A Markou

Summary

Affiliation: The Scripps Research Institute
Country: USA

Publications

  1. ncbi request reprint Diminished nicotine withdrawal in adolescent rats: implications for vulnerability to addiction
    Laura E O'Dell
    Molecular and Integrative Neuroscience Department, CVN 7, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Psychopharmacology (Berl) 186:612-9. 2006
  2. pmc Review. Neurobiology of nicotine dependence
    Athina Markou
    Department of Psychiatry, School of Medicine, University of California at San Diego, La Jolla, CA 92093 0603, USA
    Philos Trans R Soc Lond B Biol Sci 363:3159-68. 2008
  3. ncbi request reprint The nicotinic antagonist methyllycaconitine has differential effects on nicotine self-administration and nicotine withdrawal in the rat
    A Markou
    Department of Neuropharmacology, The Scripps Research Institute, 10550 North Torrey Pines Rd, La Jolla, CA 92037, USA
    Nicotine Tob Res 3:361-73. 2001
  4. ncbi request reprint Role of gamma-aminobutyric acid (GABA) and metabotropic glutamate receptors in nicotine reinforcement: potential pharmacotherapies for smoking cessation
    Athina Markou
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California 92037, USA
    Ann N Y Acad Sci 1025:491-503. 2004
  5. ncbi request reprint Metabotropic glutamate receptor antagonists: novel therapeutics for nicotine dependence and depression?
    Athina Markou
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, California 92037, USA
    Biol Psychiatry 61:17-22. 2007
  6. ncbi request reprint Fluoxetine combined with a serotonin-1A receptor antagonist reversed reward deficits observed during nicotine and amphetamine withdrawal in rats
    A A Harrison
    Scripps Research Institute, Department of Neuropharmacology, La Jolla, CA 92037, USA
    Neuropsychopharmacology 25:55-71. 2001
  7. ncbi request reprint RU 24969, a 5-HT1A/1B agonist, elevates brain stimulation reward thresholds: an effect reversed by GR 127935, a 5-HT1B/1D antagonist
    A A Harrison
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Psychopharmacology (Berl) 141:242-50. 1999
  8. ncbi request reprint Differential effects of withdrawal from chronic amphetamine or fluoxetine administration on brain stimulation reward in the rat--interactions between the two drugs
    D Lin
    Department of Neuropharmacology, Scripps Research Institute, La Jolla, CA 92037, USA
    Psychopharmacology (Berl) 145:283-94. 1999
  9. ncbi request reprint Effects of repeated withdrawal from continuous amphetamine administration on brain reward function in rats
    N E Paterson
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Psychopharmacology (Berl) 152:440-6. 2000
  10. ncbi request reprint The mGluR5 antagonist MPEP decreased nicotine self-administration in rats and mice
    Neil E Paterson
    Department of Neuropharmacology, CVN 7, The Scripps Research Institute, La Jolla, CA 92037, USA
    Psychopharmacology (Berl) 167:257-64. 2003

Detail Information

Publications90

  1. ncbi request reprint Diminished nicotine withdrawal in adolescent rats: implications for vulnerability to addiction
    Laura E O'Dell
    Molecular and Integrative Neuroscience Department, CVN 7, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Psychopharmacology (Berl) 186:612-9. 2006
    ..Enhanced reinforcing effects of nicotine during adolescence appear to contribute to the rapid development of dependence in this age group. However, the contribution of nicotine withdrawal to dependence in adolescents is unclear...
  2. pmc Review. Neurobiology of nicotine dependence
    Athina Markou
    Department of Psychiatry, School of Medicine, University of California at San Diego, La Jolla, CA 92093 0603, USA
    Philos Trans R Soc Lond B Biol Sci 363:3159-68. 2008
    ..In conclusion, glutamate, GABA and cholinergic transmission in limbic and frontal brain sites are critically involved in nicotine dependence...
  3. ncbi request reprint The nicotinic antagonist methyllycaconitine has differential effects on nicotine self-administration and nicotine withdrawal in the rat
    A Markou
    Department of Neuropharmacology, The Scripps Research Institute, 10550 North Torrey Pines Rd, La Jolla, CA 92037, USA
    Nicotine Tob Res 3:361-73. 2001
    ....
  4. ncbi request reprint Role of gamma-aminobutyric acid (GABA) and metabotropic glutamate receptors in nicotine reinforcement: potential pharmacotherapies for smoking cessation
    Athina Markou
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California 92037, USA
    Ann N Y Acad Sci 1025:491-503. 2004
    ..Thus, compounds that increase GABAergic neurotransmission and antagonists at mGluR5 have potential as anti-smoking medications for humans...
  5. ncbi request reprint Metabotropic glutamate receptor antagonists: novel therapeutics for nicotine dependence and depression?
    Athina Markou
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, California 92037, USA
    Biol Psychiatry 61:17-22. 2007
    ..Metabotropic glutamate 2/3 receptor antagonists may also be therapeutics for non-drug-induced depressions...
