Eric D Marsh

Summary

Affiliation: The Children's Hospital of Philadelphia
Country: USA

Publications

  1. ncbi Migrating partial seizures in infancy: expanding the phenotype of a rare seizure syndrome
    Eric Marsh
    The Division of Neurology and the Pediatric Regional Epilepsy Program of The Children s Hospital of Philadelphia and the University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Epilepsia 46:568-72. 2005
  2. ncbi Identification of Arx transcriptional targets in the developing basal forebrain
    Carl T Fulp
    Neuroscience Graduate Group, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Hum Mol Genet 17:3740-60. 2008
  3. ncbi Interictal EEG spikes identify the region of electrographic seizure onset in some, but not all, pediatric epilepsy patients
    Eric D Marsh
    Division of Child Neurology, Department of Neurology and Pediatrics, Children s Hospital of Philadelphia, The University of Pennsylvania, Philadelphia, PA 19104, USA
    Epilepsia 51:592-601. 2010
  4. ncbi Developing an animal model for infantile spasms: pathogenesis, problems and progress
    Eric D Marsh
    Department of Neurology, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Dis Model Mech 2:329-35. 2009
  5. ncbi Convulsive and nonconvulsive status epilepticus in children
    Nicholas S Abend
    Eric Marsh, MD, PhD Division of Neurology, Children s Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA
    Curr Treat Options Neurol 11:262-72. 2009
  6. ncbi Targeted loss of Arx results in a developmental epilepsy mouse model and recapitulates the human phenotype in heterozygous females
    Eric Marsh
    Abramson Research Center, Children s Hospital of Philadelphia, 3615 Civic Center Blvd, Philadelphia, PA 19104, USA
    Brain 132:1563-76. 2009
  7. ncbi FACS-array gene expression analysis during early development of mouse telencephalic interneurons
    Eric D Marsh
    Division of Neurology, Children s Hospital of Philadelphia and The University of Pennsylvania, Philadelphia 19130, USA
    Dev Neurobiol 68:434-45. 2008
  8. ncbi Seizures and antiepileptic drugs: does exposure alter normal brain development?
    Eric D Marsh
    Division of Child Neurology and Pediatric Regional Epilepsy Program, Children s Hospital of Philadelphia, and Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Epilepsia 47:1999-2010. 2006
  9. ncbi Loss of CDKL5 disrupts kinome profile and event-related potentials leading to autistic-like phenotypes in mice
    I Ting Judy Wang
    Department of Genetics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 109:21516-21. 2012
  10. ncbi Discrete gamma oscillations identify the seizure onset zone in some pediatric epilepsy patients
    Jay R Gupta
    Department of Neurology and Bioengineering, The University of Pennsylvania, Philadelphia, PA 19104, USA
    Conf Proc IEEE Eng Med Biol Soc 2011:3095-8. 2011

