Barbara Mason

Summary

Affiliation: The Scripps Research Institute
Country: USA

Publications

  1. pmc A proof-of-concept randomized controlled study of gabapentin: effects on cannabis use, withdrawal and executive function deficits in cannabis-dependent adults
    Barbara J Mason
    The Scripps Research Institute, Pearson Center for Alcoholism and Addiction Research, La Jolla, CA 92037, USA
    Neuropsychopharmacology 37:1689-98. 2012
  2. pmc Acamprosate for alcohol dependence: a sex-specific meta-analysis based on individual patient data
    Barbara J Mason
    Pearson Center for Alcoholism and Addiction Research, Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, California 92037, USA
    Alcohol Clin Exp Res 36:497-508. 2012
  3. pmc Acamprosate: a prototypic neuromodulator in the treatment of alcohol dependence
    Barbara J Mason
    Committee on the Neurobiology of Addictive Disorders, Pearson Center for Alcoholism and Addiction Research, The Scripps Research Institute, La Jolla, CA, USA
    CNS Neurol Disord Drug Targets 9:23-32. 2010
  4. doi request reprint The neurobiology, clinical efficacy and safety of acamprosate in the treatment of alcohol dependence
    Barbara J Mason
    Pearson Center for Alcoholism and Addiction Research, The Scripps Research Institute, 10550 North Torrey Pines Road, TPC 5, La Jolla, CA 92037, USA
    Expert Opin Drug Saf 9:177-88. 2010
  5. pmc Proof-of-concept human laboratory study for protracted abstinence in alcohol dependence: effects of gabapentin
    Barbara J Mason
    The Pearson Center for Alcoholism and Addiction Research and Laboratory of Clinical Psychopharmacology, The Scripps Research Institute, USA
    Addict Biol 14:73-83. 2009
  6. pmc Effect of positive and negative affective stimuli and beverage cues on measures of craving in non treatment-seeking alcoholics
    Barbara J Mason
    The Pearson Center for Alcoholism and Addiction Research and Laboratory of Clinical Psychopharmacology, The Scripps Research Institute, 10550 North Torrey Pines Road, TPC 5, La Jolla, CA 92037, USA
    Psychopharmacology (Berl) 200:141-50. 2008
  7. ncbi request reprint Acamprosate in the treatment of alcohol dependence: clinical and economic considerations
    Barbara J Mason
    Committee on the Neurobiology of Addictive Disorders, Laboratory of Clinical Psychopharmacology, The Scripps Research Institute, 10550 North Torrey Pines Road, TPC 5, La Jolla, CA 92037, USA
    Expert Rev Neurother 7:1465-77. 2007
  8. ncbi request reprint Effect of oral acamprosate on abstinence in patients with alcohol dependence in a double-blind, placebo-controlled trial: the role of patient motivation
    Barbara J Mason
    The Pearson Center for Alcoholism and Addiction Research and Molecular and Integrative Neurosciences Department, The Scripps Research Institute, 10550 North Torrey Pines Road, TPC 5, La Jolla, CA 92037, United States
    J Psychiatr Res 40:383-93. 2006
  9. ncbi request reprint Acamprosate in the treatment of alcohol dependence
    Barbara J Mason
    Molecular and Integrative Neurosciences Department, Pearson Centre for Alcoholism and Addiction Research, The Scripps Research Institute, 10550 North Torrey Pines Road, TPC 5, La Jolla, CA 92037, USA
    Expert Opin Pharmacother 6:2103-15. 2005
  10. ncbi request reprint Acamprosate and naltrexone treatment for alcohol dependence: an evidence-based risk-benefits assessment
    Barbara J Mason
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA, USA
    Eur Neuropsychopharmacol 13:469-75. 2003

