel therapies for pancreatic adenocarcinoma
    Simona M Pino
    Department of Gastrointestinal Medical Oncology, The University of Texas M D Anderson Cancer Center, Unit 426, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Curr Gastroenterol Rep 6:119-25. 2004
    ..The scientific rationale, mechanism of action, and clinical trial data for these novel agents are discussed...
  44. ncbi request reprint Inhibition of proliferation of PC3 cells by the branched-chain fatty acid, 12-methyltetradecanoic acid, is associated with inhibition of 5-lipoxygenase
    Peiying Yang
    Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, Texas 77090 1009, USA
    Prostate 55:281-91. 2003
    ..Here we study 12-methyltetradecanoic acid (12-MTA), a branched-chain fatty acid, isolated from a sea cucumber extract, on the growth of prostate cancer cells and investigate the underlying mechanisms of its effect...
  45. pmc Forerunner genes contiguous to RB1 contribute to the development of in situ neoplasia
    Sangkyou Lee
    Department of Pathology, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 104:13732-7. 2007
    ..We also show that homozygous inactivation of P2RY5 was antecedent to the loss of RB1 during tumor development, and that nucleotide substitutions in P2RY5 represent a cancer predisposing factor...
  46. ncbi request reprint Nuclear factor-kappaB maintains TRAIL resistance in human pancreatic cancer cells
    Sanaz Khanbolooki
    Department of Cancer Biology, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Mol Cancer Ther 5:2251-60. 2006
    ....
  47. ncbi request reprint Combination therapy with IFN-alpha plus bortezomib induces apoptosis and inhibits angiogenesis in human bladder cancer cells
    Angela Papageorgiou
    Department of Cancer Biology, The University of Texas M D Anderson Cancer Center, Box 173, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Mol Cancer Ther 5:3032-41. 2006
    ..Together, our results show that combination therapy with IFN-alpha plus bortezomib is effective but can work via different mechanisms (apoptosis versus angiogenesis inhibition) in preclinical models of human bladder cancer...
  48. ncbi request reprint Bortezomib inhibits docetaxel-induced apoptosis via a p21-dependent mechanism in human prostate cancer cells
    Steven E Canfield
    Department of Urology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, 77030, USA
    Mol Cancer Ther 5:2043-50. 2006
    ..These observations may have important implications for the ongoing bortezomib-docetaxel combination trials as well as trials using bortezomib and other cell cycle-sensitive agents...
  49. ncbi request reprint Molecular correlates of gefitinib responsiveness in human bladder cancer cells
    Marissa Shrader
    Department of Cancer Biology, The University of Texas M D Anderson Cancer Center, Unit 173, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Mol Cancer Ther 6:277-85. 2007
    ..However, comparing levels of p27(Kip1) or DNA synthesis before and after gefitinib exposure does identify the drug-sensitive cells...
  50. ncbi request reprint Mutations within the kinase domain and truncations of the epidermal growth factor receptor are rare events in bladder cancer: implications for therapy
    Kelly N Blehm
    Department of Cancer Biology, Brain Tumor Center, The University of Texas M D Anderson Cancer Center, Houston, 77030, USA
    Clin Cancer Res 12:4671-7. 2006
    ..The focus of this study was to determine if these alterations are present within the tyrosine kinase and ligand-binding domain of EGFR in urothelial carcinoma...
  51. ncbi request reprint Gefitinib reverses TRAIL resistance in human bladder cancer cell lines via inhibition of AKT-mediated X-linked inhibitor of apoptosis protein expression
    Marissa Shrader
    Departments of Cancer Biology and Urology, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Cancer Res 67:1430-5. 2007
    ....
  52. pmc NPI-0052, a novel proteasome inhibitor, induces caspase-8 and ROS-dependent apoptosis alone and in combination with HDAC inhibitors in leukemia cells
    Claudia P Miller
    Department of Pediatrics Research, University of Texas, M D Anderson Cancer Center, Houston, TX 77030, USA
    Blood 110:267-77. 2007
    ..These effects of NPI-0052, alone and in combination with HDACi, warrant further testing to determine the compound's clinical efficacy in leukemia...
