S Malik

Summary

Affiliation: The Rockefeller University
Country: USA

Publications

  1. ncbi request reprint Transcriptional regulation of the apolipoprotein AI gene
    Sohail Malik
    Laboratory of Biochemistry and Molecular Biology, Rockefeller University, 1230 York Ave, New York, NY 10021, USA
    Front Biosci 8:d360-8. 2003
  2. pmc TRAP/SMCC/mediator-dependent transcriptional activation from DNA and chromatin templates by orphan nuclear receptor hepatocyte nuclear factor 4
    Sohail Malik
    Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, NY 10021, USA
    Mol Cell Biol 22:5626-37. 2002
  3. ncbi request reprint Transcriptional regulation through Mediator-like coactivators in yeast and metazoan cells
    S Malik
    Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, NY 10021, USA
    Trends Biochem Sci 25:277-83. 2000
  4. ncbi request reprint Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators
    M Ito
    Laboratory of Biochemistry and Molecular Biology, Rockefeller University, New York, New York 10021, USA
    Mol Cell 3:361-70. 1999
  5. ncbi request reprint The USA-derived transcriptional coactivator PC2 is a submodule of TRAP/SMCC and acts synergistically with other PCs
    S Malik
    Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, New York 10021, USA
    Mol Cell 5:753-60. 2000
  6. pmc Involvement of TFIID and USA components in transcriptional activation of the human immunodeficiency virus promoter by NF-kappaB and Sp1
    M Guermah
    Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, New York 10021, USA
    Mol Cell Biol 18:3234-44. 1998
  7. ncbi request reprint A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation
    W Gu
    Laboratory of Biochemistry and Molecular Biology, Rockefeller University, New York, New York 10021, USA
    Mol Cell 3:97-108. 1999
  8. ncbi request reprint Crystal structure of negative cofactor 2 recognizing the TBP-DNA transcription complex
    K Kamada
    Laboratory of Molecular Biophysics, 1230 York Avenue, New York, NY 10021, USA
    Cell 106:71-81. 2001
  9. ncbi request reprint Coordination of p300-mediated chromatin remodeling and TRAP/mediator function through coactivator PGC-1alpha
    Annika E Wallberg
    Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, NY 10021, USA
    Mol Cell 12:1137-49. 2003
  10. pmc A dynamic model for PC4 coactivator function in RNA polymerase II transcription
    S Malik
    Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 95:2192-7. 1998

