Chitra D Mandyam

Summary

Affiliation: The Scripps Research Institute
Country: USA

Publications

  1. pmc The addicted brain craves new neurons: putative role for adult-born progenitors in promoting recovery
    Chitra D Mandyam
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA, USA
    Trends Neurosci 35:250-60. 2012
  2. pmc The presence of beta2-adrenoceptors sensitizes alpha2A-adrenoceptors to desensitization after chronic epinephrine treatment
    TASNEEM BAWA-KHALFE
    Research Center for Cardiovascular Diseases, Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases, The University of Texas Houston Health Science Center, Houston, TX, USA
    BMC Pharmacol 7:16. 2007
  3. pmc Stress experienced in utero reduces sexual dichotomies in neurogenesis, microenvironment, and cell death in the adult rat hippocampus
    Chitra D Mandyam
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, California, USA
    Dev Neurobiol 68:575-89. 2008
  4. pmc Varied access to intravenous methamphetamine self-administration differentially alters adult hippocampal neurogenesis
    Chitra D Mandyam
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA 92037, USA
    Biol Psychiatry 64:958-65. 2008
  5. pmc Methamphetamine self-administration and voluntary exercise have opposing effects on medial prefrontal cortex gliogenesis
    Chitra D Mandyam
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, California 92037, USA
    J Neurosci 27:11442-50. 2007
  6. pmc Permanent impairment of birth and survival of cortical and hippocampal proliferating cells following excessive drinking during alcohol dependence
    Heather N Richardson
    Committee on Neurobiology of Addictive Disorders, The Scripps Research Institute, 10550 North Torrey Pines Road, SP30 2400, La Jolla, CA 92037, USA
    Neurobiol Dis 36:1-10. 2009
  7. pmc Levels of neural progenitors in the hippocampus predict memory impairment and relapse to drug seeking as a function of excessive methamphetamine self-administration
    Patrick Recinto
    Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA
    Neuropsychopharmacology 37:1275-87. 2012
  8. pmc Extended access to cocaine self-administration produces long-lasting prefrontal cortex-dependent working memory impairments
    Olivier George
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA 92037, USA
    Neuropsychopharmacology 33:2474-82. 2008
  9. pmc Recruitment of medial prefrontal cortex neurons during alcohol withdrawal predicts cognitive impairment and excessive alcohol drinking
    Olivier George
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 109:18156-61. 2012
  10. pmc Extended access methamphetamine decreases immature neurons in the hippocampus which results from loss and altered development of neural progenitors without altered dynamics of the S-phase of the cell cycle
    Clara J Yuan
    Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA
    Pharmacol Biochem Behav 100:98-108. 2011

