Sendurai A Mani

Summary

Affiliation: The University of Texas
Country: USA

Publications

  1. ncbi The epithelial-mesenchymal transition generates cells with properties of stem cells
    Sendurai A Mani
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA
    Cell 133:704-15. 2008
  2. ncbi HDAC3 at the fulcrum of an epithelial-mesenchymal balance
    Sendurai A Mani
    Department of Molecular Pathology, The Center for Stem Cell and Developmental Biology, University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Mol Cell 43:697-8. 2011
  3. ncbi Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudin-low and metaplastic breast cancer subtypes
    Joseph H Taube
    Department of Molecular Pathology, University of Texas M D Anderson Cancer Center, Houston, TX 77054, USA
    Proc Natl Acad Sci U S A 107:15449-54. 2010
  4. ncbi Mesenchyme Forkhead 1 (FOXC2) plays a key role in metastasis and is associated with aggressive basal-like breast cancers
    Sendurai A Mani
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 104:10069-74. 2007
  5. ncbi Ganglioside GD2 identifies breast cancer stem cells and promotes tumorigenesis
    Venkata Lokesh Battula
    Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    J Clin Invest 122:2066-78. 2012
  6. ncbi Loss of E-cadherin promotes metastasis via multiple downstream transcriptional pathways
    Tamer T Onder
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, USA
    Cancer Res 68:3645-54. 2008
  7. ncbi The epithelial-to-mesenchymal transition and cancer stem cells: a coalition against cancer therapies
    Brett G Hollier
    Department of Molecular Pathology, University of Texas M D Anderson Cancer Center, Houston, TX 77054, USA
    J Mammary Gland Biol Neoplasia 14:29-43. 2009
  8. ncbi Exploring a new twist on tumor metastasis
    Jing Yang
    Whitehead Institute for Biomedical Research, Cambridge Center, Cambridge, Massachusetts 02142, USA
    Cancer Res 66:4549-52. 2006
  9. ncbi Slug and Sox9 cooperatively determine the mammary stem cell state
    Wenjun Guo
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Cell 148:1015-28. 2012
  10. ncbi Expression of epithelial-mesenchymal transition-inducing transcription factors in primary breast cancer: The effect of neoadjuvant therapy
    Michal Mego
    Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Int J Cancer 130:808-16. 2012

