Research Topics
Species | Pamela A MaherSummaryAffiliation: The Salk Institute Country: USA Publications
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Detail Information
Publications
Phorbol esters inhibit fibroblast growth factor-2-stimulated fibroblast proliferation by a p38 MAP kinase dependent pathwayPamela Maher
Department of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California, CA 92037, USA
Oncogene 21:1978-88. 2002..These data indicate that the effects of TPA treatment on cellular function are not only cell type but also stimulus specific and are dependent upon the distinct pathways activated downstream of each stimulus...- Tyrphostins protect neuronal cells from oxidative stressYutaka Sagara
Department of Neurosciences, University of California, San Diego, La Jolla, California 92093 0624, USA
J Biol Chem 277:36204-15. 2002..Therefore, the effects of tyrphostins on cells are not limited to their ability to inhibit tyrosine kinases... 
A broadly neuroprotective derivative of curcuminYuanbin Liu
The Salk Institute, Laboratories for Cellular Neurobiology, La Jolla, California 92037 1099, USA
J Neurochem 105:1336-45. 2008..While the creation of CNB-001 was based upon an uncommon approach to drug design, it has the potential of a lead drug candidate for treating multiple conditions involving nerve cell death...- A pyrazole derivative of curcumin enhances memoryPamela Maher
The Salk Institute, Laboratories for Cellular Neurobiology, 10010 North Torrey Pines Road, La Jolla, CA 92037 1099, USA
Neurobiol Aging 31:706-9. 2010..It is shown that CNB-001 enhances both LTP and memory... 
A novel approach to enhancing cellular glutathione levelsPamela Maher
The Salk Institute, La Jolla, California 92037, USA
J Neurochem 107:690-700. 2008..Thus, these novel EC conjugates have the potential to enhance GSH synthesis under a wide variety of forms of toxic stress...- Modulation of multiple pathways involved in the maintenance of neuronal function during aging by fisetinPamela Maher
The Salk Institute for Biological Studies, 10010 N Torrey Pines Rd, La Jolla, CA, 92037, USA
Genes Nutr 4:297-307. 2009..This wide range of actions suggests that fisetin has the ability to reduce the age-related decline in brain function... - Methylglyoxal, advanced glycation end products and autism: is there a connection?P Maher
The Salk Institute for Biological Studies, 10010 N Torrey Pines Rd, La Jolla, CA 92037, USA
Med Hypotheses 78:548-52. 2012..If future research supports this hypothesis, then by reducing the exposure to these diet-derived factors, it might be possible to decrease the prevalence of at least a subset of autism cases... - A novel approach to screening for new neuroprotective compounds for the treatment of strokePamela Maher
The Salk Institute for Biological Studies, 10010 N Torrey Pines Rd, La Jolla, CA 92037, USA
Brain Res 1173:117-25. 2007..Fisetin significantly reduced the behavioral deficits following a stroke, providing proof of principle for this novel approach to identifying new compounds for the treatment of stroke... - Flavonoids protect retinal ganglion cells from ischemia in vitroPamela Maher
The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
Exp Eye Res 86:366-74. 2008..In contrast, classical antioxidants had only a very modest effect on IAA-induced cell death. These results suggest that specific flavonoids may be useful in preventing ischemia-induced retinal ganglion cell death in vivo... - Proteasome inhibitors prevent oxidative stress-induced nerve cell death by a novel mechanismPamela Maher
The Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037, United States
Biochem Pharmacol 75:1994-2006. 2008..These data suggest that low concentrations of proteasome inhibitors induce a moderate level of mitochondrial oxidative stress which results in the activation of neuroprotective pathways... - The flavonoid fisetin promotes nerve cell survival from trophic factor withdrawal by enhancement of proteasome activityPamela Maher
The Salk Institute for Biological Studies, Cellular Neurobiology, 10010 N Torrey Pines Road, La Jolla, CA 92037, USA
Arch Biochem Biophys 476:139-44. 2008..Consistent with this observation, fisetin increased proteasome activity. Together these results demonstrate a new activity for fisetin and tie this activity to its neurotrophic effects... - Metabolic links between diabetes and Alzheimer's diseasePamela A Maher
Cellular Neurobiology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037 1099, USA
Expert Rev Neurother 9:617-30. 2009..It is therefore likely that the only successful therapy will involve the use of drugs with multiple targets in concert with changes in diet and lifestyle... - ERK activation by the polyphenols fisetin and resveratrol provides neuroprotection in multiple models of Huntington's diseasePamela Maher
Department of Cellular Neurobiology, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
Hum Mol Genet 20:261-70. 2011..Thus, fisetin, resveratrol and related compounds might be useful for the treatment of HD by virtue of their unique ability to activate ERK... - Fisetin lowers methylglyoxal dependent protein glycation and limits the complications of diabetesPamela Maher
Cellular Neurobiology Laboratory, The Salk Institute for Biological Studies, La Jolla, California, United States of America
PLoS ONE 6:e21226. 2011..Therefore, fisetin or a synthetic derivative may have potential therapeutic use for the treatment of diabetic complications... - Flavonoid fisetin promotes ERK-dependent long-term potentiation and enhances memoryPamela Maher
The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
Proc Natl Acad Sci U S A 103:16568-73. 2006..Together, these data demonstrate that the natural product fisetin can facilitate long-term memory, and therefore it may be useful for treating patients with memory disorders... - Redox control of neural function: background, mechanisms, and significancePamela Maher
