Research Topics
| CAROLE MARCUSSummaryAffiliation: The Children's Hospital of Philadelphia Country: USA Publications
Research Grants
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Detail Information
Publications
Rapid eye movement latency in children and adolescentsThornton B A Mason
Sleep Center, Children s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Pediatr Neurol 39:162-9. 2008..Healthy children exhibited rapid eye movement latencies significantly longer than adults. Normal control patients demonstrated significantly longer rapid eye movement latency than obstructive sleep apnea syndrome and narcolepsy patients...
Effects of positive airway pressure therapy on neurobehavioral outcomes in children with obstructive sleep apneaCarole L Marcus
Sleep Center, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
Am J Respir Crit Care Med 185:998-1003. 2012..However, it is not known whether positive airway pressure therapy results in improvements in the neurobehavioral abnormalities associated with childhood sleep apnea...- Randomized, double-blind clinical trial of two different modes of positive airway pressure therapy on adherence and efficacy in childrenCarole L Marcus
Sleep Center, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
J Clin Sleep Med 8:37-42. 2012..We hypothesized that Bi-Flex would result in improved adherence but similar efficacy to CPAP... 
Developmental changes in upper airway dynamicsCarole L Marcus
The Eudowood Division of Pediatric Respiratory Sciences, Johns Hopkins University, Baltimore, MD 21287 2533, USA
J Appl Physiol 97:98-108. 2004..Infants appear to have a different pattern of upper airway activation than older children. We speculate that the pharyngeal airway responses present in normal children are a compensatory response for a relatively narrow upper airway...- Upper airway dynamic responses in children with the obstructive sleep apnea syndromeCarole L Marcus
Eudowood Division of Pediatric Respiratory Sciences, Johns Hopkins University, Baltimore, MD 21287, USA
Pediatr Res 57:99-107. 2005..Further, we speculate that this compensatory response is lacking in children with OSAS, most likely due to either habituation to chronic respiratory abnormalities during sleep or to mechanical damage to the upper airway... - Pediatric sleep medicine comes into its ownCarole L Marcus
Sleep Center, Division of Pediatric Pulmonology, Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA 19104, USA
Pediatrics 113:1393-4. 2004 - Adherence to and effectiveness of positive airway pressure therapy in children with obstructive sleep apneaCarole L Marcus
Division of Pulmonary Medicine, Sleep Center, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
Pediatrics 117:e442-51. 2006..The objective of this study was to determine adherence and effectiveness of PAP (both continuous [CPAP] and bilevel [BPAP] pressure) in children with obstructive apnea... - Effect of sleep stage on breathing in children with central hypoventilationJingtao Huang
Sleep Center, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
J Appl Physiol 105:44-53. 2008..The hypoventilation in CHS is more severe during NREM than REM sleep. We speculate that this may be due to increased excitatory inputs to the respiratory system during REM sleep... - Polysomnographic values in children 2-9 years old: additional data and review of the literatureNadav Traeger
Division of Pulmonary Medicine and Sleep Disorders Center, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104-4399, USA
Pediatr Pulmonol 40:22-30. 2005..We also confirm previous data on the frequency distribution of sleep stages, SpO2, and relative rarity of respiratory events in this age group... - Upper airway collapsibility during REM sleep in children with the obstructive sleep apnea syndromeJingtao Huang
Sleep Center, Children s Hospital of Philadelphia, University of Pennsylvania School ofMedicine, Philadelphia, PA, USA
Sleep 32:1173-81. 2009..We hypothesized that children with the obstructive sleep apnea syndrome (OSAS), in contrast to age-matched control subjects, would not maintain airflow in the face of an upper airway inspiratory pressure drop during REM sleep... - Upper airway collapsibility in anesthetized childrenRonald S Litman
Department of Anesthesiology, University of Rochester, Rochester, New York, USA
Anesth Analg 102:750-4. 2006..3) cm H2O (sevoflurane versus halothane, P = 0.048). We conclude that when using dynamic application of negative airway pressure, halothane appears to cause less upper airway obstruction than sevoflurane at equipotent concentrations... - Cortical processing of respiratory afferent stimuli during sleep in children with the obstructive sleep apnea syndromeJingtao Huang