  6. ncbi request reprint Fluoxetine combined with a serotonin-1A receptor antagonist reversed reward deficits observed during nicotine and amphetamine withdrawal in rats
    A A Harrison
    Scripps Research Institute, Department of Neuropharmacology, La Jolla, CA 92037, USA
    Neuropsychopharmacology 25:55-71. 2001
    ....
  7. ncbi request reprint RU 24969, a 5-HT1A/1B agonist, elevates brain stimulation reward thresholds: an effect reversed by GR 127935, a 5-HT1B/1D antagonist
    A A Harrison
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Psychopharmacology (Berl) 141:242-50. 1999
    ..In conclusion, the results suggest that activation of 5-HT(1B) receptors reduces brain stimulation reward...
  8. ncbi request reprint Differential effects of withdrawal from chronic amphetamine or fluoxetine administration on brain stimulation reward in the rat--interactions between the two drugs
    D Lin
    Department of Neuropharmacology, Scripps Research Institute, La Jolla, CA 92037, USA
    Psychopharmacology (Berl) 145:283-94. 1999
    ..Nevertheless, the effects of long-term administration and withdrawal from other drugs, such as fluoxetine, that have the potential to elevate mood in depressed individuals have not been characterized...
  9. ncbi request reprint Effects of repeated withdrawal from continuous amphetamine administration on brain reward function in rats
    N E Paterson
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Psychopharmacology (Berl) 152:440-6. 2000
    ..The study of the effects of repeated amphetamine administration and withdrawal on brain reward function has relevance to both amphetamine dependence and non-drug-induced depressions...
  10. ncbi request reprint The mGluR5 antagonist MPEP decreased nicotine self-administration in rats and mice
    Neil E Paterson
    Department of Neuropharmacology, CVN 7, The Scripps Research Institute, La Jolla, CA 92037, USA
    Psychopharmacology (Berl) 167:257-64. 2003
    ..Metabotropic glutamate receptors 5 (mGluR5) are found in the nucleus accumbens and may play a role in modulating the post-synaptic response to both glutamate and dopamine...
  11. ncbi request reprint Group II metabotropic and alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA)/kainate glutamate receptors regulate the deficit in brain reward function associated with nicotine withdrawal in rats
    Paul J Kenny
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Pharmacol Exp Ther 306:1068-76. 2003
    ..Furthermore, it is likely that mGluII receptors generate this reward deficit, at least in part, by decreasing glutamate transmission at AMPA/kainate receptors...
  12. ncbi request reprint Prolonged nicotine dependence associated with extended access to nicotine self-administration in rats
    Neil E Paterson
    Department of Neuropharmacology CVN 7, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Psychopharmacology (Berl) 173:64-72. 2004
    ..Most nicotine self-administration (NSA) studies in rats are performed under limited-access conditions. Few studies have examined the relationship between nicotine dependence and NSA...
  13. ncbi request reprint Both GABA(B) receptor agonist and antagonists decreased brain stimulation reward in the rat
    D J Macey
    Department of Neuropharmacology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Neuropharmacology 40:676-85. 2001
    ....
  14. ncbi request reprint Serotonergic manipulations both potentiate and reduce brain stimulation reward in rats: involvement of serotonin-1A receptors
    A A Harrison
    Department of Neuropharmacology, The Scripps Research Institute, 10550 North Torrey Pines Rd, La Jolla, CA 92037, USA
    J Pharmacol Exp Ther 297:316-25. 2001
    ..In conclusion, the present data support the hypothesis that serotonin exerts an inhibitory influence on reward processes...
  15. ncbi request reprint Decreased sensitivity to the effects of dopamine D1-like, but not D2-like, receptor antagonism in the posterior hypothalamic region/anterior ventral tegmental area on brain reward function during chronic exposure to nicotine in rats
    Adrie W Bruijnzeel
    Molecular and Integrative Neuroscience Department, CVN 7, The Scripps Research Institute, La Jolla, CA 92037, USA
    Brain Res 1058:91-100. 2005
    ....
  16. ncbi request reprint Prolonged nicotine exposure does not alter GABA(B) receptor-mediated regulation of brain reward function
    Neil E Paterson
    Department of Molecular and Integrative Neuroscience, CVN 7, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Neuropharmacology 49:953-62. 2005
    ....
  17. pmc Interactive effects of the mGlu5 receptor antagonist MPEP and the mGlu2/3 receptor antagonist LY341495 on nicotine self-administration and reward deficits associated with nicotine withdrawal in rats
    Matthias E Liechti
    Department of Psychiatry, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    Eur J Pharmacol 554:164-74. 2007
    ....
  18. ncbi request reprint Nicotine potentiation of brain stimulation reward reversed by DH beta E and SCH 23390, but not by eticlopride, LY 314582 or MPEP in rats
    Amanda A Harrison
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Psychopharmacology (Berl) 160:56-66. 2002
    ..Nicotine-induced increases of dopamine in the nucleus accumbens are in part mediated by glutamatergic projections to the ventral tegmental area dopamine neurons...