Research Grants

Collaborators

Detail Information

Publications18

  1. pmc The addicted brain craves new neurons: putative role for adult-born progenitors in promoting recovery
    Chitra D Mandyam
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA, USA
    Trends Neurosci 35:250-60. 2012
    ..The normalization of drug-impaired neurogenesis or gliogenesis may help reverse neuroplasticity during abstinence and, thus, may help reduce the vulnerability to relapse and aid recovery...
  2. pmc The presence of beta2-adrenoceptors sensitizes alpha2A-adrenoceptors to desensitization after chronic epinephrine treatment
    TASNEEM BAWA-KHALFE
    Research Center for Cardiovascular Diseases, Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases, The University of Texas Houston Health Science Center, Houston, TX, USA
    BMC Pharmacol 7:16. 2007
    ....
  3. pmc Stress experienced in utero reduces sexual dichotomies in neurogenesis, microenvironment, and cell death in the adult rat hippocampus
    Chitra D Mandyam
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, California, USA
    Dev Neurobiol 68:575-89. 2008
    ....
  4. pmc Varied access to intravenous methamphetamine self-administration differentially alters adult hippocampal neurogenesis
    Chitra D Mandyam
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA 92037, USA
    Biol Psychiatry 64:958-65. 2008
    ..We examined how intravenous methamphetamine self-administration modulates active division, proliferation of late progenitors, differentiation, maturation, survival, and mature phenotype of hippocampal subgranular zone (SGZ) progenitors...
  5. pmc Methamphetamine self-administration and voluntary exercise have opposing effects on medial prefrontal cortex gliogenesis
    Chitra D Mandyam
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, California 92037, USA
    J Neurosci 27:11442-50. 2007
    ..The susceptibility of mPFC gliogenesis to even modest doses of methamphetamine could account for the pronounced pathology linked to psychostimulant abuse...
  6. pmc Permanent impairment of birth and survival of cortical and hippocampal proliferating cells following excessive drinking during alcohol dependence
    Heather N Richardson
    Committee on Neurobiology of Addictive Disorders, The Scripps Research Institute, 10550 North Torrey Pines Road, SP30 2400, La Jolla, CA 92037, USA
    Neurobiol Dis 36:1-10. 2009
    ..Increased hippocampal apoptosis and neuronal degeneration following alcohol exposure suggest a loss in neuronal turnover and indicate that the hippocampal neurogenic niche is highly vulnerable to alcohol...
  7. pmc Levels of neural progenitors in the hippocampus predict memory impairment and relapse to drug seeking as a function of excessive methamphetamine self-administration
    Patrick Recinto
    Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA
    Neuropsychopharmacology 37:1275-87. 2012
    ....
  8. pmc Extended access to cocaine self-administration produces long-lasting prefrontal cortex-dependent working memory impairments
    Olivier George
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA 92037, USA
    Neuropsychopharmacology 33:2474-82. 2008
    ....
  9. pmc Recruitment of medial prefrontal cortex neurons during alcohol withdrawal predicts cognitive impairment and excessive alcohol drinking
    Olivier George
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 109:18156-61. 2012
    ....
  10. pmc Extended access methamphetamine decreases immature neurons in the hippocampus which results from loss and altered development of neural progenitors without altered dynamics of the S-phase of the cell cycle
    Clara J Yuan
    Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA
    Pharmacol Biochem Behav 100:98-108. 2011
    ..These data suggest that altered hippocampal plasticity by methamphetamine could partially contribute to methamphetamine-induced impairments in hippocampal function...
  11. pmc Alpha 1-noradrenergic system role in increased motivation for cocaine intake in rats with prolonged access
    Sunmee Wee
    Committee on the Neurobiology of Addictive Disorders, SP30 2400, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Eur Neuropsychopharmacol 18:303-11. 2008
    ..The data suggest that activation of the alpha 1-noradrenergic system, perhaps in the BNST, is associated with increased motivation for cocaine in rats with extended access...
  12. pmc Long-lasting reduction in hippocampal neurogenesis by alcohol consumption in adolescent nonhuman primates
    Michael A Taffe
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 107:11104-9. 2010
    ..This lasting effect, observed 2 mo after alcohol discontinuation, may underlie the deficits in hippocampus-associated cognitive tasks that are observed in alcoholics...
  13. ncbi request reprint Exposure to repetitive versus varied stress during prenatal development generates two distinct anxiogenic and neuroendocrine profiles in adulthood
    Heather N Richardson
    Clayton Foundation Laboratories for Peptide Biology, The Salk Institute, La Jolla, California 92037, USA
    Endocrinology 147:2506-17. 2006
    ..The present data exemplify the differential sensitivity of the developing nervous and endocrine systems to stress, depending on not only gender but also the nature of the stressful experience endured by the mother during pregnancy...
  14. pmc μ-Opioid receptors mediate the effects of chronic ethanol binge drinking on the hippocampal neurogenic niche
    Candice Contet
    Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA, USA
    Addict Biol . 2013
    ..Altogether, our data suggest that MOR is implicated in some of the neuroplastic changes produced by chronic ethanol exposure in the DG...
  15. pmc Dynamic contribution of nestin-expressing stem cells to adult neurogenesis
    Diane C Lagace
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
    J Neurosci 27:12623-9. 2007
    ....
  16. ncbi request reprint Drug dependence and addiction, II: Adult neurogenesis and drug abuse
    Amelia J Eisch
    Dallas, TX, USA
    Am J Psychiatry 161:426. 2004
  17. ncbi request reprint Ascl1 defines sequentially generated lineage-restricted neuronal and oligodendrocyte precursor cells in the spinal cord
    James Battiste
    Center for Basic Neuroscience, UT Southwestern Medical Center, Dallas, TX 75390, USA
    Development 134:285-93. 2007
    ..Furthermore, Ascl1-null cells in the spinal cord have a diminished capacity to undergo neuronal differentiation, with a subset of these cells retaining characteristics of immature glial cells...
  18. ncbi request reprint Chronic morphine induces premature mitosis of proliferating cells in the adult mouse subgranular zone
    Chitra D Mandyam
    Department of Psychiatry, The University of Texas Southwestern Medical Center at Dallas, Texas 75390, USA
    J Neurosci Res 76:783-94. 2004
    ....

Research Grants2

  1. Regulation of Adult Neurogenesis by Methamphetamine
    CHITRA MANDYAM; Fiscal Year: 2007
    ..Taken together, our findings will improve our understanding of the complex mechanisms by which chronic exposure to psychostimulants affect adult brain function and may help generate better therapies to treat methamphetamine addiction. ..