William Mair

Summary

Affiliation: The Salk Institute
Country: USA

Publications

  1. ncbi request reprint Counting the calories: the role of specific nutrients in extension of life span by food restriction
    Matthew D W Piper
    Department of Biology, University College London, Darwin Building, Gower Street, London, WC1E 6BT, UK
    J Gerontol A Biol Sci Med Sci 60:549-55. 2005
  2. doi request reprint Aging and survival: the genetics of life span extension by dietary restriction
    William Mair
    The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Annu Rev Biochem 77:727-54. 2008
  3. pmc Lifespan extension induced by AMPK and calcineurin is mediated by CRTC-1 and CREB
    William Mair
    The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Nature 470:404-8. 2011
  4. pmc Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy
    Daniel F Egan
    Molecular and Cell Biology Laboratory, Dulbecco Center for Cancer Research, Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Science 331:456-61. 2011
  5. pmc Dietary restriction enhances germline stem cell maintenance
    William Mair
    The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Aging Cell 9:916-8. 2010
  6. pmc Optimizing dietary restriction for genetic epistasis analysis and gene discovery in C. elegans
    William Mair
    Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California, United States of America
    PLoS ONE 4:e4535. 2009
  7. ncbi request reprint SIP-ing the elixir of youth
    William Mair
    The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Cell 146:859-60. 2011
  8. pmc Chromatin-bound nuclear pore components regulate gene expression in higher eukaryotes
    Maya Capelson
    Molecular and Cellular Biology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Cell 140:372-83. 2010
  9. ncbi request reprint Demography of dietary restriction and death in Drosophila
    William Mair
    Department of Biology, University College London, Darwin Building, Gower Street, London WC1E 6BT, UK
    Science 301:1731-3. 2003
  10. pmc Calories do not explain extension of life span by dietary restriction in Drosophila
    William Mair
    Department of Biology, Centre for Research on Ageing, University College London, London, United Kingdom
    PLoS Biol 3:e223. 2005

Collaborators

Detail Information

Publications15

  1. ncbi request reprint Counting the calories: the role of specific nutrients in extension of life span by food restriction
    Matthew D W Piper
    Department of Biology, University College London, Darwin Building, Gower Street, London, WC1E 6BT, UK
    J Gerontol A Biol Sci Med Sci 60:549-55. 2005
    ..Delineation of the nutritional components that are critical for life-span extension will help to reveal the mechanisms by which it operates...
  2. doi request reprint Aging and survival: the genetics of life span extension by dietary restriction
    William Mair
    The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Annu Rev Biochem 77:727-54. 2008
    ..Here, we discuss how recent work in nonmammalian model organisms has revealed new insight into the genetics of DR and how the discovery of DR-specific transcription factors will advance our understanding of this phenomenon...
  3. pmc Lifespan extension induced by AMPK and calcineurin is mediated by CRTC-1 and CREB
    William Mair
    The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Nature 470:404-8. 2011
    ....
  4. pmc Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy
    Daniel F Egan
    Molecular and Cell Biology Laboratory, Dulbecco Center for Cancer Research, Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Science 331:456-61. 2011
    ..These findings uncover a conserved biochemical mechanism coupling nutrient status with autophagy and cell survival...
  5. pmc Dietary restriction enhances germline stem cell maintenance
    William Mair
    The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Aging Cell 9:916-8. 2010
    ..This represents the first example of DR maintaining an adult stem cell pool and suggests a potential mechanism by which DR might delay aging in the tissues of higher organisms...
  6. pmc Optimizing dietary restriction for genetic epistasis analysis and gene discovery in C. elegans
    William Mair
    Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California, United States of America
    PLoS ONE 4:e4535. 2009
    ..1, highlighting the importance of first optimizing DR to identify universal regulators of DR mediated longevity...
  7. ncbi request reprint SIP-ing the elixir of youth
    William Mair
    The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Cell 146:859-60. 2011
    ..In this issue, Lu et al. (2011) describe how age-related deacetylation of Sip2, a subunit of the AMPK homolog in yeast, acts as a life span clock that can be wound backward or forward to modulate longevity...
  8. pmc Chromatin-bound nuclear pore components regulate gene expression in higher eukaryotes
    Maya Capelson
    Molecular and Cellular Biology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Cell 140:372-83. 2010
    ....
  9. ncbi request reprint Demography of dietary restriction and death in Drosophila
    William Mair
    Department of Biology, University College London, Darwin Building, Gower Street, London WC1E 6BT, UK
    Science 301:1731-3. 2003
    ..DR of mammals may also reduce short-term risk of death, and hence DR instigated at any age could generate a full reversal of mortality...
  10. pmc Calories do not explain extension of life span by dietary restriction in Drosophila
    William Mair
    Department of Biology, Centre for Research on Ageing, University College London, London, United Kingdom
    PLoS Biol 3:e223. 2005
    ..Calorie intake is therefore not the key factor in the reduction of mortality rate by DR in this species...
  11. ncbi request reprint Dietary restriction in Drosophila
    Linda Partridge
    UCL Centre for Research on Ageing, Department of Biology, University College London, London WC1E 6BT, UK
    Mech Ageing Dev 126:938-50. 2005
    ..This rapid mortality rate recovery provides a powerful framework within which to further investigate the mechanisms by which DR extends lifespan...
  12. ncbi request reprint The effect of dietary restriction on mitochondrial protein density and flight muscle mitochondrial morphology in Drosophila
    Tapiwanashe Magwere
    University College London, Department of Biology, Darwin Building, Gower Street, London WC1E 6BT, UK
    J Gerontol A Biol Sci Med Sci 61:36-47. 2006
    ..If DR in Drosophila extends life span by reducing ROS production, then it does so through mechanisms that operate only in vivo...
  13. ncbi request reprint Dietary restriction, mortality trajectories, risk and damage
    Linda Partridge
    Department of Biology, University College London, Darwin Building, Gower Street, London WC1E 6BT, UK
    Mech Ageing Dev 126:35-41. 2005
    ..In rodents, some phenotypes associated with DR, including microarray profiles, show rapid switching with changed nutritional regime, pointing to potentially acute effects of DR in mammals...
  14. ncbi request reprint Lifespan extension by dietary restriction in female Drosophila melanogaster is not caused by a reduction in vitellogenesis or ovarian activity
    William Mair
    Department of Biology, University College London, Darwin Building, Gower Street, WC1E 6BT, UK
    Exp Gerontol 39:1011-9. 2004
    ....
  15. ncbi request reprint Comment by Matthew Piper, William Mair, Linda Partridge on Min, K.J., Flatt, T., Kulaots, I., Tatar, M. (2006) "Counting calories in Drosophila dietary restriction"Exp. Gerontology, doi:10.1016/j.exger.2006.10.009
    Matthew Piper
    Exp Gerontol 42:253-5. 2007