  19. ncbi request reprint Metabotropic glutamate 5 receptor antagonist MPEP decreased nicotine and cocaine self-administration but not nicotine and cocaine-induced facilitation of brain reward function in rats
    P J Kenny
    The Scripps Research Institute, Department of Neuropharmacology, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Ann N Y Acad Sci 1003:415-8. 2003
  20. ncbi request reprint Metabotropic glutamate 2/3 receptors in the ventral tegmental area and the nucleus accumbens shell are involved in behaviors relating to nicotine dependence
    Matthias E Liechti
    Department of Psychiatry, School of Medicine, University of California, San Diego, La Jolla, California 92093, USA
    J Neurosci 27:9077-85. 2007
    ..Together, these findings indicate an important role for mGlu2/3 receptors in the posterior VTA and the NAc shell in the mediation of the rewarding effects of nicotine and potentially in cue-induced nicotine-seeking behavior...
  21. ncbi request reprint Metabotropic glutamate 5 receptor blockade may attenuate cocaine self-administration by decreasing brain reward function in rats
    Paul J Kenny
    Department of Neuropharmacology, CVN 7, The Scripps Research Institute, La Jolla, CA 92037, USA
    Psychopharmacology (Berl) 179:247-54. 2005
    ..Evidence is accumulating that metabotropic glutamate 5 (mGlu5) receptors play an important role in regulating the reinforcing actions of drugs of abuse...
  22. pmc The mGluR2 positive allosteric modulator BINA decreases cocaine self-administration and cue-induced cocaine-seeking and counteracts cocaine-induced enhancement of brain reward function in rats
    Xinchun Jin
    Department of Psychiatry, University of California San Diego, La Jolla, 92093 0603, USA
    Neuropsychopharmacology 35:2021-36. 2010
    ..The higher selectivity of BINA compared with an mGluR2/3 agonist for drug- vs food-motivated behaviors suggests a therapeutic role for mGluR2 PAMs for the treatment of cocaine addiction and possibly other drugs of abuse...
  23. pmc Spontaneous nicotine withdrawal potentiates the effects of stress in rats
    Sietse Jonkman
    Department of Psychiatry, School of Medicine, University of California San Diego, La Jolla, CA 92093 0603, USA
    Neuropsychopharmacology 33:2131-8. 2008
    ..These findings support the hypothesis that nicotine withdrawal exacerbates stress responding, and indicate LES may be a useful model to examine withdrawal effects on anxiety...
  24. ncbi request reprint CRF and urocortin decreased brain stimulation reward in the rat: reversal by a CRF receptor antagonist
    D J Macey
    Department of Neuropharmacology, CVN 7, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Brain Res 866:82-91. 2000
    ..0 microg) without affecting other ICSS performance measures. These results indicate that CRF neurotransmission can modulate ICSS reward processes...
  25. ncbi request reprint Construct validity of a self-stimulation threshold paradigm: effects of reward and performance manipulations
    A Markou
    Department of Neuropharmacology, Scripps Research Institute, La Jolla, CA 92037
    Physiol Behav 51:111-9. 1992
    ..The results suggest that the discrete-trial current-threshold procedure can readily discriminate reward from performance treatments...
  26. ncbi request reprint Effects of repeated withdrawal episodes, nicotine dose, and duration of nicotine exposure on the severity and duration of nicotine withdrawal in rats
    Karen L Skjei
    Department of Neuropharmacology, CVN 7, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Psychopharmacology (Berl) 168:280-92. 2003
    ..The aversive aspects of nicotine withdrawal contribute to high relapse rates to tobacco smoking after cessation attempts...
  27. ncbi request reprint Nicotine self-administration acutely activates brain reward systems and induces a long-lasting increase in reward sensitivity
    Paul J Kenny
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Neuropsychopharmacology 31:1203-11. 2006
    ....
  28. ncbi request reprint Blockade of nicotinic acetylcholine or dopamine D1-like receptors in the central nucleus of the amygdala or the bed nucleus of the stria terminalis does not precipitate nicotine withdrawal in nicotine-dependent rats
    Sietse Jonkman
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, CA 92037, USA
    Neurosci Lett 400:140-5. 2006
    ..These results suggest that nACh and D1-like signalling in the CeA and the dlBNST does not develop neuroadaptations with the development of nicotine dependence that may be involved in the depression-like aspects of nicotine withdrawal...
  29. ncbi request reprint Repeated administration of the GABAB receptor agonist CGP44532 decreased nicotine self-administration, and acute administration decreased cue-induced reinstatement of nicotine-seeking in rats
    Neil E Paterson
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Neuropsychopharmacology 30:119-28. 2005
    ..125 and 0.25 mg/kg) dose-dependently decreased cue-induced reinstatement of nicotine-seeking behavior...
  30. pmc Withdrawal from chronic exposure to amphetamine, but not nicotine, leads to an immediate and enduring deficit in motivated behavior without affecting social interaction in rats
    Andre Der-Avakian
    Department of Psychiatry, School of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0603, USA
    Behav Pharmacol 21:359-68. 2010
    ..Social interaction was not affected during withdrawal from either drug. These results indicate that withdrawal from chronic amphetamine exposure leads to an immediate and enduring anhedonic state...
