CAROLE MARCUS

Summary

Affiliation: The Children's Hospital of Philadelphia
Country: USA

Publications

  1. doi request reprint Rapid eye movement latency in children and adolescents
    Thornton B A Mason
    Sleep Center, Children s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Pediatr Neurol 39:162-9. 2008
  2. pmc Effects of positive airway pressure therapy on neurobehavioral outcomes in children with obstructive sleep apnea
    Carole L Marcus
    Sleep Center, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Am J Respir Crit Care Med 185:998-1003. 2012
  3. pmc Randomized, double-blind clinical trial of two different modes of positive airway pressure therapy on adherence and efficacy in children
    Carole L Marcus
    Sleep Center, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Clin Sleep Med 8:37-42. 2012
  4. ncbi request reprint Developmental changes in upper airway dynamics
    Carole L Marcus
    The Eudowood Division of Pediatric Respiratory Sciences, Johns Hopkins University, Baltimore, MD 21287 2533, USA
    J Appl Physiol 97:98-108. 2004
  5. ncbi request reprint Upper airway dynamic responses in children with the obstructive sleep apnea syndrome
    Carole L Marcus
    Eudowood Division of Pediatric Respiratory Sciences, Johns Hopkins University, Baltimore, MD 21287, USA
    Pediatr Res 57:99-107. 2005
  6. ncbi request reprint Pediatric sleep medicine comes into its own
    Carole L Marcus
    Sleep Center, Division of Pediatric Pulmonology, Children s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA 19104, USA
    Pediatrics 113:1393-4. 2004
  7. ncbi request reprint Adherence to and effectiveness of positive airway pressure therapy in children with obstructive sleep apnea
    Carole L Marcus
    Division of Pulmonary Medicine, Sleep Center, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Pediatrics 117:e442-51. 2006
  8. pmc Effect of sleep stage on breathing in children with central hypoventilation
    Jingtao Huang
    Sleep Center, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Appl Physiol 105:44-53. 2008
  9. ncbi request reprint Polysomnographic values in children 2-9 years old: additional data and review of the literature
    Nadav Traeger
    Division of Pulmonary Medicine and Sleep Disorders Center, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104 4399, USA
    Pediatr Pulmonol 40:22-30. 2005
  10. pmc Upper airway collapsibility during REM sleep in children with the obstructive sleep apnea syndrome
    Jingtao Huang
    Sleep Center, Children s Hospital of Philadelphia, University of Pennsylvania School ofMedicine, Philadelphia, PA, USA
    Sleep 32:1173-81. 2009

