IAN JOHN MACRAE

Summary

Affiliation: The Scripps Research Institute
Country: USA

Publications

  1. pmc In vitro reconstitution of the human RISC-loading complex
    Ian J Macrae
    Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 105:512-7. 2008
  2. pmc Single-pot enzymatic synthesis of Dicer-substrate siRNAs
    Keelan Z Guiley
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA, USA
    Nucleic Acids Res 40:e40. 2012
  3. pmc Preparation and characterization of the extracellular domain of human Sid-1
    Ashley J Pratt
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, California, United States of America
    PLoS ONE 7:e33607. 2012

Research Grants

Collaborators

Detail Information

Publications3

  1. pmc In vitro reconstitution of the human RISC-loading complex
    Ian J Macrae
    Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 105:512-7. 2008
    ..Furthermore, once Ago2 is loaded with an miRNA, it tends to dissociate from the rest of the complex. These results lay the groundwork for future structural and functional dissection of RISC loading in humans...
  2. pmc Single-pot enzymatic synthesis of Dicer-substrate siRNAs
    Keelan Z Guiley
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA, USA
    Nucleic Acids Res 40:e40. 2012
    ..The overall reaction is simple, can be carried out in any laboratory with access to a PCR machine, and is amenable to high-throughput processes...
  3. pmc Preparation and characterization of the extracellular domain of human Sid-1
    Ashley J Pratt
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, California, United States of America
    PLoS ONE 7:e33607. 2012
    ..These characterizations provide inroads towards understanding the mechanism of this unique RNA transport system from structural prospective...

Research Grants4

  1. Structure and Mechanism of the RISC-loading Complex
    IAN JOHN MACRAE; Fiscal Year: 2010
    ..Results will contribute to on-going efforts to harness the RNAi process as a powerful new type of therapeutic for the treatment of human disease. ..
  2. Structure and Mechanism of the RISC-loading Complex
    IAN MACRAE; Fiscal Year: 2009
    ..Results will contribute to on-going efforts to harness the RNAi process as a powerful new type of therapeutic for the treatment of human disease. ..
  3. Structure and Mechanism of the RISC-loading Complex
    IAN JOHN MACRAE; Fiscal Year: 2011
    ..Results will contribute to on-going efforts to harness the RNAi process as a powerful new type of therapeutic for the treatment of human disease. ..
  4. Structure and Mechanism of the RISC-loading Complex
    IAN MACRAE; Fiscal Year: 2009
    ..Results will contribute to on-going efforts to harness the RNAi process as a powerful new type of therapeutic for the treatment of human disease. ..