  53. ncbi request reprint Inhibition of the phosphatidylinositol 3'-kinase-AKT pathway induces apoptosis in pancreatic carcinoma cells in vitro and in vivo
    Victor M Bondar
    Department of Surgical Oncology, University of Texas, M D Anderson Cancer Center, Box 173, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Mol Cancer Ther 1:989-97. 2002
    ..Together, our results establish that the PI3k/AKT pathway is constitutively activated in a majority of human pancreatic cancer cell lines and establish that the pathway is a promising target for therapeutic intervention...
  54. ncbi request reprint Effects of the proteasome inhibitor PS-341 on apoptosis and angiogenesis in orthotopic human pancreatic tumor xenografts
    Steffan T Nawrocki
    Department of Cancer Biology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Mol Cancer Ther 1:1243-53. 2002
    ..Taken together, our results demonstrate that PS-341 inhibits the growth of human pancreatic tumors via direct effects on tumor cells and indirect effects on the tumor vasculature...
  55. ncbi request reprint Src activation regulates anoikis in human colon tumor cell lines
    T Christopher Windham
    Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, Texas, TX 77030, USA
    Oncogene 21:7797-807. 2002
    ..These results suggest that Src activation may contribute to colon tumor progression and metastasis in part by activating Akt-mediated survival pathways that decrease sensitivity of detached cells to anoikis...
  56. doi request reprint Sensitivity to epidermal growth factor receptor inhibitor requires E-cadherin expression in urothelial carcinoma cells
    Peter C Black
    Department of Urology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 14:1478-86. 2008
    ..The aim of this study was to define molecular markers of response to cetuximab therapy in a panel of urothelial carcinoma cell lines...
  57. ncbi request reprint Bax and Bak promote apoptosis by modulating endoplasmic reticular and mitochondrial Ca2+ stores
    Leta K Nutt
    Departments of Cancer Biology and Thoracic and Cardiovascular Surgery, Section of Thoracic and Molecular Oncology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030
    J Biol Chem 277:9219-25. 2002
    ..These effects modulate the kinetics of cytochrome c release and apoptosis...
  58. ncbi request reprint Bax-mediated Ca2+ mobilization promotes cytochrome c release during apoptosis
    Leta K Nutt
    Department of Cancer Biology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 277:20301-8. 2002
    ..Together, our data demonstrate that Bax-mediated alterations in ER and mitochondrial Ca(2+) levels serve as important upstream signals for cytochrome c release in some examples of apoptosis...
  59. ncbi request reprint Anoikis is regulated by BCL-2-independent pathways in human prostate carcinoma cells
    Victor M Bondar
    Department of Cancer Biology, University of Texas, M D Anderson Cancer Center, Houston, Texas 77030, USA
    Prostate 51:42-9. 2002
    ..Apoptosis-associated DNA fragmentation was measured by agarose gel electrophoresis and propidium iodide staining and flow cytometry. Expression of BCL-2 family polypeptides was determined by immunoblotting...
  60. doi request reprint 20S ways to apoptosis
    David J McConkey
    Nat Chem Biol 4:528-9. 2008
  61. ncbi request reprint Increased apoptosis in metastatic human colonic adenocarcinomas
    Paula M Termuhlen
    Departments of Cancer Biology, Surgical Oncology, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA
    Cancer Biol Ther 1:58-63. 2002
    ..Our data demonstrate that the molecular events associated with acquisition of the metastatic phenotype sensitize colon cancer cells to some pro-apoptotic stimuli...
