Research Topics
Genomes and Genes
Species | S MalikSummaryAffiliation: The Rockefeller University Country: USA Publications
Research Grants
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Detail Information
Publications
Transcriptional regulation of the apolipoprotein AI geneSohail Malik
Laboratory of Biochemistry and Molecular Biology, Rockefeller University, 1230 York Ave, New York, NY 10021, USA
Front Biosci 8:d360-8. 2003..The review thus also describes selected examples of these phenomena with the aim of highlighting how the operative transcriptional mechanisms are likely to be continually modified while maintaining the appropriate output...
TRAP/SMCC/mediator-dependent transcriptional activation from DNA and chromatin templates by orphan nuclear receptor hepatocyte nuclear factor 4Sohail Malik
Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, NY 10021, USA
Mol Cell Biol 22:5626-37. 2002..Finally, recruitment experiments using immobilized templates strongly suggest that the functional consequences of the physical interaction probably are manifested at a postrecruitment step in the activation pathway...- Transcriptional regulation through Mediator-like coactivators in yeast and metazoan cellsS Malik
Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, NY 10021, USA
Trends Biochem Sci 25:277-83. 2000..This complex is evolutionarily related to the Mediator complex from yeast and, on the basis of its structural and functional characteristics, promises to be a key target of diverse regulatory circuits... - Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activatorsM Ito
Laboratory of Biochemistry and Molecular Biology, Rockefeller University, New York, New York 10021, USA
Mol Cell 3:361-70. 1999..Identification of the TRAP230 subunit as a previously predicted gene product also suggests a coactivator-related transcription defect in certain disease states... - The USA-derived transcriptional coactivator PC2 is a submodule of TRAP/SMCC and acts synergistically with other PCsS Malik
Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, New York 10021, USA
Mol Cell 5:753-60. 2000.... - Involvement of TFIID and USA components in transcriptional activation of the human immunodeficiency virus promoter by NF-kappaB and Sp1M Guermah
Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, New York 10021, USA
Mol Cell Biol 18:3234-44. 1998..Taken together, these data underscore the importance of both TAFs and specific USA-derived coactivators for optimal activation of the HIV-1 promoter, as well as certain parallels in their overall mechanisms of action... - A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulationW Gu
Laboratory of Biochemistry and Molecular Biology, Rockefeller University, New York, New York 10021, USA
Mol Cell 3:97-108. 1999..These findings demonstrate both positive and negative functional capabilities for the human complex, emphasize novel (CTD-independent) regulatory mechanisms, and link the complex to other human coactivator complexes... - Crystal structure of negative cofactor 2 recognizing the TBP-DNA transcription complexK Kamada
Laboratory of Molecular Biophysics, 1230 York Avenue, New York, NY 10021, USA
Cell 106:71-81. 2001..Further regulatory implications of the NC2 heterodimer structure are discussed... - Coordination of p300-mediated chromatin remodeling and TRAP/mediator function through coactivator PGC-1alphaAnnika E Wallberg
Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, NY 10021, USA
Mol Cell 12:1137-49. 2003.... - A dynamic model for PC4 coactivator function in RNA polymerase II transcriptionS Malik
Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
Proc Natl Acad Sci U S A 95:2192-7. 1998..Thus PC4 coactivator activity is realized in a stepwise series of events reminiscent of prokaryotic activation pathways involving conversion of inactive RNA polymerase-promoter complexes to an initiation-competent state... - Sequence of general transcription factor TFIIB and relationships to other initiation factorsS Malik
Laboratory of Biochemistry and Molecular Biology, Rockefeller University, New York, NY 10021
Proc Natl Acad Sci U S A 88:9553-7. 1991..These findings argue for a common origin of TFIIB, TFIID, and other general transcription factors and for the evolutionary segregation of complementary functions... - Distinct transcriptional activation functions of STAT1alpha and STAT1beta on DNA and chromatin templatesNatalia Zakharova
Laboratories of Molecular Cell Biology and Biochemistry and Molecular Biology, Rockefeller University, New York, New York 10021, USA
J Biol Chem 278:43067-73. 2003..We conclude that chromatin remodeling by p300 in vivo makes TRAP/Mediator effective in stimulating transcription... - Isolation and functional characterization of the TRAP/mediator complexSohail Malik
Laboratory of Biochemistry and Molecular Biology, Rockefeller University, New York, New York 10021, USA
Methods Enzymol 364:257-84. 2003 - Dynamic regulation of pol II transcription by the mammalian Mediator complexSohail Malik
Laboratory of Biochemistry and Molecular Biology, Rockefeller University, 1230 York Ave, New York, NY 10021, USA