Collaborators

Detail Information

Publications50

  1. doi request reprint Rapid eye movement latency in children and adolescents
    Thornton B A Mason
    Sleep Center, Children s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Pediatr Neurol 39:162-9. 2008
    ..Healthy children exhibited rapid eye movement latencies significantly longer than adults. Normal control patients demonstrated significantly longer rapid eye movement latency than obstructive sleep apnea syndrome and narcolepsy patients...
  2. pmc Effects of positive airway pressure therapy on neurobehavioral outcomes in children with obstructive sleep apnea
    Carole L Marcus
    Sleep Center, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Am J Respir Crit Care Med 185:998-1003. 2012
    ..However, it is not known whether positive airway pressure therapy results in improvements in the neurobehavioral abnormalities associated with childhood sleep apnea...
  3. pmc Randomized, double-blind clinical trial of two different modes of positive airway pressure therapy on adherence and efficacy in children
    Carole L Marcus
    Sleep Center, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Clin Sleep Med 8:37-42. 2012
    ..We hypothesized that Bi-Flex would result in improved adherence but similar efficacy to CPAP...
  4. ncbi request reprint Developmental changes in upper airway dynamics
    Carole L Marcus
    The Eudowood Division of Pediatric Respiratory Sciences, Johns Hopkins University, Baltimore, MD 21287 2533, USA
    J Appl Physiol 97:98-108. 2004
    ..Infants appear to have a different pattern of upper airway activation than older children. We speculate that the pharyngeal airway responses present in normal children are a compensatory response for a relatively narrow upper airway...
  5. ncbi request reprint Upper airway dynamic responses in children with the obstructive sleep apnea syndrome
    Carole L Marcus
    Eudowood Division of Pediatric Respiratory Sciences, Johns Hopkins University, Baltimore, MD 21287, USA
    Pediatr Res 57:99-107. 2005
    ..Further, we speculate that this compensatory response is lacking in children with OSAS, most likely due to either habituation to chronic respiratory abnormalities during sleep or to mechanical damage to the upper airway...
  6. ncbi request reprint Pediatric sleep medicine comes into its own
    Carole L Marcus
    Sleep Center, Division of Pediatric Pulmonology, Children s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA 19104, USA
    Pediatrics 113:1393-4. 2004
  7. ncbi request reprint Adherence to and effectiveness of positive airway pressure therapy in children with obstructive sleep apnea
    Carole L Marcus
    Division of Pulmonary Medicine, Sleep Center, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Pediatrics 117:e442-51. 2006
    ..The objective of this study was to determine adherence and effectiveness of PAP (both continuous [CPAP] and bilevel [BPAP] pressure) in children with obstructive apnea...
  8. pmc Effect of sleep stage on breathing in children with central hypoventilation
    Jingtao Huang
    Sleep Center, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Appl Physiol 105:44-53. 2008
    ..The hypoventilation in CHS is more severe during NREM than REM sleep. We speculate that this may be due to increased excitatory inputs to the respiratory system during REM sleep...
  9. ncbi request reprint Polysomnographic values in children 2-9 years old: additional data and review of the literature
    Nadav Traeger
    Division of Pulmonary Medicine and Sleep Disorders Center, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104 4399, USA
    Pediatr Pulmonol 40:22-30. 2005
    ..We also confirm previous data on the frequency distribution of sleep stages, SpO2, and relative rarity of respiratory events in this age group...
  10. pmc Upper airway collapsibility during REM sleep in children with the obstructive sleep apnea syndrome
    Jingtao Huang
    Sleep Center, Children s Hospital of Philadelphia, University of Pennsylvania School ofMedicine, Philadelphia, PA, USA
    Sleep 32:1173-81. 2009
    ..We hypothesized that children with the obstructive sleep apnea syndrome (OSAS), in contrast to age-matched control subjects, would not maintain airflow in the face of an upper airway inspiratory pressure drop during REM sleep...
  11. ncbi request reprint Upper airway collapsibility in anesthetized children
    Ronald S Litman
    Department of Anesthesiology, University of Rochester, Rochester, New York, USA
    Anesth Analg 102:750-4. 2006
    ..3) cm H2O (sevoflurane versus halothane, P = 0.048). We conclude that when using dynamic application of negative airway pressure, halothane appears to cause less upper airway obstruction than sevoflurane at equipotent concentrations...
  12. pmc Cortical processing of respiratory afferent stimuli during sleep in children with the obstructive sleep apnea syndrome
    Jingtao Huang
    The Sleep Center Children s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA 19104, USA
    Sleep 31:403-10. 2008
    ..We hypothesized that children with OSAS have blunted RREP responses compared to normal children during sleep...
  13. ncbi request reprint Pathophysiology of upper airway obstruction: a developmental perspective
    Raanan Arens
    Division of Pulmonary Medicine and Sleep Disorders Center, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Sleep 27:997-1019. 2004
    ..This compensatory response appears to be blunted in children with OSAS. Further research is needed to fully understand the complexities of upper airway structure and function during both normal development and disease...
  14. pmc Respiratory-related evoked potentials during sleep in children
    M Cecilia Melendres
    Johns Hopkins School of Medicine, Baltimore, MD, USA
    Sleep 31:55-61. 2008
    ..However, there have been no data on RREP during sleep in children. We thus examined children during sleep to determine whether early RREP components would be maintained during all sleep..
  15. pmc Catecholamines, adiponectin, and insulin resistance as measured by HOMA in children with obstructive sleep apnea
    Andrea Kelly
    Division Endocrinology Diabetes, The Children s Hospital of Philadelphia, Philadelphia, PA, 19104, USA
    Sleep 33:1185-91. 2010