The Sleep Center Children s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA 19104, USA
Sleep 31:403-10. 2008..We hypothesized that children with OSAS have blunted RREP responses compared to normal children during sleep... - Pathophysiology of upper airway obstruction: a developmental perspectiveRaanan Arens
Division of Pulmonary Medicine and Sleep Disorders Center, The Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
Sleep 27:997-1019. 2004..This compensatory response appears to be blunted in children with OSAS. Further research is needed to fully understand the complexities of upper airway structure and function during both normal development and disease... - Respiratory-related evoked potentials during sleep in childrenM Cecilia Melendres
Johns Hopkins School of Medicine, Baltimore, MD, USA
Sleep 31:55-61. 2008..However, there have been no data on RREP during sleep in children. We thus examined children during sleep to determine whether early RREP components would be maintained during all sleep.. - Catecholamines, adiponectin, and insulin resistance as measured by HOMA in children with obstructive sleep apneaAndrea Kelly
Division Endocrinology Diabetes, The Children s Hospital of Philadelphia, Philadelphia, PA, 19104, USA
Sleep 33:1185-91. 2010..We hypothesized that OSA is associated with worse insulin resistance and lower adiponectin after adjustment for obesity and puberty and that catecholamines might mediate these changes... - Influence of airway pressure on genioglossus activity during sleep in normal childrenEliot S Katz
Division of Pediatric Pulmonology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Am J Respir Crit Care Med 173:902-9. 2006..This suggests that additional determinants of airway patency are active, such as neuromuscular compensation... - Polysomnographic values in children undergoing puberty: pediatric vs. adult respiratory rules in adolescentsIgnacio E Tapia
Sleep Center, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 USA
Sleep 31:1737-44. 2008.... - Night-to-night variability of polysomnography in children with suspected obstructive sleep apneaEliot S Katz
Eudowood Divison of Pediatric Respiratory Sciences, Johns Hopkins University, Baltimore, Maryland, USA
J Pediatr 140:589-94. 2002..These data suggest that a single polysomnographic night is an adequate measure of the OSAS in children with symptoms of sleep-disordered breathing... - Differences in overnight polysomnography scores using the adult and pediatric criteria for respiratory events in adolescentsJennifer A Accardo
The Children s Hospital of Philadelphia, Sleep Center, Philadelphia, PA 19104, USA
Sleep 33:1333-9. 2010..Our objective was to compare pediatric and adult criteria in adolescents referred for obstructive sleep apnea (OSA). We hypothesized that pediatric criteria would capture more respiratory events than adult criteria... - Puberty and upper airway dynamics during sleepPreetam Bandla
Sleep Center, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, PA 19104, USA
Sleep 31:534-41. 2008..We hypothesized that the upper airway response to subatmospheric pressure loading decreased with increasing pubertal Tanner stage in males but remained stable during puberty in females... - Cortical processing of respiratory occlusion stimuli in children with central hypoventilation syndromeJingtao Huang
The Sleep Center, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
Am J Respir Crit Care Med 178:757-64. 2008..The ability of patients with central hypoventilation syndrome (CHS) to produce and process mechanoreceptor signals is unknown... 
Childhood obstructive sleep apnea associates with neuropsychological deficits and neuronal brain injuryAnn C Halbower
Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
PLoS Med 3:e301. 2006..We hypothesized that childhood OSA is associated with neuropsychological performance dysfunction, and with neuronal metabolite alterations in the brain, indicative of neuronal injury in areas corresponding to neuropsychological function...- Pulse transit time as a measure of arousal and respiratory effort in children with sleep-disordered breathingEliot S Katz
The Eudowood Division of Pediatric Respiratory Sciences, Johns Hopkins University, Baltimore, Maryland, USA
Pediatr Res 53:580-8. 2003..8 events/h) than primary snoring (2.2 events/h) (p < 0.05). We conclude that, in children, PTT arousals are a more sensitive measure of obstructive events than visible EEG arousals... - Upper airway sensory function in children with obstructive sleep apnea syndromeIgnacio E Tapia