Trends Biochem Sci 30:256-63. 2005..In addition, the compositional complexity of the Mediator allows for assimilation of other diverse signals such as those emanating from repressors and other coactivators... - Identification of a regulator of transcription elongation as an accessory factor for the human Mediator coactivatorSohail Malik
Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, NY 10021, USA
Proc Natl Acad Sci U S A 104:6182-7. 2007..Our data thus point to potential mechanisms for Mediator function beyond its presently believed role in promoting the initial formation of the RNA polymerase II-containing preinitiation complex... - Epigenetics? Mediator does that too!Sohail Malik
Laboratory of Biochemistry and Molecular Biology, Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
Mol Cell 31:305-6. 2008..2008) report in this issue of Molecular Cell that, by facilitating the recruitment of the G9a methyl transferase, Mediator can also promote epigenetic silencing of selected genes... - Identification of DNA-dependent protein kinase as a cofactor for the forkhead transcription factor FoxA2Adam Nock
Laboratory of Biochemistry and Molecular Biology, Rockefeller University, New York, New York 10065, USA
J Biol Chem 284:19915-26. 2009..We therefore conclude that DNA-PK-dependent phosphorylation of FoxA2 plays a critical role in its transcriptional activation function per se... - Structural and functional characterization of PC2 and RNA polymerase II-associated subpopulations of metazoan MediatorSohail Malik
Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, 1230 York Ave, 166, New York, NY 10021, USA
Mol Cell Biol 25:2117-29. 2005..Our results are thus consistent with a dynamic nature of the Mediator complex and further extend the functional similarities between Saccharomyces cerevisiae and metazoan Mediator complexes... - The metazoan Mediator co-activator complex as an integrative hub for transcriptional regulationSohail Malik
Laboratory of Biochemistry and Molecular Biology, Rockefeller University, 1230 York Avenue, New York, New York 10065, USA
Nat Rev Genet 11:761-72. 2010..These interactions ultimately allow the Mediator to deliver outputs that range from maximal activation of genes to modulation of basal transcription to long-term epigenetic silencing... - Requirement of TRAP/mediator for both activator-independent and activator-dependent transcription in conjunction with TFIID-associated TAF(II)sHwa Jin Baek
Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, New York 10021, USA
Mol Cell Biol 22:2842-52. 2002.... - Two functional modes of a nuclear receptor-recruited arginine methyltransferase in transcriptional activationMaria J Barrero
Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
Mol Cell 24:233-43. 2006..This, together with recruitment of the histone acetyltransferase p300, leads to nucleosomal alterations and subsequent RNA polymerase II preinitiation complex formation... 
V(D)J recombination: modulation of RAG1 and RAG2 cleavage activity on 12/23 substrates by whole cell extract and DNA-bending proteinsD J Sawchuk
Laboratory of Molecular Immunology, The Rockefeller University, New York 10021, USA
J Exp Med 185:2025-32. 1997..These results suggest the existence of a nucleoprotein complex at the cleavage site, consisting of architectural, catalytic, and regulatory components...- Conserved structural motifs between Xenopus and human TFIIBK Hisatake
Laboratory of Biochemistry and Molecular Biology, Rockefeller University, New York, NY 10021
Nucleic Acids Res 19:6639. 1991 - Structural and functional organization of TRAP220, the TRAP/mediator subunit that is targeted by nuclear receptorsSohail Malik
Laboratory of Biochemistry and Molecular Biology, Rockefeller University, 1230 York Ave, New York, NY 10021, USA
Mol Cell Biol 24:8244-54. 2004..The implications of these observations are discussed in terms of our present understanding of coactivator function... - A Mediator-responsive form of metazoan RNA polymerase IIXiaopeng Hu
Department of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Proc Natl Acad Sci U S A 103:9506-11. 2006..Our results reveal a transcriptional control mechanism in which Mediator-dependent regulation is enforced by means of Gdown1, which likely restricts Pol II function only to be reversed by Mediator... - A kinase subunit of the human mediator complex, CDK8, positively regulates transcriptional activationTadashi Furumoto
Graduate School of Frontier Biosciences, Osaka Universuty, Suita, Osaka 565 0871, Japan
Genes Cells 12:119-32. 2007..This, together with the effect of TMLC1 on transcription in vitro, suggests that CDK8 play positive roles in transcriptional activation... - Mammalian mediator subunit mMED8 is an Elongin BC-interacting protein that can assemble with Cul2 and Rbx1 to reconstitute a ubiquitin ligaseChristopher S Brower
Stowers Institute for Medical Research, Kansas City, MO 64110, USA
Proc Natl Acad Sci U S A 99:10353-8. 2002..Taken together, our findings are consistent with the model that MED8 could function to recruit ubiquitin ligase activity directly to the RNA polymerase II transcriptional machinery...
Research Grants
- HNF-4 and coactivators in apoAl gene regulationSohail Malik; Fiscal Year: 2007..They will also potentially reveal targets for future therapeutic developments in the metabolic and cardiovascular areas. ..