Collaborators

Detail Information

Publications14

  1. ncbi Migrating partial seizures in infancy: expanding the phenotype of a rare seizure syndrome
    Eric Marsh
    The Division of Neurology and the Pediatric Regional Epilepsy Program of The Children s Hospital of Philadelphia and the University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Epilepsia 46:568-72. 2005
    ..We report six new patients and the prospect of a more optimistic developmental outcome...
  2. ncbi Identification of Arx transcriptional targets in the developing basal forebrain
    Carl T Fulp
    Neuroscience Graduate Group, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Hum Mol Genet 17:3740-60. 2008
    ....
  3. ncbi Interictal EEG spikes identify the region of electrographic seizure onset in some, but not all, pediatric epilepsy patients
    Eric D Marsh
    Division of Child Neurology, Department of Neurology and Pediatrics, Children s Hospital of Philadelphia, The University of Pennsylvania, Philadelphia, PA 19104, USA
    Epilepsia 51:592-601. 2010
    ..Indeed, past studies suggest an inconsistent relationship between IED and seizure-onset location, although these studies were based upon relatively short EEG epochs...
  4. ncbi Developing an animal model for infantile spasms: pathogenesis, problems and progress
    Eric D Marsh
    Department of Neurology, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Dis Model Mech 2:329-35. 2009
    ..Finally, we will discuss the limitations of these models and the potential avenues for future research on IS...
  5. ncbi Convulsive and nonconvulsive status epilepticus in children
    Nicholas S Abend
    Eric Marsh, MD, PhD Division of Neurology, Children s Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA
    Curr Treat Options Neurol 11:262-72. 2009
    ..This review evaluates treatment protocols for acute SE, prolonged SE, and nonconvulsive SE, including some management strategies that use newer anticonvulsants...
  6. ncbi Targeted loss of Arx results in a developmental epilepsy mouse model and recapitulates the human phenotype in heterozygous females
    Eric Marsh
    Abramson Research Center, Children s Hospital of Philadelphia, 3615 Civic Center Blvd, Philadelphia, PA 19104, USA
    Brain 132:1563-76. 2009
    ..Given the frequency of ARX mutations in patients with infantile spasms and related disorders, our data unveil a new model for further understanding the pathogenesis of these disorders...
  7. ncbi FACS-array gene expression analysis during early development of mouse telencephalic interneurons
    Eric D Marsh
    Division of Neurology, Children s Hospital of Philadelphia and The University of Pennsylvania, Philadelphia 19130, USA
    Dev Neurobiol 68:434-45. 2008
    ..In addition, these data can be mined to uncover numerous novel genes involved in the generation of interneurons and may suggest genes/pathways potentially involved in a number of human neurological disorders...
  8. ncbi Seizures and antiepileptic drugs: does exposure alter normal brain development?
    Eric D Marsh
    Division of Child Neurology and Pediatric Regional Epilepsy Program, Children s Hospital of Philadelphia, and Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Epilepsia 47:1999-2010. 2006
    ..More research, both clinical and experimental, is needed before changes in current clinical practice, based on the scientific data, can be recommended...
  9. ncbi Loss of CDKL5 disrupts kinome profile and event-related potentials leading to autistic-like phenotypes in mice
    I Ting Judy Wang
    Department of Genetics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 109:21516-21. 2012
    ..These data demonstrate that CDKL5 regulates signal transduction pathways and mediates autistic-like phenotypes and together establish a causal role for Cdkl5 loss-of-function in neurodevelopmental disorders...
  10. ncbi Discrete gamma oscillations identify the seizure onset zone in some pediatric epilepsy patients
    Jay R Gupta
    Department of Neurology and Bioengineering, The University of Pennsylvania, Philadelphia, PA 19104, USA
    Conf Proc IEEE Eng Med Biol Soc 2011:3095-8. 2011
    ..Further research is required to help determine which patients would benefit from this technique...
  11. ncbi Comparison of novel computer detectors and human performance for spike detection in intracranial EEG
    Merritt W Brown
    Division of Child Neurology, Children s Hospital of Philadelphia, and Department of Neurology and Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA
    Clin Neurophysiol 118:1744-52. 2007
    ..Accurate automated spike detectors are necessary for understanding the role of spikes in epileptogenesis...
  12. ncbi Focal cortical dysplasia is more common in boys than in girls
    Xilma R Ortiz-Gonzalez
    Department of Pediatrics and Neurology, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Stanford, CA 94305, USA
    Epilepsy Behav 27:121-3. 2013
    ..5 (95% CI, 1.34 to 4.62) for male sex. None of the other etiologies had a male sex predominance. Future studies could examine the biological relevance and potential genetic and pathophysiological mechanisms of this observation...
  13. ncbi Delayed myelination in an intrauterine growth retardation model is mediated by oxidative stress upregulating bone morphogenetic protein 4
    Mary V Reid
    Department of Neurology, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    J Neuropathol Exp Neurol 71:640-53. 2012
    ..Together, these findings suggest that IUGR results in delayed myelination through the generation of oxidative stress that leads to BMP4 upregulation...
  14. ncbi Human and automated detection of high-frequency oscillations in clinical intracranial EEG recordings
    Andrew B Gardner
    Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Clin Neurophysiol 118:1134-43. 2007
    ..Automated tools are required to characterize these events. We present a new algorithm tuned to detect HFOs from 30 to 85 Hz, and validate it against human expert electroencephalographers...