- Sequence variation in ligand binding sites in proteinsThomas J Magliery
Department of Molecular Biophysics and Biochemistry, Yale University, PO Box 208114, New Haven, CT 06520 8114, USA
BMC Bioinformatics 6:240. 2005..In contrast, little attention has been given to the meaning of poorly-conserved sites in families of proteins, which are typically assumed to be of little structural or functional importance...
- Protein stability by number: high-throughput and statistical approaches to one of protein science's most difficult problemsThomas J Magliery
Department of Chemistry, The Ohio State University, 100 West 18th Avenue, Columbus, OH 43210, USA
Curr Opin Chem Biol 15:443-51. 2011..Protein engineering based on statistical analysis (consensus and correlated occurrences of amino acids) is promising, but much work remains to understand and implement these methods...
- Beyond consensus: statistical free energies reveal hidden interactions in the design of a TPR motifThomas J Magliery
Department of Molecular Biophysics and Biochemistry, Yale University, P O Box 208114, New Haven, CT 06520 8114, USA
J Mol Biol 343:731-45. 2004..Statistical free energy analysis provides a more complete description of "What makes a TPR a TPR?" than consensus alone, and it suggests general approaches to extend and improve the phylogenetic design of proteins...