Sleep Center, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Sleep 33:968-72. 2010..This may be due, in part, to an impairment in the afferent limb of the upper airway sensory pathway. Therefore, we hypothesized that children with OSAS had diminished upper airway sensation compared to controls... - Relationship between REM density, duty cycle, and obstructive sleep apnea in childrenLaurie Karamessinis
The Sleep Center, The Children s Hospital ofPhiladelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Sleep 30:837-43. 2007..We speculate that the increase in the duty cycle is a compensatory response to increased upper airway loads during sleep, and that this may lead to ventilatory or upper airway muscle fatigue... - Secondary narcolepsy in children with brain tumorsCarole L Marcus
The Eudowood Division of Pediatric Respiratory Sciences, Johns Hopkins University, Baltimore, MD, USA
Sleep 25:435-9. 2002..In view of the good response to treatment, we recommend that all children with excessive daytime sleepiness and hypothalamic damage be evaluated for narcolepsy... - Developmental aspects of the upper airway: report from an NHLBI Workshop, March 5-6, 2009Carole L Marcus
Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
Proc Am Thorac Soc 6:513-20. 2009..This report provides recommendations that could facilitate translation of basic research findings into practice to better diagnose, treat, and prevent airway compromise in children... - Nocturnal saturation and glucose tolerance in children with cystic fibrosisDharmeshkumar Suratwala
Children s Hospital of Philadelphia, Pulmonary Division, 9NW50, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA
Thorax 66:574-8. 2011.... - Recurrent pneumothoraces associated with nocturnal noninvasive ventilation in a patient with muscular dystrophyLee R Choo-Kang
Eudowood Division of Pediatric Respiratory Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Pediatr Pulmonol 34:73-8. 2002..Given the increasing utilization of chronic nocturnal bilevel positive airway pressure ventilation, we suggest that healthcare providers and patients be made aware of this potentially life-threatening complication... - Daytime sleepiness and hyperactivity in children with suspected sleep-disordered breathingMa Cecilia S Melendres
Eudowood Division of Pediatric Respiratory Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Pediatrics 114:768-75. 2004..However, these data should be confirmed by a population-based study... - Sleep disorders in childrenAnn C Halbower
Eudowood Division of Pediatric Respiratory Sciences, Johns Hopkins University, Baltimore, Maryland 21287, USA
Curr Opin Pulm Med 9:471-6. 2003..Infant sleep rhythm complaints from new mothers reach 46%, while childhood obstructive sleep apnea has a prevalence of 2% and adolescent insomnia with daily consequences surpasses that percentage... - Body position and obstructive sleep apnea in childrenLucila B Fernandes Do Prado
Department of Neurology and Internal Medicine, , , Brazil
Sleep 25:66-71. 2002..Obese and non-obese children showed similar positional changes. CONCLUSIONS: Children with obstructive sleep apnea, in contrast to adults, breathe best when in the supine position... - The significance of ASDA arousals in childrenMaria Cecilia Lopes
Department of Psychobiology, Federal University of Sao Paulo, Brazil
Sleep Med 9:3-8. 2007..The aim of this review is to discuss the application of conventional and unconventional markers of sleep disruption in children... - Upper airway collapsibility during sleep in upper airway resistance syndromeAvram R Gold
Division of Pulmonary/Critical Care Medicine, SUNY-Stony Brook, School of Medicine, DVA Medical Center, Northport, NY 11768, USA
Chest 121:1531-40. 2002..The upper airway collapsibility during sleep of patients with UARS is intermediate between that of normal subjects and that of patients with mild-to moderate OSA/H... - Obstructive hypopneas in children and adolescents: normal valuesManisha B Witmans
Am J Respir Crit Care Med 168:1540. 2003 - Improving pediatric compliance with positive airway pressure therapy: the impact of behavioral interventionKristine L Koontz
The Kennedy Krieger Institute, Johns Hopkins University School of Medicine, USA
Sleep 26:1010-5. 2003.... - Tolerance of esophageal pressure monitoring during polysomnography in childrenRonald D Chervin
Sleep Disorders Center Department of Neurology, University of Michigan, Ann Arbor, MI 48109 0117, USA