Detail Information

Publications20

  1. pmc A proof-of-concept randomized controlled study of gabapentin: effects on cannabis use, withdrawal and executive function deficits in cannabis-dependent adults
    Barbara J Mason
    The Scripps Research Institute, Pearson Center for Alcoholism and Addiction Research, La Jolla, CA 92037, USA
    Neuropsychopharmacology 37:1689-98. 2012
    ....
  2. pmc Acamprosate for alcohol dependence: a sex-specific meta-analysis based on individual patient data
    Barbara J Mason
    Pearson Center for Alcoholism and Addiction Research, Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, California 92037, USA
    Alcohol Clin Exp Res 36:497-508. 2012
    ..The objective of this study was to assess sex-specific differences in the efficacy, safety, and tolerability of acamprosate in the treatment of women and men with alcohol dependence...
  3. pmc Acamprosate: a prototypic neuromodulator in the treatment of alcohol dependence
    Barbara J Mason
    Committee on the Neurobiology of Addictive Disorders, Pearson Center for Alcoholism and Addiction Research, The Scripps Research Institute, La Jolla, CA, USA
    CNS Neurol Disord Drug Targets 9:23-32. 2010
    ..We believe that a neuromodulatory approach will provide a heuristic framework for developing more effective pharmacotherapies for alcohol dependence...
  4. doi request reprint The neurobiology, clinical efficacy and safety of acamprosate in the treatment of alcohol dependence
    Barbara J Mason
    Pearson Center for Alcoholism and Addiction Research, The Scripps Research Institute, 10550 North Torrey Pines Road, TPC 5, La Jolla, CA 92037, USA
    Expert Opin Drug Saf 9:177-88. 2010
    ..Its safety and efficacy have been demonstrated in a number of clinical trials worldwide and as with all pharmacotherapies for alcoholism, it is used in conjunction with psychosocial interventions...
  5. pmc Proof-of-concept human laboratory study for protracted abstinence in alcohol dependence: effects of gabapentin
    Barbara J Mason
    The Pearson Center for Alcoholism and Addiction Research and Laboratory of Clinical Psychopharmacology, The Scripps Research Institute, USA
    Addict Biol 14:73-83. 2009
    ..The study also suggests the value of cue-reactivity studies as proof-of-concept screens for potential antirelapse drugs...
  6. pmc Effect of positive and negative affective stimuli and beverage cues on measures of craving in non treatment-seeking alcoholics
    Barbara J Mason
    The Pearson Center for Alcoholism and Addiction Research and Laboratory of Clinical Psychopharmacology, The Scripps Research Institute, 10550 North Torrey Pines Road, TPC 5, La Jolla, CA 92037, USA
    Psychopharmacology (Berl) 200:141-50. 2008
    ....
  7. ncbi request reprint Acamprosate in the treatment of alcohol dependence: clinical and economic considerations
    Barbara J Mason
    Committee on the Neurobiology of Addictive Disorders, Laboratory of Clinical Psychopharmacology, The Scripps Research Institute, 10550 North Torrey Pines Road, TPC 5, La Jolla, CA 92037, USA
    Expert Rev Neurother 7:1465-77. 2007
    ..These data elucidate the economic benefits of acamprosate, as well as its effects on cognition and alcohol-related sleep disturbances...
  8. ncbi request reprint Effect of oral acamprosate on abstinence in patients with alcohol dependence in a double-blind, placebo-controlled trial: the role of patient motivation
    Barbara J Mason
    The Pearson Center for Alcoholism and Addiction Research and Molecular and Integrative Neurosciences Department, The Scripps Research Institute, 10550 North Torrey Pines Road, TPC 5, La Jolla, CA 92037, United States
    J Psychiatr Res 40:383-93. 2006
    ..The US study findings suggest that acamprosate is safe and well tolerated in a broadly inclusive sample of alcoholics and appears effective in populations of patients motivated to have a treatment goal of abstinence...
  9. ncbi request reprint Acamprosate in the treatment of alcohol dependence
    Barbara J Mason
    Molecular and Integrative Neurosciences Department, Pearson Centre for Alcoholism and Addiction Research, The Scripps Research Institute, 10550 North Torrey Pines Road, TPC 5, La Jolla, CA 92037, USA
    Expert Opin Pharmacother 6:2103-15. 2005
    ..Acamprosate received approval by the US FDA for the treatment of alcohol dependence in July 2004 and is currently prescribed in 28 countries...
  10. ncbi request reprint Acamprosate and naltrexone treatment for alcohol dependence: an evidence-based risk-benefits assessment
    Barbara J Mason
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA, USA
    Eur Neuropsychopharmacol 13:469-75. 2003
    ..The safety of the two drugs in combination has been supported by two independent double-blind studies, and combination treatment may offer an advantage for some patients...
