Pamela A Maher

Summary

Affiliation: The Salk Institute
Country: USA

Publications

  1. ncbi request reprint Phorbol esters inhibit fibroblast growth factor-2-stimulated fibroblast proliferation by a p38 MAP kinase dependent pathway
    Pamela Maher
    Department of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California, CA 92037, USA
    Oncogene 21:1978-88. 2002
  2. ncbi request reprint Tyrphostins protect neuronal cells from oxidative stress
    Yutaka Sagara
    Department of Neurosciences, University of California, San Diego, La Jolla, California 92093 0624, USA
    J Biol Chem 277:36204-15. 2002
  3. doi request reprint A broadly neuroprotective derivative of curcumin
    Yuanbin Liu
    The Salk Institute, Laboratories for Cellular Neurobiology, La Jolla, California 92037 1099, USA
    J Neurochem 105:1336-45. 2008
  4. doi request reprint A pyrazole derivative of curcumin enhances memory
    Pamela Maher
    The Salk Institute, Laboratories for Cellular Neurobiology, 10010 North Torrey Pines Road, La Jolla, CA 92037 1099, USA
    Neurobiol Aging 31:706-9. 2010
  5. pmc A novel approach to enhancing cellular glutathione levels
    Pamela Maher
    The Salk Institute, La Jolla, California 92037, USA
    J Neurochem 107:690-700. 2008
  6. pmc Effects of dimethyl fumarate on neuroprotection and immunomodulation
    Philipp Albrecht
    Department of Neurology, Heinrich Heine University Dusseldorf, Medical Faculty, Dusseldorf 40225, Germany
    J Neuroinflammation 9:163. 2012
  7. pmc Modulation of multiple pathways involved in the maintenance of neuronal function during aging by fisetin
    Pamela Maher
    The Salk Institute for Biological Studies, 10010 N Torrey Pines Rd, La Jolla, CA, 92037, USA
    Genes Nutr 4:297-307. 2009
  8. doi request reprint Methylglyoxal, advanced glycation end products and autism: is there a connection?
    P Maher
    The Salk Institute for Biological Studies, 10010 N Torrey Pines Rd, La Jolla, CA 92037, USA
    Med Hypotheses 78:548-52. 2012
  9. pmc Flavonoid fisetin promotes ERK-dependent long-term potentiation and enhances memory
    Pamela Maher
    The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 103:16568-73. 2006
  10. pmc A novel approach to screening for new neuroprotective compounds for the treatment of stroke
    Pamela Maher
    The Salk Institute for Biological Studies, 10010 N Torrey Pines Rd, La Jolla, CA 92037, USA
    Brain Res 1173:117-25. 2007