Sleep 26:1022-6. 2003..To assess tolerance of esophageal pressure monitoring (EPM) among 5- to 13-year-old children during research polysomnography at study entry and again 1 year later... - Reliability of scoring arousals in normal children and children with obstructive sleep apnea syndromeTat Kong Wong
Department of Paediatrics and Adolescent Medicine, Pamela Youde Nethersole Eastern Hospital, Hong Kong
Sleep 27:1139-45. 2004..However, the validity and reliability of scoring these shorter arousals have never been verified. Based on studies in adults, we hypothesized that interscorer agreement for scoring arousals shorter than 3 seconds was poor... - Acoustic arousal responses in children with obstructive sleep apneaGustavo A Moreira
Department of Pediatrics, , , Brazil
Pediatr Pulmonol 40:300-5. 2005..However, further studies evaluating arousal to both respiratory and nonrespiratory stimuli in the same subjects are needed... - Sleep-disordered breathing, behavior, and cognition in children before and after adenotonsillectomyRonald D Chervin
Sleep Disorders Center, Department of Neurology, University of Michigan, Ann Arbor, Michigan, USA
Pediatrics 117:e769-78. 2006.... - Subjective sleepiness and polysomnographic correlates in children scheduled for adenotonsillectomy vs other surgical careRonald D Chervin
Sleep Disorders Center, Department of Neurology, University of Michigan, Ann Arbor, MI, USA
Sleep 29:495-503. 2006.... - The visual scoring of sleep and arousal in infants and childrenMadeleine Grigg-Damberger
Department of Neurology, University of New Mexico School of Medicine, Albuquerque, NM 87131 0001, USA
J Clin Sleep Med 3:201-40. 2007..We need research comparing clinical outcomes with PSG measures to better inform clinicians and families exactly what meaning a PSG has in evaluating a child's suspected sleep disorder... - The scoring of respiratory events in sleep: reliability and validitySusan Redline
Department of Pediatrics, Case Western Reserve University, Cleveland, OH, WA 44106 6033, USA
J Clin Sleep Med 3:169-200. 2007.... - And miles to go before we sleepCarole L Marcus
Sleep Med Rev 10:79-81. 2006 - Evaluating the upper airway during wakefulness: what can it tell us about sleep?Carole L Marcus
Am J Respir Crit Care Med 169:140-1. 2004 - The toll of poverty: no respite even in sleepCarole L Marcus
J Pediatr 149:293-4. 2006 - Letter to the editor regarding our previous publication: "Secondary narcolepsy in children with brain tumors," SLEEP 2002; 25:435-439Carole L Marcus
Sleep 26:228. 2003 - Ventilatory management of sleep-disordered breathing in childrenLisa H Liner
Virtua Voorhees-West Jersey Hospital, Voorhees, New Jersey, USA
Curr Opin Pediatr 18:272-6. 2006..Strategies to improve adherence are needed. Equipment manufacturers should be encouraged to develop equipment that better meets children's needs... - Childhood obesity, inflammation, and apnea: what is the future for our children?Andrea Kelly
Am J Respir Crit Care Med 171:202-3. 2005 - Late-onset hypoventilation without PHOX2B mutation or hypothalamic abnormalitiesThornton Mason
Department of Pediatrics, , La Plata, Buenos Aires, Argentina
J Clin Sleep Med 1:169-72. 2005..This case illustrates the heterogeneity of childhood idiopathic central hypoventilation syndromes and indicates the multifactorial etiology of these syndromes...
Research Grants
- PATHOPHYSIOLOGY OF CHILDHOOD OBSTRUCTIVE SLEEP APNEACarole L Marcus; Fiscal Year: 2010..This study will help elucidate of the causes of OSAS in teenagers, and determine the effectiveness of weight loss in ameliorating these causative factors. ..
- PATHOPHYSIOLOGY OF CHILDHOOD OBSTRUCTIVE SLEEP APNEACAROLE MARCUS; Fiscal Year: 2006..These studies will help elucidate the underlying pathophysiology of childhood OSAS, resulting in better understanding and improved management of this disease. ..
- Noninvasive Ventilation in Children with Cystic FibrosisCAROLE MARCUS; Fiscal Year: 2004..In keeping with the mission of the RFA, this study will use a multidisciplinary approach to improve management and enhance the quality of life in children with chronic respiratory failure. ..
- PATHOPHYSIOLOGY OF CHILDHOOD OBSTRUCTIVE SLEEP APNEACAROLE MARCUS; Fiscal Year: 2001..The investigators propose to examine the changes in airway collapsibility that occur during childhood, and then compare normal children with children who are identified a having OSAS. ..
- Long-term effects of therapeutic caffeine use for apnea of prematurity on sleep dCarole L Marcus; Fiscal Year: 2010..This study will determine whether neonatal methylxanthine treatment results in long-term perturbations in sleep, breathing during sleep, and hence, neurocognitive and behavioral abnormalities. ..