Affiliation: The Rockefeller University
Li M, Macdonald M. Polyamines: Small Molecules with a Big Role in Promoting Virus Infection. Cell Host Microbe. 2016;20:123-4 pubmed publisher
..2016) link polyamine metabolism to the interferon response and demonstrate proviral effects for polyamines. The study points to the pathway as a potential novel pan-viral therapeutic target. ..
Macdonald M, Machlin E, Albin O, Levy D. The zinc finger antiviral protein acts synergistically with an interferon-induced factor for maximal activity against alphaviruses. J Virol. 2007;81:13509-18 pubmed
..Our findings demonstrate that ZAP can synergize with another IFN-induced factor(s) for maximal antiviral activity and that ZAP's intrinsic antiviral activity on virion production and cell survival can have cell-type-specific outcomes. ..
Bozzacco L, Yi Z, Andreo U, Conklin C, Li M, Rice C, et al
. Chaperone-Assisted Protein Folding Is Critical for Yellow Fever Virus NS3/4A Cleavage and Replication. J Virol. 2016;90:3212-28 pubmed publisher
Li M, Bozzacco L, Hoffmann H, Breton G, Loschko J, Xiao J, et al
. Interferon regulatory factor 2 protects mice from lethal viral neuroinvasion. J Exp Med. 2016;213:2931-2947 pubmed
..The work advances our understanding of host mechanisms that affect viral neuroinvasion and their contribution to immunity against CNS infections. ..
Robbiani D, Bozzacco L, Keeffe J, Khouri R, Olsen P, Gazumyan A, et al
. Recurrent Potent Human Neutralizing Antibodies to Zika Virus in Brazil and Mexico. Cell. 2017;169:597-609.e11 pubmed publisher
..Serologic testing shows that antibodies to this region correlate with serum neutralizing activity to ZIKV. Thus, high neutralizing responses to ZIKV are associated with pre-existing reactivity to DENV1 in humans. ..