Research Grants

Collaborators

Detail Information

Publications27

  1. ncbi request reprint Transcriptional regulation of the apolipoprotein AI gene
    Sohail Malik
    Laboratory of Biochemistry and Molecular Biology, Rockefeller University, 1230 York Ave, New York, NY 10021, USA
    Front Biosci 8:d360-8. 2003
    ..The review thus also describes selected examples of these phenomena with the aim of highlighting how the operative transcriptional mechanisms are likely to be continually modified while maintaining the appropriate output...
  2. pmc TRAP/SMCC/mediator-dependent transcriptional activation from DNA and chromatin templates by orphan nuclear receptor hepatocyte nuclear factor 4
    Sohail Malik
    Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, NY 10021, USA
    Mol Cell Biol 22:5626-37. 2002
    ..Finally, recruitment experiments using immobilized templates strongly suggest that the functional consequences of the physical interaction probably are manifested at a postrecruitment step in the activation pathway...
  3. ncbi request reprint Transcriptional regulation through Mediator-like coactivators in yeast and metazoan cells
    S Malik
    Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, NY 10021, USA
    Trends Biochem Sci 25:277-83. 2000
    ..This complex is evolutionarily related to the Mediator complex from yeast and, on the basis of its structural and functional characteristics, promises to be a key target of diverse regulatory circuits...
  4. ncbi request reprint Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators
    M Ito
    Laboratory of Biochemistry and Molecular Biology, Rockefeller University, New York, New York 10021, USA
    Mol Cell 3:361-70. 1999
    ..Identification of the TRAP230 subunit as a previously predicted gene product also suggests a coactivator-related transcription defect in certain disease states...
  5. ncbi request reprint The USA-derived transcriptional coactivator PC2 is a submodule of TRAP/SMCC and acts synergistically with other PCs
    S Malik
    Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, New York 10021, USA
    Mol Cell 5:753-60. 2000
    ....
  6. pmc Involvement of TFIID and USA components in transcriptional activation of the human immunodeficiency virus promoter by NF-kappaB and Sp1
    M Guermah
    Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, New York 10021, USA
    Mol Cell Biol 18:3234-44. 1998
    ..Taken together, these data underscore the importance of both TAFs and specific USA-derived coactivators for optimal activation of the HIV-1 promoter, as well as certain parallels in their overall mechanisms of action...
  7. ncbi request reprint A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation
    W Gu
    Laboratory of Biochemistry and Molecular Biology, Rockefeller University, New York, New York 10021, USA
    Mol Cell 3:97-108. 1999
    ..These findings demonstrate both positive and negative functional capabilities for the human complex, emphasize novel (CTD-independent) regulatory mechanisms, and link the complex to other human coactivator complexes...
  8. ncbi request reprint Crystal structure of negative cofactor 2 recognizing the TBP-DNA transcription complex
    K Kamada
    Laboratory of Molecular Biophysics, 1230 York Avenue, New York, NY 10021, USA
    Cell 106:71-81. 2001
    ..Further regulatory implications of the NC2 heterodimer structure are discussed...
  9. ncbi request reprint Coordination of p300-mediated chromatin remodeling and TRAP/mediator function through coactivator PGC-1alpha
    Annika E Wallberg
    Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, NY 10021, USA
    Mol Cell 12:1137-49. 2003
    ....
  10. pmc A dynamic model for PC4 coactivator function in RNA polymerase II transcription
    S Malik
    Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 95:2192-7. 1998
    ..Thus PC4 coactivator activity is realized in a stepwise series of events reminiscent of prokaryotic activation pathways involving conversion of inactive RNA polymerase-promoter complexes to an initiation-competent state...
  11. pmc Sequence of general transcription factor TFIIB and relationships to other initiation factors
    S Malik
    Laboratory of Biochemistry and Molecular Biology, Rockefeller University, New York, NY 10021
    Proc Natl Acad Sci U S A 88:9553-7. 1991
    ..These findings argue for a common origin of TFIIB, TFIID, and other general transcription factors and for the evolutionary segregation of complementary functions...
  12. ncbi request reprint Distinct transcriptional activation functions of STAT1alpha and STAT1beta on DNA and chromatin templates
    Natalia Zakharova
    Laboratories of Molecular Cell Biology and Biochemistry and Molecular Biology, Rockefeller University, New York, New York 10021, USA
    J Biol Chem 278:43067-73. 2003
    ..We conclude that chromatin remodeling by p300 in vivo makes TRAP/Mediator effective in stimulating transcription...
  13. ncbi request reprint Isolation and functional characterization of the TRAP/mediator complex
    Sohail Malik
    Laboratory of Biochemistry and Molecular Biology, Rockefeller University, New York, New York 10021, USA
    Methods Enzymol 364:257-84. 2003
  14. ncbi request reprint Dynamic regulation of pol II transcription by the mammalian Mediator complex
    Sohail Malik
    Laboratory of Biochemistry and Molecular Biology, Rockefeller University, 1230 York Ave, New York, NY 10021, USA
    Trends Biochem Sci 30:256-63. 2005
