Genomes and Genes
Affiliation: The Rockefeller University
- Association of aldehyde dehydrogenase-2 polymorphism with alcoholic polyneuropathy in humansToshihiro Masaki
Department of Neurology, National Institute on Alcoholism, Kurihama National Hospital, 5 3 1 Nobi, Yokosuka, Kanagawa 239 0841, Japan
Neurosci Lett 363:288-90. 2004....
- Prolonged central sensory conduction time in alcoholics with hypoactive aldehyde dehydrogenase-2Hitoshi Mochizuki
Department of Neurology, National Institute on Alcoholism, Kurihama National Hospital, Yokosuka, Kanagawa, Japan
Neurosci Res 50:233-6. 2004..The present result indicates that an elevated blood concentration of acetaldehyde must cause the central sensory tract involvement and that acetaldehyde is one of factors producing brain damage in alcoholics...
- Influence of genetic variations of ethanol-metabolizing enzymes on phenotypes of alcohol-related disordersSusumu Higuchi
Institute of Clinical Research, National Alcoholism Center Kurihama Hospital, Yokosuka, Kanagawa, 239 0841, Japan
Ann N Y Acad Sci 1025:472-80. 2004..Possible mechanisms of altered risk for these disorders are discussed...
- Association study of brain-derived neurotrophic factor gene polymorphism and alcoholismSachio Matsushita
National Hospital Organization, Kurihama Alcoholism Center, 5 3 1 Nobi, Yokosuka, Kanagawa 239 0841, Japan
Alcohol Clin Exp Res 28:1609-12. 2004..These lines of evidence suggested that BDNF might play some role in the development of or vulnerability to alcoholism and/or clinical characteristics of alcoholic individuals...
- Histone deacetylase inhibitor trichostatin A enhances myogenesis by coordinating muscle regulatory factors and myogenic repressorsHiroki Hagiwara
Department of Neurology, Teikyo University School of Medicine, 2 11 1 Kaga, Itabashi ku, Tokyo 173 8605, Japan
Biochem Biophys Res Commun 414:826-31. 2011..Taken together, our data demonstrate that TSA enhances myogenesis by coordinating the expression of MRFs and myogenic repressors...
- Acute axonal polyneuropathy associated with alcoholismHitoshi Mochizuki
Department of Neurology, National Institute on Alcoholism, Kurihama National Hospital, Yokosuka, Japan
Eur Neurol 50:183-4. 2003
- Benign type of central pontine myelinolysis in alcoholism--clinical, neuroradiological and electrophysiological findingsHitoshi Mochizuki
Dept of Neurology, National Institute on Alcoholism, Kurihama National Hospital, 5 3 1 Nobi, Yokosuka, Kanagawa 239 0841, Japan
J Neurol 250:1077-83. 2003..These clinical, radiological and electrophysiological findings should be of use in diagnosing CPM...
- Secretion of N-terminal domain of α-dystroglycan in cerebrospinal fluidFumiaki Saito
Department of Neurology, Teikyo University, 2 11 1 Kaga, Itabashi ku, Tokyo 173 8605, Japan
Biochem Biophys Res Commun 411:365-9. 2011..DG-N in CSF was a sialylated glycoprotein with both N- and O-linked glycan. These observations suggest that secreted α-DG-N may be transported via CSF and have yet unidentified effects on the nervous system...
- Association of dystroglycan and laminin-2 coexpression with myelinogenesis in peripheral nervesToshihiro Masaki
Department of Neurology, National Institute on Alcoholism, Kurihama National Hospital, Yokosuka, Kanagawa 239 0841, Japan
Med Electron Microsc 36:221-39. 2003..Beta-dystroglycan and laminin-2 were also coexpressed in satellite cells in dorsal root ganglia, suggesting that interaction of these two proteins plays some role in physiological functions of these cells...
- Association between a polymorphism of brain-derived neurotrophic factor gene and sporadic Parkinson's diseaseToshihiro Masaki
Ann Neurol 54:276-7. 2003
- Defective peripheral nerve myelination and neuromuscular junction formation in fukutin-deficient chimeric miceFumiaki Saito
Department of Neurology and Neuroscience, Teikyo University, Tokyo, Japan
J Neurochem 101:1712-22. 2007..They also suggest that defective glycosylation of alpha-dystroglycan may play a role in the impairment of these processes in the deficiency of fukutin...
- Motor dominant neuropathy in Sjögren's syndrome: report of two casesHitoshi Mochizuki
Third Department of Internal Medicine, National Defense Medical College, Tokorozawa, Saitama
Intern Med 41:142-6. 2002..These patients received i.v. immunoglobulin therapy. To our knowledge, this is the first report indicating that i.v. immunoglobulin has beneficial effects on motor dominant neuropathy in SS...