The Salk Institute for Biological Studies, La Jolla, California 92037, USA
Antioxid Redox Signal 8:1941-70. 2006..The sum of these effects will determine how changes in the redox environment alter overall cellular function, thereby playing a fundamental role in regulating neural cell fate and physiology... - The molecular basis of oxidative stress-induced cell death in an immortalized retinal ganglion cell linePamela Maher
Department of Cell Biology, The Scripps Research Institute, La Jolla, CA, USA
Invest Ophthalmol Vis Sci 46:749-57. 2005..To characterize the molecular basis of oxidative stress-induced death, a process that has been implicated in several chronic eye diseases, in RGC-5 cells, an immortalized retinal ganglion cell (RGC) line... - Flavonoids protect retinal ganglion cells from oxidative stress-induced deathPamela Maher
Salk Institute, La Jolla, California 92037, USA
Invest Ophthalmol Vis Sci 46:4796-803. 2005..The purpose of this study was to determine whether flavonoids, natural products that are abundant in fruits and vegetables, can protect retinal ganglion cells from oxidative stress-induced death... - A comparison of the neurotrophic activities of the flavonoid fisetin and some of its derivativesPamela Maher
The Salk Institute, 10010 N Torrey Pines Road, La Jolla, CA 92037, USA
Free Radic Res 40:1105-11. 2006..Many of these related compounds also promote nerve cell differentiation and are neuroprotective against toxic oxidative insults. However, the mechanisms underlying these neurotrophic effects differ among the compounds... - Glutathione production is regulated via distinct pathways in stressed and non-stressed cortical neuronsJoseph Burdo
The Salk Institute for Biological Studies, Cellular Neurobiology Laboratory, 10010 N Torrey Pines Rd, La Jolla, CA 92037, USA
Brain Res 1189:12-22. 2008..Together, these results demonstrate that distinct signaling pathways modulate GSH metabolism in unstressed and stressed cortical neurons... - Flavonoids protect human retinal pigment epithelial cells from oxidative-stress-induced deathAnne Hanneken
Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
Invest Ophthalmol Vis Sci 47:3164-77. 2006..To determine whether specific dietary and synthetic flavonoids can protect human retinal pigment epithelial (RPE) cells from oxidative-stress-induced death... - The flavonoid, eriodictyol, induces long-term protection in ARPE-19 cells through its effects on Nrf2 activation and phase 2 gene expressionJennifer Johnson
Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
Invest Ophthalmol Vis Sci 50:2398-406. 2009..The present study sought to determine whether eriodictyol-induced phase 2 protein expression further enhances the resistance of human ARPE-19 cells to oxidative stress... - The regulation of glucose metabolism by HIF-1 mediates a neuroprotective response to amyloid beta peptideThomas Soucek
The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
Neuron 39:43-56. 2003..As a result of Abeta-induced changes in glucose metabolism, Abeta-resistant cells are more readily killed by glucose starvation and by classes of antipsychotic drugs that inhibit glucose uptake... - Induction of PC12 cell differentiation by flavonoids is dependent upon extracellular signal-regulated kinase activationYutaka Sagara
Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA
J Neurochem 90:1144-55. 2004..These results suggest that the consumption of specific flavonoids could have further beneficial effects on nerve cells following injury, in pathological conditions or in normal aging... - Delayed treatment with a novel neurotrophic compound reduces behavioral deficits in rabbit ischemic strokePaul A Lapchak
Cedars Sinai Medical Center, Department of Neurology, Burns and Allen Research Institute, Los Angeles, California, USA
J Neurochem 116:122-31. 2011..On the basis of its in vivo efficacy and novel mode of action, we conclude that CNB-001 has a great potential for the treatment of ischemic stroke as well as other CNS pathologies... - The effects of stress and aging on glutathione metabolismPamela Maher
The Salk Institute, 10010 N. Torrey Pines Rd, La Jolla, CA 92037, USA
Ageing Res Rev 4:288-314. 2005..The evidence for such a decline is strongest in the brain where glutathione loss is implicated in both Parkinson's disease and in neuronal injury following stroke... - Neural cells secrete a unique repertoire of proteinsDavid Schubert
The Salk Institute for Biological Studies, La Jolla, California 92037 1099, USA
J Neurochem 109:427-35. 2009..In addition, many proteolytic enzymes are found outside of the cell. These data show that the extracellular space within the nervous system has a more diverse protein composition than previously thought... - Uncoupling protein 2 protects dopaminergic neurons from acute 1,2,3,6-methyl-phenyl-tetrahydropyridine toxicityBruno Conti
Harold L Dorris Neurological Research Center, Scripps Research Institute, La Jolla, California 92037, USA
J Neurochem 93:493-501. 2005..Our data suggest that UCP2 may represent a drug target for slowing the progression of Parkinson's disease... - Basal levels of eIF2alpha phosphorylation determine cellular antioxidant status by regulating ATF4 and xCT expressionJan Lewerenz
Cellular Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037, USA
J Biol Chem 284:1106-15. 2009.... - Inhibition of cell migration and angiogenesis by the amino-terminal fragment of 24kD basic fibroblast growth factorLan Ding
La Jolla Institute for Molecular Medicine, San Diego, CA 92121, USA
J Biol Chem 277:31056-61. 2002..These studies demonstrate that the amino-terminal end of 24kD basic fibroblast growth factor is responsible for an activity that inhibits the migration rates of cultured cells as well as the angiogenic response in vivo...