Collaborators

Detail Information

Publications17

  1. ncbi The epithelial-mesenchymal transition generates cells with properties of stem cells
    Sendurai A Mani
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA
    Cell 133:704-15. 2008
    ..These findings illustrate a direct link between the EMT and the gain of epithelial stem cell properties...
  2. ncbi HDAC3 at the fulcrum of an epithelial-mesenchymal balance
    Sendurai A Mani
    Department of Molecular Pathology, The Center for Stem Cell and Developmental Biology, University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Mol Cell 43:697-8. 2011
    ....
  3. ncbi Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudin-low and metaplastic breast cancer subtypes
    Joseph H Taube
    Department of Molecular Pathology, University of Texas M D Anderson Cancer Center, Houston, TX 77054, USA
    Proc Natl Acad Sci U S A 107:15449-54. 2010
    ..Additionally, the expression level of FOXC1, another EMT inducer, correlates strongly with poor survival of breast cancer patients...
  4. ncbi Mesenchyme Forkhead 1 (FOXC2) plays a key role in metastasis and is associated with aggressive basal-like breast cancers
    Sendurai A Mani
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 104:10069-74. 2007
    ..These observations indicate that FOXC2 plays a central role in promoting invasion and metastasis and that it may prove to be a highly specific molecular marker for human basal-like breast cancers...
  5. ncbi Ganglioside GD2 identifies breast cancer stem cells and promotes tumorigenesis
    Venkata Lokesh Battula
    Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    J Clin Invest 122:2066-78. 2012
    ..In summary, we identified GD2 as a new CSC-specific cell surface marker and GD3S as a potential therapeutic target for CSCs, with the possibility of improving survival and cure rates in patients with breast cancer...
  6. ncbi Loss of E-cadherin promotes metastasis via multiple downstream transcriptional pathways
    Tamer T Onder
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, USA
    Cancer Res 68:3645-54. 2008
    ..These findings indicate that E-cadherin loss in tumors contributes to metastatic dissemination by inducing wide-ranging transcriptional and functional changes...
  7. ncbi The epithelial-to-mesenchymal transition and cancer stem cells: a coalition against cancer therapies
    Brett G Hollier
    Department of Molecular Pathology, University of Texas M D Anderson Cancer Center, Houston, TX 77054, USA
    J Mammary Gland Biol Neoplasia 14:29-43. 2009
    ..The purpose of this review is to summarize the findings related to EMT and stem cells in cancer progression and therapy resistance...
  8. ncbi Exploring a new twist on tumor metastasis
    Jing Yang
    Whitehead Institute for Biomedical Research, Cambridge Center, Cambridge, Massachusetts 02142, USA
    Cancer Res 66:4549-52. 2006
    ..Here, we review the Twist signaling pathway during normal development and discuss how the transcription factor Twist and the epithelial-mesenchymal transition program impinge their biological functions during tumor metastasis...
  9. ncbi Slug and Sox9 cooperatively determine the mammary stem cell state
    Wenjun Guo
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Cell 148:1015-28. 2012
    ....
  10. ncbi Expression of epithelial-mesenchymal transition-inducing transcription factors in primary breast cancer: The effect of neoadjuvant therapy
    Michal Mego
    Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Int J Cancer 130:808-16. 2012
    ..In summary, our results demonstrate that CTCs with EMT phenotype may occur in the peripheral circulation of patients with PBC and that NAT is unable to eliminate CTCs undergoing EMT...
  11. ncbi Enrichment of a population of mammary gland cells that form mammospheres and have in vivo repopulating activity
    Mai Jing Liao
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA
    Cancer Res 67:8131-8. 2007
    ..Our identification of new cell surface markers for enriching mammosphere-initiating cells, including endoglin and prion protein, will facilitate the elucidation of the cell biology of MGSC...
  12. ncbi Epithelial-mesenchymal transition and stem cell markers in patients with HER2-positive metastatic breast cancer
    Antonio Giordano
    Department of Hematopathology, Unit 0054, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, 77030, Houston, TX, USA
    Mol Cancer Ther 11:2526-34. 2012
    ..Moreover, an enrichment of CSCs was found in CD326(-)CD45(-) cells. Additional studies are needed to determine whether EMT-CTCs and CSCs have prognostic value in patients with HER2(+) MBCs treated with trastuzumab-based therapy...
  13. ncbi Epithelial-mesenchymal transition and cancer stem cells: a dangerously dynamic duo in breast cancer progression
    Caitlin D May
    Department of Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA
    Breast Cancer Res 13:202. 2011
    ....
  14. ncbi Alternative origins of stroma in normal organs and disease
    Mikhail G Kolonin
    The Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center, 1825 Pressler St, Houston, TX 77030, USA
    Stem Cell Res 8:312-23. 2012
    ..Organ sources, relative contributions, and functions of these populations in normal development and pathology are not well understood. Innovative approaches are needed to identify markers that can distinguish these stromal populations...
  15. ncbi Epithelial-mesenchymal transition-derived cells exhibit multilineage differentiation potential similar to mesenchymal stem cells
    Venkata Lokesh Battula
    Section of Molecular Hematology and Therapy, Department of Stem Cell Transplantation, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Stem Cells 28:1435-45. 2010
    ..In conclusion, we have demonstrated that the EMT-derived cells are similar to MSCs in gene expression, multilineage differentiation, and ability to migrate towards tumor cells and wound sites...
  16. ncbi Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis
    Jing Yang
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Cell 117:927-39. 2004
    ..These results establish a mechanistic link between Twist, EMT, and tumor metastasis...
  17. ncbi Cell type-specific DNA methylation patterns in the human breast
    Noga Bloushtain-Qimron
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 105:14076-81. 2008
    ..These data suggest that epigenetically controlled transcription factors play a key role in regulating mammary epithelial cell phenotypes and imply similarities among epigenetic programs that define progenitor cell characteristics...