    ..We hypothesized that OSA is associated with worse insulin resistance and lower adiponectin after adjustment for obesity and puberty and that catecholamines might mediate these changes...
  16. pmc Influence of airway pressure on genioglossus activity during sleep in normal children
    Eliot S Katz
    Division of Pediatric Pulmonology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Am J Respir Crit Care Med 173:902-9. 2006
    ..This suggests that additional determinants of airway patency are active, such as neuromuscular compensation...
  17. pmc Polysomnographic values in children undergoing puberty: pediatric vs. adult respiratory rules in adolescents
    Ignacio E Tapia
    Sleep Center, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 USA
    Sleep 31:1737-44. 2008
    ....
  18. ncbi request reprint Night-to-night variability of polysomnography in children with suspected obstructive sleep apnea
    Eliot S Katz
    Eudowood Divison of Pediatric Respiratory Sciences, Johns Hopkins University, Baltimore, Maryland, USA
    J Pediatr 140:589-94. 2002
    ..To determine whether a single polysomnographic night was a valid measure of obstructive sleep apnea syndrome (OSAS) in children with symptoms of sleep-disordered breathing...
  19. pmc Differences in overnight polysomnography scores using the adult and pediatric criteria for respiratory events in adolescents
    Jennifer A Accardo
    The Children s Hospital of Philadelphia, Sleep Center, Philadelphia, PA 19104, USA
    Sleep 33:1333-9. 2010
    ..Our objective was to compare pediatric and adult criteria in adolescents referred for obstructive sleep apnea (OSA). We hypothesized that pediatric criteria would capture more respiratory events than adult criteria...
  20. pmc Puberty and upper airway dynamics during sleep
    Preetam Bandla
    Sleep Center, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, PA 19104, USA
    Sleep 31:534-41. 2008
    ..We hypothesized that the upper airway response to subatmospheric pressure loading decreased with increasing pubertal Tanner stage in males but remained stable during puberty in females...
  21. pmc Cortical processing of respiratory occlusion stimuli in children with central hypoventilation syndrome
    Jingtao Huang
    The Sleep Center, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Am J Respir Crit Care Med 178:757-64. 2008
    ..The ability of patients with central hypoventilation syndrome (CHS) to produce and process mechanoreceptor signals is unknown...
  22. pmc Childhood obstructive sleep apnea associates with neuropsychological deficits and neuronal brain injury
    Ann C Halbower
    Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    PLoS Med 3:e301. 2006
    ..We hypothesized that childhood OSA is associated with neuropsychological performance dysfunction, and with neuronal metabolite alterations in the brain, indicative of neuronal injury in areas corresponding to neuropsychological function...
  23. ncbi request reprint Pulse transit time as a measure of arousal and respiratory effort in children with sleep-disordered breathing
    Eliot S Katz
    The Eudowood Division of Pediatric Respiratory Sciences, Johns Hopkins University, Baltimore, Maryland, USA
    Pediatr Res 53:580-8. 2003
    ..8 events/h) than primary snoring (2.2 events/h) (p < 0.05). We conclude that, in children, PTT arousals are a more sensitive measure of obstructive events than visible EEG arousals...
  24. pmc Upper airway sensory function in children with obstructive sleep apnea syndrome
    Ignacio E Tapia
    Sleep Center, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Sleep 33:968-72. 2010
    ..This may be due, in part, to an impairment in the afferent limb of the upper airway sensory pathway. Therefore, we hypothesized that children with OSAS had diminished upper airway sensation compared to controls...
  25. pmc Relationship between REM density, duty cycle, and obstructive sleep apnea in children
    Laurie Karamessinis
    The Sleep Center, The Children s Hospital ofPhiladelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Sleep 30:837-43. 2007
    ..We speculate that the increase in the duty cycle is a compensatory response to increased upper airway loads during sleep, and that this may lead to ventilatory or upper airway muscle fatigue...
  26. ncbi request reprint Secondary narcolepsy in children with brain tumors
    Carole L Marcus
    The Eudowood Division of Pediatric Respiratory Sciences, Johns Hopkins University, Baltimore, MD, USA
    Sleep 25:435-9. 2002
    ..In view of the good response to treatment, we recommend that all children with excessive daytime sleepiness and hypothalamic damage be evaluated for narcolepsy...
  27. pmc Developmental aspects of the upper airway: report from an NHLBI Workshop, March 5-6, 2009
    Carole L Marcus
    Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Proc Am Thorac Soc 6:513-20. 2009
    ..This report provides recommendations that could facilitate translation of basic research findings into practice to better diagnose, treat, and prevent airway compromise in children...
  28. doi request reprint Nocturnal saturation and glucose tolerance in children with cystic fibrosis
    Dharmeshkumar Suratwala
    Children s Hospital of Philadelphia, Pulmonary Division, 9NW50, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA
    Thorax 66:574-8. 2011
    ....
  29. ncbi request reprint Recurrent pneumothoraces associated with nocturnal noninvasive ventilation in a patient with muscular dystrophy
    Lee R Choo-Kang
    Eudowood Division of Pediatric Respiratory Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Pediatr Pulmonol 34:73-8. 2002
    ..Given the increasing utilization of chronic nocturnal bilevel positive airway pressure ventilation, we suggest that healthcare providers and patients be made aware of this potentially life-threatening complication...
  30. ncbi request reprint Daytime sleepiness and hyperactivity in children with suspected sleep-disordered breathing
    Ma Cecilia S Melendres
    Eudowood Division of Pediatric Respiratory Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Pediatrics 114:768-75. 2004
    ..Furthermore, we hypothesized that overnight polysomnographic parameters correlated with sleepiness and hyperactivity...
  31. ncbi request reprint Sleep disorders in children