  62. ncbi request reprint Focus on bladder cancer
    Colin P N Dinney
    Department of Urology, The University of Texas M D Anderson Cancer Center, Houston, TX USA
    Cancer Cell 6:111-6. 2004
  63. pmc Human Mena+11a isoform serves as a marker of epithelial phenotype and sensitivity to epidermal growth factor receptor inhibition in human pancreatic cancer cell lines
    Maria S Pino
    Division of Medical Oncology, Regina Elena National Cancer Institute, Rome, Italy
    Clin Cancer Res 14:4943-50. 2008
    ..The aim of this study was to determine whether or not the expression of hMena isoforms correlated with sensitivity to EGFR tyrosine kinase inhibitors and could serve as markers with potential clinical use...
  64. ncbi request reprint Phase I study of recombinant human endostatin in patients with advanced solid tumors
    Roy S Herbst
    Department of Thoracic and Head and Neck Medical Oncology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Clin Oncol 20:3792-803. 2002
    ..We evaluated recombinant human endostatin (rh-Endo) in a phase I trial designed to assess safety, pharmacokinetics, and serum markers of angiogenesis in patients with solid tumors...
  65. pmc Myc regulates aggresome formation, the induction of Noxa, and apoptosis in response to the combination of bortezomib and SAHA
    Steffan T Nawrocki
    The Institute for Drug Development, Cancer Therapy and Research Center at The University of Texas Health Science Center at San Antonio, USA
    Blood 112:2917-26. 2008
    ..These data suggest that MM patients with elevated Myc activity may be particularly sensitive to the BZ + SAHA combination...
  66. doi request reprint Is vascular endothelial growth factor modulation a predictor of the therapeutic efficacy of gefitinib for bladder cancer?
    Wassim Kassouf
    Division of Urology, McGill University Health Center, Montreal, Quebec, Canada
    J Urol 180:1146-53. 2008
    ..We investigated the relationship between the modulation of vascular endothelial growth factor (Santa Cruz Biotechnology, Santa Cruz, California) expression and the biological efficacy of gefitinib for bladder cancer...
  67. ncbi request reprint Development of biologic markers of response and assessment of antiangiogenic activity in a clinical trial of human recombinant endostatin
    Roy S Herbst
    Department of Thoracic and Head and Neck Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    J Clin Oncol 20:3804-14. 2002
    ..We present the initial results of a dose-finding clinical trial of recombinant human endostatin (rh-Endo) that examined potential surrogates for response to antiangiogenic therapy...
  68. ncbi request reprint Src activation of Stat3 is an independent requirement from NF-kappaB activation for constitutive IL-8 expression in human pancreatic adenocarcinoma cells
    Jose G Trevino
    Department of Cancer Biology, Unit 179, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Angiogenesis 9:101-10. 2006
    ..We therefore suggest that Src activation, through phosphorylation of STAT3, and NF-kappaB are all required for expression of IL-8 a critical angiogenic-promoting factor in pancreatic adenocarcinomas...
  69. ncbi request reprint Transforming growth factor alpha expression drives constitutive epidermal growth factor receptor pathway activation and sensitivity to gefitinib (Iressa) in human pancreatic cancer cell lines
    Maria S Pino
    Division of Medical Oncology A, Regina Elena Cancer Institute, Rome, Italy
    Cancer Res 66:3802-12. 2006
    ..Quantification of TGF-alpha expression may therefore represent an effective means of identifying EGFR-responsive primary tumors...
  70. pmc Adenoviral transfer of mda-7 leads to BAX up-regulation and apoptosis in mesothelioma cells, and is abrogated by over-expression of BCL-XL
    Xiaobo X Cao
    Department of Thoracic and Cardiovascular Surgery, Section of Thoracic Molecular Oncology, The University of Texas M D Anderson Cancer Center, Houston, USA
    Mol Med 8:869-76. 2002
    ..We evaluated cell growth, apoptosis and tumor suppressor characteristics following forced expression of this gene in mesothelioma cell lines...
  71. ncbi request reprint Integrating basic science and clinical research in bladder cancer: update from the first bladder Specialized Program of Research Excellence (SPORE)
    Ralph A Highshaw
    Department of Urology and Cancer Biology, University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Curr Opin Urol 14:295-300. 2004
    ..To review the progress of the genitourinary SPORE (Specialized Program of Research Excellence) in bladder cancer...