Collaborators

Detail Information

Publications32

  1. ncbi request reprint Phorbol esters inhibit fibroblast growth factor-2-stimulated fibroblast proliferation by a p38 MAP kinase dependent pathway
    Pamela Maher
    Department of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California, CA 92037, USA
    Oncogene 21:1978-88. 2002
    ..These data indicate that the effects of TPA treatment on cellular function are not only cell type but also stimulus specific and are dependent upon the distinct pathways activated downstream of each stimulus...
  2. ncbi request reprint Tyrphostins protect neuronal cells from oxidative stress
    Yutaka Sagara
    Department of Neurosciences, University of California, San Diego, La Jolla, California 92093 0624, USA
    J Biol Chem 277:36204-15. 2002
    ..Therefore, the effects of tyrphostins on cells are not limited to their ability to inhibit tyrosine kinases...
  3. doi request reprint A broadly neuroprotective derivative of curcumin
    Yuanbin Liu
    The Salk Institute, Laboratories for Cellular Neurobiology, La Jolla, California 92037 1099, USA
    J Neurochem 105:1336-45. 2008
    ..While the creation of CNB-001 was based upon an uncommon approach to drug design, it has the potential of a lead drug candidate for treating multiple conditions involving nerve cell death...
  4. doi request reprint A pyrazole derivative of curcumin enhances memory
    Pamela Maher
    The Salk Institute, Laboratories for Cellular Neurobiology, 10010 North Torrey Pines Road, La Jolla, CA 92037 1099, USA
    Neurobiol Aging 31:706-9. 2010
    ..It is shown that CNB-001 enhances both LTP and memory...
  5. pmc A novel approach to enhancing cellular glutathione levels
    Pamela Maher
    The Salk Institute, La Jolla, California 92037, USA
    J Neurochem 107:690-700. 2008
    ..Thus, these novel EC conjugates have the potential to enhance GSH synthesis under a wide variety of forms of toxic stress...
  6. pmc Effects of dimethyl fumarate on neuroprotection and immunomodulation
    Philipp Albrecht
    Department of Neurology, Heinrich Heine University Dusseldorf, Medical Faculty, Dusseldorf 40225, Germany
    J Neuroinflammation 9:163. 2012
    ..These effects are presumed to originate from a combination of immunomodulatory and neuroprotective mechanisms. We aimed to clarify whether neuroprotective concentrations of dimethyl fumarate have immunomodulatory effects...
  7. pmc Modulation of multiple pathways involved in the maintenance of neuronal function during aging by fisetin
    Pamela Maher
    The Salk Institute for Biological Studies, 10010 N Torrey Pines Rd, La Jolla, CA, 92037, USA
    Genes Nutr 4:297-307. 2009
    ..This wide range of actions suggests that fisetin has the ability to reduce the age-related decline in brain function...
  8. doi request reprint Methylglyoxal, advanced glycation end products and autism: is there a connection?
    P Maher
    The Salk Institute for Biological Studies, 10010 N Torrey Pines Rd, La Jolla, CA 92037, USA
    Med Hypotheses 78:548-52. 2012
    ..If future research supports this hypothesis, then by reducing the exposure to these diet-derived factors, it might be possible to decrease the prevalence of at least a subset of autism cases...
  9. pmc Flavonoid fisetin promotes ERK-dependent long-term potentiation and enhances memory
    Pamela Maher
    The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 103:16568-73. 2006
    ..Together, these data demonstrate that the natural product fisetin can facilitate long-term memory, and therefore it may be useful for treating patients with memory disorders...
  10. pmc A novel approach to screening for new neuroprotective compounds for the treatment of stroke
    Pamela Maher
    The Salk Institute for Biological Studies, 10010 N Torrey Pines Rd, La Jolla, CA 92037, USA
    Brain Res 1173:117-25. 2007
    ..Fisetin significantly reduced the behavioral deficits following a stroke, providing proof of principle for this novel approach to identifying new compounds for the treatment of stroke...
  11. ncbi request reprint Flavonoids protect retinal ganglion cells from ischemia in vitro
    Pamela Maher
    The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Exp Eye Res 86:366-74. 2008
    ..In contrast, classical antioxidants had only a very modest effect on IAA-induced cell death. These results suggest that specific flavonoids may be useful in preventing ischemia-induced retinal ganglion cell death in vivo...