  31. ncbi request reprint The metabotropic glutamate receptor 5 antagonist MPEP decreased break points for nicotine, cocaine and food in rats
    Neil E Paterson
    Department of Neuropharmacology, CVN 7, The Scripps Research Institute, La Jolla, CA 92037, USA
    Psychopharmacology (Berl) 179:255-61. 2005
    ..The metabotropic glutamate (mGlu5) receptor subtype 5 antagonist MPEP attenuates self-administration of numerous drugs of abuse...
  32. ncbi request reprint Chronic bupropion attenuated the anhedonic component of nicotine withdrawal in rats via inhibition of dopamine reuptake in the nucleus accumbens shell
    Neil E Paterson
    Department of Psychiatry, Basic Science Building, School of Medicine, University of California San Diego, La Jolla, CA 92093 0603, USA
    Eur J Neurosci 25:3099-108. 2007
    ..In conclusion, the bupropion-induced increase in extracellular dopamine in the nucleus accumbens shell may ameliorate the anhedonia associated with nicotine withdrawal, which in turn may facilitate smoking cessation...
  33. doi request reprint Chronic bupropion differentially alters the reinforcing, reward-enhancing and conditioned motivational properties of nicotine in rats
    Neil E Paterson
    Department of Psychiatry, School of Medicine, University of California San Diego, La Jolla, CA 92093 0603, USA
    Nicotine Tob Res 10:995-1008. 2008
    ..Rather, preclinical investigations suggest that bupropion attenuates nicotine-induced enhancement of brain reward function and reverses the anhedonic, somatic, and neurochemical correlates of nicotine withdrawal...
  34. ncbi request reprint Bupropion enhances brain reward function and reverses the affective and somatic aspects of nicotine withdrawal in the rat
    John F Cryan
    Department of Neuropharmacology, CVN 7, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Psychopharmacology (Berl) 168:347-58. 2003
    ..Bupropion is an atypical antidepressant and the only non-nicotine-based therapy approved for smoking cessation. Its use has raised much debate as to how a non-nicotine-based agent can aid in smoking cessation...
  35. ncbi request reprint Conditioned nicotine withdrawal profoundly decreases the activity of brain reward systems
    Paul J Kenny
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California 92037
    J Neurosci 25:6208-12. 2005
    ....
  36. ncbi request reprint Extended access to nicotine self-administration leads to dependence: Circadian measures, withdrawal measures, and extinction behavior in rats
    Scott A Chen
    Department of Molecular and Integrative Neurosciences, SP30 2400, The Scripps Research Institute, 10550 North Torrey Pines Rd, La Jolla, CA 92037, USA
    J Pharmacol Exp Ther 320:180-93. 2007
    ..The results demonstrate that rats will self-administer nicotine to the point of producing dependence, as measured by somatic signs, resistance to extinction, and measures of food intake...
  37. pmc Positive modulation of GABA(B) receptors decreased nicotine self-administration and counteracted nicotine-induced enhancement of brain reward function in rats
    Neil E Paterson
    Department of Psychiatry, School of Medicine, University of California San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0603, USA
    J Pharmacol Exp Ther 326:306-14. 2008
    ..Thus, GABA(B) receptor-positive modulators may be useful antismoking medications...
  38. ncbi request reprint Characterization of the effects of bupropion on the reinforcing properties of nicotine and food in rats
    Adrie W Bruijnzeel
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, California 92037, USA
    Synapse 50:20-8. 2003
    ....
  39. ncbi request reprint Withdrawal from chronic amphetamine induces depressive-like behavioral effects in rodents
    John F Cryan
    Department of Neuropharmacology, Scripps Research Institute, La Jolla, California 92037, USA
    Biol Psychiatry 54:49-58. 2003
    ....
  40. ncbi request reprint Decreased prepulse inhibition during nicotine withdrawal in DBA/2J mice is reversed by nicotine self-administration
    Svetlana Semenova
    Department of Neuropharmacology, CVN 7, The Scripps Research Institute, 10550 North Torrey Pines Rd, La Jolla, CA 92037, USA
    Eur J Pharmacol 472:99-110. 2003
    ..Thus, nicotine withdrawal results in modest, but yet detectable, changes in the behavior of mice...
  41. pmc Assessment of reward responsiveness in the response bias probabilistic reward task in rats: implications for cross-species translational research
    A Der-Avakian
    Department of Psychiatry, School of Medicine, University of California San Diego, La Jolla, CA 92093 0603, USA
    Transl Psychiatry 3:e297. 2013
    ..Thus, this new procedure in rats, which is conceptually and procedurally analogous to the one used in humans, provides a reverse translational platform to investigate abnormal reward responsiveness across species...