  72. ncbi request reprint Regional effects of an antivascular endothelial growth factor receptor monoclonal antibody on receptor phosphorylation and apoptosis in human 253J B-V bladder cancer xenografts
    Darren W Davis
    Department of Cancer Biology, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Cancer Res 64:4601-10. 2004
    ..Thus, agents that target a single receptor (e.g., VEGFR-2) may not be sufficient to completely inhibit tumor angiogenesis...
  73. ncbi request reprint Direct effects of recombinant human endostatin on tumor cell IL-8 production are associated with increased endothelial cell apoptosis in an orthotopic model of human pancreatic cancer
    Chandrajit P Raut
    Department of Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Biol Ther 3:679-87. 2004
    ..However, its effectiveness in an orthotopic xenograft model of an abdominal neoplasm has not been demonstrated...
  74. ncbi request reprint Automated quantification of apoptosis after neoadjuvant chemotherapy for breast cancer: early assessment predicts clinical response
    Darren W Davis
    Department of Cancer Biology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Clin Cancer Res 9:955-60. 2003
    ....
  75. ncbi request reprint The proteasome inhibitor bortezomib synergizes with gemcitabine to block the growth of human 253JB-V bladder tumors in vivo
    Ashish M Kamat
    Department of Urology, University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Mol Cancer Ther 3:279-90. 2004
    ..Together, our results demonstrate that bortezomib has significant antiproliferative activity in aggressive bladder cancer cells, which is best exploited within the context of combination chemotherapy...
  76. ncbi request reprint The proteasome inhibitor bortezomib enhances the activity of docetaxel in orthotopic human pancreatic tumor xenografts
    Steffan T Nawrocki
    Department of Cancer Biology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Mol Cancer Ther 3:59-70. 2004
    ..Together, our results suggest that bortezomib enhances the antitumoral activity of taxanes by enforcing cell growth arrest and inhibiting angiogenesis...
  77. ncbi request reprint Quantitative analysis of biomarkers defines an optimal biological dose for recombinant human endostatin in primary human tumors
    Darren W Davis
    Department of Cancer Biology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Clin Cancer Res 10:33-42. 2004
    ..The results, including tumor blood flow measured by positron emission tomography, were analyzed using a quadratic polynomial model...
  78. ncbi request reprint The proteasome inhibitor bortezomib stabilizes a novel active form of p53 in human LNCaP-Pro5 prostate cancer cells
    Simon A Williams
    Department of Cancer Biology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Cancer Res 63:7338-44. 2003
    ..Together, our data demonstrate that bortezomib stimulates p53 activation via a novel mechanism...
  79. ncbi request reprint Differential effects of the proteasome inhibitor bortezomib on apoptosis and angiogenesis in human prostate tumor xenografts
    Simon Williams
    Department of Cancer Biology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Mol Cancer Ther 2:835-43. 2003
    ..Together, our results confirm that bortezomib is active in preclinical models of human prostate cancer, but its effects on apoptosis versus angiogenesis are cell type dependent...
  80. ncbi request reprint Antiangiogenic tumor therapy
    Darren W Davis
    Department of Cancer Biology, Box 173, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA
    Biotechniques 34:1048-50, 1052, 1054 passim. 2003
  81. ncbi request reprint Fully human anti-interleukin 8 antibody inhibits tumor growth in orthotopic bladder cancer xenografts via down-regulation of matrix metalloproteases and nuclear factor-kappaB
    Badar M Mian
    Department of Cancer Biology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 9:3167-75. 2003
    ..Human TCC cell lines 253J B-V and UM UC3 (high IL-8 producers), 253J (low IL-8), and 253J transfected with the IL-8 gene (high producer) were used...
