Zhengyu Ma

Summary

Affiliation: The Children's Hospital of Philadelphia
Country: USA

Publications

  1. doi Improved method of preparation of supported planar lipid bilayers as artificial membranes for antigen presentation
    Zhengyu Ma
    Division of Rheumatology, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Microsc Res Tech 74:1174-85. 2011
  2. pmc The receptor deformation model of TCR triggering
    Zhengyu Ma
    Department of Pediatrics, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    FASEB J 22:1002-8. 2008
  3. pmc Surface-anchored monomeric agonist pMHCs alone trigger TCR with high sensitivity
    Zhengyu Ma
    Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
    PLoS Biol 6:e43. 2008
  4. pmc T cell receptor triggering by force
    Zhengyu Ma
    Department of Pediatrics, The Children s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA 19104, USA
    Trends Immunol 31:1-6. 2010
  5. ncbi Effective gene suppression using small interfering RNA in hard-to-transfect human T cells
    Jiyi Yin
    Division of Rheumatology, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    J Immunol Methods 312:1-11. 2006
  6. ncbi Complement receptor 3 ligation of dendritic cells suppresses their stimulatory capacity
    Edward M Behrens
    Laboratory of Dendritic Cell Biology, Joseph Stokes, Jr Research Institute, Children s Hospital of Philadelphia, and Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4318, USA
    J Immunol 178:6268-79. 2007
  7. pmc Strength of PD-1 signaling differentially affects T-cell effector functions
    Fang Wei
    Department of Microbiology and Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 110:E2480-9. 2013
  8. ncbi Ligation of CD28 by its natural ligand CD86 in the absence of TCR stimulation induces lipid raft polarization in human CD4 T cells
    Birgit Kovacs
    Division of Rheumatology, Children s Hospital of Philadelphia, and Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Immunol 175:7848-54. 2005

Collaborators

Detail Information

Publications8

  1. doi Improved method of preparation of supported planar lipid bilayers as artificial membranes for antigen presentation
    Zhengyu Ma
    Division of Rheumatology, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Microsc Res Tech 74:1174-85. 2011
    ..The newly expanded pristine bilayer showed high degrees of stability, homogeneity, and fluidity. MHC and ICAM-1 molecules anchored on the bilayer diffused freely and stimulated T cell calcium flux and adhesion, respectively...
  2. pmc The receptor deformation model of TCR triggering
    Zhengyu Ma
    Department of Pediatrics, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    FASEB J 22:1002-8. 2008
    ..By introducing mechanical force into a model of T cell signal initiation, the receptor deformation model provides potential mechanistic solutions to the sensitivity and specificity of TCR triggering...
  3. pmc Surface-anchored monomeric agonist pMHCs alone trigger TCR with high sensitivity
    Zhengyu Ma
    Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
    PLoS Biol 6:e43. 2008
    ..Based on these observations, we propose the receptor deformation model of TCR triggering to explain the remarkable sensitivity and specificity of TCR triggering...
  4. pmc T cell receptor triggering by force
    Zhengyu Ma
    Department of Pediatrics, The Children s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA 19104, USA
    Trends Immunol 31:1-6. 2010
    ..The receptor deformation model, for the first time, explains all three aspects of the TCR triggering puzzle: mechanism, specificity, and sensitivity...
  5. ncbi Effective gene suppression using small interfering RNA in hard-to-transfect human T cells
    Jiyi Yin
    Division of Rheumatology, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    J Immunol Methods 312:1-11. 2006
    ..These studies demonstrate that the combination of SEC, siRNA expression vectors and Nucleofector technology can be successfully applied to hard-to-transfect human T cell lines and primary T cells to effectively silence genes...
  6. ncbi Complement receptor 3 ligation of dendritic cells suppresses their stimulatory capacity
    Edward M Behrens
    Laboratory of Dendritic Cell Biology, Joseph Stokes, Jr Research Institute, Children s Hospital of Philadelphia, and Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4318, USA
    J Immunol 178:6268-79. 2007
    ..We propose that CR3 provides a "nondanger" signal that suppresses the stimulatory capacity of DCs...
  7. pmc Strength of PD-1 signaling differentially affects T-cell effector functions
    Fang Wei
    Department of Microbiology and Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 110:E2480-9. 2013
    ..These findings provide insight into the role of PD-1 expression in enforcing T-cell exhaustion and the therapeutic potential of PD-1 blockade. ..
  8. ncbi Ligation of CD28 by its natural ligand CD86 in the absence of TCR stimulation induces lipid raft polarization in human CD4 T cells
    Birgit Kovacs
    Division of Rheumatology, Children s Hospital of Philadelphia, and Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Immunol 175:7848-54. 2005
    ..This result has implications for mechanisms of T cell activation. Abnormalities in this process may alter T and B cell tolerance and susceptibility to infection...