  42. ncbi request reprint Neurobiology of the nicotine withdrawal syndrome
    P J Kenny
    Department of Neuropharmacology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Pharmacol Biochem Behav 70:531-49. 2001
    ..The aim of the present review is to discuss preclinical findings concerning the neuroanatomical and neurochemical substrates involved in these different aspects of nicotine withdrawal...
  43. ncbi request reprint Substance dependence as a compulsive behavior
    G F Koob
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Psychopharmacol 12:39-48. 1998
    ..Challenges for the future involve not only elucidation of the neurobiological substrates of the different behavioral components of addiction, but better animal models of these components with which to effect such studies...
  44. pmc Neonatal maternal separation exacerbates the reward-enhancing effect of acute amphetamine administration and the anhedonic effect of repeated social defeat in adult rats
    A Der-Avakian
    Department of Psychiatry, School of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0603, USA
    Neuroscience 170:1189-98. 2010
    ..Thus, early life stress may increase an individual's vulnerability to depressive or addictive disorders when confronted with stress or drug challenge in adulthood...
  45. pmc The effects of the mGluR5 antagonist MPEP and the mGluR2/3 antagonist LY341495 on rats' performance in the 5-choice serial reaction time task
    Svetlana Semenova
    Department of Psychiatry, School of Medicine, University of California, San Diego, 9500 Gilman Drive, M C 0603, La Jolla, CA 92093 0603, USA
    Neuropharmacology 52:863-72. 2007
    ..Thus, blockade of mGluR5, but not mGluR2/3, decreased overall responding without affecting accuracy in the 5CSRTT...
  46. ncbi request reprint Increased GABA neurotransmission via administration of gamma-vinyl GABA decreased nicotine self-administration in the rat
    Neil E Paterson
    Department of Neuropharmacology, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    Synapse 44:252-3. 2002
  47. ncbi request reprint Neurobiological mechanisms in the transition from drug use to drug dependence
    George F Koob
    Department of Neuropharmacology, CVN 7, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Neurosci Biobehav Rev 27:739-49. 2004
    ....
  48. ncbi request reprint Nicotine withdrawal in adolescent and adult rats
    Laura E O'Dell
    Department of Neuropharmacology, CVN 7, The Scripps Research Institute, 10550 North Torrey Pines Rd, La Jolla, CA 92037, USA
    Ann N Y Acad Sci 1021:167-74. 2004
    ....
  49. ncbi request reprint Metabotropic glutamate 2/3 receptor activation induced reward deficits but did not aggravate brain reward deficits associated with spontaneous nicotine withdrawal in rats
    Matthias E Liechti
    Department of Psychiatry, School of Medicine, University of California San Diego, La Jolla, CA 92093, USA
    Biochem Pharmacol 74:1299-307. 2007
    ..Thus, this mGlu2/3 agonist does not appear to significantly influence the affective depression-like aspects of nicotine withdrawal...
  50. ncbi request reprint Effects of antalarmin, a CRF type 1 receptor antagonist, on anxiety-like behavior and motor activation in the rat
    Eric P Zorrilla
    Department of Neuropharmacology, CVN 7, The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, CA 92037, USA
    Brain Res 952:188-99. 2002
    ....
  51. ncbi request reprint Conditioned withdrawal drives heroin consumption and decreases reward sensitivity
    Paul J Kenny
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, California 92037, USA
    J Neurosci 26:5894-900. 2006
    ..Thus, conditioned stimuli predicting the onset of heroin withdrawal, and hence the reward deficits coupled with this state, may play a critical role in provoking craving and relapse in human opiate addicts...
  52. ncbi request reprint Adaptations in cholinergic transmission in the ventral tegmental area associated with the affective signs of nicotine withdrawal in rats
    Adrie W Bruijnzeel
    Department of Neuropharmacology, The Scripps Research Institute CVN 7, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Neuropharmacology 47:572-9. 2004
    ..The adaptations in cholinergic transmission in the VTA are likely to mediate, at least partly, the affective signs of nicotine withdrawal in humans...
  53. ncbi request reprint Low dose cocaine self-administration transiently increases but high dose cocaine persistently decreases brain reward function in rats
    Paul J Kenny
    Department of Neuropharmacology, CVN 7, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Eur J Neurosci 17:191-5. 2003
    ....
  54. pmc The alpha2 adrenergic receptor antagonist idazoxan, but not the serotonin-2A receptor antagonist M100907, partially attenuated reward deficits associated with nicotine, but not amphetamine, withdrawal in rats
    Svetlana Semenova
    Department of Psychiatry, School of Medicine, University of California San Diego, 9500 Gilman Drive, M C 0603, La Jolla, CA 92093 0603, USA
    Eur Neuropsychopharmacol 20:731-46. 2010
    ....
  55. ncbi request reprint The GABAB receptor agonists baclofen and CGP44532 decreased nicotine self-administration in the rat
    Neil E Paterson
    Department of Neuropharmacology CVN 7, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Psychopharmacology (Berl) 172:179-86. 2004
    ..Specifically, GABA(B) receptor agonists decreased cocaine, heroin and nicotine self-administration in rats...