  11. pmc Development of pharmacotherapies for drug addiction: a Rosetta stone approach
    George F Koob
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, 10550 North Torrey Pines Road, SP30 2400 La Jolla, California 92037, USA
    Nat Rev Drug Discov 8:500-15. 2009
    ..This approach will promote translational research and provide a heuristic framework for developing efficient and effective pharmacotherapies for addiction...
  12. doi request reprint The effects of current subsyndromal psychiatric symptoms or past psychopathology on alcohol dependence treatment outcomes and acamprosate efficacy
    Barbara J Mason
    Committee on the Neurobiology of Addictive Disorders, Pearson Center for Alcoholism and Addiction Research, The Scripps Research Institute, La Jolla, California, USA
    Am J Addict 19:147-54. 2010
    ..Am J Addict 2010;00:1-8)...
  13. ncbi request reprint Potential neuroprotective effects of acamprosate
    George F Koob
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California, USA
    Alcohol Clin Exp Res 26:586-92. 2002
    ..Siggins; (3) Acamprosate and glutamate during ethanol withdrawal, by Philippe De Witte; (4) Clinical evidence of protective CNS effects of acamprosate in alcohol-dependent individuals, by Barbara J. Mason...
  14. pmc Cost and cost-effectiveness of the COMBINE study in alcohol-dependent patients
    Gary A Zarkin
    RTI International, 3040 Cornwallis Rd, Research Triangle Park, NC 27709, USA
    Arch Gen Psychiatry 65:1214-21. 2008
    ..The costs and cost-effectiveness of these combinations are unknown and of interest to clinicians and policy makers...
  15. ncbi request reprint Acamprosate
    Barbara J Mason
    Department of Psychiatry and Behavioral Sciences, University of Miami School of Medicine, Miami, Florida 33136, USA
    Recent Dev Alcohol 16:203-15. 2003
  16. ncbi request reprint Combined pharmacotherapies and behavioral interventions for alcohol dependence: the COMBINE study: a randomized controlled trial
    Raymond F Anton
    Center for Drug and Alcohol Programs, Medical University of South Carolina, Charleston 29425, USA
    JAMA 295:2003-17. 2006
    ..Alcohol dependence treatment may include medications, behavioral therapies, or both. It is unknown how combining these treatments may impact their effectiveness, especially in the context of primary care and other nonspecialty settings...
  17. ncbi request reprint A pharmacokinetic and pharmacodynamic drug interaction study of acamprosate and naltrexone
    Barbara J Mason
    Division of Substance Abuse, Department of Psychiatry and Behavioral Sciences, University of Miami School of Medicine, Miami, FL, USA
    Neuropsychopharmacology 27:596-606. 2002
    ..A complete absence of negative interactions on measures of safety and cognitive function supports the absence of a contraindication to co-administration of acamprosate and naltrexone in clinical practice...
  18. ncbi request reprint Sertraline treatment of co-occurring alcohol dependence and major depression
    Henry R Kranzler
    Department of Psychiatry, University of Connecticut School of Medicine, Farmington, CT 06030 2103, USA
    J Clin Psychopharmacol 26:13-20. 2006
    ..This multicenter, double-blind, placebo-controlled trial of sertraline was designed to address many of the potential methodological shortcomings of studies of co-occurring disorders...
  19. ncbi request reprint Rapid and sensitive determination of nalmefene in human plasma by gas chromatography-mass spectrometry
    Shan Xie
    Analytical Psychopharmacology Laboratory, Nathan Kline Institute, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 773:143-9. 2002
    ..5 ng/ml. The method described is highly specific and reproducible, and could also be applied for the determination of naltrexone and 6beta-naltrexol. Application of the method to actual human plasma samples is demonstrated...
  20. ncbi request reprint Understanding and treating alcohol dependence
    Bankole A Johnson
    Department of Psychiatric Medicine, University of Virginia, Charlottesville, Virginia 22908 0623, USA
    Alcohol Clin Exp Res 30:567-84. 2006
    ..Johnson, DSc, MD, PhD; and (5) Differential Effects of Pharmacological Agents on Craving, by Nassima Ait-Daoud, MD...

Research Grants13

  1. Gabapentin Treatment of Cannabis Dependence
    Barbara J Mason; Fiscal Year: 2010
    ....
  2. Medication Development for Protracted Abstinence in Alcoholism
    Barbara Mason; Fiscal Year: 2009
    ..abstract_text> ..
  3. MEDICATION DEVELOPMENT FOR PROTRACTED ABSTINENCE IN ALCO
    Barbara Mason; Fiscal Year: 2003
    ..abstract_text> ..
  4. Pharmacological Treatment of Cannabis Withdrawal and Dependence
    Barbara J Mason; Fiscal Year: 2010
    ..The development of vofopitant as a novel medication for CD may have major public health benefits and is highly significant for the mission of NIDA. ..