G A Marzluf

Summary

Affiliation: The Ohio State University
Country: USA

Publications

  1. pmc Genetic regulation of nitrogen metabolism in the fungi
    G A Marzluf
    Department of Biochemistry, Ohio State University, Columbus 43210, USA
    Microbiol Mol Biol Rev 61:17-32. 1997
  2. ncbi request reprint Molecular genetics of sulfur assimilation in filamentous fungi and yeast
    G A Marzluf
    Department of Biochemistry and Program in Molecular, Cellular, and Developmental Biology, The Ohio State University, Columbus 43210, USA
    Annu Rev Microbiol 51:73-96. 1997
  3. pmc Interaction between major nitrogen regulatory protein NIT2 and pathway-specific regulatory factor NIT4 is required for their synergistic activation of gene expression in Neurospora crassa
    B Feng
    Department of Biochemistry and Program in Molecular, Cellular, and Developmental Biology, The Ohio State University, Columbus, Ohio 43210, USA
    Mol Cell Biol 18:3983-90. 1998
  4. pmc cys-3, the positive-acting sulfur regulatory gene of Neurospora crassa, encodes a protein with a putative leucine zipper DNA-binding element
    Y H Fu
    Department of Biochemistry, Ohio State University, Columbus 43210
    Mol Cell Biol 9:1120-7. 1989
  5. ncbi request reprint ASD4, a new GATA factor of Neurospora crassa, displays sequence-specific DNA binding and functions in ascus and ascospore development
    B Feng
    Department of Biochemistry, The Ohio State University, Columbus, Ohio 43210, USA
    Biochemistry 39:11065-73. 2000
  6. ncbi request reprint Two distinct protein-protein interactions between the NIT2 and NMR regulatory proteins are required to establish nitrogen metabolite repression in Neurospora crassa
    H Pan
    Department of Biochemistry, The Ohio State University, Columbus 43210, USA
    Mol Microbiol 26:721-9. 1997
  7. ncbi request reprint Nucleotide sequence and analysis of NMR, a negative-acting regulatory gene in the nitrogen circuit of Neurospora crassa
    J L Young
    Department of Biochemistry, Ohio State University, Columbus 43210
    Mol Gen Genet 222:120-8. 1990
  8. ncbi request reprint Nucleotide sequence and DNA recognition elements of alc, the structural gene which encodes allantoicase, a purine catabolic enzyme of Neurospora crassa
    H Lee
    Department of Biochemistry, Ohio State University, Columbus 43210
    Biochemistry 29:8779-87. 1990
  9. ncbi request reprint Characterization of pco-1, a newly identified gene which regulates purine catabolism in Neurospora
    T D Liu
    Department of Biochemistry, The Ohio State University, Columbus, OH 43210, USA
    Curr Genet 46:213-27. 2004
  10. pmc Binding affinity and functional significance of NIT2 and NIT4 binding sites in the promoter of the highly regulated nit-3 gene, which encodes nitrate reductase in Neurospora crassa
    T Y Chiang
    Department of Biochemistry, Ohio State University, Columbus 43210, USA
    J Bacteriol 177:6093-9. 1995

