Sendurai A Mani

Summary

Affiliation: The University of Texas
Country: USA

Publications

  1. pmc Gene expression in extratumoral microenvironment predicts clinical outcome in breast cancer patients
    Erick Roman-Perez
    Department of Epidemiology, University of North Carolina at Chapel Hill, Campus Box 7435, Chapel Hill, NC 27599, USA
    Breast Cancer Res 14:R51. 2012
  2. pmc HDAC3 at the fulcrum of an epithelial-mesenchymal balance
    Sendurai A Mani
    Department of Molecular Pathology, The Center for Stem Cell and Developmental Biology, University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Mol Cell 43:697-8. 2011
  3. pmc The epithelial-mesenchymal transition generates cells with properties of stem cells
    Sendurai A Mani
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA
    Cell 133:704-15. 2008
  4. pmc Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudin-low and metaplastic breast cancer subtypes
    Joseph H Taube
    Department of Molecular Pathology, University of Texas M D Anderson Cancer Center, Houston, TX 77054, USA
    Proc Natl Acad Sci U S A 107:15449-54. 2010
  5. pmc Mesenchyme Forkhead 1 (FOXC2) plays a key role in metastasis and is associated with aggressive basal-like breast cancers
    Sendurai A Mani
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 104:10069-74. 2007
  6. pmc Epigenetic silencing of microRNA-203 is required for EMT and cancer stem cell properties
    Joseph H Taube
    1 Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA 2 Metastasis Research Center, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA 3 Center for Stem Cells and Developmental Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    Sci Rep 3:2687. 2013
  7. pmc Epithelial-mesenchymal transition and stem cell markers in patients with HER2-positive metastatic breast cancer
    Antonio Giordano
    Department of Hematopathology, Unit 0054, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, 77030, Houston, TX, USA
    Mol Cancer Ther 11:2526-34. 2012
  8. pmc Ganglioside GD2 identifies breast cancer stem cells and promotes tumorigenesis
    Venkata Lokesh Battula
    Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    J Clin Invest 122:2066-78. 2012
  9. pmc FOXC2 expression links epithelial-mesenchymal transition and stem cell properties in breast cancer
    Brett G Hollier
    Department of Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 73:1981-92. 2013
  10. pmc Epithelial-mesenchymal transition and cancer stem cells: a dangerously dynamic duo in breast cancer progression
    Caitlin D May
    Department of Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA
    Breast Cancer Res 13:202. 2011