  12. ncbi request reprint Redox control of neural function: background, mechanisms, and significance
    Pamela Maher
    The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Antioxid Redox Signal 8:1941-70. 2006
    ..The sum of these effects will determine how changes in the redox environment alter overall cellular function, thereby playing a fundamental role in regulating neural cell fate and physiology...
  13. pmc Proteasome inhibitors prevent oxidative stress-induced nerve cell death by a novel mechanism
    Pamela Maher
    The Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037, United States
    Biochem Pharmacol 75:1994-2006. 2008
    ..These data suggest that low concentrations of proteasome inhibitors induce a moderate level of mitochondrial oxidative stress which results in the activation of neuroprotective pathways...
  14. doi request reprint The flavonoid fisetin promotes nerve cell survival from trophic factor withdrawal by enhancement of proteasome activity
    Pamela Maher
    The Salk Institute for Biological Studies, Cellular Neurobiology, 10010 N Torrey Pines Road, La Jolla, CA 92037, USA
    Arch Biochem Biophys 476:139-44. 2008
    ..Consistent with this observation, fisetin increased proteasome activity. Together these results demonstrate a new activity for fisetin and tie this activity to its neurotrophic effects...
  15. ncbi request reprint A comparison of the neurotrophic activities of the flavonoid fisetin and some of its derivatives
    Pamela Maher
    The Salk Institute, 10010 N Torrey Pines Road, La Jolla, CA 92037, USA
    Free Radic Res 40:1105-11. 2006
    ..Many of these related compounds also promote nerve cell differentiation and are neuroprotective against toxic oxidative insults. However, the mechanisms underlying these neurotrophic effects differ among the compounds...
  16. ncbi request reprint Flavonoids protect retinal ganglion cells from oxidative stress-induced death
    Pamela Maher
    Salk Institute, La Jolla, California 92037, USA
    Invest Ophthalmol Vis Sci 46:4796-803. 2005
    ..The purpose of this study was to determine whether flavonoids, natural products that are abundant in fruits and vegetables, can protect retinal ganglion cells from oxidative stress-induced death...
  17. pmc ERK activation by the polyphenols fisetin and resveratrol provides neuroprotection in multiple models of Huntington's disease
    Pamela Maher
    Department of Cellular Neurobiology, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Hum Mol Genet 20:261-70. 2011
    ..Thus, fisetin, resveratrol and related compounds might be useful for the treatment of HD by virtue of their unique ability to activate ERK...
  18. doi request reprint Metabolic links between diabetes and Alzheimer's disease
    Pamela A Maher
    Cellular Neurobiology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037 1099, USA
    Expert Rev Neurother 9:617-30. 2009
    ..It is therefore likely that the only successful therapy will involve the use of drugs with multiple targets in concert with changes in diet and lifestyle...
  19. ncbi request reprint The molecular basis of oxidative stress-induced cell death in an immortalized retinal ganglion cell line
    Pamela Maher
    Department of Cell Biology, The Scripps Research Institute, La Jolla, CA, USA
    Invest Ophthalmol Vis Sci 46:749-57. 2005
    ..To characterize the molecular basis of oxidative stress-induced death, a process that has been implicated in several chronic eye diseases, in RGC-5 cells, an immortalized retinal ganglion cell (RGC) line...
  20. pmc Fisetin lowers methylglyoxal dependent protein glycation and limits the complications of diabetes
    Pamela Maher
    Cellular Neurobiology Laboratory, The Salk Institute for Biological Studies, La Jolla, California, United States of America
    PLoS ONE 6:e21226. 2011
    ..Therefore, fisetin or a synthetic derivative may have potential therapeutic use for the treatment of diabetic complications...
  21. pmc Glutathione production is regulated via distinct pathways in stressed and non-stressed cortical neurons
    Joseph Burdo
    The Salk Institute for Biological Studies, Cellular Neurobiology Laboratory, 10010 N Torrey Pines Rd, La Jolla, CA 92037, USA
    Brain Res 1189:12-22. 2008
    ..Together, these results demonstrate that distinct signaling pathways modulate GSH metabolism in unstressed and stressed cortical neurons...
  22. ncbi request reprint Flavonoids protect human retinal pigment epithelial cells from oxidative-stress-induced death