    ..In addition, the compositional complexity of the Mediator allows for assimilation of other diverse signals such as those emanating from repressors and other coactivators...
  15. pmc Identification of a regulator of transcription elongation as an accessory factor for the human Mediator coactivator
    Sohail Malik
    Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 104:6182-7. 2007
    ..Our data thus point to potential mechanisms for Mediator function beyond its presently believed role in promoting the initial formation of the RNA polymerase II-containing preinitiation complex...
  16. doi request reprint Epigenetics? Mediator does that too!
    Sohail Malik
    Laboratory of Biochemistry and Molecular Biology, Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
    Mol Cell 31:305-6. 2008
    ..2008) report in this issue of Molecular Cell that, by facilitating the recruitment of the G9a methyl transferase, Mediator can also promote epigenetic silencing of selected genes...
  17. pmc Identification of DNA-dependent protein kinase as a cofactor for the forkhead transcription factor FoxA2
    Adam Nock
    Laboratory of Biochemistry and Molecular Biology, Rockefeller University, New York, New York 10065, USA
    J Biol Chem 284:19915-26. 2009
    ..We therefore conclude that DNA-PK-dependent phosphorylation of FoxA2 plays a critical role in its transcriptional activation function per se...
  18. pmc Structural and functional characterization of PC2 and RNA polymerase II-associated subpopulations of metazoan Mediator
    Sohail Malik
    Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, 1230 York Ave, 166, New York, NY 10021, USA
    Mol Cell Biol 25:2117-29. 2005
    ..Our results are thus consistent with a dynamic nature of the Mediator complex and further extend the functional similarities between Saccharomyces cerevisiae and metazoan Mediator complexes...
  19. pmc The metazoan Mediator co-activator complex as an integrative hub for transcriptional regulation
    Sohail Malik
    Laboratory of Biochemistry and Molecular Biology, Rockefeller University, 1230 York Avenue, New York, New York 10065, USA
    Nat Rev Genet 11:761-72. 2010
    ..These interactions ultimately allow the Mediator to deliver outputs that range from maximal activation of genes to modulation of basal transcription to long-term epigenetic silencing...
  20. pmc Requirement of TRAP/mediator for both activator-independent and activator-dependent transcription in conjunction with TFIID-associated TAF(II)s
    Hwa Jin Baek
    Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, New York 10021, USA
    Mol Cell Biol 22:2842-52. 2002
    ....
  21. pmc Two functional modes of a nuclear receptor-recruited arginine methyltransferase in transcriptional activation
    Maria J Barrero
    Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
    Mol Cell 24:233-43. 2006
    ..This, together with recruitment of the histone acetyltransferase p300, leads to nucleosomal alterations and subsequent RNA polymerase II preinitiation complex formation...
  22. pmc V(D)J recombination: modulation of RAG1 and RAG2 cleavage activity on 12/23 substrates by whole cell extract and DNA-bending proteins
    D J Sawchuk
    Laboratory of Molecular Immunology, The Rockefeller University, New York 10021, USA
    J Exp Med 185:2025-32. 1997
    ..These results suggest the existence of a nucleoprotein complex at the cleavage site, consisting of architectural, catalytic, and regulatory components...
  23. pmc Conserved structural motifs between Xenopus and human TFIIB
    K Hisatake
    Laboratory of Biochemistry and Molecular Biology, Rockefeller University, New York, NY 10021
    Nucleic Acids Res 19:6639. 1991
  24. pmc Structural and functional organization of TRAP220, the TRAP/mediator subunit that is targeted by nuclear receptors
    Sohail Malik
    Laboratory of Biochemistry and Molecular Biology, Rockefeller University, 1230 York Ave, New York, NY 10021, USA
    Mol Cell Biol 24:8244-54. 2004
    ..The implications of these observations are discussed in terms of our present understanding of coactivator function...
  25. pmc A Mediator-responsive form of metazoan RNA polymerase II
    Xiaopeng Hu
    Department of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Proc Natl Acad Sci U S A 103:9506-11. 2006
    ..Our results reveal a transcriptional control mechanism in which Mediator-dependent regulation is enforced by means of Gdown1, which likely restricts Pol II function only to be reversed by Mediator...
  26. ncbi request reprint A kinase subunit of the human mediator complex, CDK8, positively regulates transcriptional activation
    Tadashi Furumoto
    Graduate School of Frontier Biosciences, Osaka Universuty, Suita, Osaka 565 0871, Japan
    Genes Cells 12:119-32. 2007
    ..This, together with the effect of TMLC1 on transcription in vitro, suggests that CDK8 play positive roles in transcriptional activation...
  27. pmc Mammalian mediator subunit mMED8 is an Elongin BC-interacting protein that can assemble with Cul2 and Rbx1 to reconstitute a ubiquitin ligase
    Christopher S Brower
    Stowers Institute for Medical Research, Kansas City, MO 64110, USA
    Proc Natl Acad Sci U S A 99:10353-8. 2002
    ..Taken together, our findings are consistent with the model that MED8 could function to recruit ubiquitin ligase activity directly to the RNA polymerase II transcriptional machinery...

Research Grants5

  1. HNF-4 and coactivators in apoAl gene regulation
    Sohail Malik; Fiscal Year: 2007
    ..They will also potentially reveal targets for future therapeutic developments in the metabolic and cardiovascular areas. ..