  56. pmc NMDA receptors regulate nicotine-enhanced brain reward function and intravenous nicotine self-administration: role of the ventral tegmental area and central nucleus of the amygdala
    Paul J Kenny
    Department of Molecular Therapeutics, The Scripps Research Institute, Jupiter, FL 33458, USA
    Neuropsychopharmacology 34:266-81. 2009
    ..Taken together, these data suggest that NMDA receptors, including those in the CeA and VTA, gate the magnitude and valence of the effects of nicotine on brain reward systems, thereby regulating motivation to consume the drug...
  57. ncbi request reprint The mGluR5 antagonist MPEP, but not the mGluR2/3 agonist LY314582, augments PCP effects on prepulse inhibition and locomotor activity
    S A Henry
    Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093, USA
    Neuropharmacology 43:1199-209. 2002
    ..The effects of MPEP on the response to PCP may reflect the cooperation and co-localization of NMDA and mGlu5 receptors...
  58. pmc Chronic nicotine improves cognitive performance in a test of attention but does not attenuate cognitive disruption induced by repeated phencyclidine administration
    Nurith Amitai
    Department of Psychiatry, School of Medicine, University of California, San Diego, 9500 Gilman Drive, Mail Code 0603, La Jolla, CA 92093 0603, USA
    Psychopharmacology (Berl) 202:275-86. 2009
    ..Schizophrenia patients exhibit higher smoking rates compared with the general population, suggesting that attempts to self-medicate cognitive schizophrenia deficits may underlie these high smoking levels...
  59. doi request reprint Clozapine attenuates disruptions in response inhibition and task efficiency induced by repeated phencyclidine administration in the intracranial self-stimulation procedure
    Nurith Amitai
    Department of Psychiatry, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA
    Eur J Pharmacol 602:78-84. 2009
    ....
  60. ncbi request reprint Increased motivation for self-administered cocaine after escalated cocaine intake
    Neil E Paterson
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Neuroreport 14:2229-32. 2003
    ..In conclusion, the present data suggest that escalation in cocaine self-administration is associated with a significant increase in the incentive motivational value of self-administered cocaine...
  61. ncbi request reprint GABAB receptors in reward processes
    Styliani Vlachou
    Department of Psychiatry, School of Medicine, University of California San Diego, La Jolla, California, USA
    Adv Pharmacol 58:315-71. 2010
    ..g., initiation, maintenance, and relapse) on various drugs of abuse, such as cocaine, nicotine, heroin, and alcohol...
  62. ncbi request reprint Withdrawal from chronic phencyclidine treatment induces long-lasting depression in brain reward function
    Cecile Spielewoy
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Neuropsychopharmacology 28:1106-16. 2003
    ....
  63. ncbi request reprint Mild anxiogenic effects of nicotine withdrawal in mice
    Sietse Jonkman
    Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Eur J Pharmacol 516:40-5. 2005
    ..In conclusion, the present data show that nicotine withdrawal is mildly anxiogenic in C57BL/6J mice under the conditions used in the present experiments...
  64. ncbi request reprint Clozapine treatment attenuated somatic and affective signs of nicotine and amphetamine withdrawal in subsets of rats exhibiting hyposensitivity to the initial effects of clozapine
    Svetlana Semenova
    Department of Neuropharmacology, Scripps Research Institute, La Jolla, California 92037, USA
    Biol Psychiatry 54:1249-64. 2003
    ..g., anhedonia), we hypothesized that treatment with clozapine may be effective against nicotine and amphetamine withdrawal...
  65. ncbi request reprint Paroxetine combined with a 5-HT(1A) receptor antagonist reversed reward deficits observed during amphetamine withdrawal in rats
    Athina Markou
    Department of Neuropharmacology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Psychopharmacology (Berl) 178:133-42. 2005
    ..2001)...
  66. ncbi request reprint Both the shell of the nucleus accumbens and the central nucleus of the amygdala support amphetamine self-administration in rats
    Jessica Chevrette
    Department of Neuropharmacology, CVN 7, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Pharmacol Biochem Behav 71:501-7. 2002
    ..Further, the present study provides additional evidence about the functional homogeneity of the forebrain continuum called the "extended amygdala."..
  67. ncbi request reprint Exposure to chronic mild stress alters thresholds for lateral hypothalamic stimulation reward and subsequent responsiveness to amphetamine
    D Lin
    Department of Neuropharmacology, CVN 7, The Scripps Research Institute, 10550 North Torry Pines Road, La Jolla, CA 92037, USA
    Neuroscience 114:925-33. 2002
    ..These findings support the hypothesis that prior exposure to stress affects the vulnerability for drug-taking behavior by increasing the positive reinforcing properties of drug of abuse...
  68. ncbi request reprint The effect of lateral septum corticotropin-releasing factor receptor 2 activation on anxiety is modulated by stress
    Brook Henry
    Department of Molecular and Integrative Neurosciences, The Scripps Research Institute, La Jolla, California 92037, USA
    J Neurosci 26:9142-52. 2006
    ..Urocortin 2 infusion into the medial septum or lateral ventricle did not affect anxiety measures. These results indicate that the effect of septal CRF2 receptor activation on anxiety is dependent on stress level...