    Anne Hanneken
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
    Invest Ophthalmol Vis Sci 47:3164-77. 2006
    ..To determine whether specific dietary and synthetic flavonoids can protect human retinal pigment epithelial (RPE) cells from oxidative-stress-induced death...
  23. pmc Modulation of 5-lipoxygenase in proteotoxicity and Alzheimer's disease
    Elvira Valera
    The Salk Institute for Biological Studies, La Jolla, California 92037 1002, USA
    J Neurosci 33:10512-25. 2013
    ..Therefore, 5-LOX metabolism is a key element in the promotion of endoplasmic reticulum dysfunction, and its inhibition under conditions of stress is sufficient to reduce proteotoxicity both in vivo and in vitro...
  24. pmc Delayed treatment with a novel neurotrophic compound reduces behavioral deficits in rabbit ischemic stroke
    Paul A Lapchak
    Cedars Sinai Medical Center, Department of Neurology, Burns and Allen Research Institute, Los Angeles, California, USA
    J Neurochem 116:122-31. 2011
    ..On the basis of its in vivo efficacy and novel mode of action, we conclude that CNB-001 has a great potential for the treatment of ischemic stroke as well as other CNS pathologies...
  25. pmc The flavonoid, eriodictyol, induces long-term protection in ARPE-19 cells through its effects on Nrf2 activation and phase 2 gene expression
    Jennifer Johnson
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
    Invest Ophthalmol Vis Sci 50:2398-406. 2009
    ..The present study sought to determine whether eriodictyol-induced phase 2 protein expression further enhances the resistance of human ARPE-19 cells to oxidative stress...
  26. ncbi request reprint Induction of PC12 cell differentiation by flavonoids is dependent upon extracellular signal-regulated kinase activation
    Yutaka Sagara
    Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Neurochem 90:1144-55. 2004
    ..These results suggest that the consumption of specific flavonoids could have further beneficial effects on nerve cells following injury, in pathological conditions or in normal aging...
  27. ncbi request reprint The regulation of glucose metabolism by HIF-1 mediates a neuroprotective response to amyloid beta peptide
    Thomas Soucek
    The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Neuron 39:43-56. 2003
    ..As a result of Abeta-induced changes in glucose metabolism, Abeta-resistant cells are more readily killed by glucose starvation and by classes of antipsychotic drugs that inhibit glucose uptake...
  28. ncbi request reprint The effects of stress and aging on glutathione metabolism
    Pamela Maher
    The Salk Institute, 10010 N Torrey Pines Rd, La Jolla, CA 92037, USA
    Ageing Res Rev 4:288-314. 2005
    ..The evidence for such a decline is strongest in the brain where glutathione loss is implicated in both Parkinson's disease and in neuronal injury following stroke...
  29. pmc Neural cells secrete a unique repertoire of proteins
    David Schubert
    The Salk Institute for Biological Studies, La Jolla, California 92037 1099, USA
    J Neurochem 109:427-35. 2009
    ..In addition, many proteolytic enzymes are found outside of the cell. These data show that the extracellular space within the nervous system has a more diverse protein composition than previously thought...
  30. pmc Basal levels of eIF2alpha phosphorylation determine cellular antioxidant status by regulating ATF4 and xCT expression
    Jan Lewerenz
    Cellular Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Biol Chem 284:1106-15. 2009
    ....
  31. ncbi request reprint Uncoupling protein 2 protects dopaminergic neurons from acute 1,2,3,6-methyl-phenyl-tetrahydropyridine toxicity
    Bruno Conti
    Harold L Dorris Neurological Research Center, Scripps Research Institute, La Jolla, California 92037, USA
    J Neurochem 93:493-501. 2005
    ..Our data suggest that UCP2 may represent a drug target for slowing the progression of Parkinson's disease...
  32. ncbi request reprint Inhibition of cell migration and angiogenesis by the amino-terminal fragment of 24kD basic fibroblast growth factor
    Lan Ding
    La Jolla Institute for Molecular Medicine, San Diego, CA 92121, USA
    J Biol Chem 277:31056-61. 2002
    ..These studies demonstrate that the amino-terminal end of 24kD basic fibroblast growth factor is responsible for an activity that inhibits the migration rates of cultured cells as well as the angiogenic response in vivo...