Sarah E McCallum

Summary

Affiliation: The Parkinson's Institute
Country: USA

Publications

  1. ncbi request reprint Deletion of the beta 2 nicotinic acetylcholine receptor subunit alters development of tolerance to nicotine and eliminates receptor upregulation
    Sarah E McCallum
    Institute for Behavioral Genetics, University of Colorado, Boulder, CO 80309, USA
    Psychopharmacology (Berl) 184:314-27. 2006
  2. ncbi request reprint Null mutant analysis of responses to nicotine: deletion of beta2 nicotinic acetylcholine receptor subunit but not alpha7 subunit reduces sensitivity to nicotine-induced locomotor depression and hypothermia
    Theresa Tritto
    Institute for Behavioral Genetics, University of Colorado, Boulder, USA
    Nicotine Tob Res 6:145-58. 2004
  3. ncbi request reprint Subsets of acetylcholine-stimulated 86Rb+ efflux and [125I]-epibatidine binding sites in C57BL/6 mouse brain are differentially affected by chronic nicotine treatment
    Michael J Marks
    Institute for Behavioral Genetics, UCB447, University of Colorado, 1480 30th Street, Boulder, CO 80309, USA
    Neuropharmacology 46:1141-57. 2004
  4. ncbi request reprint Chronic oral nicotine normalizes dopaminergic function and synaptic plasticity in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned primates
    Maryka Quik
    The Parkinson s Institute, Sunnyvale, California 94089, USA
    J Neurosci 26:4681-9. 2006
  5. ncbi request reprint Differential declines in striatal nicotinic receptor subtype function after nigrostriatal damage in mice
    Maryka Quik
    The Parkinson s Institute, Sunnyvale, California 94089 1605, USA
    Mol Pharmacol 63:1169-79. 2003
  6. ncbi request reprint Chronic oral nicotine treatment protects against striatal degeneration in MPTP-treated primates
    Maryka Quik
    The Parkinson s Institute, Sunnyvale, California, USA
    J Neurochem 98:1866-75. 2006
  7. ncbi request reprint Differential regulation of mesolimbic alpha 3/alpha 6 beta 2 and alpha 4 beta 2 nicotinic acetylcholine receptor sites and function after long-term oral nicotine to monkeys
    Sarah E McCallum
    The Parkinson s Institute, 1170 Morse Ave, Sunnyvale, CA 94089 1605, and Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Pharmacol Exp Ther 318:381-8. 2006
  8. ncbi request reprint Increases in alpha4* but not alpha3*/alpha6* nicotinic receptor sites and function in the primate striatum following chronic oral nicotine treatment
    Sarah E McCallum
    The Parkinson s Institute, Sunnyvale, California 94089, USA
    J Neurochem 96:1028-41. 2006
  9. ncbi request reprint Decrease in alpha3*/alpha6* nicotinic receptors but not nicotine-evoked dopamine release in monkey brain after nigrostriatal damage
    Sarah E McCallum
    The Parkinson s Institute, 1170 Morse Ave, Sunnyvale, CA 94089 1605, USA
    Mol Pharmacol 68:737-46. 2005
  10. ncbi request reprint Guidelines on nicotine dose selection for in vivo research
    Shannon G Matta
    Department of Pharmacology, College of Medicine, University of Tennessee Health Science Center, 874 Union Avenue, Crowe 115, Memphis, TN 38163, USA
    Psychopharmacology (Berl) 190:269-319. 2007