  69. pmc Disruption of performance in the five-choice serial reaction time task induced by administration of N-methyl-D-aspartate receptor antagonists: relevance to cognitive dysfunction in schizophrenia
    Nurith Amitai
    Department of Psychiatry, School of Medicine, University of California, San Diego, La Jolla, California, USA
    Biol Psychiatry 68:5-16. 2010
    ..Thus, disruption of 5-CSRTT performance by NMDA antagonists represents a valuable tool for exploring the neurobiological bases of cognitive dysfunction in schizophrenia...
  70. ncbi request reprint Psychostimulant withdrawal as an inducing condition in animal models of depression
    Alasdair M Barr
    Department of Neuropharmacology, CVN 7, The Scripps Research Institute, 10550 North Torrey Pines Rd, La Jolla, CA 92037 USA
    Neurosci Biobehav Rev 29:675-706. 2005
    ..Recent progress and limitations in the development of this model, as well as future directions for research, are evaluated and discussed...
  71. ncbi request reprint Conditioned facilitation of brain reward function after repeated cocaine administration
    Paul J Kenny
    Department of Neuropharmacology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Behav Neurosci 117:1103-7. 2003
    ..These data demonstrate that cocaine-predictive conditioned stimuli induce a conditioned facilitation of brain reward function...
  72. ncbi request reprint Iloperidone reduces sensorimotor gating deficits in pharmacological models, but not a developmental model, of disrupted prepulse inhibition in rats
    Alasdair M Barr
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, CA, USA
    Neuropharmacology 51:457-65. 2006
    ..The absence of effect in isolation-reared rats may be due to the relatively small effect size of isolation rearing on PPI or dose of iloperidone...
  73. ncbi request reprint Cocaine-seeking behavior after extended cocaine-free periods in rats: role of conditioned stimuli
    Svetlana Semenova
    Department of Neuropharmacology, CVN 7, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Psychopharmacology (Berl) 168:192-200. 2003
    ..Cocaine abstinence symptoms and conditioned stimuli (CSs) previously associated with cocaine administration are postulated to contribute to relapse to drug taking in humans...
  74. pmc Affective and somatic aspects of spontaneous and precipitated nicotine withdrawal in C57BL/6J and BALB/cByJ mice
    Astrid K Stoker
    Department of Psychiatry, School of Medicine, University of California at San Diego, 9500 Gilman Drive, M C 0603, La Jolla, CA 92093 0603, USA
    Neuropharmacology 54:1223-32. 2008
    ..The current study is one of the first to demonstrate reward deficits associated with both spontaneous and nAChR antagonist-precipitated nicotine withdrawal in C57BL/6J mice...
  75. pmc Effects of metabotropic glutamate receptor 2/3 agonism and antagonism on schizophrenia-like cognitive deficits induced by phencyclidine in rats
    Nurith Amitai
    Department of Psychiatry, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Eur J Pharmacol 639:67-80. 2010
    ..Our findings also suggest that additional mechanisms, besides cortical glutamatergic transmission, may be involved in certain cognitive dysfunctions in schizophrenia...
  76. ncbi request reprint Cognitive-disruptive effects of the psychotomimetic phencyclidine and attenuation by atypical antipsychotic medications in rats
    Nurith Amitai
    Department of Psychiatry, School of Medicine, University of California San Diego, 9500 Gilman Drive, Mail Code 0603, La Jolla, CA 92093 0603, USA
    Psychopharmacology (Berl) 193:521-37. 2007
    ..The development and validation of animal models of cognitive deficits characterizing schizophrenia are crucial for clarifying the underlying neuropathology and discovery of improved treatments for such deficits...
  77. ncbi request reprint Animal models and treatments for addiction and depression co-morbidity
    Neil E Paterson
    Department of Psychiatry, School of Medicine, University of California, San Diego, 9500 Gilman Drive, MC0603, La Jolla, CA 92093, USA
    Neurotox Res 11:1-32. 2007
    ....
  78. ncbi request reprint A 'crash' course on psychostimulant withdrawal as a model of depression
    Alasdair M Barr
    Associate Professor, Dept of Neuropharmacology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Trends Pharmacol Sci 23:475-82. 2002
    ..Current advances and limitations in the development of this model, together with recent evidence that psychostimulant withdrawal in rodents can be used to screen for novel, rapidly acting antidepressant treatments, are discussed...
  79. ncbi request reprint Active immunisation against nicotine blocks the reward facilitating effects of nicotine and partially prevents nicotine withdrawal in the rat as measured by dopamine output in the nucleus accumbens, brain reward thresholds and somatic signs
    Nina Lindblom
    Department of Physiology and Pharmacology, Section of Neuropsychopharmacology, Karolinska Institutet, Nanna Svartz vag 2, 171 77, Stockholm, Sweden
    Naunyn Schmiedebergs Arch Pharmacol 372:182-94. 2005
    ..Furthermore, since the withdrawal syndrome in rats was attenuated by immunisation, the nicotine withdrawal in smokers should not be worsened but may even be ameliorated during a quit attempt...