  82. ncbi request reprint Nuclear factor-kappaB mediates angiogenesis and metastasis of human bladder cancer through the regulation of interleukin-8
    Takashi Karashima
    Departments of Cancer Biology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 9:2786-97. 2003
    ....
  83. ncbi request reprint Intravesical Ad-IFNalpha causes marked regression of human bladder cancer growing orthotopically in nude mice and overcomes resistance to IFN-alpha protein
    William F Benedict
    Department of Genitourinary Medical Oncology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Mol Ther 10:525-32. 2004
    ..These findings demonstrate that Ad-IFNalpha can overcome resistance to IFN-alpha protein both in vitro and in vivo and support evaluation of intravesical Ad-IFNalpha/Syn3 for the treatment of superficial bladder cancer...
  84. ncbi request reprint Bortezomib abolishes tumor necrosis factor-related apoptosis-inducing ligand resistance via a p21-dependent mechanism in human bladder and prostate cancer cells
    Laura M Lashinger
    Department of Cancer Biology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 65:4902-8. 2005
    ....
  85. ncbi request reprint Indirect effects of Bax and Bak initiate the mitochondrial alterations that lead to cytochrome c release during arsenic trioxide-induced apoptosis
    Leta K Nutt
    Institute of Environmental Medicine, Division of Toxicology, Karolinska Institutet, Stockholm, Sweden
    Cancer Biol Ther 4:459-67. 2005
    ..Furthermore, the results implicate reactive oxygen species in a concentration-dependent mechanistic switch between apoptosis and necrosis...
  86. ncbi request reprint Uncoupling between epidermal growth factor receptor and downstream signals defines resistance to the antiproliferative effect of Gefitinib in bladder cancer cells
    Wassim Kassouf
    Department of Urology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 65:10524-35. 2005
    ....
  87. ncbi request reprint Prostaglandin E2 drives cyclooxygenase-2 expression via cyclic AMP response element activation in human pancreatic cancer cells
    Maria S Pino
    Division of Medical Oncology A, Regina Elena Cancer Institute, Rome Italy
    Cancer Biol Ther 4:1263-9. 2005
    ..Understanding the pathways that control COX-2 expression may lead to a better understanding of its dysregulation in pancreatic carcinomas and facilitate the development of novel therapeutic approaches...
  88. ncbi request reprint Pharmacodynamic analysis of target inhibition and endothelial cell death in tumors treated with the vascular endothelial growth factor receptor antagonists SU5416 or SU6668
    Darren W Davis
    Department of Cancer Biology, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Clin Cancer Res 11:678-89. 2005
    ....
  89. ncbi request reprint Role of tumor necrosis factor-related apoptosis-inducing ligand in interferon-induced apoptosis in human bladder cancer cells
    Angela Papageorgiou
    Department of Cancer Biology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Cancer Res 64:8973-9. 2004
    ..Combination therapy strategies aimed at overcoming TRAIL resistance may be very effective in restoring IFN sensitivity in a subset of human bladder tumors...
  90. ncbi request reprint Bortezomib inhibits PKR-like endoplasmic reticulum (ER) kinase and induces apoptosis via ER stress in human pancreatic cancer cells
    Steffan T Nawrocki
    Department of Cancer Biology, University of Texas MD Anderson Cancer Center, Houston, 77030, USA
    Cancer Res 65:11510-9. 2005
    ..Taken together, the results show that bortezomib induces a unique type of ER stress compared with other ER stress agents characterized by an absence of eif2alpha phosphorylation, ubiquitylated protein accumulation, and proteotoxicity...
  91. ncbi request reprint Chemotherapy-induced apoptosis and Bcl-2 levels correlate with breast cancer response to chemotherapy
    Thomas A Buchholz
    Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer J 9:33-41. 2003
    ..We investigated whether changes in tumor cell apoptosis and Bcl-2 expression immediately after chemotherapy correlated with response to breast cancer treatment...