Detail Information

Publications10

  1. ncbi request reprint Deletion of the beta 2 nicotinic acetylcholine receptor subunit alters development of tolerance to nicotine and eliminates receptor upregulation
    Sarah E McCallum
    Institute for Behavioral Genetics, University of Colorado, Boulder, CO 80309, USA
    Psychopharmacology (Berl) 184:314-27. 2006
    ..However, the mechanism for chronic tolerance is unclear because a direct relationship between tolerance and receptor upregulation is not consistently observed...
  2. ncbi request reprint Null mutant analysis of responses to nicotine: deletion of beta2 nicotinic acetylcholine receptor subunit but not alpha7 subunit reduces sensitivity to nicotine-induced locomotor depression and hypothermia
    Theresa Tritto
    Institute for Behavioral Genetics, University of Colorado, Boulder, USA
    Nicotine Tob Res 6:145-58. 2004
    ..0 mg/kg) blocked all responses following 1.0 mg/kg nicotine. This finding suggests receptors that include the beta2 nAChR subunit partially mediate nicotine's effects on locomotor activity and body temperature...
  3. ncbi request reprint Subsets of acetylcholine-stimulated 86Rb+ efflux and [125I]-epibatidine binding sites in C57BL/6 mouse brain are differentially affected by chronic nicotine treatment
    Michael J Marks
    Institute for Behavioral Genetics, UCB447, University of Colorado, 1480 30th Street, Boulder, CO 80309, USA
    Neuropharmacology 46:1141-57. 2004
    ..Likely alpha3beta4-nAChR binding sites were unaffected even at the highest dose (4.0 mg/kg/h, approximately 210 ng/ml). A third set of diverse nAChR binding sites increased in some brain regions, but only after high-dose treatment...
  4. ncbi request reprint Chronic oral nicotine normalizes dopaminergic function and synaptic plasticity in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned primates
    Maryka Quik
    The Parkinson s Institute, Sunnyvale, California 94089, USA
    J Neurosci 26:4681-9. 2006
    ..These cellular alterations may underlie the ability of nicotine to maintain/restore normal function with nigrostriatal damage...
  5. ncbi request reprint Differential declines in striatal nicotinic receptor subtype function after nigrostriatal damage in mice
    Maryka Quik
    The Parkinson s Institute, Sunnyvale, California 94089 1605, USA
    Mol Pharmacol 63:1169-79. 2003
    ..These data suggest that the declines in nAChR sites observed in Parkinson's disease brains may be of functional significance...
  6. ncbi request reprint Chronic oral nicotine treatment protects against striatal degeneration in MPTP-treated primates
    Maryka Quik
    The Parkinson s Institute, Sunnyvale, California, USA
    J Neurochem 98:1866-75. 2006
    ..These data further support the possibility that nicotine contributes to the lower incidence of Parkinson's disease in smokers...
  7. ncbi request reprint Differential regulation of mesolimbic alpha 3/alpha 6 beta 2 and alpha 4 beta 2 nicotinic acetylcholine receptor sites and function after long-term oral nicotine to monkeys
    Sarah E McCallum
    The Parkinson s Institute, 1170 Morse Ave, Sunnyvale, CA 94089 1605, and Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Pharmacol Exp Ther 318:381-8. 2006
    ....
  8. ncbi request reprint Increases in alpha4* but not alpha3*/alpha6* nicotinic receptor sites and function in the primate striatum following chronic oral nicotine treatment
    Sarah E McCallum
    The Parkinson s Institute, Sunnyvale, California 94089, USA
    J Neurochem 96:1028-41. 2006
    ..Such knowledge is important for understanding nicotine dependence and the consequences of nicotine administration for the treatment of neurological disorders...
  9. ncbi request reprint Decrease in alpha3*/alpha6* nicotinic receptors but not nicotine-evoked dopamine release in monkey brain after nigrostriatal damage
    Sarah E McCallum
    The Parkinson s Institute, 1170 Morse Ave, Sunnyvale, CA 94089 1605, USA
    Mol Pharmacol 68:737-46. 2005
    ..Maintenance of function in putamen, a region with a selective loss of dopaminergic terminals, may be important in PD...
  10. ncbi request reprint Guidelines on nicotine dose selection for in vivo research
    Shannon G Matta
    Department of Pharmacology, College of Medicine, University of Tennessee Health Science Center, 874 Union Avenue, Crowe 115, Memphis, TN 38163, USA
    Psychopharmacology (Berl) 190:269-319. 2007
    ..In many cases, such discrepancies could be attributed to the complex variables comprising species-specific in vivo responses to acute or chronic nicotine exposure...