  80. ncbi request reprint Evaluation of reward processes in an animal model of depression
    David A Slattery
    Neuroscience Research, Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland
    Psychopharmacology (Berl) 190:555-68. 2007
    ..Deficits in reward function, which underlie anhedonia, can be readily assessed in animals. Therefore, anhedonia may serve as an endophenotype for understanding the neural circuitry and molecular pathways underlying depression...
  81. pmc The reelin receptors VLDLR and ApoER2 regulate sensorimotor gating in mice
    Alasdair M Barr
    Department of Psychiatry, University of British Columbia, Vancouver, B C, Canada
    Neuropharmacology 52:1114-23. 2007
    ..These findings have relevance to a range of neuropsychiatric disorders that involve sensorimotor gating deficits, including schizophrenia...
  82. ncbi request reprint Lack of depression-like effects of saccharin deprivation in rats: forced swim test, differential reinforcement of low rates and intracranial self-stimulation procedures
    Irina A Sukhotina
    Institute of Pharmacology, Lab of Behavioral Pharmacology, Pavlov Medical University, 6 8 Lev Tolstoy Street, St Petersburg 197089, Russia
    Behav Neurosci 117:970-7. 2003
    ..In contrast, saccharin-deprived rats demonstrated improved performance in the behavioral paradigms used here...
  83. pmc Inactivation of the 5-HT(7) receptor partially blocks phencyclidine-induced disruption of prepulse inhibition
    Svetlana Semenova
    Department of Psychiatry, University of California, San Diego, USA
    Biol Psychiatry 63:98-105. 2008
    ..Further, several antidepressant and antipsychotic drugs have high affinity for the 5-HT(7) receptor...
  84. ncbi request reprint The GABAB receptor-positive modulator GS39783 and the GABAB receptor agonist baclofen attenuate the reward-facilitating effects of cocaine: intracranial self-stimulation studies in the rat
    David A Slattery
    Psychiatry Program, Neuroscience Research, Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland
    Neuropsychopharmacology 30:2065-72. 2005
    ..Therefore, GABAB-positive modulation may represent a novel therapeutic strategy for the treatment of cocaine dependence and possibly other drugs of abuse without the side effects of full GABAB receptor agonists...
  85. pmc Chronic nicotine administration improves attention while nicotine withdrawal induces performance deficits in the 5-choice serial reaction time task in rats
    Svetlana Semenova
    Department of Psychiatry, School of Medicine, University of California at San Diego, 9500 Gilman Drive, M C 0603 La Jolla, California 92093, USA
    Pharmacol Biochem Behav 87:360-8. 2007
    ..These results provide evidence that chronic, but not acute, nicotine administration induced accuracy improvement under baseline conditions, while nicotine withdrawal produced some limited performance deficits...
  86. ncbi request reprint Non-nicotinic neuropharmacological strategies for nicotine dependence: beyond bupropion
    John F Cryan
    Neuroscience Disease Area, The Novartis Institutes for BioMedical Research, WSJ 386 344Novartis Pharma AG CH 4002, Basel, Switzerland
    Drug Discov Today 8:1025-34. 2003
    ....
  87. ncbi request reprint Metabotropic glutamate receptor (mGluR5) antagonist MPEP attenuated cue- and schedule-induced reinstatement of nicotine self-administration behavior in rats
    Anton Y Bespalov
    Institute of Pharmacology, Pavlov Medical University, St Petersburg, Russia
    Neuropharmacology 49:167-78. 2005
    ....
  88. ncbi request reprint Neurobiological evidence for hedonic allostasis associated with escalating cocaine use
    Serge H Ahmed
    Laboratoire de Neuropsychobiologie des Desadaptations, Universite de Bordeaux 2, CNRS UMR 5541, 146 rue Leo Saignat, Bordeaux 33076, France
    Nat Neurosci 5:625-6. 2002
    ....
  89. pmc Role for hypocretin in mediating stress-induced reinstatement of cocaine-seeking behavior
    Benjamin Boutrel
    Center for Psychiatric Neuroscience and Service Universitaire de Psychiatrie de l Enfant et de l Adolescent, Centre Hospitalier Universitaire Vaudois Département de Psychiatrie, University of Lausanne, Prilly, Switzerland
    Proc Natl Acad Sci U S A 102:19168-73. 2005
    ..These findings reveal a previously unidentified role for hypocretins in driving drug seeking through activation of stress pathways in the brain...
  90. pmc The effects of chronic versus acute desipramine on nicotine withdrawal and nicotine self-administration in the rat
    Neil E Paterson
    Department of Psychiatry, Semel Institute for Neuroscience and Human Behavior, University of California at Los Angeles, Los Angeles, CA 90095 1563, USA
    Psychopharmacology (Berl) 198:351-62. 2008
    ..These aversive aspects of nicotine withdrawal and the rewarding effects of nicotine play major roles in maintaining nicotine dependence...