Research Topics
Species | SUSAN REGINA MALLERYSummaryAffiliation: The Ohio State University Country: USA Publications
Research Grants
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Detail Information
Publications
AIDS-related Kaposi's sarcoma cells rapidly internalize endostatin, which co-localizes to tropomysin microfilaments and inhibits cytokine-mediated migration and invasionSusan R Mallery
Department of Oral Maxillofacial Surgery and Pathology, College of Dentistry, Ohio State University, Columbus 43218, USA
J Cell Biochem 89:133-43. 2003..As a consequence of its combined angiostatic and antitumorigenic activities, endostatin could provide dual therapeutic benefits for patients with mucocutaneous KS...
Nanoparticles for local drug delivery to the oral mucosa: proof of principle studiesAndrew S Holpuch
Division of Oral and Maxillofacial Surgery, Pathology and Anesthesiology, College of Dentistry, The Ohio State University, Columbus, Ohio, USA
Pharm Res 27:1224-36. 2010..To determine if solid lipid nanoparticles represent a viable strategy for local delivery of poorly water soluble and unstable chemopreventive compounds to human oral tissues...- Sustained angiogenesis enables in vivo transplantation of mucocutaneous derived AIDS-related Kaposi's sarcoma cells in murine hostsS R Mallery
College of Dentistry, Department of Oral and Maxillofacial Surgery and Pathology and College of Pharmacy, Division of Pharmaceutics, Ohio State University, Columbus, OH 43210, USA
Carcinogenesis 21:1647-53. 2000..Establishment and maintenance of an extensive host vascular network should augment success rates for in vivo transplantation of numerous other human cell strains or lines... - Topical application of a bioadhesive black raspberry gel modulates gene expression and reduces cyclooxygenase 2 protein in human premalignant oral lesionsSusan R Mallery
Department of Oral and Maxillofacial Surgery, College of Dentistry, The Ohio State University Comprehensive Cancer Center and Solove Research Institute, Columbus, Ohio, USA
Cancer Res 68:4945-57. 2008..In a patient subset, berry gel application also reduced vascular densities in the superficial connective tissues and induced genes associated with keratinocyte terminal differentiation... - Formulation and in-vitro and in-vivo evaluation of a mucoadhesive gel containing freeze dried black raspberries: implications for oral cancer chemopreventionSusan R Mallery
Department of Oral Maxillofacial Surgery and Pathology, College of Dentistry, The Ohio State University, Columbus, OH 43210 1241, USA
Pharm Res 24:728-37. 2007.... - Effects of human oral mucosal tissue, saliva, and oral microflora on intraoral metabolism and bioactivation of black raspberry anthocyaninsSusan R Mallery
Division of Oral Maxillofacial Surgery, Pathology and Anesthesiology, College of Dentistry, 2191B Postle Hall, 305 W 12th Ave, The Ohio State University, Columbus, OH 43210, USA
Cancer Prev Res (Phila) 4:1209-21. 2011..Notably, interpatient differences in anthocyanin bioactivation and capacities for enteric recycling would impact treatment as retention of bioactivated chemopreventives at the target site would sustain therapeutic effectiveness... - Implications for oxidative and nitrative stress in the pathogenesis of AIDS-related Kaposi's sarcomaSusan R Mallery
Department of Oral Maxillofacial Surgery and Pathology, College of Dentistry, Ohio State University, Columbus, Ohio, USA
Carcinogenesis 25:597-603. 2004.... - Effects of 10-hydroxycamptothecin, delivered from locally injectable poly(lactide-co-glycolide) microspheres, in a murine human oral squamous cell carcinoma regression modelS R Mallery
Department of Oral Maxillofacial Surgery and Pathology, College of Dentistry, Ohio State University, Columbus 43218 2357, USA
Anticancer Res 21:1713-22. 2001..However, due to their acidic, camptothecin-stabilizing microclimate, PLGA microspheres could provide a novel delivery system for camptothecin-based induction chemotherapy... - Endostatin inhibits migration and invasion of head and neck squamous cell carcinoma cellsRalph F Wilson
Departments of Oral Maxillofacial Surgery and Pathology and Periodontology, College of Dentistry, Ohio State University, Columbus, Ohio, USA