  92. ncbi request reprint Bortezomib sensitizes pancreatic cancer cells to endoplasmic reticulum stress-mediated apoptosis
    Steffan T Nawrocki
    Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, 77030, USA
    Cancer Res 65:11658-66. 2005
    ..Taken together, our data establish that bortezomib sensitizes pancreatic cancer cells to ER stress-induced apoptosis and show that bortezomib strongly enhances the anticancer activity of cisplatin...
  93. ncbi request reprint Celecoxib inhibits angiogenesis by inducing endothelial cell apoptosis in human pancreatic tumor xenografts
    Chandrajit P Raut
    Department of Surgical Oncology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Biol Ther 3:1217-24. 2004
    ..Together, our results demonstrate that the anti-angiogeneic effects of NSAIDs in human pancreatic cancer cells are exerted via direct effects on endothelial cells...
  94. ncbi request reprint Aggresome disruption: a novel strategy to enhance bortezomib-induced apoptosis in pancreatic cancer cells
    Steffan T Nawrocki
    Department of Cancer Biology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Cancer Res 66:3773-81. 2006
    ....
  95. pmc Targeting endoplasmic reticulum protein transport: a novel strategy to kill malignant B cells and overcome fludarabine resistance in CLL
    Jennifer S Carew
    Department of Molecular Pathology, University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Blood 107:222-31. 2006
    ....
  96. ncbi request reprint Phase II study of the antiangiogenic agent SU5416 in patients with advanced soft tissue sarcomas
    John V Heymach
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts, USA
    Clin Cancer Res 10:5732-40. 2004
    ..This Phase II study was conducted to investigate the safety and efficacy of SU5416 for patients with soft tissue sarcomas...
  97. pmc Disruption of Mekk2 in mice reveals an unexpected role for MEKK2 in modulating T-cell receptor signal transduction
    Zijian Guo
    Department of Immunology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Mol Cell Biol 22:5761-8. 2002
    ..Neither extracellular signal-regulated kinase nor p38 MAPK activation was affected in Mekk2(-/-) T cells. In conclusion, we found that MEKK2 may be required for controlling the strength of TCR/CD3 signaling...
  98. ncbi request reprint Comparative study of various biological parameters, including expression of survivin, between primary and metastatic human colonic adenocarcinomas
    Tomoyuki Agui
    Department of General and Gastroenterological Surgery, Osaka Medical College, Takatsuki City, Japan
    Anticancer Res 22:1769-76. 2002
    ....
  99. ncbi request reprint Measurement of changes in intracellular calcium during apoptosis
    David J McConkey
    Department of Cancer Biology, The University of Texas M D Anderson Cancer Center, Houston, USA
    Methods Mol Biol 282:117-30. 2004
    ..In this chapter, we provide detailed methods for measuring cytosolic, ER, and mitochondrial Ca2+ levels in whole using commercially available fluorescent dyes, identifying key potential pitfalls and alternative strategies...
  100. ncbi request reprint Interferon-alpha induces TRAIL expression and cell death via an IRF-1-dependent mechanism in human bladder cancer cells
    Angela Papageorgiou
    Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Biol Ther 6:872-9. 2007
    ..Together, our results demonstrate that IFNalpha induces TRAIL expression via a STAT-1/IRF-1-dependent mechanism in human bladder cancer cells, and this induction of TRAIL plays an important role in IFNalpha-induced cell killing...
  101. ncbi request reprint Emerging drugs for targeted therapy of bladder cancer
    Piyush K Agarwal
    Department of Urology, University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA
    Expert Opin Emerg Drugs 12:435-48. 2007
    ..In this report, the authors summarize the results of several such studies and discuss the rationale and potential use of novel targeted drugs in the treatment of bladder cancer...

Research Grants3

  1. Proteasome Inhibition and ER Stress
    David McConkey; Fiscal Year: 2009
    ....
  2. Proteasome Inhibition and ER Stress
    David J McConkey; Fiscal Year: 2010
    ....
  3. Proteasome Inhibition and ER Stress
    David J McConkey; Fiscal Year: 2011
    ....