Detail Information

Publications27

  1. pmc Gene expression in extratumoral microenvironment predicts clinical outcome in breast cancer patients
    Erick Roman-Perez
    Department of Epidemiology, University of North Carolina at Chapel Hill, Campus Box 7435, Chapel Hill, NC 27599, USA
    Breast Cancer Res 14:R51. 2012
    ..We hypothesized that gene expression subtypes of breast cancer microenvironment can be defined and that these microenvironment subtypes have clinical relevance...
  2. pmc HDAC3 at the fulcrum of an epithelial-mesenchymal balance
    Sendurai A Mani
    Department of Molecular Pathology, The Center for Stem Cell and Developmental Biology, University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Mol Cell 43:697-8. 2011
    ....
  3. pmc The epithelial-mesenchymal transition generates cells with properties of stem cells
    Sendurai A Mani
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA
    Cell 133:704-15. 2008
    ..These findings illustrate a direct link between the EMT and the gain of epithelial stem cell properties...
  4. pmc Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudin-low and metaplastic breast cancer subtypes
    Joseph H Taube
    Department of Molecular Pathology, University of Texas M D Anderson Cancer Center, Houston, TX 77054, USA
    Proc Natl Acad Sci U S A 107:15449-54. 2010
    ..Additionally, the expression level of FOXC1, another EMT inducer, correlates strongly with poor survival of breast cancer patients...
  5. pmc Mesenchyme Forkhead 1 (FOXC2) plays a key role in metastasis and is associated with aggressive basal-like breast cancers
    Sendurai A Mani
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 104:10069-74. 2007
    ..These observations indicate that FOXC2 plays a central role in promoting invasion and metastasis and that it may prove to be a highly specific molecular marker for human basal-like breast cancers...
  6. pmc Epigenetic silencing of microRNA-203 is required for EMT and cancer stem cell properties
    Joseph H Taube
    1 Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA 2 Metastasis Research Center, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA 3 Center for Stem Cells and Developmental Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    Sci Rep 3:2687. 2013
    ..Our data suggest that restoring miR-203 expression levels may inhibit metastasis and combat deregulated Wnt signaling. ..
  7. pmc Epithelial-mesenchymal transition and stem cell markers in patients with HER2-positive metastatic breast cancer
    Antonio Giordano
    Department of Hematopathology, Unit 0054, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, 77030, Houston, TX, USA
    Mol Cancer Ther 11:2526-34. 2012
    ..Moreover, an enrichment of CSCs was found in CD326(-)CD45(-) cells. Additional studies are needed to determine whether EMT-CTCs and CSCs have prognostic value in patients with HER2(+) MBCs treated with trastuzumab-based therapy...
  8. pmc Ganglioside GD2 identifies breast cancer stem cells and promotes tumorigenesis
    Venkata Lokesh Battula
    Section of Molecular Hematology and Therapy, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    J Clin Invest 122:2066-78. 2012
    ..In summary, we identified GD2 as a new CSC-specific cell surface marker and GD3S as a potential therapeutic target for CSCs, with the possibility of improving survival and cure rates in patients with breast cancer...
  9. pmc FOXC2 expression links epithelial-mesenchymal transition and stem cell properties in breast cancer
    Brett G Hollier
    Department of Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 73:1981-92. 2013
    ..Thus, FOXC2 or its associated gene expression program may provide an effective target for anti-EMT-based therapies for the treatment of claudin-low/basal B breast tumors or other EMT-/CSC-enriched tumors...
  10. pmc Epithelial-mesenchymal transition and cancer stem cells: a dangerously dynamic duo in breast cancer progression
    Caitlin D May
    Department of Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA
    Breast Cancer Res 13:202. 2011
    ....
  11. pmc Overexpression of snail induces epithelial-mesenchymal transition and a cancer stem cell-like phenotype in human colorectal cancer cells
    Fan Fan
    Department of Cancer Biology, University of Texas MD Anderson Cancer Center Houston, Texas, USA
    Cancer Med 1:5-16. 2012
    ..Increased Snail expression induces EMT and the CSC-like phenotype in CRC cells, which enhance cancer cell invasion and chemoresistance. Thus, Snail is a potential therapeutic target in metastatic CRC...
  12. doi request reprint Loss of E-cadherin promotes metastasis via multiple downstream transcriptional pathways
    Tamer T Onder
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, USA
    Cancer Res 68:3645-54. 2008
    ..These findings indicate that E-cadherin loss in tumors contributes to metastatic dissemination by inducing wide-ranging transcriptional and functional changes...
  13. ncbi request reprint Exploring a new twist on tumor metastasis
    Jing Yang
    Whitehead Institute for Biomedical Research, Cambridge Center, Cambridge, Massachusetts 02142, USA
    Cancer Res 66:4549-52. 2006
    ..Here, we review the Twist signaling pathway during normal development and discuss how the transcription factor Twist and the epithelial-mesenchymal transition program impinge their biological functions during tumor metastasis...
  14. doi request reprint The epithelial-to-mesenchymal transition and cancer stem cells: a coalition against cancer therapies
    Brett G Hollier
    Department of Molecular Pathology, University of Texas M D Anderson Cancer Center, Houston, TX 77054, USA
    J Mammary Gland Biol Neoplasia 14:29-43. 2009
    ..The purpose of this review is to summarize the findings related to EMT and stem cells in cancer progression and therapy resistance...