    Ann C Halbower
    Eudowood Division of Pediatric Respiratory Sciences, Johns Hopkins University, Baltimore, Maryland 21287, USA
    Curr Opin Pulm Med 9:471-6. 2003
    ..Infant sleep rhythm complaints from new mothers reach 46%, while childhood obstructive sleep apnea has a prevalence of 2% and adolescent insomnia with daily consequences surpasses that percentage...
  32. ncbi request reprint Body position and obstructive sleep apnea in children
    Lucila B Fernandes Do Prado
    Department of Neurology and Internal Medicine, Universidade Federal de Sao Paulo Escola Paulista de Medicina, Sao Paulo, Brazil
    Sleep 25:66-71. 2002
    ..However, the relationship between sleep position and obstructive apnea in children is unknown. The objective of this study was to evaluate the relationship between obstructive apnea and body position during sleep in children...
  33. ncbi request reprint The significance of ASDA arousals in children
    Maria Cecilia Lopes
    Department of Psychobiology, Federal University of Sao Paulo, Brazil
    Sleep Med 9:3-8. 2007
    ..The aim of this review is to discuss the application of conventional and unconventional markers of sleep disruption in children...
  34. ncbi request reprint Upper airway collapsibility during sleep in upper airway resistance syndrome
    Avram R Gold
    Division of Pulmonary Critical Care Medicine, SUNY Stony Brook, School of Medicine, DVA Medical Center, Northport, NY 11768, USA
    Chest 121:1531-40. 2002
    ..To compare upper airway collapsibility during sleep between patients with upper airway resistance syndrome (UARS), normal subjects, and patients with obstructive sleep apnea/hypopnea syndrome (OSA/H)...
  35. ncbi request reprint Obstructive hypopneas in children and adolescents: normal values
    Manisha B Witmans
    Am J Respir Crit Care Med 168:1540. 2003
  36. ncbi request reprint Improving pediatric compliance with positive airway pressure therapy: the impact of behavioral intervention
    Kristine L Koontz
    The Kennedy Krieger Institute, Johns Hopkins University School of Medicine, USA
    Sleep 26:1010-5. 2003
    ....
  37. ncbi request reprint Tolerance of esophageal pressure monitoring during polysomnography in children
    Ronald D Chervin
    Sleep Disorders Center Department of Neurology, University of Michigan, Ann Arbor, MI 48109 0117, USA
    Sleep 26:1022-6. 2003
    ..To assess tolerance of esophageal pressure monitoring (EPM) among 5- to 13-year-old children during research polysomnography at study entry and again 1 year later...
  38. ncbi request reprint Reliability of scoring arousals in normal children and children with obstructive sleep apnea syndrome
    Tat Kong Wong
    Department of Paediatrics and Adolescent Medicine, Pamela Youde Nethersole Eastern Hospital, Hong Kong
    Sleep 27:1139-45. 2004
    ..However, the validity and reliability of scoring these shorter arousals have never been verified. Based on studies in adults, we hypothesized that interscorer agreement for scoring arousals shorter than 3 seconds was poor...
  39. ncbi request reprint Acoustic arousal responses in children with obstructive sleep apnea
    Gustavo A Moreira
    Department of Pediatrics, Universidade Federal de Sao Paulo, Sao Paulo, Brazil
    Pediatr Pulmonol 40:300-5. 2005
    ..However, further studies evaluating arousal to both respiratory and nonrespiratory stimuli in the same subjects are needed...
  40. pmc Sleep-disordered breathing, behavior, and cognition in children before and after adenotonsillectomy
    Ronald D Chervin
    Sleep Disorders Center, Department of Neurology, University of Michigan, Ann Arbor, Michigan, USA
    Pediatrics 117:e769-78. 2006
    ....
  41. pmc Subjective sleepiness and polysomnographic correlates in children scheduled for adenotonsillectomy vs other surgical care
    Ronald D Chervin
    Sleep Disorders Center, Department of Neurology, University of Michigan, Ann Arbor, MI, USA
    Sleep 29:495-503. 2006
    ....
  42. ncbi request reprint The visual scoring of sleep and arousal in infants and children
    Madeleine Grigg-Damberger
    Department of Neurology, University of New Mexico School of Medicine, Albuquerque, NM 87131 0001, USA
    J Clin Sleep Med 3:201-40. 2007
    ..We need research comparing clinical outcomes with PSG measures to better inform clinicians and families exactly what meaning a PSG has in evaluating a child's suspected sleep disorder...
  43. ncbi request reprint The scoring of respiratory events in sleep: reliability and validity
    Susan Redline
    Department of Pediatrics, Case Western Reserve University, Cleveland, OH, WA 44106 6033, USA
    J Clin Sleep Med 3:169-200. 2007
    ....
  44. ncbi request reprint And miles to go before we sleep
    Carole L Marcus
    Sleep Med Rev 10:79-81. 2006
  45. ncbi request reprint Evaluating the upper airway during wakefulness: what can it tell us about sleep?
    Carole L Marcus
    Am J Respir Crit Care Med 169:140-1. 2004
  46. ncbi request reprint The toll of poverty: no respite even in sleep
    Carole L Marcus
    J Pediatr 149:293-4. 2006
  47. ncbi request reprint Letter to the editor regarding our previous publication: "Secondary narcolepsy in children with brain tumors," SLEEP 2002; 25:435-439
    Carole L Marcus
    Sleep 26:228. 2003
  48. ncbi request reprint Ventilatory management of sleep-disordered breathing in children
    Lisa H Liner
    Virtua Voorhees West Jersey Hospital, Voorhees, New Jersey, USA
    Curr Opin Pediatr 18:272-6. 2006
    ..The purpose of this review is to summarize the current management of continuous positive airway pressure and noninvasive positive pressure ventilation in children with sleep-disordered breathing...
  49. ncbi request reprint Childhood obesity, inflammation, and apnea: what is the future for our children?
    Andrea Kelly
    Am J Respir Crit Care Med 171:202-3. 2005
  50. ncbi request reprint Late-onset hypoventilation without PHOX2B mutation or hypothalamic abnormalities
    Virginia D'Alessandro
    Department of Pediatrics, Children s Hospital Sor MarĂ­a Ludovica, La Plata, Buenos Aires, Argentina
    J Clin Sleep Med 1:169-72. 2005
    ..This case illustrates the heterogeneity of childhood idiopathic central hypoventilation syndromes and indicates the multifactorial etiology of these syndromes...

