R MacKinnon

Summary

Affiliation: The Rockefeller University
Country: USA

Publications

  1. ncbi request reprint Structural conservation in prokaryotic and eukaryotic potassium channels
    R MacKinnon
    Laboratory of Molecular Neurobiology and Biophysics and the Howard Hughes Medical Institute, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Science 280:106-9. 1998
  2. ncbi request reprint The structure of the potassium channel: molecular basis of K+ conduction and selectivity
    D A Doyle
    Laboratory of Molecular Neurobiology and Biophysics and the Howard Hughes Medical Institute, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Science 280:69-77. 1998
  3. ncbi request reprint Energetic and structural interactions between delta-dendrotoxin and a voltage-gated potassium channel
    J P Imredy
    Howard Hughes Medical Institute, Laboratory of Molecular Neurobiology and Biophysics, New York, NY 10021, USA
    J Mol Biol 296:1283-94. 2000
  4. ncbi request reprint Structure of the RCK domain from the E. coli K+ channel and demonstration of its presence in the human BK channel
    Y Jiang
    Laboratory of Molecular Neurobiology and Biophysics, Rockefeller University, New York, NY 10021, USA
    Neuron 29:593-601. 2001
  5. ncbi request reprint Crystal structure and functional analysis of the HERG potassium channel N terminus: a eukaryotic PAS domain
    J H Morais Cabral
    Laboratory of Molecular Neurobiology and Biophysics, Rockefeller University, New York, New York 10021, USA
    Cell 95:649-55. 1998
  6. ncbi request reprint Structure of the cytoplasmic beta subunit-T1 assembly of voltage-dependent K+ channels
    J M Gulbis
    Howard Hughes Medical Institute and Laboratory of Molecular Neurobiology and Biophysics, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Science 289:123-7. 2000

Collaborators

  • A G Lee
  • M Li
  • M Zhou
  • J M Gulbis
  • B T Chait
  • Y Jiang
  • J P Imredy
  • D A Doyle
  • S L Cohen
  • J H Morais Cabral
  • M Cadene
  • A Pico
  • S Mann
  • J Morais Cabral
  • R A Pfuetzner
  • A Kuo

Detail Information

Publications8

  1. ncbi request reprint Structural conservation in prokaryotic and eukaryotic potassium channels
    R MacKinnon
    Laboratory of Molecular Neurobiology and Biophysics and the Howard Hughes Medical Institute, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Science 280:106-9. 1998
    ..The results show that a prokaryotic K+ channel has the same pore structure as eukaryotic K+ channels. This structural conservation, through application of techniques presented here, offers a new approach for K+ channel pharmacology...
  2. ncbi request reprint The structure of the potassium channel: molecular basis of K+ conduction and selectivity
    D A Doyle
    Laboratory of Molecular Neurobiology and Biophysics and the Howard Hughes Medical Institute, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Science 280:69-77. 1998
    ..The architecture of the pore establishes the physical principles underlying selective K+ conduction...
  3. ncbi request reprint Energetic and structural interactions between delta-dendrotoxin and a voltage-gated potassium channel
    J P Imredy
    Howard Hughes Medical Institute, Laboratory of Molecular Neurobiology and Biophysics, New York, NY 10021, USA
    J Mol Biol 296:1283-94. 2000
    ..These results constrain the possible orientation of dendrotoxin with respect to the K(+) channel structure. We propose that dendrotoxin binds near the pore entryway but does not act as a physical plug...
  4. ncbi request reprint Structure of the RCK domain from the E. coli K+ channel and demonstration of its presence in the human BK channel
    Y Jiang
    Laboratory of Molecular Neurobiology and Biophysics, Rockefeller University, New York, NY 10021, USA
    Neuron 29:593-601. 2001
    ....
  5. ncbi request reprint Crystal structure and functional analysis of the HERG potassium channel N terminus: a eukaryotic PAS domain
    J H Morais Cabral
    Laboratory of Molecular Neurobiology and Biophysics, Rockefeller University, New York, New York 10021, USA
    Cell 95:649-55. 1998
    ..The presence of the domain attached to the channel slows the rate of deactivation. Given the roles of PAS domains in biology, we propose that the HERG N-terminal domain has a regulatory function...
  6. ncbi request reprint Structure of the cytoplasmic beta subunit-T1 assembly of voltage-dependent K+ channels
    J M Gulbis
    Howard Hughes Medical Institute and Laboratory of Molecular Neurobiology and Biophysics, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Science 289:123-7. 2000
    ..The inactivation peptides of voltage-dependent K(+) channels reach their site of action by entering these openings...