Zhengyu Ma

Summary

Affiliation: The Children's Hospital of Philadelphia
Country: USA

Publications

  1. ncbi Improved method of preparation of supported planar lipid bilayers as artificial membranes for antigen presentation
    Zhengyu Ma
    Division of Rheumatology, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Microsc Res Tech 74:1174-85. 2011
  2. ncbi The receptor deformation model of TCR triggering
    Zhengyu Ma
    Department of Pediatrics, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    FASEB J 22:1002-8. 2008
  3. ncbi Surface-anchored monomeric agonist pMHCs alone trigger TCR with high sensitivity
    Zhengyu Ma
    Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
    PLoS Biol 6:e43. 2008
  4. ncbi T cell receptor triggering by force
    Zhengyu Ma
    Department of Pediatrics, The Children s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA 19104, USA
    Trends Immunol 31:1-6. 2010
  5. ncbi Effective gene suppression using small interfering RNA in hard-to-transfect human T cells
    Jiyi Yin
    Division of Rheumatology, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA
    J Immunol Methods 312:1-11. 2006
  6. ncbi Complement receptor 3 ligation of dendritic cells suppresses their stimulatory capacity
    Edward M Behrens
    Laboratory of Dendritic Cell Biology, Joseph Stokes, Jr Research Institute, Children s Hospital of Philadelphia, and Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4318, USA
    J Immunol 178:6268-79. 2007
  7. ncbi Ligation of CD28 by its natural ligand CD86 in the absence of TCR stimulation induces lipid raft polarization in human CD4 T cells
    Birgit Kovacs
    Division of Rheumatology, Children s Hospital of Philadelphia, and Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Immunol 175:7848-54. 2005

Collaborators

Detail Information

Publications7

  1. ncbi Improved method of preparation of supported planar lipid bilayers as artificial membranes for antigen presentation
    Zhengyu Ma
    Division of Rheumatology, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Microsc Res Tech 74:1174-85. 2011
    ..The newly expanded pristine bilayer showed high degrees of stability, homogeneity, and fluidity. MHC and ICAM-1 molecules anchored on the bilayer diffused freely and stimulated T cell calcium flux and adhesion, respectively...
  2. ncbi The receptor deformation model of TCR triggering
    Zhengyu Ma
    Department of Pediatrics, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    FASEB J 22:1002-8. 2008
    ..By introducing mechanical force into a model of T cell signal initiation, the receptor deformation model provides potential mechanistic solutions to the sensitivity and specificity of TCR triggering...
  3. ncbi Surface-anchored monomeric agonist pMHCs alone trigger TCR with high sensitivity
    Zhengyu Ma
    Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
    PLoS Biol 6:e43. 2008
    ..Based on these observations, we propose the receptor deformation model of TCR triggering to explain the remarkable sensitivity and specificity of TCR triggering...
  4. ncbi T cell receptor triggering by force
    Zhengyu Ma
    Department of Pediatrics, The Children s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA 19104, USA
    Trends Immunol 31:1-6. 2010
    ..The receptor deformation model, for the first time, explains all three aspects of the TCR triggering puzzle: mechanism, specificity, and sensitivity...
  5. ncbi Effective gene suppression using small interfering RNA in hard-to-transfect human T cells
    Jiyi Yin
    Division of Rheumatology, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA
    J Immunol Methods 312:1-11. 2006
    ..These studies demonstrate that the combination of SEC, siRNA expression vectors and Nucleofector technology can be successfully applied to hard-to-transfect human T cell lines and primary T cells to effectively silence genes...
  6. ncbi Complement receptor 3 ligation of dendritic cells suppresses their stimulatory capacity
    Edward M Behrens
    Laboratory of Dendritic Cell Biology, Joseph Stokes, Jr Research Institute, Children s Hospital of Philadelphia, and Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4318, USA
    J Immunol 178:6268-79. 2007
    ..We propose that CR3 provides a "nondanger" signal that suppresses the stimulatory capacity of DCs...
  7. ncbi Ligation of CD28 by its natural ligand CD86 in the absence of TCR stimulation induces lipid raft polarization in human CD4 T cells
    Birgit Kovacs
    Division of Rheumatology, Children s Hospital of Philadelphia, and Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Immunol 175:7848-54. 2005
    ..This result has implications for mechanisms of T cell activation. Abnormalities in this process may alter T and B cell tolerance and susceptibility to infection...