Anticancer Res 23:1289-95. 2003..Our data imply that endostatin's clinical efficacy extends beyond angiostatic properties to encompass a direct anti-tumorigenic effect against HNSCC cells... - Suppression of the tumorigenic phenotype in human oral squamous cell carcinoma cells by an ethanol extract derived from freeze-dried black raspberriesKapila A Rodrigo
Department of Oral Maxillofacial Surgery and Pathology, College of Dentistry, The Ohio State University, Columbus 43210, USA
Nutr Cancer 54:58-68. 2006..These data imply that RO-ET is a promising candidate for use as a chemopreventive agent in persons with oral epithelial dysplasia... - Distribution of anthocyanins delivered from a bioadhesive black raspberry gel following topical intraoral application in normal healthy volunteersCarlos M Ugalde
Division of Oral Maxillofacial Surgery, Pathology and Anesthesiology, College of Dentistry, The Ohio State University, Columbus, Ohio, USA
Pharm Res 26:977-86. 2009..Accordingly, this study assessed the distribution of anthocyanins from the 10% (w/w) FBR gel in saliva, oral tissues and plasma... - Effects of a topically applied bioadhesive berry gel on loss of heterozygosity indices in premalignant oral lesionsBrian S Shumway
Department of Oral and Maxillofacial Surgery, Anesthesiology and Pathology, College of Dentistry, The Ohio State University, Columbus, OH 43210 1241, USA
Clin Cancer Res 14:2421-30. 2008..Previously, our laboratories have shown that FBRs are well tolerated and possess potent antioxidant, apoptotic, and differentiation-inducing properties... - The effects of reactive species on the tumorigenic phenotype of human head and neck squamous cell carcinoma (HNSCC) cellsJennifer E Bradburn
Integrated Biomedical Sciences Graduate Program, School of Biomedical Sciences, The Ohio State University College of Medicine, Columbus, OH 43210, USA
Anticancer Res 27:3819-27. 2007.... - AIDS-associated malignanciesManisha H Shah
Divisions of Hematology-Oncology and Human Cancer Genetics, Department of Internal Medicine, Comprehensive Cancer Center, Ohio State University, A 438 Starling Loving Hall, 320 West 10th Avenue, Columbus, OH 43210, USA
Cancer Chemother Biol Response Modif 20:633-64. 2002 - A rapid and sensitive LC-MS/MS method for quantification of four anthocyanins and its application in a clinical pharmacology study of a bioadhesive black raspberry gelYonghua Ling
College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA
J Chromatogr B Analyt Technol Biomed Life Sci 877:4027-34. 2009..Measurable saliva and tissue levels of the FBR anthocyanins confirmed that gel-delivered anthocyanins are readily distributed to saliva and easily penetrate human oral mucosa... - Human head and neck squamous cell carcinoma cells are both targets and effectors for the angiogenic cytokine, VEGFMeng Tong
Department of Oral Maxillofacial Surgery, Pathology and Anesthesiology, College of Dentistry, The Ohio State University, Columbus, Ohio 43210, USA
J Cell Biochem 105:1202-10. 2008..These data introduce the prospect that VEGF targeted therapy has the potential to fulfill both anti-angiogenic and anti-tumorigenic functions... - Expression of the serine protease DESC1 correlates directly with normal keratinocyte differentiation and inversely with head and neck squamous cell carcinoma progressionParish P Sedghizadeh
Department of Oral and Maxillofacial Surgery, Oral and Maxillofacial Pathology and Dental Anesthesiology, Ohio State University, College of Dentistry, 305 West 12th Avenue, 2196 Postle Hall, Columbus, OH 43218 2357, USA
Head Neck 28:432-40. 2006..As part of ongoing studies aimed at identifying the molecular events involved in head and neck squamous cell carcinoma progression, we recently isolated a novel serine protease, DESC1. This study was conducted to further characterize DESC1... - Curcumin activates the aryl hydrocarbon receptor yet significantly inhibits (-)-benzo(a)pyrene-7R-trans-7,8-dihydrodiol bioactivation in oral squamous cell carcinoma cells and oral mucosaAnthony L Rinaldi
College of Dentistry, Departments of Orthodontics and Oral Maxillofacial Surgery and Pathology, Ohio State University, Columbus, Ohio 43218, USA