Research Grants15

  1. PATHOPHYSIOLOGY OF CHILDHOOD OBSTRUCTIVE SLEEP APNEA
    Carole L Marcus; Fiscal Year: 2010
    ..This study will help elucidate of the causes of OSAS in teenagers, and determine the effectiveness of weight loss in ameliorating these causative factors. ..
  2. PATHOPHYSIOLOGY OF CHILDHOOD OBSTRUCTIVE SLEEP APNEA
    CAROLE MARCUS; Fiscal Year: 2006
    ..These studies will help elucidate the underlying pathophysiology of childhood OSAS, resulting in better understanding and improved management of this disease. ..
  3. Noninvasive Ventilation in Children with Cystic Fibrosis
    CAROLE MARCUS; Fiscal Year: 2004
    ..In keeping with the mission of the RFA, this study will use a multidisciplinary approach to improve management and enhance the quality of life in children with chronic respiratory failure. ..
  4. PATHOPHYSIOLOGY OF CHILDHOOD OBSTRUCTIVE SLEEP APNEA
    CAROLE MARCUS; Fiscal Year: 2001
    ..The investigators propose to examine the changes in airway collapsibility that occur during childhood, and then compare normal children with children who are identified a having OSAS. ..
  5. Long-term effects of therapeutic caffeine use for apnea of prematurity on sleep d
    Carole L Marcus; Fiscal Year: 2010
    ..This study will determine whether neonatal methylxanthine treatment results in long-term perturbations in sleep, breathing during sleep, and hence, neurocognitive and behavioral abnormalities. ..