  15. pmc Slug and Sox9 cooperatively determine the mammary stem cell state
    Wenjun Guo
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Cell 148:1015-28. 2012
    ....
  16. pmc Expression of epithelial-mesenchymal transition-inducing transcription factors in primary breast cancer: The effect of neoadjuvant therapy
    Michal Mego
    Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Int J Cancer 130:808-16. 2012
    ..In summary, our results demonstrate that CTCs with EMT phenotype may occur in the peripheral circulation of patients with PBC and that NAT is unable to eliminate CTCs undergoing EMT...
  17. ncbi request reprint Enrichment of a population of mammary gland cells that form mammospheres and have in vivo repopulating activity
    Mai Jing Liao
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA
    Cancer Res 67:8131-8. 2007
    ..Our identification of new cell surface markers for enriching mammosphere-initiating cells, including endoglin and prion protein, will facilitate the elucidation of the cell biology of MGSC...
  18. pmc Endothelial cells promote the colorectal cancer stem cell phenotype through a soluble form of Jagged-1
    Jia Lu
    Department of Cancer Biology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Cell 23:171-85. 2013
    ..Collectively, ECs play an active role in promoting Notch signaling and the CSC phenotype by secreting soluble Jagged-1...
  19. pmc Genomic copy number imbalances associated with bone and non-bone metastasis of early-stage breast cancer
    Yanhong Liu
    Department of Pediatrics, Dan L Duncan Cancer Center, Baylor College of Medicine, Houston, TX, USA
    Breast Cancer Res Treat 143:189-201. 2014
    ..Distinct CNIs are independently associated with bone and non-bone metastasis for early-stage breast cancer patients across cohorts. These data warrant consideration for tailoring surveillance and management of metastasis risk. ..
  20. pmc Sheep, wolf, or werewolf: cancer stem cells and the epithelial-to-mesenchymal transition
    Jeffrey T Chang
    Department of Integrative Biology and Pharmacology, Medical School, University of Texas Health Science Center, Houston, TX 77030, United States School of Biomedical Informatics, University of Texas Health Science Center, Houston, TX 77030, United States Institute of Molecular Medicine, University of Texas Health Science Center, Houston, TX 77030, United States Electronic address
    Cancer Lett 341:16-23. 2013
    ..Therefore, there is intense interest in understanding these two types of CSSs, how they differ from differentiated cancer cells, the mechanisms that drive their phenotypes, and how that knowledge can be incorporated into therapeutics. ..
  21. pmc BSTA promotes mTORC2-mediated phosphorylation of Akt1 to suppress expression of FoxC2 and stimulate adipocyte differentiation
    Yixin Yao
    Department of Gastrointestinal Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Sci Signal 6:ra2. 2013
    ..These findings indicate that BSTA is a molecular switch that promotes phosphorylation of Akt1 at Ser⁴⁷³ and reveal an mTORC2-BSTA-Akt1-FoxC2-mediated signaling mechanism that is critical for adipocyte differentiation...
  22. pmc CCAT2, a novel noncoding RNA mapping to 8q24, underlies metastatic progression and chromosomal instability in colon cancer
    Hui Ling
    Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Genome Res 23:1446-61. 2013
    ..Our results support a new mechanism of MYC and WNT regulation by the novel lncRNA CCAT2 in colorectal cancer pathogenesis, and provide an alternative explanation of the SNP-conferred cancer risk. ..
  23. pmc Epidermal growth factor down-regulates the expression of neutrophil gelatinase-associated lipocalin (NGAL) through E-cadherin in pancreatic cancer cells
    Zhimin Tong
    Department of Gastroenterology, Hepatology, and Nutrition, The University of Texas M D Anderson Cancer Center, Houston, Texas
    Cancer 117:2408-18. 2011
    ..Because the epidermal growth factor (EGF)-EGF receptor (EGFR) axis is up-regulated significantly in PDAC, they examined EGF-mediated NGAL regulation in these cells...
  24. pmc Alternative origins of stroma in normal organs and disease
    Mikhail G Kolonin
    The Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center, 1825 Pressler St, Houston, TX 77030, USA
    Stem Cell Res 8:312-23. 2012
    ..Organ sources, relative contributions, and functions of these populations in normal development and pathology are not well understood. Innovative approaches are needed to identify markers that can distinguish these stromal populations...
  25. pmc Epithelial-mesenchymal transition-derived cells exhibit multilineage differentiation potential similar to mesenchymal stem cells
    Venkata Lokesh Battula
    Section of Molecular Hematology and Therapy, Department of Stem Cell Transplantation, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Stem Cells 28:1435-45. 2010
    ..In conclusion, we have demonstrated that the EMT-derived cells are similar to MSCs in gene expression, multilineage differentiation, and ability to migrate towards tumor cells and wound sites...
  26. ncbi request reprint Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis
    Jing Yang
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Cell 117:927-39. 2004
    ..These results establish a mechanistic link between Twist, EMT, and tumor metastasis...
  27. pmc Cell type-specific DNA methylation patterns in the human breast
    Noga Bloushtain-Qimron
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 105:14076-81. 2008
    ..These data suggest that epigenetically controlled transcription factors play a key role in regulating mammary epithelial cell phenotypes and imply similarities among epigenetic programs that define progenitor cell characteristics...