Cancer Res 62:5451-6. 2002..Because CYP1A1 is one of the primary carcinogen-activating enzymes in oral mucosa, the use of curcumin as an oral cavity chemopreventive agent could have significant clinical impact via its ability to inhibit carcinogen bioactivation... - AIDS-associated malignanciesManisha H Shah
The Ohio State University, Columbus 43210, USA
Cancer Chemother Biol Response Modif 21:717-46. 2003 - Alterations of p16(INK4a) and p14(ARF) in patients with severe oral epithelial dysplasiaLaura A Kresty
Division of Environmental Health Sciences, School of Public Health, Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA
Cancer Res 62:5295-300. 2002..These data support that INK4a/ARF locus alterations are frequent events preceding the development of oral cancer and that p16(INK4a) inactivation occurs to a greater extent in oral dysplasia than does p14(ARF) inactivation... - Chemoprevention of oral cancer by black raspberriesBruce C Casto
Division of Environmental Health Sciences, School of Public Health, Ohio State University, Columbus, OH 43210, USA
Anticancer Res 22:4005-15. 2002..These experiments support previous studies from our laboratories showing the chemopreventive activity of black raspberries and show, for the first time, that dietary black raspberries will inhibit tumor formation in the oral cavity... - Activation of Akt and mTOR in CD34+/K15+ keratinocyte stem cells and skin tumors during multi-stage mouse skin carcinogenesisNesrine I Affara
Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, OH 43210, USA
Anticancer Res 26:2805-20. 2006..Strategies that target pAkt and pmTOR may deplete both cells within the CD34+/K]5+ KSCs compartment, as well as impacting the survival of nonproliferating suprabasal cells within pre-malignant papillomas... - Sanguinarine activates polycyclic aromatic hydrocarbon associated metabolic pathways in human oral keratinocytes and tissuesJeffrey M Karp
The Ohio State University College of Dentistry, Department of Pediatric Dentistry, Columbus, OH 43210, USA
Toxicol Lett 158:50-60. 2005..Persons who respond to sanguinarine exposure with induction of primarily Phase I relative to Phase II enzymes are, therefore, at risk for sanguinarine bioactivation and its potential mutagenic effects... - Activated Akt-1 in specific cell populations during multi-stage skin carcinogenesisNesrine I Affara
Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, College of Medicine, Columbus, Ohio 43210, USA
Anticancer Res 24:2773-81. 2004.... - Reduced nonprotein thiols inhibit activation and function of MMP-9: implications for chemopreventionPing Pei
Department of Oral Maxillofacial Surgery and Pathology, College of Dentistry, The Ohio State University, Columbus, OH 43210, USA
Free Radic Biol Med 41:1315-24. 2006..Collectively, these data demonstrate that nonprotein thiols suppress MMP-9 activation and function and introduce the prospect for their use in chemopreventive applications... - Dynamic and biphasic modulation of nitrosation reaction by superoxide dismutasesTeh-Min Hu
Division of Pharmaceutics, College of Pharmacy, Columbus, OH 43210-1241, USA
Biochem Biophys Res Commun 295:1125-34. 2002..Our findings likely reflect the complex and dynamic nature of SOD interactions with oxidative and nitrosative species...
Research Grants
- Chemoprevention of Head & Neck Cancer Using Controlled Release PolymersSusan R Mallery; Fiscal Year: 2010....
- Role of Oxidants & Angiogenesis in Kaposi's SarcomaSusan Mallery; Fiscal Year: 2007..Elucidation of these interactions will not only clarify KS pathogenic mechanisms, but will also identify sites for KS therapeutic intervention. ..
- Formulation & Evaluation of Bioadhesive Gels for Oral Cancer ChemopreventionSusan Mallery; Fiscal Year: 2006..These studies will design and test bioadhesive gels that contain naturally derived cancer fighting compounds in human volunteers to determine the gels' abilities to effectively deliver the cancer preventing agents to the mouth tissues. ..
- Chemoprevention of Oral Dysplasia by Black RaspberriesSusan Mallery; Fiscal Year: 2005..This experimental design (comparison of pretreatment and post-treatments tissues) permits each patient to serve as their own internal control. ..
- Chemoprevention of Head & Neck Cancer Using Controlled Release PolymersSusan R Mallery; Fiscal Year: 2011....