Collaborators

Detail Information

Publications13

  1. pmc Genetic regulation of nitrogen metabolism in the fungi
    G A Marzluf
    Department of Biochemistry, Ohio State University, Columbus 43210, USA
    Microbiol Mol Biol Rev 61:17-32. 1997
    ..Nitrogen metabolic regulation appears to play a significant role in the pathogenicity of certain animal and plant fungal pathogens...
  2. ncbi request reprint Molecular genetics of sulfur assimilation in filamentous fungi and yeast
    G A Marzluf
    Department of Biochemistry and Program in Molecular, Cellular, and Developmental Biology, The Ohio State University, Columbus 43210, USA
    Annu Rev Microbiol 51:73-96. 1997
    ....
  3. pmc Interaction between major nitrogen regulatory protein NIT2 and pathway-specific regulatory factor NIT4 is required for their synergistic activation of gene expression in Neurospora crassa
    B Feng
    Department of Biochemistry and Program in Molecular, Cellular, and Developmental Biology, The Ohio State University, Columbus, Ohio 43210, USA
    Mol Cell Biol 18:3983-90. 1998
    ..We propose that protein-protein interactions of the individual GATA factors with additional pathway-specific regulatory factors determine each of their specific regulatory functions...
  4. pmc cys-3, the positive-acting sulfur regulatory gene of Neurospora crassa, encodes a protein with a putative leucine zipper DNA-binding element
    Y H Fu
    Department of Biochemistry, Ohio State University, Columbus 43210
    Mol Cell Biol 9:1120-7. 1989
    ..A cys-3 mutant and a cys-3 temperature-sensitive mutant lead to substitutions of glutamine for basic amino acids within the charged region and thus may alter DNA-binding properties of the cys-3 protein...
  5. ncbi request reprint ASD4, a new GATA factor of Neurospora crassa, displays sequence-specific DNA binding and functions in ascus and ascospore development
    B Feng
    Department of Biochemistry, The Ohio State University, Columbus, Ohio 43210, USA
    Biochemistry 39:11065-73. 2000
    ..These results suggest that the ASD4 protein functions positively as a transcriptional regulator of sexual development in Neurospora...
  6. ncbi request reprint Two distinct protein-protein interactions between the NIT2 and NMR regulatory proteins are required to establish nitrogen metabolite repression in Neurospora crassa
    H Pan
    Department of Biochemistry, The Ohio State University, Columbus 43210, USA
    Mol Microbiol 26:721-9. 1997
    ..These results provide compelling evidence that the specific NIT2-NMR interactions have a regulatory function and play a central role in establishing nitrogen metabolite repression...
  7. ncbi request reprint Nucleotide sequence and analysis of NMR, a negative-acting regulatory gene in the nitrogen circuit of Neurospora crassa
    J L Young
    Department of Biochemistry, Ohio State University, Columbus 43210
    Mol Gen Genet 222:120-8. 1990
    ..Transformation assays showed that the proteins lacking up to 16% of the carboxyl-terminus were still functional. Homology searches showed that the nmr protein is homologous to the yeast arginine regulatory gene AR-GRII...
  8. ncbi request reprint Nucleotide sequence and DNA recognition elements of alc, the structural gene which encodes allantoicase, a purine catabolic enzyme of Neurospora crassa
    H Lee
    Department of Biochemistry, Ohio State University, Columbus 43210
    Biochemistry 29:8779-87. 1990
    ..Mutant NIT2/beta-gal fusion proteins with amino acid substitutions in a putative zinc-finger motif were shown to be completely deficient in the ability to bind to the alc promoter DNA fragment...
  9. ncbi request reprint Characterization of pco-1, a newly identified gene which regulates purine catabolism in Neurospora
    T D Liu
    Department of Biochemistry, The Ohio State University, Columbus, OH 43210, USA
    Curr Genet 46:213-27. 2004
    ..Induction of the xdh gene and synthesis of xanthine dehydrogenase is completely dependent upon PCO1, but does not require the global-acting NIT2 protein, suggesting that it is controlled by a novel regulatory mechanism...
  10. pmc Binding affinity and functional significance of NIT2 and NIT4 binding sites in the promoter of the highly regulated nit-3 gene, which encodes nitrate reductase in Neurospora crassa
    T Y Chiang
    Department of Biochemistry, Ohio State University, Columbus 43210, USA
    J Bacteriol 177:6093-9. 1995
    ..A significant NIT2-NIT4 protein-protein interaction might occur upon their binding to nearby sites...
  11. ncbi request reprint cys-3, the positive-acting sulfur regulatory gene of Neurospora crassa, encodes a sequence-specific DNA-binding protein
    Y H Fu
    Department of Biochemistry, Ohio State University, Columbus 43210
    J Biol Chem 265:11942-7. 1990
    ..Two mutant CYS3 proteins, altered in the basic region of the DNA-binding domain, failed to bind to either the cys-14 or the cys-3 upstream recognition elements...
  12. ncbi request reprint Novel compound heterozygous laminina2-chain gene (LAMA2) mutations in congenital muscular dystrophy. Mutations in brief no. 159. Online
    J T Mendell
    Department of Biochemistry, Ohio State University, 1654 Upham Drive, Columbus 43210, Ohio, USA
    Hum Mutat 12:135. 1998
    ..By either mechanism the phenotype of congenital muscular dystrophy is believed to be the result of disruption of linkage between the extracellular matrix and the dystrophin glycoprotein complex...
  13. ncbi request reprint Heterologous expression and regulation of the Neurospora crassa nit-4 pathway-specific regulatory gene for nitrate assimilation in Aspergillus nidulans
    K L Hawker
    Plant Molecular Genetics Unit, University of St Andrews, Fife, UK
    Gene 100:237-40. 1991
    ..However, NR levels are modestly higher than wt under all growth conditions...